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The map label for this gene is hisC

Identifier: 150007615

GI number: 150007615

Start: 1123488

End: 1124525

Strand: Direct

Name: hisC

Synonym: BDI_0968

Alternate gene names: 150007615

Gene position: 1123488-1124525 (Clockwise)

Preceding gene: 150007614

Following gene: 150007616

Centisome position: 23.35

GC content: 47.98

Gene sequence:

>1038_bases
ATGAAAGACCTAAAAGATTTAGTAAGACCGAATGTCTGGAATTTGAAACCGTATTCATCCGCACGTGATGAGTTTCATGG
GGATGCCTCCGTTTTTCTGGACGCGAATGAGAATCCGTGGAATATGCCGTATAACCGTTATCCCGATCCCTTGCAGTGGA
AATTGAAGGATCGTCTGGCCGTGTTGAAAGGCGTGGACCGTAGCTCGATCTTCTTGGGCAATGGCAGTGACGAGGCCATC
GATCTGGTGATCCGTGCTTTTTGCGAGCCGGGGTTGGATAGTGTAGTGACGATCTCGCCGTCGTATGGCATGTATGAGGT
GGCAGCGAATGTAAATAACGTGGAATGCCGTAAGGTTTCTTTGGACGAAAACTTTGATTTGGATGCGGAAGCCGTATTGG
AATCGGCGGACGAGTGGACAAAAGTGATCTTCCTATGTTCTCCGAATAACCCTAGTGGCAACAGTCTGGATCGTGGCTCG
ATCTATAAGATCTTGAAGAATTATGAAGGAATCGTGGTGATCGATGAGGCTTATATCGACTTCTCCGCTTATCCCTCTTT
CTTGAAGGAATTATCCGGGTTCCCGAATCTGATCGTTCTTCAAACCTTGTCGAAAGCGTGGGGAGCGGCGGGTATTCGTT
TGGGTATGGCATTCGCCTCTCCGGAGATTATCGGTGTCTTGAATAAGATCAAATATCCGTATAACGTCAACCAGCTTACA
CAGGAGAAAGCTTTGGAGCTCTTGAACGACGAGGCGACCATGAAGCACCAAGTGAACGAGATCCTCACGGAGCGTAACCG
GCTGGAGAAGATCCTGTCCGAGCCTCCTTTCTCCTATCAAGTATATCCTTCGGACGCTAATTTCTTGTTGGTGAATGTCG
CCAAGGCGGATGCCATGTATAATGGGCTCGTGAAGAAAGGGATCGTAGTGCGTAACCGTAGTAACGTGCAGAAATGCCGG
GGTTGCCTTCGTATTACGATCGGTACGCCGAAAGAGAATGATAGCTTATTGAACGCGATGAAAAACATGAAATTATGA

Upstream 100 bases:

>100_bases
CCGATGGTATCCGTGCCTTGGGTAGTACGATCCAAACCATGGCGGCCAACGAGCAGCTGGATGCTCACCGCAACGCAGTA
ACAATTAGATTGAACACGAT

Downstream 100 bases:

>100_bases
GCACGAGGAAAAGAGCGTTGTTTATCGACCGGGACGGCACGCTTGTAAAAGAGCCGCCCGTAGATTATCAATTGGATAGC
TTGGAGAAACTAGAGTTTGT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKDLKDLVRPNVWNLKPYSSARDEFHGDASVFLDANENPWNMPYNRYPDPLQWKLKDRLAVLKGVDRSSIFLGNGSDEAI
DLVIRAFCEPGLDSVVTISPSYGMYEVAANVNNVECRKVSLDENFDLDAEAVLESADEWTKVIFLCSPNNPSGNSLDRGS
IYKILKNYEGIVVIDEAYIDFSAYPSFLKELSGFPNLIVLQTLSKAWGAAGIRLGMAFASPEIIGVLNKIKYPYNVNQLT
QEKALELLNDEATMKHQVNEILTERNRLEKILSEPPFSYQVYPSDANFLLVNVAKADAMYNGLVKKGIVVRNRSNVQKCR
GCLRITIGTPKENDSLLNAMKNMKL

Sequences:

>Translated_345_residues
MKDLKDLVRPNVWNLKPYSSARDEFHGDASVFLDANENPWNMPYNRYPDPLQWKLKDRLAVLKGVDRSSIFLGNGSDEAI
DLVIRAFCEPGLDSVVTISPSYGMYEVAANVNNVECRKVSLDENFDLDAEAVLESADEWTKVIFLCSPNNPSGNSLDRGS
IYKILKNYEGIVVIDEAYIDFSAYPSFLKELSGFPNLIVLQTLSKAWGAAGIRLGMAFASPEIIGVLNKIKYPYNVNQLT
QEKALELLNDEATMKHQVNEILTERNRLEKILSEPPFSYQVYPSDANFLLVNVAKADAMYNGLVKKGIVVRNRSNVQKCR
GCLRITIGTPKENDSLLNAMKNMKL
>Mature_345_residues
MKDLKDLVRPNVWNLKPYSSARDEFHGDASVFLDANENPWNMPYNRYPDPLQWKLKDRLAVLKGVDRSSIFLGNGSDEAI
DLVIRAFCEPGLDSVVTISPSYGMYEVAANVNNVECRKVSLDENFDLDAEAVLESADEWTKVIFLCSPNNPSGNSLDRGS
IYKILKNYEGIVVIDEAYIDFSAYPSFLKELSGFPNLIVLQTLSKAWGAAGIRLGMAFASPEIIGVLNKIKYPYNVNQLT
QEKALELLNDEATMKHQVNEILTERNRLEKILSEPPFSYQVYPSDANFLLVNVAKADAMYNGLVKKGIVVRNRSNVQKCR
GCLRITIGTPKENDSLLNAMKNMKL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=349, Percent_Identity=36.676217765043, Blast_Score=233, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6322075, Length=376, Percent_Identity=39.0957446808511, Blast_Score=243, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_PARD8 (A6LAM2)

Other databases:

- EMBL:   CP000140
- RefSeq:   YP_001302358.1
- ProteinModelPortal:   A6LAM2
- SMR:   A6LAM2
- STRING:   A6LAM2
- GeneID:   5306122
- GenomeReviews:   CP000140_GR
- KEGG:   pdi:BDI_0968
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   RDFSKEP
- BioCyc:   PDIS435591:BDI_0968-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 38729; Mature: 38729

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDLKDLVRPNVWNLKPYSSARDEFHGDASVFLDANENPWNMPYNRYPDPLQWKLKDRLA
CCCHHHHHCCCCCCCCCCCCHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
VLKGVDRSSIFLGNGSDEAIDLVIRAFCEPGLDSVVTISPSYGMYEVAANVNNVECRKVS
HHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCEEEECCCCCEEEEECCCCCCEEEEEE
LDENFDLDAEAVLESADEWTKVIFLCSPNNPSGNSLDRGSIYKILKNYEGIVVIDEAYID
CCCCCCCCHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCC
FSAYPSFLKELSGFPNLIVLQTLSKAWGAAGIRLGMAFASPEIIGVLNKIKYPYNVNQLT
HHHHHHHHHHHCCCCCEEHHHHHHHHHCCCHHEEEHHHCCCHHHHHHHHCCCCCCHHHHH
QEKALELLNDEATMKHQVNEILTERNRLEKILSEPPFSYQVYPSDANFLLVNVAKADAMY
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEHHHHHHH
NGLVKKGIVVRNRSNVQKCRGCLRITIGTPKENDSLLNAMKNMKL
HHHHHCCEEEECCCCHHHHCCEEEEEECCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MKDLKDLVRPNVWNLKPYSSARDEFHGDASVFLDANENPWNMPYNRYPDPLQWKLKDRLA
CCCHHHHHCCCCCCCCCCCCHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
VLKGVDRSSIFLGNGSDEAIDLVIRAFCEPGLDSVVTISPSYGMYEVAANVNNVECRKVS
HHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCEEEECCCCCEEEEECCCCCCEEEEEE
LDENFDLDAEAVLESADEWTKVIFLCSPNNPSGNSLDRGSIYKILKNYEGIVVIDEAYID
CCCCCCCCHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCC
FSAYPSFLKELSGFPNLIVLQTLSKAWGAAGIRLGMAFASPEIIGVLNKIKYPYNVNQLT
HHHHHHHHHHHCCCCCEEHHHHHHHHHCCCHHEEEHHHCCCHHHHHHHHCCCCCCHHHHH
QEKALELLNDEATMKHQVNEILTERNRLEKILSEPPFSYQVYPSDANFLLVNVAKADAMY
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEHHHHHHH
NGLVKKGIVVRNRSNVQKCRGCLRITIGTPKENDSLLNAMKNMKL
HHHHHCCEEEECCCCHHHHCCEEEEEECCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA