Click here to switch to the map view.

The map label for this gene is mepA [H]

Identifier: 150007819

GI number: 150007819

Start: 1371319

End: 1372668

Strand: Reverse

Name: mepA [H]

Synonym: BDI_1177

Alternate gene names: 150007819

Gene position: 1372668-1371319 (Counterclockwise)

Preceding gene: 150007827

Following gene: 150007818

Centisome position: 28.53

GC content: 49.41

Gene sequence:

>1350_bases
ATGGCAAAACAAAATTCTCCATTGGTATTAGGGACCGAGCCTATCGGTAAATTACTTACGCAATATGCGATTCCTGCGAT
TATCGCTATGACAGCTTCTTCTTTATATAATATGGCCGATAGTATTTTTATTGGCCATGGAGTGGGGGCGTTAGCGATTT
CCGGCCTAGCCTTGACCTTTCCGTTGATGAACTTGGCGGCCGCCTTCGGTTCGTTGGTGGGAGTCGGCGCCTCTACGTTG
GTTGCCGTGAAGTTGGGGCAGAAAGATTATGAGGGGGCGAATAAGGTGTTGGGGAATGTGTTGATCTTGAATGTGGTTTT
GGGCGTCGCTTTCACGATCGCTTTCTTGTTCTTGCTTGATCCCGTACTGTACTTTTTCGGTGCTAGTGAGAACACGATCT
CATATGCCCGTGATTATATGCGGATTATTCTGTATGGCAATGTGGTTACGCATATGTATCTGGGATTAAACGCGGTCTTG
CGCTCCTCGGGGTTCCCGAAGATGGCGATGTATGCTACGTTAGCGTCGGTCGTTATCAATTGCGCCTTGAATCCGTTGTT
TATCTTTGGGTTTGGATGGGGTATCAAAGGGTCGGCTTGGGCGACGGTGATCTCGCAGGTGATCTCGCTTACCGGGCAGT
TGATTCATTTCTCGGGACCAAAGCAACTCCTTCATTTCAAGAAAGGTATTTATAGGCTGCGCTCGGAGATCGTGAAAGGT
ATCTTGTCGATCGGTTTATCTCCGTTCTTGATGAACCTTTGTTCCTGCTTGATCGTGATCCTTATCAACCGGGGATTGAA
AGAGCATGGGGGAGATATGGCGATTGGCGCTTATGGTATCGTGAACCGTATCGCTTTTCTTTTCGTGATGATTATCATGG
GATTTAATCAGGGTATGCAACCGATAGCCGGTTATAATTATGGTGCCCGACTCTATTCCCGGGTGACGGACGTGACCCGG
CTGACGATGCGCTGGGCGGTAGGAGTGGCTACGCTGGGGTTCTTGCTTTGCCAGTTGGTGCCGTCGTGGATCGTCCGTAT
GTTTACGAGTGACGGGGAGTTGATCAGTGCCGCCTCTTATGGCCTGCACATCGTCTTCGCCGTATTCCCGATCGTGGGCT
TCCAGATGGTGGCGACTAACTTCTTCCTTTCCATCGGCATGTCTAAGAAAGCGATCTTTCTCTCCTTGACCCGGCAGATG
CTTTTCTTGATACCCTGTTTAATCCTCCTCCCCCCGTTATTCGGAACTCTCGGTGTCTGGATCAGTATGCCTATCGCCGA
TACGGTGGCGGCGATCGTGACGGCGATCGTGCTTGTGAAACAATTTAAACAATTCAAATATGGAACATAA

Upstream 100 bases:

>100_bases
ATGGGATATCAACTGTTTCTCTGTTTCCATTTGATTAGATTCATAAGGTTATACCTTACAAAAGTAGGAAAATAAATCGA
AATATCCGTATCTTCGCGGC

Downstream 100 bases:

