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The map label for this gene is gmk [H]

Identifier: 150006825

GI number: 150006825

Start: 168654

End: 169220

Strand: Reverse

Name: gmk [H]

Synonym: BDI_0156

Alternate gene names: 150006825

Gene position: 169220-168654 (Counterclockwise)

Preceding gene: 150006826

Following gene: 150006824

Centisome position: 3.52

GC content: 46.21

Gene sequence:

>567_bases
ATGGCTGGCAAATTAATTATCTTCTCCGCACCCTCGGGTTCCGGAAAATCAACCATTATTAATTATCTTTTGAAACAAGA
TTTACACCTTCGCTTCTCCATCTCGGCTACCAGCCGGGCTCCGCGGGGAACCGAGAAGAATGGTGTGGAATATTATTTCC
TTACGCCGGAAGAGTTCCGCAGTCGTATCGCTAATGGAGACTTCTTGGAATATGAGGAGGTGTATACCGATAAATATTAC
GGTACGTTAAAGAGCGAGGTAGAGCGTATCTTGAACGAAGGGGATAACGTGATTTTCGATGTGGATGTGGTAGGCGGATG
CAATATCAAGAAATTCTATGGAGACCGTGCCCTGTCTGTCTTTATCCAACCTCCTTGCATCGATGACCTACGGAAGCGAT
TGGAAGGACGGGGAACAGACAGCCCGGAAGTTATCGAAAGCCGTATCGCCAAGGCTGAGTATGAATTAGGGTTCACGGGA
CAGTTTGATAAGGTTGTCGTAAACGATGATCTGGAGACTGCCCAAAAAGACGCGTTGAAGATCATTCGTGAGTTCTTAAA
CAAATAG

Upstream 100 bases:

>100_bases
GCAACCACGCCGAGATGCAGAAGATCGTGGTCCAGATGAAAGACGAGTTGGAACAAATCAAGGAACAGGTACTAAACGTA
TTATAATAAGATTAACGAGA

Downstream 100 bases:

>100_bases
TCTATGTCTAATATATTCAAGAATACCCGTTTTATGATGGGGCTTTCTATCGTTTGTGGGATAGCGAGCCTCGTATTAGG
TGGTATTAGCCTGTATTATA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MAGKLIIFSAPSGSGKSTIINYLLKQDLHLRFSISATSRAPRGTEKNGVEYYFLTPEEFRSRIANGDFLEYEEVYTDKYY
GTLKSEVERILNEGDNVIFDVDVVGGCNIKKFYGDRALSVFIQPPCIDDLRKRLEGRGTDSPEVIESRIAKAEYELGFTG
QFDKVVVNDDLETAQKDALKIIREFLNK

Sequences:

>Translated_188_residues
MAGKLIIFSAPSGSGKSTIINYLLKQDLHLRFSISATSRAPRGTEKNGVEYYFLTPEEFRSRIANGDFLEYEEVYTDKYY
GTLKSEVERILNEGDNVIFDVDVVGGCNIKKFYGDRALSVFIQPPCIDDLRKRLEGRGTDSPEVIESRIAKAEYELGFTG
QFDKVVVNDDLETAQKDALKIIREFLNK
>Mature_187_residues
AGKLIIFSAPSGSGKSTIINYLLKQDLHLRFSISATSRAPRGTEKNGVEYYFLTPEEFRSRIANGDFLEYEEVYTDKYYG
TLKSEVERILNEGDNVIFDVDVVGGCNIKKFYGDRALSVFIQPPCIDDLRKRLEGRGTDSPEVIESRIAKAEYELGFTGQ
FDKVVVNDDLETAQKDALKIIREFLNK

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=193, Percent_Identity=35.7512953367876, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI4504221, Length=193, Percent_Identity=35.7512953367876, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI226874831, Length=193, Percent_Identity=35.7512953367876, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI111154074, Length=167, Percent_Identity=29.940119760479, Blast_Score=67, Evalue=7e-12,
Organism=Escherichia coli, GI1790080, Length=183, Percent_Identity=43.1693989071038, Blast_Score=139, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17508835, Length=193, Percent_Identity=37.3056994818653, Blast_Score=117, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI193203132, Length=193, Percent_Identity=37.3056994818653, Blast_Score=116, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6320662, Length=175, Percent_Identity=41.1428571428571, Blast_Score=139, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21356141, Length=173, Percent_Identity=37.5722543352601, Blast_Score=102, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 21282; Mature: 21151

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGKLIIFSAPSGSGKSTIINYLLKQDLHLRFSISATSRAPRGTEKNGVEYYFLTPEEFR
CCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEEEECHHHHH
SRIANGDFLEYEEVYTDKYYGTLKSEVERILNEGDNVIFDVDVVGGCNIKKFYGDRALSV
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHCCEEEEE
FIQPPCIDDLRKRLEGRGTDSPEVIESRIAKAEYELGFTGQFDKVVVNDDLETAQKDALK
EECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHH
IIREFLNK
HHHHHHCC
>Mature Secondary Structure 
AGKLIIFSAPSGSGKSTIINYLLKQDLHLRFSISATSRAPRGTEKNGVEYYFLTPEEFR
CCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEEEECHHHHH
SRIANGDFLEYEEVYTDKYYGTLKSEVERILNEGDNVIFDVDVVGGCNIKKFYGDRALSV
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHCCEEEEE
FIQPPCIDDLRKRLEGRGTDSPEVIESRIAKAEYELGFTGQFDKVVVNDDLETAQKDALK
EECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHH
IIREFLNK
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]