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The map label for this gene is mutS [H]

Identifier: 150006747

GI number: 150006747

Start: 77085

End: 78893

Strand: Reverse

Name: mutS [H]

Synonym: BDI_0073

Alternate gene names: 150006747

Gene position: 78893-77085 (Counterclockwise)

Preceding gene: 150006759

Following gene: 150006745

Centisome position: 1.64

GC content: 47.1

Gene sequence:

>1809_bases
ATGGAAGAAATCTATAGTTATTACAAAGAAAATATCGACGCTTATACACGGCGCTTGGGTAATTTGAAAAAGAATATCCA
TTTGATGGGGAGTATCCGGTTGGCTTTAGTGGTGGGAGCGATCCTCTCCTTATGGATATTCAGGGATGAGAGTTGGCAAT
GGCTGACAGGGATCACCTTCGCTTATATCATCCCGTTCGCGCTCCTGATGTGGTACCATAATAAAATGTACGCACGAAAA
GTATACGCCGAGACCTTGATCAAACTGAACGAGGATGAGCTAAAAGGACTGGACTATGATTTCAGTGCGTTCGACGGGGC
GGCCGATAAGATCTCGGGCGAGCACTCTTTCTGCTTGGATCTGGATGTGTTTGGAGACCGCTCCTTGTTTCAATCGCTCA
ATCGTACCGTAACCGGGTTCGGGCGGGAACGACTGGCCGGTTGGCTCTCGAATCCCTTGACGGATAAGAAGGAGATCGTC
AAACGGCAAGAGGCTGTCAAGGAATTAGCGACTTTATCCGCCTTACGGCAGCATTTCTATGTGACGGGAATCATCCGGCA
GGACACGCAAGATACGAGAGACAACGATATCAACTTTATGGACCGACTCACTCAGCGTAAGCATAAATTCGTTGATAGCC
TACCGTGGAAACTATTGATCTGGGCGGTCCCAGTGTTGTGGATCGTATTGGGTATCGCTTACTCGCTGGATTGGATCAGC
GGGAGTTTATTGAATATTTATTTCTTAATCACGTTAGTGATCGCTTACGGACGAGCCAAGGAAATCAATGCGCTTTACGC
GACCGTCAATAAGATGGAGTCTATTTTCAATCGGTACTCAAAGCTGATGCAATGTGTGGAAGAAGATAATTTCCAGTCGG
AAGAGCTGAAAGAGATCAGCGGGCAATTAGCGAATGAGAAGGAATTGGCCTCGCATGCTATCAAACGCTTGTCGTCGTAT
ATCGGAGGATTAGACCAACGATTCAGTTTGGCGGGTATCATTTTCAATCTCTTCTACTTGCGGGATACACGCCATGCCAT
CCTTTTGGAACGCTGGATTCAGACTTACTCCGATAAACTTCCGCTTTGGTTCGACGCGCTGGCTCGTTTCGACGCGCTGA
ACTCGTTGGGTGGTTTCGCTTTCAACCATCCGGAATACATCTATCCGGAGATTGCCGACACTTATTTCCAGATGGAAGGC
AAGGCTTTGGGACATCCTCTTTTGAACCGGGAAGTCTGCGTAAAGAACGATATCGATATCCGCAAAAGTCCTTGGTTCCT
GATTATCACCGGAGCGAATATGGCCGGAAAAAGTACATACCTCCGGACGATCGGTGTCAATTACTTATTGGCTTGCGTAG
GCGCTCCGGTCTGCGCCGCCTCCTTGACGGTTTATCCCGCCCACATGGTTACCAGCTTACGTACCTCGGATTCCTTGGCT
AGCAACGAGTCTTATTTCTTCGCGGAGTTGAAACGGCTGAAAATGATTATCGACAGGCTGCAAAACGGGGAGAAGCTATT
TATCATCTTGGACGAGATCTTGAAGGGAACAAATTCTATCGACAAGCAGAAAGGCTCTCTTGCCCTTATGAAACAGCTGG
TCGCTTATAAGGCTTGCGGCATCATCGCCACCCACGATTTAGTGTTGGGTACTTTGGAGGAAGAGTTCCCGGAACAAATA
AAGAATTACCGCTTCGAAGCGGATATAAAAGACGAGGAGCTATCCTTCTCTTATCAACTAAGAGAAGGAATAGCCCAGAA
TATGAATGCTTGTTTCTTAATGAACAAGATGGGAATCTTGTTTAATTGA

Upstream 100 bases:

>100_bases
TTTATCGCCCAAATTACATGAATAATGGTCATTTCACCTATGAATATAATATATAAACCAAAATTCAAGAGGTTAGTTCA
TTTTTCCTATATTCGCGGCT

Downstream 100 bases:

>100_bases
AAATTGAGACAAGTGATAAAATAACTGTCACTTGTCAACTGCCAACTACTTTTTGTATTTGGTTTTGATTGCGGGTAGGA
CTTTTTGGATTTCCGCTATA

Product: DNA mismatch repair protein MutS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MEEIYSYYKENIDAYTRRLGNLKKNIHLMGSIRLALVVGAILSLWIFRDESWQWLTGITFAYIIPFALLMWYHNKMYARK
VYAETLIKLNEDELKGLDYDFSAFDGAADKISGEHSFCLDLDVFGDRSLFQSLNRTVTGFGRERLAGWLSNPLTDKKEIV
KRQEAVKELATLSALRQHFYVTGIIRQDTQDTRDNDINFMDRLTQRKHKFVDSLPWKLLIWAVPVLWIVLGIAYSLDWIS
GSLLNIYFLITLVIAYGRAKEINALYATVNKMESIFNRYSKLMQCVEEDNFQSEELKEISGQLANEKELASHAIKRLSSY
IGGLDQRFSLAGIIFNLFYLRDTRHAILLERWIQTYSDKLPLWFDALARFDALNSLGGFAFNHPEYIYPEIADTYFQMEG
KALGHPLLNREVCVKNDIDIRKSPWFLIITGANMAGKSTYLRTIGVNYLLACVGAPVCAASLTVYPAHMVTSLRTSDSLA
SNESYFFAELKRLKMIIDRLQNGEKLFIILDEILKGTNSIDKQKGSLALMKQLVAYKACGIIATHDLVLGTLEEEFPEQI
KNYRFEADIKDEELSFSYQLREGIAQNMNACFLMNKMGILFN

Sequences:

>Translated_602_residues
MEEIYSYYKENIDAYTRRLGNLKKNIHLMGSIRLALVVGAILSLWIFRDESWQWLTGITFAYIIPFALLMWYHNKMYARK
VYAETLIKLNEDELKGLDYDFSAFDGAADKISGEHSFCLDLDVFGDRSLFQSLNRTVTGFGRERLAGWLSNPLTDKKEIV
KRQEAVKELATLSALRQHFYVTGIIRQDTQDTRDNDINFMDRLTQRKHKFVDSLPWKLLIWAVPVLWIVLGIAYSLDWIS
GSLLNIYFLITLVIAYGRAKEINALYATVNKMESIFNRYSKLMQCVEEDNFQSEELKEISGQLANEKELASHAIKRLSSY
IGGLDQRFSLAGIIFNLFYLRDTRHAILLERWIQTYSDKLPLWFDALARFDALNSLGGFAFNHPEYIYPEIADTYFQMEG
KALGHPLLNREVCVKNDIDIRKSPWFLIITGANMAGKSTYLRTIGVNYLLACVGAPVCAASLTVYPAHMVTSLRTSDSLA
SNESYFFAELKRLKMIIDRLQNGEKLFIILDEILKGTNSIDKQKGSLALMKQLVAYKACGIIATHDLVLGTLEEEFPEQI
KNYRFEADIKDEELSFSYQLREGIAQNMNACFLMNKMGILFN
>Mature_602_residues
MEEIYSYYKENIDAYTRRLGNLKKNIHLMGSIRLALVVGAILSLWIFRDESWQWLTGITFAYIIPFALLMWYHNKMYARK
VYAETLIKLNEDELKGLDYDFSAFDGAADKISGEHSFCLDLDVFGDRSLFQSLNRTVTGFGRERLAGWLSNPLTDKKEIV
KRQEAVKELATLSALRQHFYVTGIIRQDTQDTRDNDINFMDRLTQRKHKFVDSLPWKLLIWAVPVLWIVLGIAYSLDWIS
GSLLNIYFLITLVIAYGRAKEINALYATVNKMESIFNRYSKLMQCVEEDNFQSEELKEISGQLANEKELASHAIKRLSSY
IGGLDQRFSLAGIIFNLFYLRDTRHAILLERWIQTYSDKLPLWFDALARFDALNSLGGFAFNHPEYIYPEIADTYFQMEG
KALGHPLLNREVCVKNDIDIRKSPWFLIITGANMAGKSTYLRTIGVNYLLACVGAPVCAASLTVYPAHMVTSLRTSDSLA
SNESYFFAELKRLKMIIDRLQNGEKLFIILDEILKGTNSIDKQKGSLALMKQLVAYKACGIIATHDLVLGTLEEEFPEQI
KNYRFEADIKDEELSFSYQLREGIAQNMNACFLMNKMGILFN

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=235, Percent_Identity=30.2127659574468, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1789089, Length=231, Percent_Identity=30.7359307359307, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17508445, Length=261, Percent_Identity=28.3524904214559, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17534743, Length=247, Percent_Identity=25.1012145748988, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17508447, Length=216, Percent_Identity=29.6296296296296, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324482, Length=240, Percent_Identity=29.1666666666667, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320302, Length=232, Percent_Identity=27.5862068965517, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24584320, Length=240, Percent_Identity=27.0833333333333, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664545, Length=259, Percent_Identity=26.6409266409266, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 69152; Mature: 69152

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEIYSYYKENIDAYTRRLGNLKKNIHLMGSIRLALVVGAILSLWIFRDESWQWLTGITF
CHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
AYIIPFALLMWYHNKMYARKVYAETLIKLNEDELKGLDYDFSAFDGAADKISGEHSFCLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHCCCCHHHCCCCCCEEEE
LDVFGDRSLFQSLNRTVTGFGRERLAGWLSNPLTDKKEIVKRQEAVKELATLSALRQHFY
EECCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VTGIIRQDTQDTRDNDINFMDRLTQRKHKFVDSLPWKLLIWAVPVLWIVLGIAYSLDWIS
HEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GSLLNIYFLITLVIAYGRAKEINALYATVNKMESIFNRYSKLMQCVEEDNFQSEELKEIS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
GQLANEKELASHAIKRLSSYIGGLDQRFSLAGIIFNLFYLRDTRHAILLERWIQTYSDKL
HHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
PLWFDALARFDALNSLGGFAFNHPEYIYPEIADTYFQMEGKALGHPLLNREVCVKNDIDI
CHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCC
RKSPWFLIITGANMAGKSTYLRTIGVNYLLACVGAPVCAASLTVYPAHMVTSLRTSDSLA
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCC
SNESYFFAELKRLKMIIDRLQNGEKLFIILDEILKGTNSIDKQKGSLALMKQLVAYKACG
CCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHC
IIATHDLVLGTLEEEFPEQIKNYRFEADIKDEELSFSYQLREGIAQNMNACFLMNKMGIL
HHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHHHHHCCCCEEHHHCCCCC
FN
CC
>Mature Secondary Structure
MEEIYSYYKENIDAYTRRLGNLKKNIHLMGSIRLALVVGAILSLWIFRDESWQWLTGITF
CHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
AYIIPFALLMWYHNKMYARKVYAETLIKLNEDELKGLDYDFSAFDGAADKISGEHSFCLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHCCCCHHHCCCCCCEEEE
LDVFGDRSLFQSLNRTVTGFGRERLAGWLSNPLTDKKEIVKRQEAVKELATLSALRQHFY
EECCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VTGIIRQDTQDTRDNDINFMDRLTQRKHKFVDSLPWKLLIWAVPVLWIVLGIAYSLDWIS
HEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GSLLNIYFLITLVIAYGRAKEINALYATVNKMESIFNRYSKLMQCVEEDNFQSEELKEIS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
GQLANEKELASHAIKRLSSYIGGLDQRFSLAGIIFNLFYLRDTRHAILLERWIQTYSDKL
HHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
PLWFDALARFDALNSLGGFAFNHPEYIYPEIADTYFQMEGKALGHPLLNREVCVKNDIDI
CHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCC
RKSPWFLIITGANMAGKSTYLRTIGVNYLLACVGAPVCAASLTVYPAHMVTSLRTSDSLA
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCC
SNESYFFAELKRLKMIIDRLQNGEKLFIILDEILKGTNSIDKQKGSLALMKQLVAYKACG
CCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHC
IIATHDLVLGTLEEEFPEQIKNYRFEADIKDEELSFSYQLREGIAQNMNACFLMNKMGIL
HHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHHHHHCCCCEEHHHCCCCC
FN
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]