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The map label for this gene is patB [H]

Identifier: 150007629

GI number: 150007629

Start: 1142224

End: 1143390

Strand: Direct

Name: patB [H]

Synonym: BDI_0982

Alternate gene names: 150007629

Gene position: 1142224-1143390 (Clockwise)

Preceding gene: 150007628

Following gene: 150007632

Centisome position: 23.74

GC content: 45.67

Gene sequence:

>1167_bases
ATGAGATATAACTTCGATGAAATAGTGCCTCGTACCGGTACGAACTCCTATAAATGGGATAGCGCTGTGGATACGGATGT
TCTACCGATGTGGGTGGCCGATATGGATTTCCGTACGGCACCCGTTATTATCGAAACCTTACGGCAACGTGTAGAACATG
GTATTTTCGGTTATACTCGAGTACCGGATGCATATTACGAAGCGGTGACAGGCTGGTTTGAACGTCGGCATGGATGGCAA
ATACGAAAAGAATGGATGATTTGTACCTCCGGAGTTGTTCCGGCAATTTCTGCCGTTATCAAGGCGCTAACCGAGCCGGG
TGATAAAGTACTGGTGCAGACTCCGGTTTATAACTGTTTTTTCTCGTCCATCCGCAATAACAGATGTGAGATTATCCGCA
CCCCTTTGTCTTATGCCCATGATACATTCACGATTGATTATGAGGATTTGGAGAAAAAAGCCGCTGATCCGAAGGTAAAG
GTCATGCTGTTGTGTAATCCTCATAATCCCGCTGGAAGGGTATGGACACGTGAGGAACTAAGTCGTATCGGCAAGATCTG
TATCCGTAATGGCCTAATAGTCGTATCAGATGAGATACATTGCGAACTCGTATTTCCGGGATATACTTTTACACCGTTTG
CATCTATCTCAGAAGAATTCCTACGGCATTCCGTGACATGCCTGTCGCCTAGCAAGGCTTTCAATATCGCTGGATTACAA
ATCGCCAATATCGTGTGTTACGATGAGAACCTACGTCGGAAGATAGACCGGGCAATCAATATCAACGAGGTATGCGATGT
GAATCCTTTTGGTGTAATAGCTACCATAGCGGCCTATAATGAGGGAGAGGAATGGCTGTCGCAACTGATCGATTATTTAT
GGCAGAATTACTTATACATGAAAGATTTTTGCGGGAAATATCTGCCGGACTTTCCGATAACCTTGTTGGAAGGCACTTAT
CTTGTATGGATGGATTGCCGTAAGTTAGGTAAATCATCGGAAGAATTGGAGCACTTGCTGATCGAGAAAGCGAAGCTATG
GCTCAATGCCGGAACGATGTATGGAGCAGAAGGCGAAGGCTTCATGCGTTGGAATATCGCTTGTCCACGTTCCTCGCTGA
TAAAGGGGGTGGAGCTGTTCAGGGATTTTGTAGGCTGTGCCTGTTAA

Upstream 100 bases:

>100_bases
GAAGCTATGGTGAGGTAATCCTCGACGAGAACATTAAGGCTCCGGGTAATTGCCAACTGAGGCTATGGAATGAACGTACT
TGCTTTTCCGCATAAAGAAT

Downstream 100 bases:

>100_bases
AGAATAGTGATGATAGAAAACGTGAGAAGGGGAAAACATCTATTGCTTTCCCCTTCTTTCATATATCTCTCACTAGATAA
AAGATTCGTTTTACTCGATC

Product: putative aminotransferase B

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MRYNFDEIVPRTGTNSYKWDSAVDTDVLPMWVADMDFRTAPVIIETLRQRVEHGIFGYTRVPDAYYEAVTGWFERRHGWQ
IRKEWMICTSGVVPAISAVIKALTEPGDKVLVQTPVYNCFFSSIRNNRCEIIRTPLSYAHDTFTIDYEDLEKKAADPKVK
VMLLCNPHNPAGRVWTREELSRIGKICIRNGLIVVSDEIHCELVFPGYTFTPFASISEEFLRHSVTCLSPSKAFNIAGLQ
IANIVCYDENLRRKIDRAININEVCDVNPFGVIATIAAYNEGEEWLSQLIDYLWQNYLYMKDFCGKYLPDFPITLLEGTY
LVWMDCRKLGKSSEELEHLLIEKAKLWLNAGTMYGAEGEGFMRWNIACPRSSLIKGVELFRDFVGCAC

Sequences:

>Translated_388_residues
MRYNFDEIVPRTGTNSYKWDSAVDTDVLPMWVADMDFRTAPVIIETLRQRVEHGIFGYTRVPDAYYEAVTGWFERRHGWQ
IRKEWMICTSGVVPAISAVIKALTEPGDKVLVQTPVYNCFFSSIRNNRCEIIRTPLSYAHDTFTIDYEDLEKKAADPKVK
VMLLCNPHNPAGRVWTREELSRIGKICIRNGLIVVSDEIHCELVFPGYTFTPFASISEEFLRHSVTCLSPSKAFNIAGLQ
IANIVCYDENLRRKIDRAININEVCDVNPFGVIATIAAYNEGEEWLSQLIDYLWQNYLYMKDFCGKYLPDFPITLLEGTY
LVWMDCRKLGKSSEELEHLLIEKAKLWLNAGTMYGAEGEGFMRWNIACPRSSLIKGVELFRDFVGCAC
>Mature_388_residues
MRYNFDEIVPRTGTNSYKWDSAVDTDVLPMWVADMDFRTAPVIIETLRQRVEHGIFGYTRVPDAYYEAVTGWFERRHGWQ
IRKEWMICTSGVVPAISAVIKALTEPGDKVLVQTPVYNCFFSSIRNNRCEIIRTPLSYAHDTFTIDYEDLEKKAADPKVK
VMLLCNPHNPAGRVWTREELSRIGKICIRNGLIVVSDEIHCELVFPGYTFTPFASISEEFLRHSVTCLSPSKAFNIAGLQ
IANIVCYDENLRRKIDRAININEVCDVNPFGVIATIAAYNEGEEWLSQLIDYLWQNYLYMKDFCGKYLPDFPITLLEGTY
LVWMDCRKLGKSSEELEHLLIEKAKLWLNAGTMYGAEGEGFMRWNIACPRSSLIKGVELFRDFVGCAC

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=185, Percent_Identity=28.1081081081081, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI56713254, Length=185, Percent_Identity=28.1081081081081, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1787909, Length=382, Percent_Identity=35.6020942408377, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1788722, Length=370, Percent_Identity=23.2432432432432, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788627, Length=174, Percent_Identity=24.1379310344828, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994476, Length=141, Percent_Identity=29.7872340425532, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994472, Length=141, Percent_Identity=29.7872340425532, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17567369, Length=141, Percent_Identity=31.2056737588652, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322401, Length=264, Percent_Identity=26.1363636363636, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI28573069, Length=273, Percent_Identity=25.2747252747253, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24646114, Length=273, Percent_Identity=25.2747252747253, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28573067, Length=273, Percent_Identity=25.2747252747253, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28573065, Length=273, Percent_Identity=25.2747252747253, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44521; Mature: 44521

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYNFDEIVPRTGTNSYKWDSAVDTDVLPMWVADMDFRTAPVIIETLRQRVEHGIFGYTR
CCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHEECCCCCHHHHHHHHHHHHHHHCCCCCCC
VPDAYYEAVTGWFERRHGWQIRKEWMICTSGVVPAISAVIKALTEPGDKVLVQTPVYNCF
CCHHHHHHHHHHHHHHCCCEEHHHHEEECCCHHHHHHHHHHHHHCCCCEEEEECCHHHHH
FSSIRNNRCEIIRTPLSYAHDTFTIDYEDLEKKAADPKVKVMLLCNPHNPAGRVWTREEL
HHHHCCCCEEEEECCHHHCCCEEEEEHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHH
SRIGKICIRNGLIVVSDEIHCELVFPGYTFTPFASISEEFLRHSVTCLSPSKAFNIAGLQ
HHHHHHHHHCCEEEEECCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCEECCEE
IANIVCYDENLRRKIDRAININEVCDVNPFGVIATIAAYNEGEEWLSQLIDYLWQNYLYM
EEEEEEECHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCHHH
KDFCGKYLPDFPITLLEGTYLVWMDCRKLGKSSEELEHLLIEKAKLWLNAGTMYGAEGEG
HHHHHHHCCCCCEEHHCCCEEEEEEHHHHCCCHHHHHHHHHHHHHHHEECCEEECCCCCC
FMRWNIACPRSSLIKGVELFRDFVGCAC
EEEEEEECCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRYNFDEIVPRTGTNSYKWDSAVDTDVLPMWVADMDFRTAPVIIETLRQRVEHGIFGYTR
CCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHEECCCCCHHHHHHHHHHHHHHHCCCCCCC
VPDAYYEAVTGWFERRHGWQIRKEWMICTSGVVPAISAVIKALTEPGDKVLVQTPVYNCF
CCHHHHHHHHHHHHHHCCCEEHHHHEEECCCHHHHHHHHHHHHHCCCCEEEEECCHHHHH
FSSIRNNRCEIIRTPLSYAHDTFTIDYEDLEKKAADPKVKVMLLCNPHNPAGRVWTREEL
HHHHCCCCEEEEECCHHHCCCEEEEEHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHH
SRIGKICIRNGLIVVSDEIHCELVFPGYTFTPFASISEEFLRHSVTCLSPSKAFNIAGLQ
HHHHHHHHHCCEEEEECCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCEECCEE
IANIVCYDENLRRKIDRAININEVCDVNPFGVIATIAAYNEGEEWLSQLIDYLWQNYLYM
EEEEEEECHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCHHH
KDFCGKYLPDFPITLLEGTYLVWMDCRKLGKSSEELEHLLIEKAKLWLNAGTMYGAEGEG
HHHHHHHCCCCCEEHHCCCEEEEEEHHHHCCCHHHHHHHHHHHHHHHEECCEEECCCCCC
FMRWNIACPRSSLIKGVELFRDFVGCAC
EEEEEEECCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]