>100_bases
CGTGATATTACCTGCGGAATGGTATCCGCAAAGTGCCGTGCAGCTTACGTGGCCGCATGAGAATACGGATTGGGCCCCGA
TATTGGACGAGGTGATTCCT

Product: putative Na+-driven multidrug efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MAKQNSPLVLGTEPIGKLLTQYAIPAIIAMTASSLYNMADSIFIGHGVGALAISGLALTFPLMNLAAAFGSLVGVGASTL
VAVKLGQKDYEGANKVLGNVLILNVVLGVAFTIAFLFLLDPVLYFFGASENTISYARDYMRIILYGNVVTHMYLGLNAVL
RSSGFPKMAMYATLASVVINCALNPLFIFGFGWGIKGSAWATVISQVISLTGQLIHFSGPKQLLHFKKGIYRLRSEIVKG
ILSIGLSPFLMNLCSCLIVILINRGLKEHGGDMAIGAYGIVNRIAFLFVMIIMGFNQGMQPIAGYNYGARLYSRVTDVTR
LTMRWAVGVATLGFLLCQLVPSWIVRMFTSDGELISAASYGLHIVFAVFPIVGFQMVATNFFLSIGMSKKAIFLSLTRQM
LFLIPCLILLPPLFGTLGVWISMPIADTVAAIVTAIVLVKQFKQFKYGT

Sequences:

>Translated_449_residues
MAKQNSPLVLGTEPIGKLLTQYAIPAIIAMTASSLYNMADSIFIGHGVGALAISGLALTFPLMNLAAAFGSLVGVGASTL
VAVKLGQKDYEGANKVLGNVLILNVVLGVAFTIAFLFLLDPVLYFFGASENTISYARDYMRIILYGNVVTHMYLGLNAVL
RSSGFPKMAMYATLASVVINCALNPLFIFGFGWGIKGSAWATVISQVISLTGQLIHFSGPKQLLHFKKGIYRLRSEIVKG
ILSIGLSPFLMNLCSCLIVILINRGLKEHGGDMAIGAYGIVNRIAFLFVMIIMGFNQGMQPIAGYNYGARLYSRVTDVTR
LTMRWAVGVATLGFLLCQLVPSWIVRMFTSDGELISAASYGLHIVFAVFPIVGFQMVATNFFLSIGMSKKAIFLSLTRQM
LFLIPCLILLPPLFGTLGVWISMPIADTVAAIVTAIVLVKQFKQFKYGT
>Mature_448_residues
AKQNSPLVLGTEPIGKLLTQYAIPAIIAMTASSLYNMADSIFIGHGVGALAISGLALTFPLMNLAAAFGSLVGVGASTLV
AVKLGQKDYEGANKVLGNVLILNVVLGVAFTIAFLFLLDPVLYFFGASENTISYARDYMRIILYGNVVTHMYLGLNAVLR
SSGFPKMAMYATLASVVINCALNPLFIFGFGWGIKGSAWATVISQVISLTGQLIHFSGPKQLLHFKKGIYRLRSEIVKGI
LSIGLSPFLMNLCSCLIVILINRGLKEHGGDMAIGAYGIVNRIAFLFVMIIMGFNQGMQPIAGYNYGARLYSRVTDVTRL
TMRWAVGVATLGFLLCQLVPSWIVRMFTSDGELISAASYGLHIVFAVFPIVGFQMVATNFFLSIGMSKKAIFLSLTRQML
FLIPCLILLPPLFGTLGVWISMPIADTVAAIVTAIVLVKQFKQFKYGT

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48539; Mature: 48408

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQNSPLVLGTEPIGKLLTQYAIPAIIAMTASSLYNMADSIFIGHGVGALAISGLALTF
CCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
PLMNLAAAFGSLVGVGASTLVAVKLGQKDYEGANKVLGNVLILNVVLGVAFTIAFLFLLD
HHHHHHHHHHHHHHCCHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVLYFFGASENTISYARDYMRIILYGNVVTHMYLGLNAVLRSSGFPKMAMYATLASVVIN
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
CALNPLFIFGFGWGIKGSAWATVISQVISLTGQLIHFSGPKQLLHFKKGIYRLRSEIVKG
HCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
ILSIGLSPFLMNLCSCLIVILINRGLKEHGGDMAIGAYGIVNRIAFLFVMIIMGFNQGMQ
HHHHCCHHHHHHHHHHHHHHHHHCCHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCC
PIAGYNYGARLYSRVTDVTRLTMRWAVGVATLGFLLCQLVPSWIVRMFTSDGELISAASY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHH
GLHIVFAVFPIVGFQMVATNFFLSIGMSKKAIFLSLTRQMLFLIPCLILLPPLFGTLGVW
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISMPIADTVAAIVTAIVLVKQFKQFKYGT
HHCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AKQNSPLVLGTEPIGKLLTQYAIPAIIAMTASSLYNMADSIFIGHGVGALAISGLALTF
CCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH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HHCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA