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The map label for this gene is barA [H]

Identifier: 150007276

GI number: 150007276

Start: 732510

End: 734885

Strand: Reverse

Name: barA [H]

Synonym: BDI_0621

Alternate gene names: 150007276

Gene position: 734885-732510 (Counterclockwise)

Preceding gene: 150007295

Following gene: 150007271

Centisome position: 15.27

GC content: 41.29

Gene sequence:

>2376_bases
ATGACAAGCGAAAGCAAAAAAGAAAAGTTAAATAAAAACGAGCTATTAGCTAATTATCAATATCTCATGGATACGATCTG
GACTATCTATTTGGAAGACGGAAGCGTCGATATACTTAAATATTCAATGAATCCGGAATTAGTTAATACAAAACAAGATT
ATACCAGCCTTGCCAACATTCTAAGAAACGACATCTATTCTCCAGACCGTAGTTTATGGGATGAAACGGTTTCGCTTGAA
GTTTTCTTTAGAATGATAGCCGAAGGATGTTTTCATAAAACATTTGACTTACGTTTCTGCAACGATCACTTCGGTTTTGA
ATGGCACGAAACTTTTATCGATATTCTTGTTAACAACGAAGGTATCCCTGATAGAATCCTTTTATCTAGCCGTAATATCA
ACGATTTCAGAAAAGCGCAAATTATAGAAACCGCCGTAAGATCAGAATATGATTACGTAATCTATATTGAAGCTTCGAAA
AATAGCTATGTCATGTATACCTCCGGCTCGGAGAGCTATAGTCCCCCTCCTATCGCCAGCTATGACTATGATGGAGTAGT
CGCCTCATATAACCGGCAATATATGGCACCTGAGCTTCACGAAGAAATGACTGAGAAACTACAGATCGCTCATATAGAAC
CGATACTACGGAAACATGGAGAATATATCGTATATGGCACCATGATAGAGAATGGCGTAAACCGGGAAAAGAAAATGCGA
TTCAGCTATTACGACAGGGAAAAGAACATATGGTTAATGACTCGAACTGATATAACGGAAATCAAAGAAGAAAGAAAACA
AAAAAAACTGTTGCAGGAAGCTTTACAGAGCGCTAATGCCGCCAACCGTGCCAAAACTGATTTCCTATCCCGGATGAGCC
ATGACATCCGCACTCCTATCAACGCCATCGTCGGTATGACAGCGATAGCTCGCCTGCACATGGATGACCAGATGCGTATA
GCTGATTGCTTAAAGAAAATAACCATTTCCTCCAAACTCTTATTAAATCTGATCAATGAGGTACTGGATATGTCTAAACT
GGAAAGTGATAAGATCATGCTGACAGAAGAGGCATTCAAGATCAACGAGCTATTAGAGAGTTTATTCGTCATGGTGCAAC
CGGCCTTTGAAGCGAAAAAGCAAAAGTTTCAGATACATGTCACCAAGATAAAACACGAATGCCTTATAGGTGACGTGCAA
CGTATACAGCAAGCATTGTTGAACATGCTTACAAATGCGATCAAATATACTCCGGAAGACGGGCAAATACAACTAACGGT
AGAAGAGAAACCTTCTGTCTATAACGGTTACGGCCAGTTTGAAATAACCGTAACGGATAACGGTATAGGAATGAAACCAG
AATTTCTGGAAAAAGTATTCGAACCTTTCGAGCGGTCGGATGACAAGGCCATTCGCAATATCCAAGGGACTGGTCTCGGC
ATGGCTATCAGCCGCCATATCGCCCAGATAATGAACGGAGACATTCTTGTGGAAAGTGAATATGGAAAAGGCTCCAAATT
CACCATGAGGTTTCATGTCAAACTGGGAAGTACGAATGAATACGACAATAATATATTGGTAGACCTACCAGTACTGGTAG
TAGATGACGATGAGGTATCCTGCGAGATCGCTTATGAAAACCTCCAAGAATTAGGGATGAAACCGGAATGGGTTCTTTCC
GGTGAAAAGGCCGTACAAAAAGTAATCGACGGAGACACTTACTTTGCTATTATCATAGATTTAATGATGCCCGGCATGAA
CGGCATCGAAACCACCATAAAAATAAGGGAATACGTGGAACCAGATACTCCGATCATCATCATATCAGCATACGATTATT
CCGGTTACGAATTTGAGGCAGTAAAAGCTGGCGTCAACGGCTTCATAAGCAAGCCTATCATGAAATCCAAGCTATTCCAT
TTAATGAAAAAATTTGCCTCAGACAAAAAGGAAGACGAGCAAGTCCTTATCACACCGACTCATATCATATCTTTTCCCGG
CAAACGGATACTGGTCGTGGAAGACAATGACCTAAACCGCGAGATAGCGTATGAATTGCTGCAAGAAACCCATGCAGAAG
TCGAGACAGCTTGCGACGGACAAGAAGCCGTTGATAAAGTCGCCGCTTCACCCGAAGGTTATTACGATTTTATAATCATG
GATATACAGATGCCTGTAATGGATGGACTCGAAGCGACAAGGCAAATTCGTCATCTCGACCGTCAAGATATCAAAGATAT
GCCCATTATAGCCATGTCTGCCAATGCTTTCGCCGAAGATGTACGGCTAAGTCTGGAAGCCGGCATGAACGAACATATCG
CAAAACCGATCGAGATAGACAAATTATATGGAATTATGAGGAAATGGTTCCAGTAA

Upstream 100 bases:

>100_bases
TGATTTTATCTCTTATATACATATTATTTACCTACTTTCGCGGAATATCCTTGAAAGCACAAGGATATAAGTGCATTCAT
AAACGAGCAAGAATACAAAC

Downstream 100 bases:

>100_bases
AAAAAGCCGGAATCTCTTCCGGCCTTCTCCAAACTCAATGAATCACCTTTTTACTTCTTGCAATCGCAAGTTGAATATGC
TACCAACATCCAAACCAATT

Product: two-component hybrid sensor kinase/response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 791; Mature: 790

Protein sequence:

>791_residues
MTSESKKEKLNKNELLANYQYLMDTIWTIYLEDGSVDILKYSMNPELVNTKQDYTSLANILRNDIYSPDRSLWDETVSLE
VFFRMIAEGCFHKTFDLRFCNDHFGFEWHETFIDILVNNEGIPDRILLSSRNINDFRKAQIIETAVRSEYDYVIYIEASK
NSYVMYTSGSESYSPPPIASYDYDGVVASYNRQYMAPELHEEMTEKLQIAHIEPILRKHGEYIVYGTMIENGVNREKKMR
FSYYDREKNIWLMTRTDITEIKEERKQKKLLQEALQSANAANRAKTDFLSRMSHDIRTPINAIVGMTAIARLHMDDQMRI
ADCLKKITISSKLLLNLINEVLDMSKLESDKIMLTEEAFKINELLESLFVMVQPAFEAKKQKFQIHVTKIKHECLIGDVQ
RIQQALLNMLTNAIKYTPEDGQIQLTVEEKPSVYNGYGQFEITVTDNGIGMKPEFLEKVFEPFERSDDKAIRNIQGTGLG
MAISRHIAQIMNGDILVESEYGKGSKFTMRFHVKLGSTNEYDNNILVDLPVLVVDDDEVSCEIAYENLQELGMKPEWVLS
GEKAVQKVIDGDTYFAIIIDLMMPGMNGIETTIKIREYVEPDTPIIIISAYDYSGYEFEAVKAGVNGFISKPIMKSKLFH
LMKKFASDKKEDEQVLITPTHIISFPGKRILVVEDNDLNREIAYELLQETHAEVETACDGQEAVDKVAASPEGYYDFIIM
DIQMPVMDGLEATRQIRHLDRQDIKDMPIIAMSANAFAEDVRLSLEAGMNEHIAKPIEIDKLYGIMRKWFQ

Sequences:

>Translated_791_residues
MTSESKKEKLNKNELLANYQYLMDTIWTIYLEDGSVDILKYSMNPELVNTKQDYTSLANILRNDIYSPDRSLWDETVSLE
VFFRMIAEGCFHKTFDLRFCNDHFGFEWHETFIDILVNNEGIPDRILLSSRNINDFRKAQIIETAVRSEYDYVIYIEASK
NSYVMYTSGSESYSPPPIASYDYDGVVASYNRQYMAPELHEEMTEKLQIAHIEPILRKHGEYIVYGTMIENGVNREKKMR
FSYYDREKNIWLMTRTDITEIKEERKQKKLLQEALQSANAANRAKTDFLSRMSHDIRTPINAIVGMTAIARLHMDDQMRI
ADCLKKITISSKLLLNLINEVLDMSKLESDKIMLTEEAFKINELLESLFVMVQPAFEAKKQKFQIHVTKIKHECLIGDVQ
RIQQALLNMLTNAIKYTPEDGQIQLTVEEKPSVYNGYGQFEITVTDNGIGMKPEFLEKVFEPFERSDDKAIRNIQGTGLG
MAISRHIAQIMNGDILVESEYGKGSKFTMRFHVKLGSTNEYDNNILVDLPVLVVDDDEVSCEIAYENLQELGMKPEWVLS
GEKAVQKVIDGDTYFAIIIDLMMPGMNGIETTIKIREYVEPDTPIIIISAYDYSGYEFEAVKAGVNGFISKPIMKSKLFH
LMKKFASDKKEDEQVLITPTHIISFPGKRILVVEDNDLNREIAYELLQETHAEVETACDGQEAVDKVAASPEGYYDFIIM
DIQMPVMDGLEATRQIRHLDRQDIKDMPIIAMSANAFAEDVRLSLEAGMNEHIAKPIEIDKLYGIMRKWFQ
>Mature_790_residues
TSESKKEKLNKNELLANYQYLMDTIWTIYLEDGSVDILKYSMNPELVNTKQDYTSLANILRNDIYSPDRSLWDETVSLEV
FFRMIAEGCFHKTFDLRFCNDHFGFEWHETFIDILVNNEGIPDRILLSSRNINDFRKAQIIETAVRSEYDYVIYIEASKN
SYVMYTSGSESYSPPPIASYDYDGVVASYNRQYMAPELHEEMTEKLQIAHIEPILRKHGEYIVYGTMIENGVNREKKMRF
SYYDREKNIWLMTRTDITEIKEERKQKKLLQEALQSANAANRAKTDFLSRMSHDIRTPINAIVGMTAIARLHMDDQMRIA
DCLKKITISSKLLLNLINEVLDMSKLESDKIMLTEEAFKINELLESLFVMVQPAFEAKKQKFQIHVTKIKHECLIGDVQR
IQQALLNMLTNAIKYTPEDGQIQLTVEEKPSVYNGYGQFEITVTDNGIGMKPEFLEKVFEPFERSDDKAIRNIQGTGLGM
AISRHIAQIMNGDILVESEYGKGSKFTMRFHVKLGSTNEYDNNILVDLPVLVVDDDEVSCEIAYENLQELGMKPEWVLSG
EKAVQKVIDGDTYFAIIIDLMMPGMNGIETTIKIREYVEPDTPIIIISAYDYSGYEFEAVKAGVNGFISKPIMKSKLFHL
MKKFASDKKEDEQVLITPTHIISFPGKRILVVEDNDLNREIAYELLQETHAEVETACDGQEAVDKVAASPEGYYDFIIMD
IQMPVMDGLEATRQIRHLDRQDIKDMPIIAMSANAFAEDVRLSLEAGMNEHIAKPIEIDKLYGIMRKWFQ

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=583, Percent_Identity=27.958833619211, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI48994928, Length=430, Percent_Identity=30, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI87081816, Length=393, Percent_Identity=27.735368956743, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI145693157, Length=284, Percent_Identity=32.0422535211268, Blast_Score=132, Evalue=8e-32,
Organism=Escherichia coli, GI1788713, Length=466, Percent_Identity=27.8969957081545, Blast_Score=127, Evalue=4e-30,
Organism=Escherichia coli, GI1786600, Length=226, Percent_Identity=26.5486725663717, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1788549, Length=265, Percent_Identity=28.3018867924528, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790346, Length=212, Percent_Identity=30.188679245283, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1786912, Length=241, Percent_Identity=24.4813278008299, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1786783, Length=226, Percent_Identity=23.0088495575221, Blast_Score=77, Evalue=5e-15,
Organism=Escherichia coli, GI1788393, Length=227, Percent_Identity=26.431718061674, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1790436, Length=228, Percent_Identity=28.0701754385965, Blast_Score=73, Evalue=9e-14,
Organism=Escherichia coli, GI1787894, Length=235, Percent_Identity=25.9574468085106, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788279, Length=211, Percent_Identity=24.1706161137441, Blast_Score=67, Evalue=6e-12,
Organism=Escherichia coli, GI1790861, Length=251, Percent_Identity=24.7011952191235, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=124, Percent_Identity=42.741935483871, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322000, Length=126, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323034, Length=158, Percent_Identity=29.746835443038, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR019247
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF09984 DUF2222; PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 91011; Mature: 90880

