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The map label for this gene is ilvD [H]

Identifier: 150006841

GI number: 150006841

Start: 182385

End: 184109

Strand: Reverse

Name: ilvD [H]

Synonym: BDI_0172

Alternate gene names: 150006841

Gene position: 184109-182385 (Counterclockwise)

Preceding gene: 150006842

Following gene: 150006840

Centisome position: 3.83

GC content: 48.12

Gene sequence:

>1725_bases
ATGAAAAGCCAGCAATTACGAAAACTAGCGCCGGAGCTGGATTCACTCCGGCTAGGCAGCGGTTGGAAAATCGACGAATT
GAGTAAACCGCAAATCATTGTAGAAAGCAGTTACGGACATAGCCATCCGGGAAGCGCCCATCTGGATAAATTGGTGGACG
AGGCCGGAATCGGTATAAAGGAAAAGGGGGGACGTGCCGCAAACTACTTCGTCACTGATATTTGTGATGGAGAGGCGCAG
GGACACGATGGTATGAACTACTCATTAGTCTCCCGTGATATCATGGCCGCCATGATGGAGATTCATGTAAAAGCGACTCC
TTTCGACGCTGGTGTCTTTATAGCCAGTTGCGACAAATCCGTCCCTGCGCATTTGATGGCGATAGCCCGGCTAGATATGC
CTGCTATATTCATGCCCGGTGGTATAATGAAAGCCGGTCCCAACCTACTCACGTTAGAACAAATCGGTACCTATAGCGCC
CAATACGAGCGAAAAGAAATAACGGAAGAACAATTCATGGTTTATAAGCGTGACGCATGTCCGGATTGTGGAGCTTGCTC
TTTCATGGGTACCGCCTCTACGATGCAAGTAATGGCAGAAGCGCTTGGCATCGCTTTACCGGGCTCCGCCTTGATCCCCG
CCCATTTACCCGAGTTAAAAGAAACCGCCCGTAAAGCCGGAGAACATGCACTCGGACTGGCGAAAGAAGAGTTAAAACCC
TCCGATATCATGACGATACAAGCGTTTGAAAATGCGATCATGGTACATGCCGCCATAGCGGGTTCCAGCAACAGCCTGCT
TCATCTTCCAGCTATCGCCCATGAACTGGGAATCCAGTTATCACCGGATTTGTTCGACAAGATACATCGTAAGATCCCCT
ACCTTTTAAATATACGTCCCAGCGGTTTTTGGCCCGGCGAATATTTCTGGTATGCGGGAGGCGTACCGGCGATCATGAAA
GAAATCAAGGAATTCCTCCATCTCGATGTCAAGACCGTTACCGGCAGAACATTGGGAGAAAACTTAAAAGATTTACAACT
CAACGGCTTCTATGAGAATTGCCATAAATATCTTCCTGCCCTAGGAGTAAAGGTTGGCGATATTATCAAACCTCTTCATA
CACCGATCAAGGCACAAGGAGCCATCGCTATATTGAAAGGAAATTTAGCGCCCGAAGGGGCAGTCGTAAAACATTCGGCG
ATTTCACCCCGCTTGATGCAAGTCACCCTGAAAGCGAGGGTATTCGATTGTGAGGAGAACGCTATTGAGGCGGTATTACA
AAAGAAAATCCATCCGGGAGAAGCGGTATTTATCCGTTATGAAGGACCGAAAGGAAGTGGAATGCCAGAAATGTTTTATA
CGACAGAAGCGATCGCCTCCGATCCTGAGTTGGTAGAGACCATCGCATTGATCACCGACGGTCGTTTCTCCGGAGCGACC
CGAGGCCCGGCGATCGGACATGTATCCCCGGAGGCTTCCGAGGGGGGACCAATCGCCTTGGTCGAGAACGATGACTTGAT
CCGTATCGATATTCCAGCGAGAACATTGGATATAATCGGTACCGACAGTATTGAGAGAAGCGTGGAAGAGATAGAAAAGA
TCCTATCCGAAAGGCGTGCACATTGGATAAAATCAGAGTCACAATATAAAAAAGGAATCCTTGATATTTATACACACAAT
AGCGTCTCCCCCATGAAAGGGGCATATATGGAATTTTTTATGTAA

Upstream 100 bases:

>100_bases
TAATCTTAATCGGTATCGGTACAAAAATTTTAATAGAGCATTTATTCTTTAGCTAGGGATACCTTATTGAATAAATAACC
TTATACATTAATTAATAGAC

Downstream 100 bases:

