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The map label for this gene is tsaA [H]

Identifier: 150006768

GI number: 150006768

Start: 104129

End: 104761

Strand: Reverse

Name: tsaA [H]

Synonym: BDI_0094

Alternate gene names: 150006768

Gene position: 104761-104129 (Counterclockwise)

Preceding gene: 150006774

Following gene: 150006766

Centisome position: 2.18

GC content: 43.13

Gene sequence:

>633_bases
ATGAAAGCATTAATAGGTAAAAAGGCACCGGAATTCCACGCTCCGGCAGTAGTGAATGGCAATGAGATCATCGAGGATTT
CTCTTTGGAACAATATGTAGGCAAGAAGTATGTAGTCATGTTTTTCTATCCGATGGACTTTACATTCGTTTGCCCGACAG
AATTACATGCCTTCCAACAAAAGTTACAGGAATTCGAAAGACGTAACGTAGCGGTGGTTGGTTGCTCCGTTGATTCTCAA
TTTTCTCATTTCGCATGGTTAAACCAAGATAAGAATAAAGGAGGTATCCATGGGGTGACTTATCCACTCGTATCCGATTT
TTCCAAAACCATCTCTGAAAACTTTGGCGTATTAGCCGCTGATTATATTACAAACGAAAGTGGAGAACTTATCTCCAGAG
GAAATCCGGTCGCTTACCGGGGTCTGTTCCTGATTGACAAAGAGGGCTTGATCCGTCATTATGTAATCAACGATTTACCA
TTAGGCCGTAACGTAGACGAGGCTCTCCGTATGGTCGATGCCTTACAGCACTTCGAAGAATATGGCGAGGTTTGCCCGGC
AAATTGGTCCAAAGGAAAAGACGCCATGAAAGCGACAAACGCAGGAGTCTCTAATTATTTAAGCCATCATTGA

Upstream 100 bases:

>100_bases
AAACTTTAGGTCTATTTCACAAGAAAATCAGTCTCTTTACTAAAAAGCAACAACAAACCTTCACTTACGCTTGTTACTTA
ACAAACAAATTAATTATAAT

Downstream 100 bases:

>100_bases
TATATTGCAAGAAAGGGGGCTAGGCCCCCTTTCTTATACTATTGAGACAATCGTTTACACTTTCCCGAGATATGCGAGAT
ATCTAGACGTAAGATATTAG

Product: thioredoxin peroxidase

Products: NA

Alternate protein names: 26 kDa antigen; Thioredoxin reductase [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MKALIGKKAPEFHAPAVVNGNEIIEDFSLEQYVGKKYVVMFFYPMDFTFVCPTELHAFQQKLQEFERRNVAVVGCSVDSQ
FSHFAWLNQDKNKGGIHGVTYPLVSDFSKTISENFGVLAADYITNESGELISRGNPVAYRGLFLIDKEGLIRHYVINDLP
LGRNVDEALRMVDALQHFEEYGEVCPANWSKGKDAMKATNAGVSNYLSHH

Sequences:

>Translated_210_residues
MKALIGKKAPEFHAPAVVNGNEIIEDFSLEQYVGKKYVVMFFYPMDFTFVCPTELHAFQQKLQEFERRNVAVVGCSVDSQ
FSHFAWLNQDKNKGGIHGVTYPLVSDFSKTISENFGVLAADYITNESGELISRGNPVAYRGLFLIDKEGLIRHYVINDLP
LGRNVDEALRMVDALQHFEEYGEVCPANWSKGKDAMKATNAGVSNYLSHH
>Mature_210_residues
MKALIGKKAPEFHAPAVVNGNEIIEDFSLEQYVGKKYVVMFFYPMDFTFVCPTELHAFQQKLQEFERRNVAVVGCSVDSQ
FSHFAWLNQDKNKGGIHGVTYPLVSDFSKTISENFGVLAADYITNESGELISRGNPVAYRGLFLIDKEGLIRHYVINDLP
LGRNVDEALRMVDALQHFEEYGEVCPANWSKGKDAMKATNAGVSNYLSHH

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=208, Percent_Identity=46.6346153846154, Blast_Score=202, Evalue=2e-52,
Organism=Homo sapiens, GI4505591, Length=208, Percent_Identity=46.1538461538462, Blast_Score=195, Evalue=3e-50,
Organism=Homo sapiens, GI32455266, Length=208, Percent_Identity=46.1538461538462, Blast_Score=195, Evalue=3e-50,
Organism=Homo sapiens, GI32455264, Length=208, Percent_Identity=46.1538461538462, Blast_Score=195, Evalue=3e-50,
Organism=Homo sapiens, GI5453549, Length=206, Percent_Identity=45.1456310679612, Blast_Score=187, Evalue=6e-48,
Organism=Homo sapiens, GI5802974, Length=202, Percent_Identity=46.039603960396, Blast_Score=186, Evalue=1e-47,
Organism=Homo sapiens, GI32483377, Length=200, Percent_Identity=46.5, Blast_Score=186, Evalue=1e-47,
Organism=Homo sapiens, GI33188454, Length=91, Percent_Identity=51.6483516483517, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI4758638, Length=196, Percent_Identity=28.0612244897959, Blast_Score=90, Evalue=1e-18,
Organism=Escherichia coli, GI1786822, Length=195, Percent_Identity=31.7948717948718, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI193204376, Length=209, Percent_Identity=45.933014354067, Blast_Score=191, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI32565831, Length=209, Percent_Identity=45.933014354067, Blast_Score=190, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17554494, Length=200, Percent_Identity=45, Blast_Score=177, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI25153706, Length=198, Percent_Identity=26.7676767676768, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323613, Length=199, Percent_Identity=44.2211055276382, Blast_Score=170, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6320661, Length=197, Percent_Identity=43.6548223350254, Blast_Score=160, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6319407, Length=192, Percent_Identity=31.7708333333333, Blast_Score=105, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24656348, Length=195, Percent_Identity=48.2051282051282, Blast_Score=190, Evalue=7e-49,
Organism=Drosophila melanogaster, GI17864676, Length=195, Percent_Identity=48.2051282051282, Blast_Score=190, Evalue=7e-49,
Organism=Drosophila melanogaster, GI17157991, Length=203, Percent_Identity=44.3349753694581, Blast_Score=187, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24641739, Length=203, Percent_Identity=44.3349753694581, Blast_Score=187, Evalue=3e-48,
Organism=Drosophila melanogaster, GI17738015, Length=208, Percent_Identity=43.75, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21357347, Length=205, Percent_Identity=41.9512195121951, Blast_Score=171, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24581278, Length=196, Percent_Identity=31.1224489795918, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17975518, Length=196, Percent_Identity=31.6326530612245, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24652436, Length=196, Percent_Identity=31.6326530612245, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24652434, Length=196, Percent_Identity=31.6326530612245, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 23629; Mature: 23629

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALIGKKAPEFHAPAVVNGNEIIEDFSLEQYVGKKYVVMFFYPMDFTFVCPTELHAFQQ
CCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCEEEEEEEECCCEEEECCHHHHHHHH
KLQEFERRNVAVVGCSVDSQFSHFAWLNQDKNKGGIHGVTYPLVSDFSKTISENFGVLAA
HHHHHHHCCEEEEEECCCCCHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEE
DYITNESGELISRGNPVAYRGLFLIDKEGLIRHYVINDLPLGRNVDEALRMVDALQHFEE
HEEECCCCCHHHCCCCEEEEEEEEECCCCCEEHHHHCCCCCCCCHHHHHHHHHHHHHHHH
YGEVCPANWSKGKDAMKATNAGVSNYLSHH
HHCCCCCCCCCCHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure
MKALIGKKAPEFHAPAVVNGNEIIEDFSLEQYVGKKYVVMFFYPMDFTFVCPTELHAFQQ
CCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCEEEEEEEECCCEEEECCHHHHHHHH
KLQEFERRNVAVVGCSVDSQFSHFAWLNQDKNKGGIHGVTYPLVSDFSKTISENFGVLAA
HHHHHHHCCEEEEEECCCCCHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEE
DYITNESGELISRGNPVAYRGLFLIDKEGLIRHYVINDLPLGRNVDEALRMVDALQHFEE
HEEECCCCCHHHCCCCEEEEEEEEECCCCCEEHHHHCCCCCCCCHHHHHHHHHHHHHHHH
YGEVCPANWSKGKDAMKATNAGVSNYLSHH
HHCCCCCCCCCCHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682; 1987145 [H]