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The map label for this gene is nhaA

Identifier: 150007575

GI number: 150007575

Start: 1068925

End: 1070286

Strand: Direct

Name: nhaA

Synonym: BDI_0928

Alternate gene names: 150007575

Gene position: 1068925-1070286 (Clockwise)

Preceding gene: 150007574

Following gene: 150007578

Centisome position: 22.22

GC content: 47.5

Gene sequence:

>1362_bases
ATGGACCGTACGATTAATGTTATCCTTAAACCGTTGCGTCGCTTCGCTATACAGAAGCCGAACGCTAGTCTTTTATTGTT
TGCCGCTACCATCGTTGCTATGGTCTTGGCCAATTCGCCTTGGGCAGATAGGTATCACCAGTTATTAGCTTTTCCAATCG
ATCTGCAAGCCGGGCAGTTTAACTTCTTTGCGCATCATGGCGAGACCATGTCTATGCTGGCTTTCGTGAACGACGCCCTT
ATGGCGGTTTTCTTTTTCGTGATCGGTCTGGAGATCAAGCAAGAGGTATTGATCGGTGAGTTGAGTTCCGTGCGGAAGGC
GCTATTGCCTATTATCGCCGCCTGTGGTGGAATGATCGTGCCGGTCTTATTTTATATGTTAGTATGTAATACGCCTCCCG
AGGTAAACGGGGCGGCTATTCCGATGGCTACGGATATCGCTTTCGCCTTGGCCGTATTGGGCTTGTTGGGGAAGCGGGTG
CCGTTGAGCATGCGTATCTTCTTGACCGCCTTGGCTGTGGTGGATGATATTGGAGGTATCATAATTATCGCCCTGTTTTA
TAGCGGGCATATCGCTTTCGAGCCTTTGTTGATATCCCTGATAGTCCTCGCTTTGTTGTATGTGGGAGGAAAGTTCCGGG
TACACAACCGATTGTTTTTCTATATCGGTGGCTTTATCGTTTGGCTGCTATTTCTGGAGTCAGGAATCCATCCGACAATC
GCCGGCGTGTTGATCGCCTTTACGGTTCCTGCCCGTCCGGTTGTTAAGCTAGATGATTTCACGTGTGATATGACCGGGTA
TTTGAATATGCTGGACTATACCGAGGTTCGTCAGTCCCGTAAAGCGGAAGTGCTTACGCCTACACAAATTCAGGTATTGA
ATAACATCCATACGTTGGCGGATAAAACGATCAGTCCGTTGCAGACCATCGCTGATAAGTTGCATCCTTTGGTAAACTAT
GTGATACTTCCTTTATTCGCTTTCGTGAATGCCGGTGTGACATTCGGGGATATCCAACCCCAGACATTAGTTAATGTACC
GTTGGCGGTGTTCGTGGGCCTATTTGTAGGAAAGACATTAGGTATATTCTCTTTCTCTTACTTGTTCGCGTGTACGCCAT
TTGCCTCCATGCCTACAGGCATGAGCAAGCGTAATTTATTTGGAGTATCCATGTTGGGAGGAATCGGTTTCACGGTCGCT
TTGTTTATAGCGAATCTTTCCTTTGACGGCAGTACGGCGGCGGGTGCCGATCTCTTGAATCAGGCGAAGCTGGGTGTATT
CACGGGATCGTTTATATCCGGTCTTTGCGGTTATCTGGTATTGAAATGGGTTTTACCTAAAGAAAAAGTGGAAACGATCT
AA

Upstream 100 bases:

>100_bases
TGAAGGTATTTCAAGATGATATTCCGTTTCCCTCTTGGGAGGGAAACGGAATAGTCATAGTACGATCAATTGTTGAAGAC
CTTCATCTAACTTATTATTT

Downstream 100 bases:

>100_bases
ATAAAAAGGCAGTCCGGCAAGGACTGCCTTTTACATTATATTATGCCGTAACTAAAGTTTCGTGAGATCTTGTTGCCATG
TAATATATGATTTGATAATT

Product: Na+/H+ antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MDRTINVILKPLRRFAIQKPNASLLLFAATIVAMVLANSPWADRYHQLLAFPIDLQAGQFNFFAHHGETMSMLAFVNDAL
MAVFFFVIGLEIKQEVLIGELSSVRKALLPIIAACGGMIVPVLFYMLVCNTPPEVNGAAIPMATDIAFALAVLGLLGKRV
PLSMRIFLTALAVVDDIGGIIIIALFYSGHIAFEPLLISLIVLALLYVGGKFRVHNRLFFYIGGFIVWLLFLESGIHPTI
AGVLIAFTVPARPVVKLDDFTCDMTGYLNMLDYTEVRQSRKAEVLTPTQIQVLNNIHTLADKTISPLQTIADKLHPLVNY
VILPLFAFVNAGVTFGDIQPQTLVNVPLAVFVGLFVGKTLGIFSFSYLFACTPFASMPTGMSKRNLFGVSMLGGIGFTVA
LFIANLSFDGSTAAGADLLNQAKLGVFTGSFISGLCGYLVLKWVLPKEKVETI

Sequences:

>Translated_453_residues
MDRTINVILKPLRRFAIQKPNASLLLFAATIVAMVLANSPWADRYHQLLAFPIDLQAGQFNFFAHHGETMSMLAFVNDAL
MAVFFFVIGLEIKQEVLIGELSSVRKALLPIIAACGGMIVPVLFYMLVCNTPPEVNGAAIPMATDIAFALAVLGLLGKRV
PLSMRIFLTALAVVDDIGGIIIIALFYSGHIAFEPLLISLIVLALLYVGGKFRVHNRLFFYIGGFIVWLLFLESGIHPTI
AGVLIAFTVPARPVVKLDDFTCDMTGYLNMLDYTEVRQSRKAEVLTPTQIQVLNNIHTLADKTISPLQTIADKLHPLVNY
VILPLFAFVNAGVTFGDIQPQTLVNVPLAVFVGLFVGKTLGIFSFSYLFACTPFASMPTGMSKRNLFGVSMLGGIGFTVA
LFIANLSFDGSTAAGADLLNQAKLGVFTGSFISGLCGYLVLKWVLPKEKVETI
>Mature_453_residues
MDRTINVILKPLRRFAIQKPNASLLLFAATIVAMVLANSPWADRYHQLLAFPIDLQAGQFNFFAHHGETMSMLAFVNDAL
MAVFFFVIGLEIKQEVLIGELSSVRKALLPIIAACGGMIVPVLFYMLVCNTPPEVNGAAIPMATDIAFALAVLGLLGKRV
PLSMRIFLTALAVVDDIGGIIIIALFYSGHIAFEPLLISLIVLALLYVGGKFRVHNRLFFYIGGFIVWLLFLESGIHPTI
AGVLIAFTVPARPVVKLDDFTCDMTGYLNMLDYTEVRQSRKAEVLTPTQIQVLNNIHTLADKTISPLQTIADKLHPLVNY
VILPLFAFVNAGVTFGDIQPQTLVNVPLAVFVGLFVGKTLGIFSFSYLFACTPFASMPTGMSKRNLFGVSMLGGIGFTVA
LFIANLSFDGSTAAGADLLNQAKLGVFTGSFISGLCGYLVLKWVLPKEKVETI

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=408, Percent_Identity=37.9901960784314, Blast_Score=241, Evalue=6e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA_PARD8 (A6LAI2)

Other databases:

- EMBL:   CP000140
- RefSeq:   YP_001302318.1
- ProteinModelPortal:   A6LAI2
- SMR:   A6LAI2
- STRING:   A6LAI2
- GeneID:   5306082
- GenomeReviews:   CP000140_GR
- KEGG:   pdi:BDI_0928
- eggNOG:   COG3004
- HOGENOM:   HBG665619
- OMA:   HGFGIPM
- ProtClustDB:   CLSK822286
- BioCyc:   PDIS435591:BDI_0928-MONOMER
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 49257; Mature: 49257

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xca68d2c)-; HASH(0xcf931a4)-; HASH(0xc8ef494)-; HASH(0xbaf6994)-; HASH(0xc08f098)-; HASH(0xdab46a8)-; HASH(0xd7713cc)-; HASH(0xcb7d7dc)-; HASH(0xd16be44)-; HASH(0xd0c58cc)-; HASH(0xdab47b0)-;

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRTINVILKPLRRFAIQKPNASLLLFAATIVAMVLANSPWADRYHQLLAFPIDLQAGQF
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCEECCCCCE
NFFAHHGETMSMLAFVNDALMAVFFFVIGLEIKQEVLIGELSSVRKALLPIIAACGGMIV
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
PVLFYMLVCNTPPEVNGAAIPMATDIAFALAVLGLLGKRVPLSMRIFLTALAVVDDIGGI
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHH
IIIALFYSGHIAFEPLLISLIVLALLYVGGKFRVHNRLFFYIGGFIVWLLFLESGIHPTI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHH
AGVLIAFTVPARPVVKLDDFTCDMTGYLNMLDYTEVRQSRKAEVLTPTQIQVLNNIHTLA
HHHHHHHCCCCCCEEEECCCEECHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
DKTISPLQTIADKLHPLVNYVILPLFAFVNAGVTFGDIQPQTLVNVPLAVFVGLFVGKTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHCHHHHHHHHHHHHHH
GIFSFSYLFACTPFASMPTGMSKRNLFGVSMLGGIGFTVALFIANLSFDGSTAAGADLLN
HHHHHHHHHHHCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
QAKLGVFTGSFISGLCGYLVLKWVLPKEKVETI
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCH
>Mature Secondary Structure
MDRTINVILKPLRRFAIQKPNASLLLFAATIVAMVLANSPWADRYHQLLAFPIDLQAGQF
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCEECCCCCE
NFFAHHGETMSMLAFVNDALMAVFFFVIGLEIKQEVLIGELSSVRKALLPIIAACGGMIV
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
PVLFYMLVCNTPPEVNGAAIPMATDIAFALAVLGLLGKRVPLSMRIFLTALAVVDDIGGI
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHH
IIIALFYSGHIAFEPLLISLIVLALLYVGGKFRVHNRLFFYIGGFIVWLLFLESGIHPTI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHH
AGVLIAFTVPARPVVKLDDFTCDMTGYLNMLDYTEVRQSRKAEVLTPTQIQVLNNIHTLA
HHHHHHHCCCCCCEEEECCCEECHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
DKTISPLQTIADKLHPLVNYVILPLFAFVNAGVTFGDIQPQTLVNVPLAVFVGLFVGKTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHCHHHHHHHHHHHHHH
GIFSFSYLFACTPFASMPTGMSKRNLFGVSMLGGIGFTVALFIANLSFDGSTAAGADLLN
HHHHHHHHHHHCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
QAKLGVFTGSFISGLCGYLVLKWVLPKEKVETI
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA