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The map label for this gene is pepP [H]

Identifier: 150007740

GI number: 150007740

Start: 1274194

End: 1275567

Strand: Direct

Name: pepP [H]

Synonym: BDI_1098

Alternate gene names: 150007740

Gene position: 1274194-1275567 (Clockwise)

Preceding gene: 150007733

Following gene: 150007743

Centisome position: 26.48

GC content: 48.11

Gene sequence:

>1374_bases
ATGTTCAGTAAAGAAACTTATATGGCCCGCCGGGCTAAGCTGAAACAAACCATAGGTTCCGGTTTGTTGCTATTCCTTGG
AAACGACGAGAGTGGGATGAACTACGCCGATAATACGTATCACTTCCGTCAAGACTCTACCTTCTTGTATTTCTTCGGAT
TGCCATACGCCGGGTTATCCGCTATCATCGATATCGATAACGATAAGGAGATCATCTTTGGCGATGAGTTGACTATAGAC
GCGATTGTATGGATGGGTACGCAGCCCACCCTAAAAGAGAAGAGCGAGGCCGCAGGTATCAAGGAAGTCCGTCCTTTTAA
GGAGATCGAGACTTATTTGAAGAATGCCCAGCAAAAAGGCCAGCCAATCCATTATCTGCCGACGTATCGTGCGGAACACC
AGATCAAGTTATTCCAATGGTTGGGTATCGTACCCGGTGCGGAGAAACCTTCCGTGCCTTTTATCATGGGTGTCGTAAAC
CAACGGAATTACAAGAGCGAGGAAGAAATTGCCGAGATCGAGAAAGCCTGTATCGTAACCGCCGATATGCACCTGACTGC
CATGCGTACCGTACGTCCGGGAATCCGGGAGTCGGATGTAGCGGCTGCCGTTGCGGAAGTCGCTTTCGCCAACAATTACC
AGCTCTCCTTCCCTATCATCGCCACGATCAATGGGCAGACCTTGCACAACCATGATCATAGTCATATGATTAAGAGCGGT
GATATGCTATTATTGGACGCCGGTGCCGAGACTGAGATGGGATATGCCGGAGATATGTCGTCCACCATCCCAGCCGACTC
TAAGTTCACGACCCGTCAAAAAGACATCTATGATATTCAAGTAGCCGCCCATGAAGCTGCCGTAGCGGCTTTGCGCCCGG
GTATTCCTTTCGTGGATGTATATGAGTTGTCTTGTAAAGTGATCATGGAGGGCTTAAAGGACCTTGGTTTCGTGAAAGGA
GATCCGATGGAAGCCGTAAAAGCCGGTGCTCACGCCATGTTTATGCCTTGTGGCTTAGGCCATATGATGGGATTGGATGT
ACATGATATGGAGAATCTGGGAGAGGTATACGTTGGTTATGACGGACAGCCGAAGAGTACGGAATTCGGACGTAAGTCAT
TGCGCTTGGGACGTAAGCTGGAACCGGGTTTTGTCTTGACCATCGAGCCGGGTGTATACTTCATCCCTGAATTAATGGAT
TTATGGAGAGGCCAGAACAAGTTCACCGAATTCATCAATTACGAGAAGTTGTTTACATATAAAGATTTCAGTGGCATACG
TAACGAGGAAGACTATCTGATTACCGAGAACGGCGCTCGTCTATTAGGAAAGAAGATCCCTTTGCGTACGGAAGAAGTAG
AAGCAATTCGATAA

Upstream 100 bases:

>100_bases
GTTACATTTTACATGGGCTAATGTAAGAAATAATTTCGAATGTCGGCCTAGTATATTACATTAATTACTATCTTTGGTAC
ACTAACAAAAAATAATCCTT

Downstream 100 bases:

>100_bases
ATCCTATACATTATTATATATAAGCTTATGCAAAAGGGAGAGCCTTAAAAACAGCTCTCCCTTTTTGGGCTAAACGAGAA
AGACAATGTATGAAACGATT

Product: Xaa-Pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MFSKETYMARRAKLKQTIGSGLLLFLGNDESGMNYADNTYHFRQDSTFLYFFGLPYAGLSAIIDIDNDKEIIFGDELTID
AIVWMGTQPTLKEKSEAAGIKEVRPFKEIETYLKNAQQKGQPIHYLPTYRAEHQIKLFQWLGIVPGAEKPSVPFIMGVVN
QRNYKSEEEIAEIEKACIVTADMHLTAMRTVRPGIRESDVAAAVAEVAFANNYQLSFPIIATINGQTLHNHDHSHMIKSG
DMLLLDAGAETEMGYAGDMSSTIPADSKFTTRQKDIYDIQVAAHEAAVAALRPGIPFVDVYELSCKVIMEGLKDLGFVKG
DPMEAVKAGAHAMFMPCGLGHMMGLDVHDMENLGEVYVGYDGQPKSTEFGRKSLRLGRKLEPGFVLTIEPGVYFIPELMD
LWRGQNKFTEFINYEKLFTYKDFSGIRNEEDYLITENGARLLGKKIPLRTEEVEAIR

Sequences:

>Translated_457_residues
MFSKETYMARRAKLKQTIGSGLLLFLGNDESGMNYADNTYHFRQDSTFLYFFGLPYAGLSAIIDIDNDKEIIFGDELTID
AIVWMGTQPTLKEKSEAAGIKEVRPFKEIETYLKNAQQKGQPIHYLPTYRAEHQIKLFQWLGIVPGAEKPSVPFIMGVVN
QRNYKSEEEIAEIEKACIVTADMHLTAMRTVRPGIRESDVAAAVAEVAFANNYQLSFPIIATINGQTLHNHDHSHMIKSG
DMLLLDAGAETEMGYAGDMSSTIPADSKFTTRQKDIYDIQVAAHEAAVAALRPGIPFVDVYELSCKVIMEGLKDLGFVKG
DPMEAVKAGAHAMFMPCGLGHMMGLDVHDMENLGEVYVGYDGQPKSTEFGRKSLRLGRKLEPGFVLTIEPGVYFIPELMD
LWRGQNKFTEFINYEKLFTYKDFSGIRNEEDYLITENGARLLGKKIPLRTEEVEAIR
>Mature_457_residues
MFSKETYMARRAKLKQTIGSGLLLFLGNDESGMNYADNTYHFRQDSTFLYFFGLPYAGLSAIIDIDNDKEIIFGDELTID
AIVWMGTQPTLKEKSEAAGIKEVRPFKEIETYLKNAQQKGQPIHYLPTYRAEHQIKLFQWLGIVPGAEKPSVPFIMGVVN
QRNYKSEEEIAEIEKACIVTADMHLTAMRTVRPGIRESDVAAAVAEVAFANNYQLSFPIIATINGQTLHNHDHSHMIKSG
DMLLLDAGAETEMGYAGDMSSTIPADSKFTTRQKDIYDIQVAAHEAAVAALRPGIPFVDVYELSCKVIMEGLKDLGFVKG
DPMEAVKAGAHAMFMPCGLGHMMGLDVHDMENLGEVYVGYDGQPKSTEFGRKSLRLGRKLEPGFVLTIEPGVYFIPELMD
LWRGQNKFTEFINYEKLFTYKDFSGIRNEEDYLITENGARLLGKKIPLRTEEVEAIR

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI149589008, Length=464, Percent_Identity=28.8793103448276, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI260593663, Length=459, Percent_Identity=28.322440087146, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI260593665, Length=308, Percent_Identity=32.1428571428571, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI11559925, Length=489, Percent_Identity=24.7443762781186, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI1789275, Length=474, Percent_Identity=30.8016877637131, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1790282, Length=300, Percent_Identity=30.6666666666667, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1788728, Length=240, Percent_Identity=25.4166666666667, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17508215, Length=473, Percent_Identity=30.6553911205074, Blast_Score=180, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6321118, Length=442, Percent_Identity=26.0180995475113, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320922, Length=223, Percent_Identity=27.8026905829596, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357079, Length=459, Percent_Identity=32.4618736383442, Blast_Score=192, Evalue=5e-49,
Organism=Drosophila melanogaster, GI19920384, Length=458, Percent_Identity=25.1091703056769, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 51260; Mature: 51260

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSKETYMARRAKLKQTIGSGLLLFLGNDESGMNYADNTYHFRQDSTFLYFFGLPYAGLS
CCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCCCE
AIIDIDNDKEIIFGDELTIDAIVWMGTQPTLKEKSEAAGIKEVRPFKEIETYLKNAQQKG
EEEECCCCCEEEECCCEEEEEEEEECCCCCHHHHHHHCCCHHCCCHHHHHHHHHHHHHCC
QPIHYLPTYRAEHQIKLFQWLGIVPGAEKPSVPFIMGVVNQRNYKSEEEIAEIEKACIVT
CCEEECCCCCCCCCEEEEHHHCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHEEEE
ADMHLTAMRTVRPGIRESDVAAAVAEVAFANNYQLSFPIIATINGQTLHNHDHSHMIKSG
ECCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEECCCEEECCCCHHHCCCC
DMLLLDAGAETEMGYAGDMSSTIPADSKFTTRQKDIYDIQVAAHEAAVAALRPGIPFVDV
CEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHCCCCCEEEH
YELSCKVIMEGLKDLGFVKGDPMEAVKAGAHAMFMPCGLGHMMGLDVHDMENLGEVYVGY
HHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEECCCHHHCCCCHHHHHCCCCEEECC
DGQPKSTEFGRKSLRLGRKLEPGFVLTIEPGVYFIPELMDLWRGQNKFTEFINYEKLFTY
CCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCEEHHHHHHHHCCCHHHHHHHCHHHEEEE
KDFSGIRNEEDYLITENGARLLGKKIPLRTEEVEAIR
CCCCCCCCCCCEEEECCCHHHHHCCCCCCCHHHHHCC
>Mature Secondary Structure
MFSKETYMARRAKLKQTIGSGLLLFLGNDESGMNYADNTYHFRQDSTFLYFFGLPYAGLS
CCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCCCE
AIIDIDNDKEIIFGDELTIDAIVWMGTQPTLKEKSEAAGIKEVRPFKEIETYLKNAQQKG
EEEECCCCCEEEECCCEEEEEEEEECCCCCHHHHHHHCCCHHCCCHHHHHHHHHHHHHCC
QPIHYLPTYRAEHQIKLFQWLGIVPGAEKPSVPFIMGVVNQRNYKSEEEIAEIEKACIVT
CCEEECCCCCCCCCEEEEHHHCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHEEEE
ADMHLTAMRTVRPGIRESDVAAAVAEVAFANNYQLSFPIIATINGQTLHNHDHSHMIKSG
ECCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEECCCEEECCCCHHHCCCC
DMLLLDAGAETEMGYAGDMSSTIPADSKFTTRQKDIYDIQVAAHEAAVAALRPGIPFVDV
CEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHCCCCCEEEH
YELSCKVIMEGLKDLGFVKGDPMEAVKAGAHAMFMPCGLGHMMGLDVHDMENLGEVYVGY
HHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEECCCHHHCCCCHHHHHCCCCEEECC
DGQPKSTEFGRKSLRLGRKLEPGFVLTIEPGVYFIPELMDLWRGQNKFTEFINYEKLFTY
CCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCEEHHHHHHHHCCCHHHHHHHCHHHEEEE
KDFSGIRNEEDYLITENGARLLGKKIPLRTEEVEAIR
CCCCCCCCCCCEEEECCCHHHHHCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]