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The map label for this gene is lysS

Identifier: 150006819

GI number: 150006819

Start: 160667

End: 162397

Strand: Reverse

Name: lysS

Synonym: BDI_0150

Alternate gene names: 150006819

Gene position: 162397-160667 (Counterclockwise)

Preceding gene: 150006820

Following gene: 150006818

Centisome position: 3.38

GC content: 46.97

Gene sequence:

>1731_bases
ATGAATCTATTAGAACTGAGTGAACAGGAAATAATAAGACGTAATAGCATGGAGCAGTTGCGTCAGATGGGGATAGAGCC
TTATCCCGCAGCTGAGTATGTAACGAACGCATTTTCCAAAGAAATAAAAGAGACATTCAAAGACGACGCTGAGCCACGCC
CGGTAAGTATCGCCGGCCGTATCATGAGCCGTCGTATCATGGGTAAGGCTTCCTTCATGGAATTACAGGATTCCGAGGGT
AGAATACAGGTCTATATCTCCCGTGACGATATTTGCCCGGATGAGAATAAGGACACCTACAATGTCGTTTTCAAGAAATT
ACTGGATATCGGTGATTTCGTCGGGATCAAGGGATTCGTTTTCCGTACTCAGATGGGAGAGATTTCCGTTCATGCGCAAG
AATTGACAGTTTTGTCTAAATCACTTCGTCCGCTACCGGTCGTTAAATATAAGGACGGTGTCGCTTACGACGGTTTTAAT
GACCCGGAGCTTCGTTATCGCCAGCGTTACGTGGATTTGGTAGTAAACGAGGGTGTAAAAGATATTTTCATGAAACGTGC
GGCTATCATCAAGACCATGCGTACCGCCTTGGATGAGGCCGGATACACGGAGGTAGAGACTCCGATCCTGCAATCTATCG
CAGGAGGAGCCAGCGCACGTCCATTCATCACGCATCACAACTCTTTGGATATCGATCTGTATTTGCGTATCGCTACCGAG
TTGTATTTGAAACGATTGATCGTCGGTGGATTCGAGGGTGTATATGAGATCGGTAAGAATTTCCGTAACGAGGGTATGGA
CCGTACGCACAACCCGGAGTTCACTTGTATGGAACTTTATGTCCAATACAAGGACTATAACTGGATGATGAGCTTCACTG
AGAAGCTGTTGGAGCGTATCTGTATCGCCGTGAACGGTACGAGCGAGAGCACGATCGACGGTAAGACAATCAGCTTCAAG
GCTCCTTTCCGCCGCTTGCCGATCTTGGAGGCGATCAAGGAAAAGACGGGTTACGACTTGGAAGGTAAGACAGAGGACGA
GATTCGTGCGATCTGCAAGGAATTGAAGATGGAGATCGACGATACGATGGGTAAAGGTAAATTGATCGACGAGATCTTCG
GGGAGTTCTGCGAGGGTACGTTTATCCAGCCGACCTTCATCATCGACTATCCGGTTGAGATGAGTCCGCTGACTAAGATG
CACCGTAGCAAACCGGGATTGACCGAACGCTTCGAGTTGATGGTAAACGGAAAGGAATTGGCGAACGCTTATAGCGAGCT
GAACGATCCGATCGACCAAGAAGAACGTTTCAAGGAGCAATTACGCTTGAGCGAGAAAGGGGACGACGAGGCGATGTTCA
TCGATCAAGATTTCTTACGCGCCCTTCAATTCGGTATGCCTCCTACGTCGGGTATCGGTATCGGTATCGACCGTCTGGTT
ATGTTGATGACCGGACAGACAACAATCCAAGAAGTATTGCTTTTCCCGCAAATGCGTCCGGAGAAAACTGTAAAAAAAGA
TAACGCAGACAAATACGTGGCCTTAGGCATTTCAGAGGAGTGGGTTCCCGCTTTGCAAAAAGCCGGCTATCTGACGGTTG
AAATGCTGAAAAATGCGAACGCAAACAAATTAAGACAAGAGCTTTGCGAGCTTAATAAAAAATATAAGTTAGAACTGCAA
AATCCTACGGTCCAAGAAATAGAAGCTTGGATAGCCAATGTAGGAGAATAA

Upstream 100 bases:

>100_bases
GAACAAACAAGATCGGTGACCTCAACCTTTTACCACATAAGTCAGCATAAATCAGAAATATTTTGTACTTTTGCGCCGTA
TTATACAAAATAATAGCATA

Downstream 100 bases:

>100_bases
AAGCGTGATACGATGGATTTGCCCGGAAAAATCGCGATAATGGGAGGTGGTAGCTGGGCTACCGCCTTAGCCAAGATCGT
ACTTTCAACTCAAGATAGTA

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MNLLELSEQEIIRRNSMEQLRQMGIEPYPAAEYVTNAFSKEIKETFKDDAEPRPVSIAGRIMSRRIMGKASFMELQDSEG
RIQVYISRDDICPDENKDTYNVVFKKLLDIGDFVGIKGFVFRTQMGEISVHAQELTVLSKSLRPLPVVKYKDGVAYDGFN
DPELRYRQRYVDLVVNEGVKDIFMKRAAIIKTMRTALDEAGYTEVETPILQSIAGGASARPFITHHNSLDIDLYLRIATE
LYLKRLIVGGFEGVYEIGKNFRNEGMDRTHNPEFTCMELYVQYKDYNWMMSFTEKLLERICIAVNGTSESTIDGKTISFK
APFRRLPILEAIKEKTGYDLEGKTEDEIRAICKELKMEIDDTMGKGKLIDEIFGEFCEGTFIQPTFIIDYPVEMSPLTKM
HRSKPGLTERFELMVNGKELANAYSELNDPIDQEERFKEQLRLSEKGDDEAMFIDQDFLRALQFGMPPTSGIGIGIDRLV
MLMTGQTTIQEVLLFPQMRPEKTVKKDNADKYVALGISEEWVPALQKAGYLTVEMLKNANANKLRQELCELNKKYKLELQ
NPTVQEIEAWIANVGE

Sequences:

>Translated_576_residues
MNLLELSEQEIIRRNSMEQLRQMGIEPYPAAEYVTNAFSKEIKETFKDDAEPRPVSIAGRIMSRRIMGKASFMELQDSEG
RIQVYISRDDICPDENKDTYNVVFKKLLDIGDFVGIKGFVFRTQMGEISVHAQELTVLSKSLRPLPVVKYKDGVAYDGFN
DPELRYRQRYVDLVVNEGVKDIFMKRAAIIKTMRTALDEAGYTEVETPILQSIAGGASARPFITHHNSLDIDLYLRIATE
LYLKRLIVGGFEGVYEIGKNFRNEGMDRTHNPEFTCMELYVQYKDYNWMMSFTEKLLERICIAVNGTSESTIDGKTISFK
APFRRLPILEAIKEKTGYDLEGKTEDEIRAICKELKMEIDDTMGKGKLIDEIFGEFCEGTFIQPTFIIDYPVEMSPLTKM
HRSKPGLTERFELMVNGKELANAYSELNDPIDQEERFKEQLRLSEKGDDEAMFIDQDFLRALQFGMPPTSGIGIGIDRLV
MLMTGQTTIQEVLLFPQMRPEKTVKKDNADKYVALGISEEWVPALQKAGYLTVEMLKNANANKLRQELCELNKKYKLELQ
NPTVQEIEAWIANVGE
>Mature_576_residues
MNLLELSEQEIIRRNSMEQLRQMGIEPYPAAEYVTNAFSKEIKETFKDDAEPRPVSIAGRIMSRRIMGKASFMELQDSEG
RIQVYISRDDICPDENKDTYNVVFKKLLDIGDFVGIKGFVFRTQMGEISVHAQELTVLSKSLRPLPVVKYKDGVAYDGFN
DPELRYRQRYVDLVVNEGVKDIFMKRAAIIKTMRTALDEAGYTEVETPILQSIAGGASARPFITHHNSLDIDLYLRIATE
LYLKRLIVGGFEGVYEIGKNFRNEGMDRTHNPEFTCMELYVQYKDYNWMMSFTEKLLERICIAVNGTSESTIDGKTISFK
APFRRLPILEAIKEKTGYDLEGKTEDEIRAICKELKMEIDDTMGKGKLIDEIFGEFCEGTFIQPTFIIDYPVEMSPLTKM
HRSKPGLTERFELMVNGKELANAYSELNDPIDQEERFKEQLRLSEKGDDEAMFIDQDFLRALQFGMPPTSGIGIGIDRLV
MLMTGQTTIQEVLLFPQMRPEKTVKKDNADKYVALGISEEWVPALQKAGYLTVEMLKNANANKLRQELCELNKKYKLELQ
NPTVQEIEAWIANVGE

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI5031815, Length=517, Percent_Identity=41.9729206963249, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI194272210, Length=517, Percent_Identity=41.9729206963249, Blast_Score=390, Evalue=1e-108,
Organism=Escherichia coli, GI1790571, Length=500, Percent_Identity=47.4, Blast_Score=467, Evalue=1e-133,
Organism=Escherichia coli, GI1789256, Length=509, Percent_Identity=46.1689587426326, Blast_Score=455, Evalue=1e-129,
Organism=Escherichia coli, GI87082379, Length=325, Percent_Identity=31.3846153846154, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17535925, Length=528, Percent_Identity=42.4242424242424, Blast_Score=388, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17535927, Length=528, Percent_Identity=42.4242424242424, Blast_Score=388, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71994340, Length=528, Percent_Identity=42.4242424242424, Blast_Score=387, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI32566633, Length=322, Percent_Identity=22.6708074534161, Blast_Score=79, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6320242, Length=516, Percent_Identity=40.3100775193798, Blast_Score=365, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6324256, Length=483, Percent_Identity=32.9192546583851, Blast_Score=193, Evalue=7e-50,
Organism=Saccharomyces cerevisiae, GI6321807, Length=520, Percent_Identity=24.4230769230769, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24640849, Length=517, Percent_Identity=40.0386847195358, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24640851, Length=517, Percent_Identity=40.0386847195358, Blast_Score=375, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYK_PARD8 (A6L8C6)

Other databases:

- EMBL:   CP000140
- RefSeq:   YP_001301562.1
- ProteinModelPortal:   A6L8C6
- SMR:   A6L8C6
- STRING:   A6L8C6
- GeneID:   5305241
- GenomeReviews:   CP000140_GR
- KEGG:   pdi:BDI_0150
- eggNOG:   COG1190
- HOGENOM:   HBG631383
- OMA:   GHPQMMS
- ProtClustDB:   PRK00484
- BioCyc:   PDIS435591:BDI_0150-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00252
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PANTHER:   PTHR22594:SF4
- PRINTS:   PR00982
- TIGRFAMs:   TIGR00499

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.6

Molecular weight: Translated: 65958; Mature: 65958

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLELSEQEIIRRNSMEQLRQMGIEPYPAAEYVTNAFSKEIKETFKDDAEPRPVSIAGR
CCCHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
IMSRRIMGKASFMELQDSEGRIQVYISRDDICPDENKDTYNVVFKKLLDIGDFVGIKGFV
HHHHHHHCCHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEE
FRTQMGEISVHAQELTVLSKSLRPLPVVKYKDGVAYDGFNDPELRYRQRYVDLVVNEGVK
EEEECCCEEEHHHHHHHHHHCCCCCCEEEECCCCEECCCCCHHHHHHHHHHHHHHHCCHH
DIFMKRAAIIKTMRTALDEAGYTEVETPILQSIAGGASARPFITHHNSLDIDLYLRIATE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHH
LYLKRLIVGGFEGVYEIGKNFRNEGMDRTHNPEFTCMELYVQYKDYNWMMSFTEKLLERI
HHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHH
CIAVNGTSESTIDGKTISFKAPFRRLPILEAIKEKTGYDLEGKTEDEIRAICKELKMEID
HEEECCCCCCCCCCCEEEECCCHHHCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
DTMGKGKLIDEIFGEFCEGTFIQPTFIIDYPVEMSPLTKMHRSKPGLTERFELMVNGKEL
HCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHCCCCCCCHHHHHEECHHHH
ANAYSELNDPIDQEERFKEQLRLSEKGDDEAMFIDQDFLRALQFGMPPTSGIGIGIDRLV
HHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHCCCCCCCCCCCHHHHH
MLMTGQTTIQEVLLFPQMRPEKTVKKDNADKYVALGISEEWVPALQKAGYLTVEMLKNAN
HHHCCCHHHHHHHHCCCCCCCHHHCCCCCCCEEEECCCHHHHHHHHHCCCEEEHHHHCCC
ANKLRQELCELNKKYKLELQNPTVQEIEAWIANVGE
HHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MNLLELSEQEIIRRNSMEQLRQMGIEPYPAAEYVTNAFSKEIKETFKDDAEPRPVSIAGR
CCCHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
IMSRRIMGKASFMELQDSEGRIQVYISRDDICPDENKDTYNVVFKKLLDIGDFVGIKGFV
HHHHHHHCCHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEE
FRTQMGEISVHAQELTVLSKSLRPLPVVKYKDGVAYDGFNDPELRYRQRYVDLVVNEGVK
EEEECCCEEEHHHHHHHHHHCCCCCCEEEECCCCEECCCCCHHHHHHHHHHHHHHHCCHH
DIFMKRAAIIKTMRTALDEAGYTEVETPILQSIAGGASARPFITHHNSLDIDLYLRIATE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHH
LYLKRLIVGGFEGVYEIGKNFRNEGMDRTHNPEFTCMELYVQYKDYNWMMSFTEKLLERI
HHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHH
CIAVNGTSESTIDGKTISFKAPFRRLPILEAIKEKTGYDLEGKTEDEIRAICKELKMEID
HEEECCCCCCCCCCCEEEECCCHHHCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
DTMGKGKLIDEIFGEFCEGTFIQPTFIIDYPVEMSPLTKMHRSKPGLTERFELMVNGKEL
HCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHCCCCCCCHHHHHEECHHHH
ANAYSELNDPIDQEERFKEQLRLSEKGDDEAMFIDQDFLRALQFGMPPTSGIGIGIDRLV
HHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHCCCCCCCCCCCHHHHH
MLMTGQTTIQEVLLFPQMRPEKTVKKDNADKYVALGISEEWVPALQKAGYLTVEMLKNAN
HHHCCCHHHHHHHHCCCCCCCHHHCCCCCCCEEEECCCHHHHHHHHHCCCEEEHHHHCCC
ANKLRQELCELNKKYKLELQNPTVQEIEAWIANVGE
HHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA