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The map label for this gene is hisB [H]

Identifier: 150007616

GI number: 150007616

Start: 1124522

End: 1125658

Strand: Direct

Name: hisB [H]

Synonym: BDI_0969

Alternate gene names: 150007616

Gene position: 1124522-1125658 (Clockwise)

Preceding gene: 150007615

Following gene: 150007621

Centisome position: 23.37

GC content: 52.59

Gene sequence:

>1137_bases
ATGAGCACGAGGAAAAGAGCGTTGTTTATCGACCGGGACGGCACGCTTGTAAAAGAGCCGCCCGTAGATTATCAATTGGA
TAGCTTGGAGAAACTAGAGTTTGTCCCGAAGGTGATGCGTAACCTCTATTTCATTCGCGAGCGGTTGGATTTCGAGTTCG
TGATGGTCTCCAACCAAGACGGGCTGGGAACGCCCTCTTTCCCGGAGGAGACTTTCTGGCCTGCCCATAACTTGATGCTA
AAGACGCTGGAAGGCGAGGGGATCGTGTTCGACGATATCTTGATCGATCCTTCCTTTCCCGAGGATAATTCCCCGAATCG
TAAGCCTCGTACGGGAATGCTCACGAAATATATGACCGGTGAATACGATCTGGAGAATAGTTTCGTGATCGGGGACCGCC
TTACGGATATGGAGTTGGCCCATAATCTGGGCGCTAAAGGTATCTGGTTGCGCCCGGAGGAGGGAGCGGAGAGTGAGTTG
GCGGCTTACGCTACCTCATTGTCTCCCGCCTATATCACGGATGATTGGGATAAGATCACCGAGTATCTGTTTGCCGGCGA
GCGTCGTGCGGTCGTACGGCGTGCCACGAAGGAGACGGACATCTATGTGGACTGGAATCTGGATGGAACCGGAAAGACAT
CGATCTCTACCGGGCTTGGTTTCTTCGATCATATGTTGGATCAGATCGGTAAGCATTCCGGTACGGATCTGACGGTACGG
GTAAAAGGCGACCTGGAGGTCGACGAGCATCATACGATAGAGGATACGGCGATTGCCCTTGGCGAGGCGATGCTGAAAGC
GCTGGGTGATAAGCGAGGGATCGAGCGTTATGGCTATTGCCTTCCGATGGACGATTGCTTGTGTAGTGTGGCGCTGGATT
TCGGTGGCCGTCCTTGGTTGGTTTGGGACGCTGAGTTCCACCGTGAGAAAGTGGGAGATATGCCTACGGAGATGTTCCTC
CATTTCTTCAAGAGCTTGAGCGACGCTGCCCGCATGAATTTGAATATCCGTGCCGAGGGTACGAACGAGCATCATAAGAT
AGAAGGTATCTTCAAGGCTTTGGCCCGCTCGATCAAGATGGCGATCCGACGAGATATTTATCGGTTTGAGCTACCGAGTA
CGAAAGGGCTCTTGTAA

Upstream 100 bases:

>100_bases
ACCGTAGTAACGTGCAGAAATGCCGGGGTTGCCTTCGTATTACGATCGGTACGCCGAAAGAGAATGATAGCTTATTGAAC
GCGATGAAAAACATGAAATT

Downstream 100 bases:

>100_bases
TCTGTAAAAAACACTACTGTATTTGTGCACGAATACAGTAGTGTTTTAGTCTGAATACTATTGTGTTTATCCACAAACAC
TATAGTGTTTTCGACTCAGA

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD [H]

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MSTRKRALFIDRDGTLVKEPPVDYQLDSLEKLEFVPKVMRNLYFIRERLDFEFVMVSNQDGLGTPSFPEETFWPAHNLML
KTLEGEGIVFDDILIDPSFPEDNSPNRKPRTGMLTKYMTGEYDLENSFVIGDRLTDMELAHNLGAKGIWLRPEEGAESEL
AAYATSLSPAYITDDWDKITEYLFAGERRAVVRRATKETDIYVDWNLDGTGKTSISTGLGFFDHMLDQIGKHSGTDLTVR
VKGDLEVDEHHTIEDTAIALGEAMLKALGDKRGIERYGYCLPMDDCLCSVALDFGGRPWLVWDAEFHREKVGDMPTEMFL
HFFKSLSDAARMNLNIRAEGTNEHHKIEGIFKALARSIKMAIRRDIYRFELPSTKGLL

Sequences:

>Translated_378_residues
MSTRKRALFIDRDGTLVKEPPVDYQLDSLEKLEFVPKVMRNLYFIRERLDFEFVMVSNQDGLGTPSFPEETFWPAHNLML
KTLEGEGIVFDDILIDPSFPEDNSPNRKPRTGMLTKYMTGEYDLENSFVIGDRLTDMELAHNLGAKGIWLRPEEGAESEL
AAYATSLSPAYITDDWDKITEYLFAGERRAVVRRATKETDIYVDWNLDGTGKTSISTGLGFFDHMLDQIGKHSGTDLTVR
VKGDLEVDEHHTIEDTAIALGEAMLKALGDKRGIERYGYCLPMDDCLCSVALDFGGRPWLVWDAEFHREKVGDMPTEMFL
HFFKSLSDAARMNLNIRAEGTNEHHKIEGIFKALARSIKMAIRRDIYRFELPSTKGLL
>Mature_377_residues
STRKRALFIDRDGTLVKEPPVDYQLDSLEKLEFVPKVMRNLYFIRERLDFEFVMVSNQDGLGTPSFPEETFWPAHNLMLK
TLEGEGIVFDDILIDPSFPEDNSPNRKPRTGMLTKYMTGEYDLENSFVIGDRLTDMELAHNLGAKGIWLRPEEGAESELA
AYATSLSPAYITDDWDKITEYLFAGERRAVVRRATKETDIYVDWNLDGTGKTSISTGLGFFDHMLDQIGKHSGTDLTVRV
KGDLEVDEHHTIEDTAIALGEAMLKALGDKRGIERYGYCLPMDDCLCSVALDFGGRPWLVWDAEFHREKVGDMPTEMFLH
FFKSLSDAARMNLNIRAEGTNEHHKIEGIFKALARSIKMAIRRDIYRFELPSTKGLL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=375, Percent_Identity=46.1333333333333, Blast_Score=335, Evalue=4e-93,
Organism=Escherichia coli, GI1786399, Length=158, Percent_Identity=29.746835443038, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=38.0733944954128, Blast_Score=151, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =3.1.3.15; =4.2.1.19 [H]

Molecular weight: Translated: 43053; Mature: 42922

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRKRALFIDRDGTLVKEPPVDYQLDSLEKLEFVPKVMRNLYFIRERLDFEFVMVSNQD
CCCCCCEEEEECCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCC
GLGTPSFPEETFWPAHNLMLKTLEGEGIVFDDILIDPSFPEDNSPNRKPRTGMLTKYMTG
CCCCCCCCCCCCCCHHHEEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHCCCC
EYDLENSFVIGDRLTDMELAHNLGAKGIWLRPEEGAESELAAYATSLSPAYITDDWDKIT
CCCCCCCEEECCCCHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHCCCCCEECCCHHHHH
EYLFAGERRAVVRRATKETDIYVDWNLDGTGKTSISTGLGFFDHMLDQIGKHSGTDLTVR
HHHHCCCHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEE
VKGDLEVDEHHTIEDTAIALGEAMLKALGDKRGIERYGYCLPMDDCLCSVALDFGGRPWL
EECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHCCCCCEEE
VWDAEFHREKVGDMPTEMFLHFFKSLSDAARMNLNIRAEGTNEHHKIEGIFKALARSIKM
EECHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHH
AIRRDIYRFELPSTKGLL
HHHHHHHEEECCCCCCCC
>Mature Secondary Structure 
STRKRALFIDRDGTLVKEPPVDYQLDSLEKLEFVPKVMRNLYFIRERLDFEFVMVSNQD
CCCCCEEEEECCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCC
GLGTPSFPEETFWPAHNLMLKTLEGEGIVFDDILIDPSFPEDNSPNRKPRTGMLTKYMTG
CCCCCCCCCCCCCCHHHEEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHCCCC
EYDLENSFVIGDRLTDMELAHNLGAKGIWLRPEEGAESELAAYATSLSPAYITDDWDKIT
CCCCCCCEEECCCCHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHCCCCCEECCCHHHHH
EYLFAGERRAVVRRATKETDIYVDWNLDGTGKTSISTGLGFFDHMLDQIGKHSGTDLTVR
HHHHCCCHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEE
VKGDLEVDEHHTIEDTAIALGEAMLKALGDKRGIERYGYCLPMDDCLCSVALDFGGRPWL
EECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHCCCCCEEE
VWDAEFHREKVGDMPTEMFLHFFKSLSDAARMNLNIRAEGTNEHHKIEGIFKALARSIKM
EECHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHH
AIRRDIYRFELPSTKGLL
HHHHHHHEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA