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The map label for this gene is mro [H]

Identifier: 150008295

GI number: 150008295

Start: 1967017

End: 1968093

Strand: Direct

Name: mro [H]

Synonym: BDI_1664

Alternate gene names: 150008295

Gene position: 1967017-1968093 (Clockwise)

Preceding gene: 150008291

Following gene: 150008296

Centisome position: 40.88

GC content: 45.31

Gene sequence:

>1077_bases
ATGAAGAACATAAATACACTGTCGGGCTTGTCTGTTGCTAACTTCAGCAAGCAAATTGACGGGAAAGAAACGGCGCTTTA
TACCCTGTGTAACAAGGTTGGAGCAGAGCTAGCGATCACGAATTATGGAGCGAAAATCGTCTCACTGATGGTTCCGGATA
AGAACGGAAAAATGACCGATGTCGTTACTGGCCATAATTCGATTGAAGAGTACTTAACATCAGAAGAACCTTATTTCGGT
GCCATTTGCGGTCGTTATGGAAATCGTATCGCCGCTGGAAAATTCACGATCGACGGTATTACTTATGACAAATTAGCCAT
AAATAATGGCCCCAATAGCTTGCATGGCGGAATCAAGGGATTCAATGCGGTCGTATGGGACGCCAAACAAATAGACGAGC
AAACCATTGAGTTGAAATATACCTCCGCCGATGGCGAGGAAGGTTTCCCCGGAGAACTAAAGACAACCGTAACTTATCAT
CTGACAAATGAGAATGAGGTCGTTATCTCCTATCAAGCCTCTACGGACAAACCTACGGTCTTGAATCTAACCAATCATTC
TTATTTTAACCTATCCGGTGCGGGAGACCCTTATATAGGAGACCATATTCTCACGATCAACGCCGACTATTATCTGCCTA
CAGACAATACGGCAATCCCGTACGGACCTAAAGAGAAGGTAGAAGGTACACCGATGGACTTCCGGACTCCTCATGAGGTA
GGCGAACGAATCAATGACAATTTCGAACAGCTTATATTCGGTAAGGGATATGACCACACGTACATATTAAATAAAGAGGA
CAACGAACTTTCTTACTGCGCTCGCTGCTCCTCCCCCAAGACCGGTATCGTAATGGAAACTTATACGACTCAACCGGGCG
TGCAATTATACACAGGTAACTGGATGACTGGGAATTTCGAAGGTAAGAACGGACAACGCTACCCGGAACGGGCCGCTTTA
TGTCTGGAAACCCAACATTTCCCCGATAGCCCCAACAAACCGGAATATCCGACAACGGAACTCCGCCCGGGCGAGGTTTT
CCAAAGTACTACTATTTATAAATTCAGTGTAGAATAA

Upstream 100 bases:

>100_bases
TAGACAAATCTAAAATCATGCTATAAAACATTATTCAGAAAGGTTATAAATACAAAGAAGAAAGTTACTTTTACACGCAA
TTTCAATAATATTGATACGC

Downstream 100 bases:

>100_bases
GAGAATAATTTAAGTAATCTAATAATCTAAAACAACAAAAAAGAAATGGAATCAACAGCAAAAAAGAATTACACATTGCC
TATTATCATGATGGTGGCTC

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MKNINTLSGLSVANFSKQIDGKETALYTLCNKVGAELAITNYGAKIVSLMVPDKNGKMTDVVTGHNSIEEYLTSEEPYFG
AICGRYGNRIAAGKFTIDGITYDKLAINNGPNSLHGGIKGFNAVVWDAKQIDEQTIELKYTSADGEEGFPGELKTTVTYH
LTNENEVVISYQASTDKPTVLNLTNHSYFNLSGAGDPYIGDHILTINADYYLPTDNTAIPYGPKEKVEGTPMDFRTPHEV
GERINDNFEQLIFGKGYDHTYILNKEDNELSYCARCSSPKTGIVMETYTTQPGVQLYTGNWMTGNFEGKNGQRYPERAAL
CLETQHFPDSPNKPEYPTTELRPGEVFQSTTIYKFSVE

Sequences:

>Translated_358_residues
MKNINTLSGLSVANFSKQIDGKETALYTLCNKVGAELAITNYGAKIVSLMVPDKNGKMTDVVTGHNSIEEYLTSEEPYFG
AICGRYGNRIAAGKFTIDGITYDKLAINNGPNSLHGGIKGFNAVVWDAKQIDEQTIELKYTSADGEEGFPGELKTTVTYH
LTNENEVVISYQASTDKPTVLNLTNHSYFNLSGAGDPYIGDHILTINADYYLPTDNTAIPYGPKEKVEGTPMDFRTPHEV
GERINDNFEQLIFGKGYDHTYILNKEDNELSYCARCSSPKTGIVMETYTTQPGVQLYTGNWMTGNFEGKNGQRYPERAAL
CLETQHFPDSPNKPEYPTTELRPGEVFQSTTIYKFSVE
>Mature_358_residues
MKNINTLSGLSVANFSKQIDGKETALYTLCNKVGAELAITNYGAKIVSLMVPDKNGKMTDVVTGHNSIEEYLTSEEPYFG
AICGRYGNRIAAGKFTIDGITYDKLAINNGPNSLHGGIKGFNAVVWDAKQIDEQTIELKYTSADGEEGFPGELKTTVTYH
LTNENEVVISYQASTDKPTVLNLTNHSYFNLSGAGDPYIGDHILTINADYYLPTDNTAIPYGPKEKVEGTPMDFRTPHEV
GERINDNFEQLIFGKGYDHTYILNKEDNELSYCARCSSPKTGIVMETYTTQPGVQLYTGNWMTGNFEGKNGQRYPERAAL
CLETQHFPDSPNKPEYPTTELRPGEVFQSTTIYKFSVE

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=319, Percent_Identity=47.6489028213166, Blast_Score=300, Evalue=2e-81,
Organism=Escherichia coli, GI1786971, Length=342, Percent_Identity=36.8421052631579, Blast_Score=226, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17557428, Length=330, Percent_Identity=31.5151515151515, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI115533334, Length=330, Percent_Identity=31.5151515151515, Blast_Score=173, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6319493, Length=354, Percent_Identity=28.5310734463277, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324399, Length=337, Percent_Identity=29.080118694362, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6322004, Length=359, Percent_Identity=25.3481894150418, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24659048, Length=340, Percent_Identity=37.9411764705882, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24583720, Length=336, Percent_Identity=36.6071428571429, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24668278, Length=354, Percent_Identity=34.4632768361582, Blast_Score=225, Evalue=4e-59,
Organism=Drosophila melanogaster, GI24668282, Length=366, Percent_Identity=31.9672131147541, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24641876, Length=372, Percent_Identity=30.6451612903226, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 39700; Mature: 39700

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNINTLSGLSVANFSKQIDGKETALYTLCNKVGAELAITNYGAKIVSLMVPDKNGKMTD
CCCCCCCCCCEEHHHHHHCCCCHHHHHHHHHHHCCEEEEEECCCEEEEEEECCCCCCEEE
VVTGHNSIEEYLTSEEPYFGAICGRYGNRIAAGKFTIDGITYDKLAINNGPNSLHGGIKG
EEECCHHHHHHHCCCCCEEHHHHHHCCCEEEECEEEECCEEEEEEEECCCCCHHCCCCCC
FNAVVWDAKQIDEQTIELKYTSADGEEGFPGELKTTVTYHLTNENEVVISYQASTDKPTV
CEEEEECHHHCCCEEEEEEEECCCCCCCCCCCEEEEEEEEEECCCEEEEEEECCCCCCEE
LNLTNHSYFNLSGAGDPYIGDHILTINADYYLPTDNTAIPYGPKEKVEGTPMDFRTPHEV
EEECCCCEEEECCCCCCCCCCEEEEEECCEEECCCCCCCCCCCHHCCCCCCCCCCCHHHH
GERINDNFEQLIFGKGYDHTYILNKEDNELSYCARCSSPKTGIVMETYTTQPGVQLYTGN
HHHHCCCHHHEEECCCCCEEEEEECCCCCCHHEEECCCCCCCEEEEEECCCCCCEEEECC
WMTGNFEGKNGQRYPERAALCLETQHFPDSPNKPEYPTTELRPGEVFQSTTIYKFSVE
EEEEEEECCCCCCCCCHHEEEEEECCCCCCCCCCCCCCCCCCCCCEECCEEEEEEEEC
>Mature Secondary Structure
MKNINTLSGLSVANFSKQIDGKETALYTLCNKVGAELAITNYGAKIVSLMVPDKNGKMTD
CCCCCCCCCCEEHHHHHHCCCCHHHHHHHHHHHCCEEEEEECCCEEEEEEECCCCCCEEE
VVTGHNSIEEYLTSEEPYFGAICGRYGNRIAAGKFTIDGITYDKLAINNGPNSLHGGIKG
EEECCHHHHHHHCCCCCEEHHHHHHCCCEEEECEEEECCEEEEEEEECCCCCHHCCCCCC
FNAVVWDAKQIDEQTIELKYTSADGEEGFPGELKTTVTYHLTNENEVVISYQASTDKPTV
CEEEEECHHHCCCEEEEEEEECCCCCCCCCCCEEEEEEEEEECCCEEEEEEECCCCCCEE
LNLTNHSYFNLSGAGDPYIGDHILTINADYYLPTDNTAIPYGPKEKVEGTPMDFRTPHEV
EEECCCCEEEECCCCCCCCCCEEEEEECCEEECCCCCCCCCCCHHCCCCCCCCCCCHHHH
GERINDNFEQLIFGKGYDHTYILNKEDNELSYCARCSSPKTGIVMETYTTQPGVQLYTGN
HHHHCCCHHHEEECCCCCEEEEEECCCCCCHHEEECCCCCCCEEEEEECCCCCCEEEECC
WMTGNFEGKNGQRYPERAALCLETQHFPDSPNKPEYPTTELRPGEVFQSTTIYKFSVE
EEEEEEECCCCCCCCCHHEEEEEECCCCCCCCCCCCCCCCCCCCCEECCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]