>100_bases
GTTCGCGACATAAAATTTCATAATGATGCGCAAGAATATTACCATATTAGTCAGCCTGTTGATCTTATCGCTTACGGCTT
GCTCGGACAAGGGCCAATAT

Product: dihydroxyacid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MKSQQLRKLAPELDSLRLGSGWKIDELSKPQIIVESSYGHSHPGSAHLDKLVDEAGIGIKEKGGRAANYFVTDICDGEAQ
GHDGMNYSLVSRDIMAAMMEIHVKATPFDAGVFIASCDKSVPAHLMAIARLDMPAIFMPGGIMKAGPNLLTLEQIGTYSA
QYERKEITEEQFMVYKRDACPDCGACSFMGTASTMQVMAEALGIALPGSALIPAHLPELKETARKAGEHALGLAKEELKP
SDIMTIQAFENAIMVHAAIAGSSNSLLHLPAIAHELGIQLSPDLFDKIHRKIPYLLNIRPSGFWPGEYFWYAGGVPAIMK
EIKEFLHLDVKTVTGRTLGENLKDLQLNGFYENCHKYLPALGVKVGDIIKPLHTPIKAQGAIAILKGNLAPEGAVVKHSA
ISPRLMQVTLKARVFDCEENAIEAVLQKKIHPGEAVFIRYEGPKGSGMPEMFYTTEAIASDPELVETIALITDGRFSGAT
RGPAIGHVSPEASEGGPIALVENDDLIRIDIPARTLDIIGTDSIERSVEEIEKILSERRAHWIKSESQYKKGILDIYTHN
SVSPMKGAYMEFFM

Sequences:

>Translated_574_residues
MKSQQLRKLAPELDSLRLGSGWKIDELSKPQIIVESSYGHSHPGSAHLDKLVDEAGIGIKEKGGRAANYFVTDICDGEAQ
GHDGMNYSLVSRDIMAAMMEIHVKATPFDAGVFIASCDKSVPAHLMAIARLDMPAIFMPGGIMKAGPNLLTLEQIGTYSA
QYERKEITEEQFMVYKRDACPDCGACSFMGTASTMQVMAEALGIALPGSALIPAHLPELKETARKAGEHALGLAKEELKP
SDIMTIQAFENAIMVHAAIAGSSNSLLHLPAIAHELGIQLSPDLFDKIHRKIPYLLNIRPSGFWPGEYFWYAGGVPAIMK
EIKEFLHLDVKTVTGRTLGENLKDLQLNGFYENCHKYLPALGVKVGDIIKPLHTPIKAQGAIAILKGNLAPEGAVVKHSA
ISPRLMQVTLKARVFDCEENAIEAVLQKKIHPGEAVFIRYEGPKGSGMPEMFYTTEAIASDPELVETIALITDGRFSGAT
RGPAIGHVSPEASEGGPIALVENDDLIRIDIPARTLDIIGTDSIERSVEEIEKILSERRAHWIKSESQYKKGILDIYTHN
SVSPMKGAYMEFFM
>Mature_574_residues
MKSQQLRKLAPELDSLRLGSGWKIDELSKPQIIVESSYGHSHPGSAHLDKLVDEAGIGIKEKGGRAANYFVTDICDGEAQ
GHDGMNYSLVSRDIMAAMMEIHVKATPFDAGVFIASCDKSVPAHLMAIARLDMPAIFMPGGIMKAGPNLLTLEQIGTYSA
QYERKEITEEQFMVYKRDACPDCGACSFMGTASTMQVMAEALGIALPGSALIPAHLPELKETARKAGEHALGLAKEELKP
SDIMTIQAFENAIMVHAAIAGSSNSLLHLPAIAHELGIQLSPDLFDKIHRKIPYLLNIRPSGFWPGEYFWYAGGVPAIMK
EIKEFLHLDVKTVTGRTLGENLKDLQLNGFYENCHKYLPALGVKVGDIIKPLHTPIKAQGAIAILKGNLAPEGAVVKHSA
ISPRLMQVTLKARVFDCEENAIEAVLQKKIHPGEAVFIRYEGPKGSGMPEMFYTTEAIASDPELVETIALITDGRFSGAT
RGPAIGHVSPEASEGGPIALVENDDLIRIDIPARTLDIIGTDSIERSVEEIEKILSERRAHWIKSESQYKKGILDIYTHN
SVSPMKGAYMEFFM

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=595, Percent_Identity=34.9579831932773, Blast_Score=297, Evalue=1e-81,
Organism=Escherichia coli, GI1786464, Length=563, Percent_Identity=34.8134991119005, Blast_Score=281, Evalue=5e-77,
Organism=Escherichia coli, GI2367371, Length=567, Percent_Identity=34.7442680776014, Blast_Score=275, Evalue=5e-75,
Organism=Escherichia coli, GI1788157, Length=453, Percent_Identity=31.3465783664459, Blast_Score=200, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6322476, Length=553, Percent_Identity=36.3471971066908, Blast_Score=303, Evalue=6e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 62621; Mature: 62621

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00589 PTS_HPR_SER ; PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSQQLRKLAPELDSLRLGSGWKIDELSKPQIIVESSYGHSHPGSAHLDKLVDEAGIGIK
CCCHHHHHHCCCHHCEECCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCEE
EKGGRAANYFVTDICDGEAQGHDGMNYSLVSRDIMAAMMEIHVKATPFDAGVFIASCDKS
CCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCEEEEECCCC
VPAHLMAIARLDMPAIFMPGGIMKAGPNLLTLEQIGTYSAQYERKEITEEQFMVYKRDAC
CHHHHHHHHHCCCCEEECCCCCHHCCCCEEEHHHHCCCHHHHHHHHCCHHHHHEEECCCC
PDCGACSFMGTASTMQVMAEALGIALPGSALIPAHLPELKETARKAGEHALGLAKEELKP
CCCCCCCCCCCHHHHHHHHHHHCEECCCCCCCCCCCHHHHHHHHHCCHHHHCCHHHHCCC
SDIMTIQAFENAIMVHAAIAGSSNSLLHLPAIAHELGIQLSPDLFDKIHRKIPYLLNIRP
CCEEEEEECCCEEEEEEEEECCCCCEEECCHHHHHHCCCCCHHHHHHHHHCCCEEEEECC
SGFWPGEYFWYAGGVPAIMKEIKEFLHLDVKTVTGRTLGENLKDLQLNGFYENCHKYLPA
CCCCCCCCEEECCCHHHHHHHHHHHHCCCHHEECCCHHHCCCHHEEECCHHHHHHHHHHH
LGVKVGDIIKPLHTPIKAQGAIAILKGNLAPEGAVVKHSAISPRLMQVTLKARVFDCEEN
HCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEECCCCCHHEEEEEEHHEECCHHH
AIEAVLQKKIHPGEAVFIRYEGPKGSGMPEMFYTTEAIASDPELVETIALITDGRFSGAT
HHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHEEHHHHCCCHHHHHHHHHHCCCCCCCCC
RGPAIGHVSPEASEGGPIALVENDDLIRIDIPARTLDIIGTDSIERSVEEIEKILSERRA
CCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHH
HWIKSESQYKKGILDIYTHNSVSPMKGAYMEFFM
HHHCCHHHHHCCCEEEEECCCCCCCCCHHHHHCC
>Mature Secondary Structure
MKSQQLRKLAPELDSLRLGSGWKIDELSKPQIIVESSYGHSHPGSAHLDKLVDEAGIGIK
CCCHHHHHHCCCHHCEECCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCEE
EKGGRAANYFVTDICDGEAQGHDGMNYSLVSRDIMAAMMEIHVKATPFDAGVFIASCDKS
CCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCEEEEECCCC
VPAHLMAIARLDMPAIFMPGGIMKAGPNLLTLEQIGTYSAQYERKEITEEQFMVYKRDAC
CHHHHHHHHHCCCCEEECCCCCHHCCCCEEEHHHHCCCHHHHHHHHCCHHHHHEEECCCC
PDCGACSFMGTASTMQVMAEALGIALPGSALIPAHLPELKETARKAGEHALGLAKEELKP
CCCCCCCCCCCHHHHHHHHHHHCEECCCCCCCCCCCHHHHHHHHHCCHHHHCCHHHHCCC
SDIMTIQAFENAIMVHAAIAGSSNSLLHLPAIAHELGIQLSPDLFDKIHRKIPYLLNIRP
CCEEEEEECCCEEEEEEEEECCCCCEEECCHHHHHHCCCCCHHHHHHHHHCCCEEEEECC
SGFWPGEYFWYAGGVPAIMKEIKEFLHLDVKTVTGRTLGENLKDLQLNGFYENCHKYLPA
CCCCCCCCEEECCCHHHHHHHHHHHHCCCHHEECCCHHHCCCHHEEECCHHHHHHHHHHH
LGVKVGDIIKPLHTPIKAQGAIAILKGNLAPEGAVVKHSAISPRLMQVTLKARVFDCEEN
HCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEECCCCCHHEEEEEEHHEECCHHH
AIEAVLQKKIHPGEAVFIRYEGPKGSGMPEMFYTTEAIASDPELVETIALITDGRFSGAT
HHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHEEHHHHCCCHHHHHHHHHHCCCCCCCCC
RGPAIGHVSPEASEGGPIALVENDDLIRIDIPARTLDIIGTDSIERSVEEIEKILSERRA
CCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHH
HWIKSESQYKKGILDIYTHNSVSPMKGAYMEFFM
HHHCCHHHHHCCCEEEEECCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA