Click here to switch to the map view.

The map label for this gene is kbl [C]

Identifier: 150007877

GI number: 150007877

Start: 1435595

End: 1436785

Strand: Direct

Name: kbl [C]

Synonym: BDI_1237

Alternate gene names: 150007877

Gene position: 1435595-1436785 (Clockwise)

Preceding gene: 150007875

Following gene: 150007878

Centisome position: 29.84

GC content: 50.88

Gene sequence:

>1191_bases
ATGTACGGAAAACTTAAAGAATTCTTGACAAATGAACTTGAAGGCATCAAAGCCGCTGGTTTATACAAGAACGAGCGTAT
CATTACTACGCCGCAGAGAGCCGACATCAAAGTAAATGCCGGAAGTGATGTTTTAAACTTCTGCGCCAACAACTATCTTG
GCCTGTCCGATAACCAACGACTGATCAAGGCCGCGAAAGAAGCCATGGATACACACGGTTATGGCATGTCGTCCGTTCGT
TTCATCTGTGGAACGCAGGATTTGCACAAGCAATTGGAGGCAGCCATCTCCGACTATTTCAAGACAGAGGACACGATCCT
TTACGCCGCATGTTTCGACGCTAACGGTGGTTTGTTTGAGCCGTTGTTTGGCGAGGAAGACGCTATCATCTCGGATGCCT
TGAACCACGCCTCTATCATCGACGGTGTTCGTTTATGCAAGGCGAAACGTTATCGCTACGCTAACGCCGACATGGCGGAC
TTGGAACGTTGCCTACAAGAGGCGCAGGCCCAACGTCACCGTATCATCGCCACGGACGGCGTGTTCTCCATGGACGGCAA
TGTCGCTCCGATGGACAAGATTTGCGAGCTTGCCGAGAAATATGACGCATTGGTTATGGTGGACGAGTCTCACTCTGCCG
GTGTCGTAGGCCCGACGGGTCATGGCGTAGCCGAGCAGTTTGATGTTTACGGACGTGTAGATATCTTCACGGGTACGCTG
GGTAAGGCGTTCGGTGGTGCCATGGGTGGCTTCACGACCGGAAAGAAGGAGATTATCGATATGTTACGCCAACGTTCTCG
CCCCTACTTGTTCTCCAACTCCGTGGCTCCGGCCATCGTAGGCGCAAGCTTGGAGATGTTCAAGATGTTGAAGGAGAGCG
ACGCTTTACATACGAAATTAATGAACAACGTAAGCTACTTCCGCGACAAGATGCTGGCAGCCGGTTTCGATATCAAGCCG
ACTCAATCCGCTATCTGCGCCGTTATGTTGTACGACGCTAAGTTGTCTCAAGATTTCGCCGCCAAGATGCAGGAAGAGGG
TATTTACGTAACCGGTTTCTATTACCCGGTAGTACCGAAGGGACAAGCTCGTATCCGTGTACAATTGTCCGCCGGCCACG
AGACTGAGCATCTGGACAAGGCTATCGCAGCGTTTATCAAGGTAGGAAAAGAGCTAGGCGTTATCAAATAA

Upstream 100 bases:

>100_bases
TTTTTAGTATTAAAATTCAAAAAAAAAACAGACCTTTGTCTGTCGCTTTGACAACGAAGCTACTACTCACATCTAAATAC
TAATAAAAAACGAAGTTTTT

Downstream 100 bases:

>100_bases
CACCTCTCTCATTCATCATACAAGGCCACATCCGGGCAAGATGATCTGGATGTGGCTTTTTAATCACTAAGAACAATCAT
GCAACTCAGTAACTACCATA

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MYGKLKEFLTNELEGIKAAGLYKNERIITTPQRADIKVNAGSDVLNFCANNYLGLSDNQRLIKAAKEAMDTHGYGMSSVR
FICGTQDLHKQLEAAISDYFKTEDTILYAACFDANGGLFEPLFGEEDAIISDALNHASIIDGVRLCKAKRYRYANADMAD
LERCLQEAQAQRHRIIATDGVFSMDGNVAPMDKICELAEKYDALVMVDESHSAGVVGPTGHGVAEQFDVYGRVDIFTGTL
GKAFGGAMGGFTTGKKEIIDMLRQRSRPYLFSNSVAPAIVGASLEMFKMLKESDALHTKLMNNVSYFRDKMLAAGFDIKP
TQSAICAVMLYDAKLSQDFAAKMQEEGIYVTGFYYPVVPKGQARIRVQLSAGHETEHLDKAIAAFIKVGKELGVIK

Sequences:

