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The map label for this gene is pth

Identifier: 150006996

GI number: 150006996

Start: 380205

End: 380768

Strand: Reverse

Name: pth

Synonym: BDI_0332

Alternate gene names: 150006996

Gene position: 380768-380205 (Counterclockwise)

Preceding gene: 150006997

Following gene: 150006995

Centisome position: 7.91

GC content: 46.99

Gene sequence:

>564_bases
ATGAAATATTTGATAACAGGACTTGGTAATATCGGTTCCGAATATTGGGGAACCCGCCATAATATAGGTTTCCGGGTTGT
CAACCATCTGGTAGAGAGCGTAGGAGGCAATTTCACTGAGGAGCGATACGGGGCAATCGCACGCATACGGGTGAAAAACT
GTGACTTGATCGTGCTAAAGCCGAATACCTTTATGAACCTCAGCGGCAACGCCGTTCGGTACTGGTTGCAAAAAGAGAAC
ATTCCCGTGGAAAATCTATTGATTGTCGTAGATGATCTGGCATTGCCATTCGGAACCTTACGTCTGAAACCAAAGGGTAG
CGACGCCGGGCATAACGGGTTGAAGAATATCGCCCAGTTATTGAATACGCAGGAATATTCCCGCCTTCGTTTCGGCATAG
GCAGCGATTTTCCACGGGGCGGACAGATCGATTACGTGCTAGGGAAATTTCCCCCGGAGGAATTGCAATTGATGCCAGAG
ATATTGGATCGTGCGACAGAGATCATCAAGAGCTTCTGCCTCGCCGGCATCCAGATTACGATGAATCAATTTAATAATAA
ATAA

Upstream 100 bases:

>100_bases
CAGGCTAAAGGATAATCTGAGGTAAAAACATTATTACAATACATGAAGGGGAGGATATTCATAGAATGTTCTTCCCCTTT
CTTTTATAGATTCGAGGATA

Downstream 100 bases:

>100_bases
AAAGAGACTGAGAATACAGATATGAACGAGGTACGTATCGATAAATGGATGTGGGCGACCCGTATCTTTAAGACCCGCAC
GATAGCCGCGGAAGCTTGCA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MKYLITGLGNIGSEYWGTRHNIGFRVVNHLVESVGGNFTEERYGAIARIRVKNCDLIVLKPNTFMNLSGNAVRYWLQKEN
IPVENLLIVVDDLALPFGTLRLKPKGSDAGHNGLKNIAQLLNTQEYSRLRFGIGSDFPRGGQIDYVLGKFPPEELQLMPE
ILDRATEIIKSFCLAGIQITMNQFNNK

Sequences:

>Translated_187_residues
MKYLITGLGNIGSEYWGTRHNIGFRVVNHLVESVGGNFTEERYGAIARIRVKNCDLIVLKPNTFMNLSGNAVRYWLQKEN
IPVENLLIVVDDLALPFGTLRLKPKGSDAGHNGLKNIAQLLNTQEYSRLRFGIGSDFPRGGQIDYVLGKFPPEELQLMPE
ILDRATEIIKSFCLAGIQITMNQFNNK
>Mature_187_residues
MKYLITGLGNIGSEYWGTRHNIGFRVVNHLVESVGGNFTEERYGAIARIRVKNCDLIVLKPNTFMNLSGNAVRYWLQKEN
IPVENLLIVVDDLALPFGTLRLKPKGSDAGHNGLKNIAQLLNTQEYSRLRFGIGSDFPRGGQIDYVLGKFPPEELQLMPE
ILDRATEIIKSFCLAGIQITMNQFNNK

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=172, Percent_Identity=35.4651162790698, Blast_Score=102, Evalue=2e-22,
Organism=Escherichia coli, GI1787455, Length=185, Percent_Identity=36.7567567567568, Blast_Score=94, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_PARD8 (A6L8V3)

Other databases:

- EMBL:   CP000140
- RefSeq:   YP_001301739.1
- STRING:   A6L8V3
- GeneID:   5305487
- GenomeReviews:   CP000140_GR
- KEGG:   pdi:BDI_0332
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- BioCyc:   PDIS435591:BDI_0332-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21024; Mature: 21024

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYLITGLGNIGSEYWGTRHNIGFRVVNHLVESVGGNFTEERYGAIARIRVKNCDLIVLK
CCEEEECCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHCCEEEEEECCCCEEEEC
PNTFMNLSGNAVRYWLQKENIPVENLLIVVDDLALPFGTLRLKPKGSDAGHNGLKNIAQL
CCCEEECCCCEEEEEEECCCCCHHHEEEEEECCCCCCCEEEECCCCCCCCCHHHHHHHHH
LNTQEYSRLRFGIGSDFPRGGQIDYVLGKFPPEELQLMPEILDRATEIIKSFCLAGIQIT
HCCHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
MNQFNNK
EHHCCCC
>Mature Secondary Structure
MKYLITGLGNIGSEYWGTRHNIGFRVVNHLVESVGGNFTEERYGAIARIRVKNCDLIVLK
CCEEEECCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHCCEEEEEECCCCEEEEC
PNTFMNLSGNAVRYWLQKENIPVENLLIVVDDLALPFGTLRLKPKGSDAGHNGLKNIAQL
CCCEEECCCCEEEEEEECCCCCHHHEEEEEECCCCCCCEEEECCCCCCCCCHHHHHHHHH
LNTQEYSRLRFGIGSDFPRGGQIDYVLGKFPPEELQLMPEILDRATEIIKSFCLAGIQIT
HCCHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
MNQFNNK
EHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA