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The map label for this gene is vipA [H]

Identifier: 150007947

GI number: 150007947

Start: 1518118

End: 1519407

Strand: Reverse

Name: vipA [H]

Synonym: BDI_1308

Alternate gene names: 150007947

Gene position: 1519407-1518118 (Counterclockwise)

Preceding gene: 150007948

Following gene: 150007941

Centisome position: 31.58

GC content: 46.05

Gene sequence:

>1290_bases
ATGTATACAAAGTTACTAGATAAACAAACGAAACTTGCCCTAATCGGACTAGGATATGTCGGGCTTCCTATCGCGATGGA
ATTCGCTAAACATGTTTCCGTTATCGGATTTGATATCAACGAGGATCGCTTGGACAAGCTTCGGAACTGTATTGATCCGT
GTGGTGAGCTTCCTACTGAGGTATTTGAACATAAAGATATCACATTTACTTCTTCTATAGAAAAGTTGCGGGAGGCTTCC
TTTTACGTTATAGCTGTTCCTACCCCGATAGACAGCCATAACGAGCCGGATCTATCCCCTTTGTTGGGTGCGACCCGCAC
GGTAGGCAAAGTCCTTAAACGAGGCGATTATGTAGTATACGAATCTACCGTATATCCGGGATGTACGGAAGAGGATTGCA
TCCCGATCTTGGAGGAGGTTTCAGGGTTGAGAGTAGGAGAGGACTTTAAGGTTGGATACTCACCGGAACGAATCAATCCG
GGTGATAAGGTACATACCTTGGTAAATACCGTGAAGATCGTTTCCGGCTGCGATGCCGAAGCTTTGGAAACGATATCGGA
AGTCTATAAGCTGGTCGTTCAAGCGGGGTTGCACCGTGCGCCTAGTATCAAGGTAGCCGAAGCCGCCAAGATTATCGAGA
ATACCCAGCGTGACGTGAATATAGCCCTTATGAACGAGCTTTCCATTATTTTCGATCGAATGGGGGTAAATACGTTTGAT
GTATTGAAAGCCGCCGGAACGAAATGGAATTTCCTGCCTTTCTCTCCCGGATTGGTAGGTGGGCATTGTATAGGGGTAGA
TCCTTACTATCTGGTGCATAAAGCCAAAGAATTGCAATATCACACGAAGATGATCAACTCCGGTCGCTACGTGAACGATT
CCATGGGACGGTATATCGGAAAGAAGGTCGTGAAAAAGATTATCTCGCAGGGGAAAAATATCCTAGGAGCGCATGTGTTG
GTGATGGGTATGACTTTTAAGGAAAACGTATCGGATATACGTAACTCGAAAGTAGCCGATATTATCAATGAGTTTAAGGA
CTTCGGAGCCGAGGTCGATGTGATGGATCCGTTCGCTTCCCCTTTGGAAGTATTGCAAGAGTACGGTATCCGGTTAGTAG
AGAGGCCCGGGAAGAAATATGATGCGGTAGTGGTAGCTGTCGCTCATACGACTTATTTGAAGCTGGATGAGTCCTACTTC
ATGTCGATCACGAATGAACATGCCGTGTTGGCGGACGTGAAAGGAGTCTATCGAGGTAGCATCCATCAGATGATCTATTG
GAGTCTGTAA

Upstream 100 bases:

>100_bases
CCGTTAGGTAAACTGAAGATTGCTACATTTGCATACAATCTCGTCTGTTTGGGACACTCCTTGGAACCCGGACTTTTAAG
TAGAATGATGAAATAATAAG

Downstream 100 bases:

>100_bases
TTGTTAAAAAGTAACACAAGCTGCAAAGAAGTTTCGATAAACTTAAAAAAATGTGTTGTACAATATCTTTTTTTATTTGC
TCAATTATATTAATTAGCCC

Product: UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MYTKLLDKQTKLALIGLGYVGLPIAMEFAKHVSVIGFDINEDRLDKLRNCIDPCGELPTEVFEHKDITFTSSIEKLREAS
FYVIAVPTPIDSHNEPDLSPLLGATRTVGKVLKRGDYVVYESTVYPGCTEEDCIPILEEVSGLRVGEDFKVGYSPERINP
GDKVHTLVNTVKIVSGCDAEALETISEVYKLVVQAGLHRAPSIKVAEAAKIIENTQRDVNIALMNELSIIFDRMGVNTFD
VLKAAGTKWNFLPFSPGLVGGHCIGVDPYYLVHKAKELQYHTKMINSGRYVNDSMGRYIGKKVVKKIISQGKNILGAHVL
VMGMTFKENVSDIRNSKVADIINEFKDFGAEVDVMDPFASPLEVLQEYGIRLVERPGKKYDAVVVAVAHTTYLKLDESYF
MSITNEHAVLADVKGVYRGSIHQMIYWSL

Sequences:

>Translated_429_residues
MYTKLLDKQTKLALIGLGYVGLPIAMEFAKHVSVIGFDINEDRLDKLRNCIDPCGELPTEVFEHKDITFTSSIEKLREAS
FYVIAVPTPIDSHNEPDLSPLLGATRTVGKVLKRGDYVVYESTVYPGCTEEDCIPILEEVSGLRVGEDFKVGYSPERINP
GDKVHTLVNTVKIVSGCDAEALETISEVYKLVVQAGLHRAPSIKVAEAAKIIENTQRDVNIALMNELSIIFDRMGVNTFD
VLKAAGTKWNFLPFSPGLVGGHCIGVDPYYLVHKAKELQYHTKMINSGRYVNDSMGRYIGKKVVKKIISQGKNILGAHVL
VMGMTFKENVSDIRNSKVADIINEFKDFGAEVDVMDPFASPLEVLQEYGIRLVERPGKKYDAVVVAVAHTTYLKLDESYF
MSITNEHAVLADVKGVYRGSIHQMIYWSL
>Mature_429_residues
MYTKLLDKQTKLALIGLGYVGLPIAMEFAKHVSVIGFDINEDRLDKLRNCIDPCGELPTEVFEHKDITFTSSIEKLREAS
FYVIAVPTPIDSHNEPDLSPLLGATRTVGKVLKRGDYVVYESTVYPGCTEEDCIPILEEVSGLRVGEDFKVGYSPERINP
GDKVHTLVNTVKIVSGCDAEALETISEVYKLVVQAGLHRAPSIKVAEAAKIIENTQRDVNIALMNELSIIFDRMGVNTFD
VLKAAGTKWNFLPFSPGLVGGHCIGVDPYYLVHKAKELQYHTKMINSGRYVNDSMGRYIGKKVVKKIISQGKNILGAHVL
VMGMTFKENVSDIRNSKVADIINEFKDFGAEVDVMDPFASPLEVLQEYGIRLVERPGKKYDAVVVAVAHTTYLKLDESYF
MSITNEHAVLADVKGVYRGSIHQMIYWSL

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=434, Percent_Identity=22.5806451612903, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI48994968, Length=433, Percent_Identity=30.2540415704388, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1788340, Length=365, Percent_Identity=22.7397260273973, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560350, Length=395, Percent_Identity=24.0506329113924, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17136908, Length=439, Percent_Identity=21.6400911161731, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 47713; Mature: 47713

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTKLLDKQTKLALIGLGYVGLPIAMEFAKHVSVIGFDINEDRLDKLRNCIDPCGELPTE
CCCHHHCCCCCEEEEECCHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHCCHHH
VFEHKDITFTSSIEKLREASFYVIAVPTPIDSHNEPDLSPLLGATRTVGKVLKRGDYVVY
HHCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEE
ESTVYPGCTEEDCIPILEEVSGLRVGEDFKVGYSPERINPGDKVHTLVNTVKIVSGCDAE
ECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHH
ALETISEVYKLVVQAGLHRAPSIKVAEAAKIIENTQRDVNIALMNELSIIFDRMGVNTFD
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHCCCCHHH
VLKAAGTKWNFLPFSPGLVGGHCIGVDPYYLVHKAKELQYHTKMINSGRYVNDSMGRYIG
HHHHCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
KKVVKKIISQGKNILGAHVLVMGMTFKENVSDIRNSKVADIINEFKDFGAEVDVMDPFAS
HHHHHHHHHCCCHHHHHHHHHEECCHHHHHHHHHCCHHHHHHHHHHHCCCCEEECCCCHH
PLEVLQEYGIRLVERPGKKYDAVVVAVAHTTYLKLDESYFMSITNEHAVLADVKGVYRGS
HHHHHHHHCCCEECCCCCCCCEEEEEEEEHEEEEECHHHHEEECCCCEEHHHHHHHHHCC
IHQMIYWSL
HHHHEEECC
>Mature Secondary Structure
MYTKLLDKQTKLALIGLGYVGLPIAMEFAKHVSVIGFDINEDRLDKLRNCIDPCGELPTE
CCCHHHCCCCCEEEEECCHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHCCHHH
VFEHKDITFTSSIEKLREASFYVIAVPTPIDSHNEPDLSPLLGATRTVGKVLKRGDYVVY
HHCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEE
ESTVYPGCTEEDCIPILEEVSGLRVGEDFKVGYSPERINPGDKVHTLVNTVKIVSGCDAE
ECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHH
ALETISEVYKLVVQAGLHRAPSIKVAEAAKIIENTQRDVNIALMNELSIIFDRMGVNTFD
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHCCCCHHH
VLKAAGTKWNFLPFSPGLVGGHCIGVDPYYLVHKAKELQYHTKMINSGRYVNDSMGRYIG
HHHHCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
KKVVKKIISQGKNILGAHVLVMGMTFKENVSDIRNSKVADIINEFKDFGAEVDVMDPFAS
HHHHHHHHHCCCHHHHHHHHHEECCHHHHHHHHHCCHHHHHHHHHHHCCCCEEECCCCHH
PLEVLQEYGIRLVERPGKKYDAVVVAVAHTTYLKLDESYFMSITNEHAVLADVKGVYRGS
HHHHHHHHCCCEECCCCCCCCEEEEEEEEHEEEEECHHHHEEECCCCEEHHHHHHHHHCC
IHQMIYWSL
HHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8248629; 8331073; 11677608; 12644504 [H]