>Translated_396_residues
MYGKLKEFLTNELEGIKAAGLYKNERIITTPQRADIKVNAGSDVLNFCANNYLGLSDNQRLIKAAKEAMDTHGYGMSSVR
FICGTQDLHKQLEAAISDYFKTEDTILYAACFDANGGLFEPLFGEEDAIISDALNHASIIDGVRLCKAKRYRYANADMAD
LERCLQEAQAQRHRIIATDGVFSMDGNVAPMDKICELAEKYDALVMVDESHSAGVVGPTGHGVAEQFDVYGRVDIFTGTL
GKAFGGAMGGFTTGKKEIIDMLRQRSRPYLFSNSVAPAIVGASLEMFKMLKESDALHTKLMNNVSYFRDKMLAAGFDIKP
TQSAICAVMLYDAKLSQDFAAKMQEEGIYVTGFYYPVVPKGQARIRVQLSAGHETEHLDKAIAAFIKVGKELGVIK
>Mature_396_residues
MYGKLKEFLTNELEGIKAAGLYKNERIITTPQRADIKVNAGSDVLNFCANNYLGLSDNQRLIKAAKEAMDTHGYGMSSVR
FICGTQDLHKQLEAAISDYFKTEDTILYAACFDANGGLFEPLFGEEDAIISDALNHASIIDGVRLCKAKRYRYANADMAD
LERCLQEAQAQRHRIIATDGVFSMDGNVAPMDKICELAEKYDALVMVDESHSAGVVGPTGHGVAEQFDVYGRVDIFTGTL
GKAFGGAMGGFTTGKKEIIDMLRQRSRPYLFSNSVAPAIVGASLEMFKMLKESDALHTKLMNNVSYFRDKMLAAGFDIKP
TQSAICAVMLYDAKLSQDFAAKMQEEGIYVTGFYYPVVPKGQARIRVQLSAGHETEHLDKAIAAFIKVGKELGVIK

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=393, Percent_Identity=53.4351145038168, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI284448556, Length=420, Percent_Identity=50, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI83977442, Length=364, Percent_Identity=32.1428571428571, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI83977440, Length=364, Percent_Identity=32.1428571428571, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI83977444, Length=364, Percent_Identity=32.1428571428571, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI4502025, Length=355, Percent_Identity=30.9859154929577, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI40316939, Length=355, Percent_Identity=30.9859154929577, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI119220554, Length=368, Percent_Identity=31.7934782608696, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI4758668, Length=367, Percent_Identity=32.6975476839237, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI5454084, Length=395, Percent_Identity=25.8227848101266, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1790046, Length=397, Percent_Identity=61.7128463476071, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI1786993, Length=341, Percent_Identity=30.2052785923754, Blast_Score=169, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71994529, Length=392, Percent_Identity=58.9285714285714, Blast_Score=458, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI32566772, Length=370, Percent_Identity=30.5405405405405, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17560912, Length=359, Percent_Identity=28.6908077994429, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17560914, Length=359, Percent_Identity=28.6908077994429, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71982617, Length=313, Percent_Identity=26.517571884984, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71982625, Length=313, Percent_Identity=26.517571884984, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320438, Length=372, Percent_Identity=30.6451612903226, Blast_Score=190, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=29.3478260869565, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323954, Length=269, Percent_Identity=28.2527881040892, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24662918, Length=395, Percent_Identity=55.6962025316456, Blast_Score=448, Evalue=1e-126,
Organism=Drosophila melanogaster, GI17137420, Length=349, Percent_Identity=30.6590257879656, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI17136286, Length=370, Percent_Identity=31.0810810810811, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI24653280, Length=341, Percent_Identity=25.5131964809384, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24653276, Length=341, Percent_Identity=25.5131964809384, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24653278, Length=341, Percent_Identity=25.5131964809384, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011282
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43491; Mature: 43491

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGKLKEFLTNELEGIKAAGLYKNERIITTPQRADIKVNAGSDVLNFCANNYLGLSDNQR
CCCHHHHHHHHHHCCCEECCCCCCCEEEECCCCCEEEEECCHHHHHHHHCCCCCCCCCHH
LIKAAKEAMDTHGYGMSSVRFICGTQDLHKQLEAAISDYFKTEDTILYAACFDANGGLFE
HHHHHHHHHHHCCCCCCHHEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCC
PLFGEEDAIISDALNHASIIDGVRLCKAKRYRYANADMADLERCLQEAQAQRHRIIATDG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCEEEEECC
VFSMDGNVAPMDKICELAEKYDALVMVDESHSAGVVGPTGHGVAEQFDVYGRVDIFTGTL
EEECCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHCCEEEEEEECCH
GKAFGGAMGGFTTGKKEIIDMLRQRSRPYLFSNSVAPAIVGASLEMFKMLKESDALHTKL
HHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCHHHHHCHHHHHHHHHHHHHHHHHH
MNNVSYFRDKMLAAGFDIKPTQSAICAVMLYDAKLSQDFAAKMQEEGIYVTGFYYPVVPK
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCC
GQARIRVQLSAGHETEHLDKAIAAFIKVGKELGVIK
CCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYGKLKEFLTNELEGIKAAGLYKNERIITTPQRADIKVNAGSDVLNFCANNYLGLSDNQR
CCCHHHHHHHHHHCCCEECCCCCCCEEEECCCCCEEEEECCHHHHHHHHCCCCCCCCCHH
LIKAAKEAMDTHGYGMSSVRFICGTQDLHKQLEAAISDYFKTEDTILYAACFDANGGLFE
HHHHHHHHHHHCCCCCCHHEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCC
PLFGEEDAIISDALNHASIIDGVRLCKAKRYRYANADMADLERCLQEAQAQRHRIIATDG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCEEEEECC
VFSMDGNVAPMDKICELAEKYDALVMVDESHSAGVVGPTGHGVAEQFDVYGRVDIFTGTL
EEECCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHCCEEEEEEECCH
GKAFGGAMGGFTTGKKEIIDMLRQRSRPYLFSNSVAPAIVGASLEMFKMLKESDALHTKL
HHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCHHHHHCHHHHHHHHHHHHHHHHHH
MNNVSYFRDKMLAAGFDIKPTQSAICAVMLYDAKLSQDFAAKMQEEGIYVTGFYYPVVPK
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCC
GQARIRVQLSAGHETEHLDKAIAAFIKVGKELGVIK
CCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]