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The map label for this gene is hisC [C]

Identifier: 150008101

GI number: 150008101

Start: 1706531

End: 1708348

Strand: Direct

Name: hisC [C]

Synonym: BDI_1465

Alternate gene names: 150008101

Gene position: 1706531-1708348 (Clockwise)

Preceding gene: 150008100

Following gene: 150008102

Centisome position: 35.47

GC content: 37.68

Gene sequence:

>1818_bases
ATGCAAGCGATCATATTAGCGGCAGGCATGGGCAAACGCCTTAAAGAGTTGACAAAAAACAACACAAAATGCATGATTAA
GGTACATAATCAAACCTTAATCGAACGTATGCTTAAACAACTGGAAGCTCTATCTCTGAAACGTATAATTATCGTGATAG
GTTATAAAGGAGAAAAGGTACGTGAGCTTATCGGAGATAAGATAAACAACACTCCTGTTCTTTATGTAGAGAACAATGTA
TATGATAAAACAAATAATATATACTCGCTATATCTCGCTAAAAACTATCTGGTGGAGGACGAGACAATTCTACTTGAATC
CGATCTAATTTTTGAGAACTCCATTCTCAGCAAATTGATAAACCATCCCTATCCAAATTTGGCAGTAGTTGCCAAATACC
AAAGTTGGATGGATGGTACCGTCGTACGGCTGGATGAGGATAACAATATATTGAACTTCATCTCAAAGAAAGCGTTTCAA
TTTTGCCAAAAGGAGTCTTATTACAAGACCGTAAATATATATAAATTCAGTAAGGAATTTTCCACTAATAAGTATATTCC
GTTCTTGGAAGCTTATTGTAAAGCCCTCGGTAATAATGAATACTACGAACAAGTTCTAAAGGTAATATCCTTATTAGACA
GACCGGATTTAAAGGCCTTGACGATTACAACCGAAAAATGGTATGAGATAGATGACCAACAGGACTTAAATAATGCGGAA
GCCTTATTTTCGGAAGGCAAGCAAGCATTATCTTTATACGGCAAACGTTACGGTGGATACTGGCGTTTCCCTATGTTATT
GGATTTCTGCTATCTCGTCAACCCTTATTTCCCAAATACCCGATTGAAGGAAGAAATGAAAGCCAATTTCGATACTCTCC
TTACCGAATATCCTTCCGGTATGCAAGAAAACGCTCAACTAGCCGCCCGTTATGCGGGAATATCCTCCGAACAAATCATC
GTAGGAAACGGAGCGGCCGAGTTAATCAGTGGTTATATGCGTATGACCTCTAAGTATACCACAGGAGTTATATTACCAAC
ATTCGAGGAATACCCGAACCGTTTGGCCCCTAAGCAGCTGGTGTATTATACTCCCAGCAACCGAGACTTCTCTTATACTG
CTTTAGACATTATATCTTTCTTTGATAACAAAGCGATTGAGCAACTTTTGATAATTAACCCTGATAACCCATCTGGAAAT
TTATTATCTAAAAATGAGATATTTGCGCTAGTCGAATGGTCCGAACGAAAAGGGATTCGTTTAATCATAGATGAATCTTT
CCTTGATTTCGCAAATCCTGAAAATAAACTTTCCCTGTTAGATAAAGAGCTTTTAAACAAATATCCACATTTGATTGTCA
TTAAGAGCATATCAAAGTCATACGGCGTTCCCGGATTACGATTAGGTTTCTTAGCGTCGGGAAACAAAGATCTCATAAGA
ACGTTGAAAAAAGACATATCGATTTGGAACATCAACTCCTTCGCTGAATTTTATATGCAGATTTTCGTGAAATACAGTGA
TGACTACGACAAAGCCTGCCATAAATTCTTAAACGAAAGAGAGCGTTTCTTCCAGAATCTACAGGCAGTCTCATATCTTA
GGGTTATTCCTTCCGCCGCAAATTATTTCTTATGTGAAGTAACCGATACTTACACATCGGAGGAACTTTGTAGCTCTTTA
TTGTCGGGAAATAATATCTTGATAAAAAACTGTGGAACTAAAGCAGGGTTTGAAGGGAAACAATATATCCGAATCGCTAT
CCGGAACAAGGAAGACAATGATAAGCTAATAGAAGCGCTGACTTCATTGAATAAATAA

Upstream 100 bases:

>100_bases
TTATAAAGACAACCCCTTCTCGGTTATGTACAGTCAAATTGATATTTTGACAGTAAAATCGACAGGGGTATTTGTTTATA
CAATTAAAAAAGAATAAGAT

Downstream 100 bases:

>100_bases
GGAAGTTCAATCCGGTCTTTATTATATGGAAATAAAAAAGAAGCTCAAGAATCCTATGGTTATAAATTTTATCTCCTTGG
CATTGCTCCAAGGAGTTAAT

Product: hemolysin erythrocyte lysis protein 2

Products: 2-Oxoglutarate; L-Histidinol phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MQAIILAAGMGKRLKELTKNNTKCMIKVHNQTLIERMLKQLEALSLKRIIIVIGYKGEKVRELIGDKINNTPVLYVENNV
YDKTNNIYSLYLAKNYLVEDETILLESDLIFENSILSKLINHPYPNLAVVAKYQSWMDGTVVRLDEDNNILNFISKKAFQ
FCQKESYYKTVNIYKFSKEFSTNKYIPFLEAYCKALGNNEYYEQVLKVISLLDRPDLKALTITTEKWYEIDDQQDLNNAE
ALFSEGKQALSLYGKRYGGYWRFPMLLDFCYLVNPYFPNTRLKEEMKANFDTLLTEYPSGMQENAQLAARYAGISSEQII
VGNGAAELISGYMRMTSKYTTGVILPTFEEYPNRLAPKQLVYYTPSNRDFSYTALDIISFFDNKAIEQLLIINPDNPSGN
LLSKNEIFALVEWSERKGIRLIIDESFLDFANPENKLSLLDKELLNKYPHLIVIKSISKSYGVPGLRLGFLASGNKDLIR
TLKKDISIWNINSFAEFYMQIFVKYSDDYDKACHKFLNERERFFQNLQAVSYLRVIPSAANYFLCEVTDTYTSEELCSSL
LSGNNILIKNCGTKAGFEGKQYIRIAIRNKEDNDKLIEALTSLNK

Sequences:

>Translated_605_residues
MQAIILAAGMGKRLKELTKNNTKCMIKVHNQTLIERMLKQLEALSLKRIIIVIGYKGEKVRELIGDKINNTPVLYVENNV
YDKTNNIYSLYLAKNYLVEDETILLESDLIFENSILSKLINHPYPNLAVVAKYQSWMDGTVVRLDEDNNILNFISKKAFQ
FCQKESYYKTVNIYKFSKEFSTNKYIPFLEAYCKALGNNEYYEQVLKVISLLDRPDLKALTITTEKWYEIDDQQDLNNAE
ALFSEGKQALSLYGKRYGGYWRFPMLLDFCYLVNPYFPNTRLKEEMKANFDTLLTEYPSGMQENAQLAARYAGISSEQII
VGNGAAELISGYMRMTSKYTTGVILPTFEEYPNRLAPKQLVYYTPSNRDFSYTALDIISFFDNKAIEQLLIINPDNPSGN
LLSKNEIFALVEWSERKGIRLIIDESFLDFANPENKLSLLDKELLNKYPHLIVIKSISKSYGVPGLRLGFLASGNKDLIR
TLKKDISIWNINSFAEFYMQIFVKYSDDYDKACHKFLNERERFFQNLQAVSYLRVIPSAANYFLCEVTDTYTSEELCSSL
LSGNNILIKNCGTKAGFEGKQYIRIAIRNKEDNDKLIEALTSLNK
>Mature_605_residues
MQAIILAAGMGKRLKELTKNNTKCMIKVHNQTLIERMLKQLEALSLKRIIIVIGYKGEKVRELIGDKINNTPVLYVENNV
YDKTNNIYSLYLAKNYLVEDETILLESDLIFENSILSKLINHPYPNLAVVAKYQSWMDGTVVRLDEDNNILNFISKKAFQ
FCQKESYYKTVNIYKFSKEFSTNKYIPFLEAYCKALGNNEYYEQVLKVISLLDRPDLKALTITTEKWYEIDDQQDLNNAE
ALFSEGKQALSLYGKRYGGYWRFPMLLDFCYLVNPYFPNTRLKEEMKANFDTLLTEYPSGMQENAQLAARYAGISSEQII
VGNGAAELISGYMRMTSKYTTGVILPTFEEYPNRLAPKQLVYYTPSNRDFSYTALDIISFFDNKAIEQLLIINPDNPSGN
LLSKNEIFALVEWSERKGIRLIIDESFLDFANPENKLSLLDKELLNKYPHLIVIKSISKSYGVPGLRLGFLASGNKDLIR
TLKKDISIWNINSFAEFYMQIFVKYSDDYDKACHKFLNERERFFQNLQAVSYLRVIPSAANYFLCEVTDTYTSEELCSSL
LSGNNILIKNCGTKAGFEGKQYIRIAIRNKEDNDKLIEALTSLNK

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To Rhizobium NGR234A y4qD [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=301, Percent_Identity=23.5880398671096, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6322075, Length=335, Percent_Identity=24.1791044776119, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.9 [C]

Molecular weight: Translated: 69702; Mature: 69702

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAIILAAGMGKRLKELTKNNTKCMIKVHNQTLIERMLKQLEALSLKRIIIVIGYKGEKV
CCEEEEECCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCEEEEEEEEECCCHHH
RELIGDKINNTPVLYVENNVYDKTNNIYSLYLAKNYLVEDETILLESDLIFENSILSKLI
HHHHCCCCCCCEEEEEECCCCCCCCCEEEEEEEECEEECCCEEEEECCHHHHHHHHHHHH
NHPYPNLAVVAKYQSWMDGTVVRLDEDNNILNFISKKAFQFCQKESYYKTVNIYKFSKEF
HCCCCCEEEEEEHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEECHHC
STNKYIPFLEAYCKALGNNEYYEQVLKVISLLDRPDLKALTITTEKWYEIDDQQDLNNAE
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECHHHEECCCCCCCCHHH
ALFSEGKQALSLYGKRYGGYWRFPMLLDFCYLVNPYFPNTRLKEEMKANFDTLLTEYPSG
HHHHCCHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHCCCC
MQENAQLAARYAGISSEQIIVGNGAAELISGYMRMTSKYTTGVILPTFEEYPNRLAPKQL
CHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCEEEECHHHCCCCCCCCEE
VYYTPSNRDFSYTALDIISFFDNKAIEQLLIINPDNPSGNLLSKNEIFALVEWSERKGIR
EEECCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCCEE
LIIDESFLDFANPENKLSLLDKELLNKYPHLIVIKSISKSYGVPGLRLGFLASGNKDLIR
EEEECCHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECHHHCCCCCEEEEEEECCCHHHHH
TLKKDISIWNINSFAEFYMQIFVKYSDDYDKACHKFLNERERFFQNLQAVSYLRVIPSAA
HHHHCCCEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NYFLCEVTDTYTSEELCSSLLSGNNILIKNCGTKAGFEGKQYIRIAIRNKEDNDKLIEAL
CEEEEEEECCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEEECCCCHHHHHHHH
TSLNK
HHCCC
>Mature Secondary Structure
MQAIILAAGMGKRLKELTKNNTKCMIKVHNQTLIERMLKQLEALSLKRIIIVIGYKGEKV
CCEEEEECCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCEEEEEEEEECCCHHH
RELIGDKINNTPVLYVENNVYDKTNNIYSLYLAKNYLVEDETILLESDLIFENSILSKLI
HHHHCCCCCCCEEEEEECCCCCCCCCEEEEEEEECEEECCCEEEEECCHHHHHHHHHHHH
NHPYPNLAVVAKYQSWMDGTVVRLDEDNNILNFISKKAFQFCQKESYYKTVNIYKFSKEF
HCCCCCEEEEEEHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEECHHC
STNKYIPFLEAYCKALGNNEYYEQVLKVISLLDRPDLKALTITTEKWYEIDDQQDLNNAE
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECHHHEECCCCCCCCHHH
ALFSEGKQALSLYGKRYGGYWRFPMLLDFCYLVNPYFPNTRLKEEMKANFDTLLTEYPSG
HHHHCCHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHCCCC
MQENAQLAARYAGISSEQIIVGNGAAELISGYMRMTSKYTTGVILPTFEEYPNRLAPKQL
CHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCEEEECHHHCCCCCCCCEE
VYYTPSNRDFSYTALDIISFFDNKAIEQLLIINPDNPSGNLLSKNEIFALVEWSERKGIR
EEECCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCCEE
LIIDESFLDFANPENKLSLLDKELLNKYPHLIVIKSISKSYGVPGLRLGFLASGNKDLIR
EEEECCHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECHHHCCCCCEEEEEEECCCHHHHH
TLKKDISIWNINSFAEFYMQIFVKYSDDYDKACHKFLNERERFFQNLQAVSYLRVIPSAA
HHHHCCCEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NYFLCEVTDTYTSEELCSSLLSGNNILIKNCGTKAGFEGKQYIRIAIRNKEDNDKLIEAL
CEEEEEEECCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEEECCCCHHHHHHHH
TSLNK
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-Glutamate; 3-(Imidazol-4-yl)-2-oxopropyl phosphate [C]

Specific reaction: L-Glutamate + 3-(Imidazol-4-yl)-2-oxopropyl phosphate --> 2-Oxoglutarate + L-Histidinol phosphate [C]

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]