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN ; PS00659 GLYCOSYL_HYDROL_F5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSESKKEKLNKNELLANYQYLMDTIWTIYLEDGSVDILKYSMNPELVNTKQDYTSLANI
CCCCHHHHHCCHHHHHHHHHHHHHHEEEEEECCCCEEEEEEECCCCEECCHHHHHHHHHH
LRNDIYSPDRSLWDETVSLEVFFRMIAEGCFHKTFDLRFCNDHFGFEWHETFIDILVNNE
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHEEHEECCC
GIPDRILLSSRNINDFRKAQIIETAVRSEYDYVIYIEASKNSYVMYTSGSESYSPPPIAS
CCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCC
YDYDGVVASYNRQYMAPELHEEMTEKLQIAHIEPILRKHGEYIVYGTMIENGVNREKKMR
CCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHCCCCHHHHHE
FSYYDREKNIWLMTRTDITEIKEERKQKKLLQEALQSANAANRAKTDFLSRMSHDIRTPI
EHEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
NAIVGMTAIARLHMDDQMRIADCLKKITISSKLLLNLINEVLDMSKLESDKIMLTEEAFK
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHH
INELLESLFVMVQPAFEAKKQKFQIHVTKIKHECLIGDVQRIQQALLNMLTNAIKYTPED
HHHHHHHHHHHHCCHHHHCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
GQIQLTVEEKPSVYNGYGQFEITVTDNGIGMKPEFLEKVFEPFERSDDKAIRNIQGTGLG
CEEEEEEECCCCEECCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCHH
MAISRHIAQIMNGDILVESEYGKGSKFTMRFHVKLGSTNEYDNNILVDLPVLVVDDDEVS
HHHHHHHHHHHCCCEEEEECCCCCCEEEEEEEEEECCCCCCCCEEEEEEEEEEECCCCCE
CEIAYENLQELGMKPEWVLSGEKAVQKVIDGDTYFAIIIDLMMPGMNGIETTIKIREYVE
EEEEHHHHHHCCCCCCEEECCHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHEEEHHHCC
PDTPIIIISAYDYSGYEFEAVKAGVNGFISKPIMKSKLFHLMKKFASDKKEDEQVLITPT
CCCCEEEEEECCCCCCEEHHHHHCHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEH
HIISFPGKRILVVEDNDLNREIAYELLQETHAEVETACDGQEAVDKVAASPEGYYDFIIM
HEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEE
DIQMPVMDGLEATRQIRHLDRQDIKDMPIIAMSANAFAEDVRLSLEAGMNEHIAKPIEID
EEECHHHHHHHHHHHHHHCCHHCCCCCCEEEEECCHHHHHHHHHHHCCCHHHCCCCCHHH
KLYGIMRKWFQ
HHHHHHHHHCC
>Mature Secondary Structure 
TSESKKEKLNKNELLANYQYLMDTIWTIYLEDGSVDILKYSMNPELVNTKQDYTSLANI
CCCHHHHHCCHHHHHHHHHHHHHHEEEEEECCCCEEEEEEECCCCEECCHHHHHHHHHH
LRNDIYSPDRSLWDETVSLEVFFRMIAEGCFHKTFDLRFCNDHFGFEWHETFIDILVNNE
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHEEHEECCC
GIPDRILLSSRNINDFRKAQIIETAVRSEYDYVIYIEASKNSYVMYTSGSESYSPPPIAS
CCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCC
YDYDGVVASYNRQYMAPELHEEMTEKLQIAHIEPILRKHGEYIVYGTMIENGVNREKKMR
CCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHCCCCHHHHHE
FSYYDREKNIWLMTRTDITEIKEERKQKKLLQEALQSANAANRAKTDFLSRMSHDIRTPI
EHEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
NAIVGMTAIARLHMDDQMRIADCLKKITISSKLLLNLINEVLDMSKLESDKIMLTEEAFK
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHH
INELLESLFVMVQPAFEAKKQKFQIHVTKIKHECLIGDVQRIQQALLNMLTNAIKYTPED
HHHHHHHHHHHHCCHHHHCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
GQIQLTVEEKPSVYNGYGQFEITVTDNGIGMKPEFLEKVFEPFERSDDKAIRNIQGTGLG
CEEEEEEECCCCEECCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCHH
MAISRHIAQIMNGDILVESEYGKGSKFTMRFHVKLGSTNEYDNNILVDLPVLVVDDDEVS
HHHHHHHHHHHCCCEEEEECCCCCCEEEEEEEEEECCCCCCCCEEEEEEEEEEECCCCCE
CEIAYENLQELGMKPEWVLSGEKAVQKVIDGDTYFAIIIDLMMPGMNGIETTIKIREYVE
EEEEHHHHHHCCCCCCEEECCHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHEEEHHHCC
PDTPIIIISAYDYSGYEFEAVKAGVNGFISKPIMKSKLFHLMKKFASDKKEDEQVLITPT
CCCCEEEEEECCCCCCEEHHHHHCHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEH
HIISFPGKRILVVEDNDLNREIAYELLQETHAEVETACDGQEAVDKVAASPEGYYDFIIM
HEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEE
DIQMPVMDGLEATRQIRHLDRQDIKDMPIIAMSANAFAEDVRLSLEAGMNEHIAKPIEID
EEECHHHHHHHHHHHHHHCCHHCCCCCCEEEEECCHHHHHHHHHHHCCCHHHCCCCCHHH
KLYGIMRKWFQ
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]