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The map label for this gene is yeiA [H]

Identifier: 150007812

GI number: 150007812

Start: 1362206

End: 1363699

Strand: Direct

Name: yeiA [H]

Synonym: BDI_1170

Alternate gene names: 150007812

Gene position: 1362206-1363699 (Clockwise)

Preceding gene: 150007811

Following gene: 150007813

Centisome position: 28.31

GC content: 55.35

Gene sequence:

>1494_bases
ATGAAGACAAACCTCCTCCAGAGAAAACGCCTCCTAACGGAAGAATCGAATCGCTGTTATCTGTGCGATGCCCCTGTCTG
CACAAAGGCATGCAAGCCCGGACTAGATCCGGGCCGCTTGCTGCGGGCCTGTAAAATGGACAACCTAGCGGGAGCTATCC
TCCGGGCCTACCAGATGGAAGCCTGCAGGGATTGCGACGGGTATCCTTGCGAGAAGGCCTGCCTCCGCGGACGAACCGAC
CGGGCGATATCCATCACTCAAATCGTACGGCAATTGCAAGATATGCCAAACCCGACGGATAGTTCTCCCCTCACTTCGTC
TCCGGACTTGGCGATCGACTTTTGCGGCATCCGCTGCGCCAACCCCTTTATACTGGCCTCCTCGCCCGTAGCCCATAATT
ACGAGATGTGCGTCCGGGCCCTCGAAGCCGGTTGGGCCGGTATCTGCTTCAAGACGATATCATTCTATCCGAGCCATGAG
GTATCCCCCCGCTTCGACCAAATGGAGGTGGATGGCGTGCCTTTCATCGGATTCAAGAACATGGAACAATTGTCGGAAGC
CTCTGTCGAAGAGAATTTCGATACTCTCTATCGCCTCAAGCAACGCTATCCTGACAAATTAATCATCTCCTCCATTATGG
GACGGACAGACGATGAGTGGACACGGCTTGCCCAATATTCCACGCAGGCTGGGGCCGATATCATTGAGTGCAACTTCTCT
TGCCCACAAATGACGCAAGAAGGGATGGGCAGCGACGTAGGACAAAGCCCGGAACTGGTACGCCGGTTCACCGCCGCCAC
ACGCCGGGGTACCCATCTGCCGATACTAGCGAAGATGACACCGAATATCGGGCAGATGACACCCGTGGCGCTCGCCGCCC
ACGAAGGAGGAGCCACCGGGATAGCCGCCATCAACACCATCAAATGTATCACCCGTATCGATGAGAAAGCACTTACGGCC
CGGCCCGTTGTCTGCGGACTGAGCAGCGTGTCCGGCTATTCGGGGAAAGCCGTGCGCCCTATCGCTCTCCGGTTCATACA
TGAGCTGGCGAGCGATCCTTCTGCCGGCAAGATGCCTATCAGCGGGATAGGCGGTATAGAGACTTGGCGGGATGCCCTCG
ATTTCCTGCTACTAGGCTGCACGAACCTACAGATATGTACCGCCGTGATGCAATACGGCTTCCGGATCATCGACGATCTA
TGCGAAGGGTTACGACTGTTCATGCAAGAGAACGGATATAAAACCCTATCCGACCTCATAGGTATCGCTTTACCGAACAT
CGTACCCCCCGAGAAACTGGAACGTACGCAGATACACCGCCCGACAGTAGATAACAGCCTATGCCTCGGCTGCGGACGCT
GTTTCGTTTCCTGTAACGACGGTGGACATCAAGCTATCCGTTTCACCTCTATGCGCAAACCGGTGATAGACGAGCAAAAA
TGTGTCGGCTGCCATCTTTGCGCATTAGTATGCCCAACCTTCGCCATACATTGA

Upstream 100 bases:

>100_bases
AAGCAATCTTCAGCCTGCCCGGACACCTGTACACCGTGGAGGTCGTGACCGAACGTTACCGGAAAGTACAGAAAGTAGTG
AGATAATACAGTTAGAAGCC

Downstream 100 bases:

>100_bases
CAGGATGAGGATCGAGACGGGACACCTTATTCTACTATCCATACTTCTTCTGTGCCCGCTAGTCCATTCAGACCTGCGGG
CACAAGAGAAGACACCCGTC

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MKTNLLQRKRLLTEESNRCYLCDAPVCTKACKPGLDPGRLLRACKMDNLAGAILRAYQMEACRDCDGYPCEKACLRGRTD
RAISITQIVRQLQDMPNPTDSSPLTSSPDLAIDFCGIRCANPFILASSPVAHNYEMCVRALEAGWAGICFKTISFYPSHE
VSPRFDQMEVDGVPFIGFKNMEQLSEASVEENFDTLYRLKQRYPDKLIISSIMGRTDDEWTRLAQYSTQAGADIIECNFS
CPQMTQEGMGSDVGQSPELVRRFTAATRRGTHLPILAKMTPNIGQMTPVALAAHEGGATGIAAINTIKCITRIDEKALTA
RPVVCGLSSVSGYSGKAVRPIALRFIHELASDPSAGKMPISGIGGIETWRDALDFLLLGCTNLQICTAVMQYGFRIIDDL
CEGLRLFMQENGYKTLSDLIGIALPNIVPPEKLERTQIHRPTVDNSLCLGCGRCFVSCNDGGHQAIRFTSMRKPVIDEQK
CVGCHLCALVCPTFAIH

Sequences:

>Translated_497_residues
MKTNLLQRKRLLTEESNRCYLCDAPVCTKACKPGLDPGRLLRACKMDNLAGAILRAYQMEACRDCDGYPCEKACLRGRTD
RAISITQIVRQLQDMPNPTDSSPLTSSPDLAIDFCGIRCANPFILASSPVAHNYEMCVRALEAGWAGICFKTISFYPSHE
VSPRFDQMEVDGVPFIGFKNMEQLSEASVEENFDTLYRLKQRYPDKLIISSIMGRTDDEWTRLAQYSTQAGADIIECNFS
CPQMTQEGMGSDVGQSPELVRRFTAATRRGTHLPILAKMTPNIGQMTPVALAAHEGGATGIAAINTIKCITRIDEKALTA
RPVVCGLSSVSGYSGKAVRPIALRFIHELASDPSAGKMPISGIGGIETWRDALDFLLLGCTNLQICTAVMQYGFRIIDDL
CEGLRLFMQENGYKTLSDLIGIALPNIVPPEKLERTQIHRPTVDNSLCLGCGRCFVSCNDGGHQAIRFTSMRKPVIDEQK
CVGCHLCALVCPTFAIH
>Mature_497_residues
MKTNLLQRKRLLTEESNRCYLCDAPVCTKACKPGLDPGRLLRACKMDNLAGAILRAYQMEACRDCDGYPCEKACLRGRTD
RAISITQIVRQLQDMPNPTDSSPLTSSPDLAIDFCGIRCANPFILASSPVAHNYEMCVRALEAGWAGICFKTISFYPSHE
VSPRFDQMEVDGVPFIGFKNMEQLSEASVEENFDTLYRLKQRYPDKLIISSIMGRTDDEWTRLAQYSTQAGADIIECNFS
CPQMTQEGMGSDVGQSPELVRRFTAATRRGTHLPILAKMTPNIGQMTPVALAAHEGGATGIAAINTIKCITRIDEKALTA
RPVVCGLSSVSGYSGKAVRPIALRFIHELASDPSAGKMPISGIGGIETWRDALDFLLLGCTNLQICTAVMQYGFRIIDDL
CEGLRLFMQENGYKTLSDLIGIALPNIVPPEKLERTQIHRPTVDNSLCLGCGRCFVSCNDGGHQAIRFTSMRKPVIDEQK
CVGCHLCALVCPTFAIH

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=334, Percent_Identity=35.9281437125749, Blast_Score=192, Evalue=8e-49,
Organism=Escherichia coli, GI87082059, Length=392, Percent_Identity=55.1020408163265, Blast_Score=464, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI71984108, Length=344, Percent_Identity=36.046511627907, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24640763, Length=350, Percent_Identity=36.2857142857143, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI18858217, Length=350, Percent_Identity=36.2857142857143, Blast_Score=199, Evalue=4e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 54627; Mature: 54627

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
8.9 %Cys+Met (Translated Protein)
5.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
8.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTNLLQRKRLLTEESNRCYLCDAPVCTKACKPGLDPGRLLRACKMDNLAGAILRAYQME
CCCHHHHHHHHHHCCCCCEEEECCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ACRDCDGYPCEKACLRGRTDRAISITQIVRQLQDMPNPTDSSPLTSSPDLAIDFCGIRCA
HHHCCCCCCHHHHHHCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCEEC
NPFILASSPVAHNYEMCVRALEAGWAGICFKTISFYPSHEVSPRFDQMEVDGVPFIGFKN
CCEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCCC
MEQLSEASVEENFDTLYRLKQRYPDKLIISSIMGRTDDEWTRLAQYSTQAGADIIECNFS
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCC
CPQMTQEGMGSDVGQSPELVRRFTAATRRGTHLPILAKMTPNIGQMTPVALAAHEGGATG
CHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCH
IAAINTIKCITRIDEKALTARPVVCGLSSVSGYSGKAVRPIALRFIHELASDPSAGKMPI
HHHHHHHHHHHHHHHHHHHCCCHHHCCHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
SGIGGIETWRDALDFLLLGCTNLQICTAVMQYGFRIIDDLCEGLRLFMQENGYKTLSDLI
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
GIALPNIVPPEKLERTQIHRPTVDNSLCLGCGRCFVSCNDGGHQAIRFTSMRKPVIDEQK
HHHCCCCCCHHHHHHHHCCCCCCCCCHHEECCEEEEEECCCCCCEEEECCCCCCCCCCHH
CVGCHLCALVCPTFAIH
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTNLLQRKRLLTEESNRCYLCDAPVCTKACKPGLDPGRLLRACKMDNLAGAILRAYQME
CCCHHHHHHHHHHCCCCCEEEECCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ACRDCDGYPCEKACLRGRTDRAISITQIVRQLQDMPNPTDSSPLTSSPDLAIDFCGIRCA
HHHCCCCCCHHHHHHCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCEEC
NPFILASSPVAHNYEMCVRALEAGWAGICFKTISFYPSHEVSPRFDQMEVDGVPFIGFKN
CCEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCCC
MEQLSEASVEENFDTLYRLKQRYPDKLIISSIMGRTDDEWTRLAQYSTQAGADIIECNFS
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCC
CPQMTQEGMGSDVGQSPELVRRFTAATRRGTHLPILAKMTPNIGQMTPVALAAHEGGATG
CHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCH
IAAINTIKCITRIDEKALTARPVVCGLSSVSGYSGKAVRPIALRFIHELASDPSAGKMPI
HHHHHHHHHHHHHHHHHHHCCCHHHCCHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
SGIGGIETWRDALDFLLLGCTNLQICTAVMQYGFRIIDDLCEGLRLFMQENGYKTLSDLI
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
GIALPNIVPPEKLERTQIHRPTVDNSLCLGCGRCFVSCNDGGHQAIRFTSMRKPVIDEQK
HHHCCCCCCHHHHHHHHCCCCCCCCCHHEECCEEEEEECCCCCCEEEECCCCCCCCCCHH
CVGCHLCALVCPTFAIH
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]