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The map label for this gene is hex20 [H]

Identifier: 150006724

GI number: 150006724

Start: 48324

End: 50039

Strand: Reverse

Name: hex20 [H]

Synonym: BDI_0050

Alternate gene names: 150006724

Gene position: 50039-48324 (Counterclockwise)

Preceding gene: 150006726

Following gene: 150006723

Centisome position: 1.04

GC content: 46.56

Gene sequence:

>1716_bases
ATGAAAAGAATCACTCTCGCATGGGCATTGACCCTCTGTAGTTTTATTACATTTATCGCCTGTTCATCCCCAGATGTTGG
AGAAAGAAGCGTAAGCATTATCCCCGCTCCGGCCCAAATGACAGTAGGCGAAGGTACATTCACGATCCATCCCGGCATCG
AGATCGGTTATGCGGACGAATCCTTAAAGGGTATGGGCGAGTTGCTATCCAACGAGATAGAAAAGCTATCCGGCATCAAG
CTGGCTTCCGCCTCAGACAAAGAATCGAATTGCATCATCTTCCTCGAGTTGACAGATCCGAAAGAGTTCGCCGACCTGCC
AAAAGCTTATGGATTGAGTCCGAAAGATAGTGTCCCCGTAGATGAGTCTTACTCCCTCTCCATCCAAAAGAGAAACATCT
ACATCAAGGCCACTACCCTAGAAGGTATCTATCGAGGTATCACTACCTTGAAACAAATCGTGGGTGGTAATCTACAACCC
GGAGGCGAGAAGATTTATCTACCGCTACTGGAAGTGAAGGACTCACCTCGTTTCGCTTGGCGTGGGCTTTCTTTCGATGT
ATCTCGTTGCTTCTTCGATCCCGAGGAAGTGAAACAAGTGATCGATATGATCGCCTTATATAAGATGAACGTACTGCATA
TGCATCTTTCCGATAACCAAGGCTGGCGTATCGAGATCAAGAAATATCCCGAGCTAGCGGAAATAGGAGGTCAACTTCCC
AACAACGGGAGAAAAGGAGGCTATTATACGCAAGAGGAATTCAAGGATCTCGTTAATTACGCAAAAGAACGCTTCATCAC
GATCATCCCGGAAGTAGATATCCCGGGGCATACAGCTGCCATATTCGCCGCTTATCCGGACTTTAAGAACGCTGTCAAAT
TCAAGACCAATGTTAACATCCCGGGACAGGCCTTCAATGCCCTCGACGTAGATGATCCGAAAGCGATGCAATTTACGGAG
GATGTTATCGCGGAGCTAGCCGCTTTAGCACCCGGAAACTACATTCATATCGGAGGTGACGAGGCGATCGGCTTACCCCA
TGATAAGTTCGTCCGTTTTATAAATAAGACACGGGAAATCGTATTGAAGAATGGAAAGAAAATGGTCGGCTGGCAAGAAA
CCGCCCGTGCGGATATCTCGGAAGGCGATGTCATCCAGCACTGGATTTATCTGAAGCAAAAAAACGAGGACTCTTCTAAG
AAAAAAGATAATATACCTGCCGAATATAAAGAGATCATGGCCTTATTCGCCGAATTCATGAAAGAGGCACCAAAAGATCC
GGGTCTTGGTATATCCAAAAAAGCGAAAGTGATTCTCTCGCCGAGCGGTTACGTTTATCTGGACCATAAATATCTGGAAC
CAAGTGCGGACTCCACCCAAAACGCGGAGCAAGAACGTTTAGGTATGGCCGCCTACGAGAAACAAACGATCCAAGAAATG
TACGACTGGGACCCGATGACCTTCAACCCGACTGTAGAGAATCCTCAAAAAGATGTAGCGGGTATAGAAGCCGCTATCTG
GTGCGAGACGATCACCAATTTCAGAGATCTGCAATTCCTGTTAATGCCTCGTTTGGCAGGTGTCGCCGAAAAAGGTTGGT
CCAAAGTAGAGAACACACATTGGGACGAATATAAAGTAAGACTTGGTGCGCAAGCCCCCTTATGGGAAAAGGCCGATTGG
AACTATTTTAAATCATCCTTAGTGGATTGGAAATAA

Upstream 100 bases:

>100_bases
GAAATTCTCTTTGATCATAGCACACTTTTGTGAAATTCGCGTAAAAGTAAAAACAAATCCTTACTTTTGCCATGATATAA
CCTATAAATTTAAAATAAGA

Downstream 100 bases:

>100_bases
CAGTACAAAATCTTCATAATATTACGAATATTTCGAAACAAATTAAATATCTTTGTCCTATCAACTTTAGGACAAAGATA
TTTTTATGAATAAATGGCTT

Product: beta-N-acetylhexosaminidase

Products: NA

Alternate protein names: Beta-N-acetylgalactosaminidase; Beta-N-acetylglucosaminidase; Hex20 [H]

Number of amino acids: Translated: 571; Mature: 571

Protein sequence:

>571_residues
MKRITLAWALTLCSFITFIACSSPDVGERSVSIIPAPAQMTVGEGTFTIHPGIEIGYADESLKGMGELLSNEIEKLSGIK
LASASDKESNCIIFLELTDPKEFADLPKAYGLSPKDSVPVDESYSLSIQKRNIYIKATTLEGIYRGITTLKQIVGGNLQP
GGEKIYLPLLEVKDSPRFAWRGLSFDVSRCFFDPEEVKQVIDMIALYKMNVLHMHLSDNQGWRIEIKKYPELAEIGGQLP
NNGRKGGYYTQEEFKDLVNYAKERFITIIPEVDIPGHTAAIFAAYPDFKNAVKFKTNVNIPGQAFNALDVDDPKAMQFTE
DVIAELAALAPGNYIHIGGDEAIGLPHDKFVRFINKTREIVLKNGKKMVGWQETARADISEGDVIQHWIYLKQKNEDSSK
KKDNIPAEYKEIMALFAEFMKEAPKDPGLGISKKAKVILSPSGYVYLDHKYLEPSADSTQNAEQERLGMAAYEKQTIQEM
YDWDPMTFNPTVENPQKDVAGIEAAIWCETITNFRDLQFLLMPRLAGVAEKGWSKVENTHWDEYKVRLGAQAPLWEKADW
NYFKSSLVDWK

Sequences:

>Translated_571_residues
MKRITLAWALTLCSFITFIACSSPDVGERSVSIIPAPAQMTVGEGTFTIHPGIEIGYADESLKGMGELLSNEIEKLSGIK
LASASDKESNCIIFLELTDPKEFADLPKAYGLSPKDSVPVDESYSLSIQKRNIYIKATTLEGIYRGITTLKQIVGGNLQP
GGEKIYLPLLEVKDSPRFAWRGLSFDVSRCFFDPEEVKQVIDMIALYKMNVLHMHLSDNQGWRIEIKKYPELAEIGGQLP
NNGRKGGYYTQEEFKDLVNYAKERFITIIPEVDIPGHTAAIFAAYPDFKNAVKFKTNVNIPGQAFNALDVDDPKAMQFTE
DVIAELAALAPGNYIHIGGDEAIGLPHDKFVRFINKTREIVLKNGKKMVGWQETARADISEGDVIQHWIYLKQKNEDSSK
KKDNIPAEYKEIMALFAEFMKEAPKDPGLGISKKAKVILSPSGYVYLDHKYLEPSADSTQNAEQERLGMAAYEKQTIQEM
YDWDPMTFNPTVENPQKDVAGIEAAIWCETITNFRDLQFLLMPRLAGVAEKGWSKVENTHWDEYKVRLGAQAPLWEKADW
NYFKSSLVDWK
>Mature_571_residues
MKRITLAWALTLCSFITFIACSSPDVGERSVSIIPAPAQMTVGEGTFTIHPGIEIGYADESLKGMGELLSNEIEKLSGIK
LASASDKESNCIIFLELTDPKEFADLPKAYGLSPKDSVPVDESYSLSIQKRNIYIKATTLEGIYRGITTLKQIVGGNLQP
GGEKIYLPLLEVKDSPRFAWRGLSFDVSRCFFDPEEVKQVIDMIALYKMNVLHMHLSDNQGWRIEIKKYPELAEIGGQLP
NNGRKGGYYTQEEFKDLVNYAKERFITIIPEVDIPGHTAAIFAAYPDFKNAVKFKTNVNIPGQAFNALDVDDPKAMQFTE
DVIAELAALAPGNYIHIGGDEAIGLPHDKFVRFINKTREIVLKNGKKMVGWQETARADISEGDVIQHWIYLKQKNEDSSK
KKDNIPAEYKEIMALFAEFMKEAPKDPGLGISKKAKVILSPSGYVYLDHKYLEPSADSTQNAEQERLGMAAYEKQTIQEM
YDWDPMTFNPTVENPQKDVAGIEAAIWCETITNFRDLQFLLMPRLAGVAEKGWSKVENTHWDEYKVRLGAQAPLWEKADW
NYFKSSLVDWK

Specific function: Catalyzes the cleavage of beta-N-acetylglucosaminides and beta-N-acetylgalactosaminides. Also catalyzes the hydrolysis of N-acetylchitooligomers. May be involved in chitin degradation. It is not able to cleave beta-glucosides [H]

COG id: COG3525

COG function: function code G; N-acetyl-beta-hexosaminidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 20 family [H]

Homologues:

Organism=Homo sapiens, GI189181666, Length=442, Percent_Identity=25.5656108597285, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI4504373, Length=454, Percent_Identity=24.0088105726872, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17569815, Length=450, Percent_Identity=26, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI17933586, Length=290, Percent_Identity=27.5862068965517, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI45551090, Length=436, Percent_Identity=24.7706422018349, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24653074, Length=436, Percent_Identity=24.7706422018349, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24657468, Length=240, Percent_Identity=27.5, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17647501, Length=240, Percent_Identity=27.5, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281365639, Length=240, Percent_Identity=27.5, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24657474, Length=240, Percent_Identity=27.5, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015882
- InterPro:   IPR001540
- InterPro:   IPR015883
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00728 Glyco_hydro_20; PF02838 Glyco_hydro_20b [H]

EC number: =3.2.1.52 [H]

Molecular weight: Translated: 64255; Mature: 64255

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRITLAWALTLCSFITFIACSSPDVGERSVSIIPAPAQMTVGEGTFTIHPGIEIGYADE
CCEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEECCCEEEECCCCEEECCCH
SLKGMGELLSNEIEKLSGIKLASASDKESNCIIFLELTDPKEFADLPKAYGLSPKDSVPV
HHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEEECCCHHHHHCHHHCCCCCCCCCCC
DESYSLSIQKRNIYIKATTLEGIYRGITTLKQIVGGNLQPGGEKIYLPLLEVKDSPRFAW
CCCCEEEEEEEEEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEE
RGLSFDVSRCFFDPEEVKQVIDMIALYKMNVLHMHLSDNQGWRIEIKKYPELAEIGGQLP
ECCCEEHHHHCCCHHHHHHHHHHHHHHHCEEEEEEECCCCCEEEEEECCCCHHHHCCCCC
NNGRKGGYYTQEEFKDLVNYAKERFITIIPEVDIPGHTAAIFAAYPDFKNAVKFKTNVNI
CCCCCCCCCCHHHHHHHHHHHHHCEEEEEECCCCCCCCEEEEEECCCCCCCEEEEECCCC
PGQAFNALDVDDPKAMQFTEDVIAELAALAPGNYIHIGGDEAIGLPHDKFVRFINKTREI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHH
VLKNGKKMVGWQETARADISEGDVIQHWIYLKQKNEDSSKKKDNIPAEYKEIMALFAEFM
HHHCCCEEECCHHHHHCCCCCCCCEEEEEEEEECCCCCCHHCCCCCHHHHHHHHHHHHHH
KEAPKDPGLGISKKAKVILSPSGYVYLDHKYLEPSADSTQNAEQERLGMAAYEKQTIQEM
HHCCCCCCCCCCCCCEEEECCCCEEEEECEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
YDWDPMTFNPTVENPQKDVAGIEAAIWCETITNFRDLQFLLMPRLAGVAEKGWSKVENTH
HCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
WDEYKVRLGAQAPLWEKADWNYFKSSLVDWK
CCCEEEEECCCCCCCCCCCHHHHHHHCCCCC
>Mature Secondary Structure
MKRITLAWALTLCSFITFIACSSPDVGERSVSIIPAPAQMTVGEGTFTIHPGIEIGYADE
CCEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEECCCEEEECCCCEEECCCH
SLKGMGELLSNEIEKLSGIKLASASDKESNCIIFLELTDPKEFADLPKAYGLSPKDSVPV
HHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEEECCCHHHHHCHHHCCCCCCCCCCC
DESYSLSIQKRNIYIKATTLEGIYRGITTLKQIVGGNLQPGGEKIYLPLLEVKDSPRFAW
CCCCEEEEEEEEEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEE
RGLSFDVSRCFFDPEEVKQVIDMIALYKMNVLHMHLSDNQGWRIEIKKYPELAEIGGQLP
ECCCEEHHHHCCCHHHHHHHHHHHHHHHCEEEEEEECCCCCEEEEEECCCCHHHHCCCCC
NNGRKGGYYTQEEFKDLVNYAKERFITIIPEVDIPGHTAAIFAAYPDFKNAVKFKTNVNI
CCCCCCCCCCHHHHHHHHHHHHHCEEEEEECCCCCCCCEEEEEECCCCCCCEEEEECCCC
PGQAFNALDVDDPKAMQFTEDVIAELAALAPGNYIHIGGDEAIGLPHDKFVRFINKTREI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHH
VLKNGKKMVGWQETARADISEGDVIQHWIYLKQKNEDSSKKKDNIPAEYKEIMALFAEFM
HHHCCCEEECCHHHHHCCCCCCCCEEEEEEEEECCCCCCHHCCCCCHHHHHHHHHHHHHH
KEAPKDPGLGISKKAKVILSPSGYVYLDHKYLEPSADSTQNAEQERLGMAAYEKQTIQEM
HHCCCCCCCCCCCCCEEEECCCCEEEEECEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
YDWDPMTFNPTVENPQKDVAGIEAAIWCETITNFRDLQFLLMPRLAGVAEKGWSKVENTH
HCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
WDEYKVRLGAQAPLWEKADWNYFKSSLVDWK
CCCEEEEECCCCCCCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA