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The map label for this gene is patB [H]

Identifier: 150006659

GI number: 150006659

Start: 5149179

End: 5150342

Strand: Direct

Name: patB [H]

Synonym: BVU_4180

Alternate gene names: 150006659

Gene position: 5149179-5150342 (Clockwise)

Preceding gene: 150006658

Following gene: 150006660

Centisome position: 99.73

GC content: 46.05

Gene sequence:

>1164_bases
ATGAAATACAACTTTGACAAACAAATTTCAAGACGGGGAACCGATTCCTACAAATGGGATAGCGCAGAAAGCGAAAATGT
ATTGCCGATGTGGGTGGCTGACATGGATTTCCGTACAGCTCCCGCTATCGTCGATGCTTTACGCCGACGGGTAGAACACG
GCATTTTCGGTTATACCCGTGTGCCCGACAGTTACTACGAGGCTGTTACAGGCTGGTTCGCACGTCGTCACGGTTGGACG
ATTGACCGTGAATGGATAATTTACACATCGGGCGTAGTCCCAGCCATCTCGGCAGTCATCAAGGCTTTGACCGTTCCGGG
AGATAAGGTATTGGTGCAGACCCCGGTCTATAATTGTTTCTTTTCTTCAATCCGTAACAATGGGTGTGAAATGGTATCAT
CACCGTTGGTCTTTGCAAGTAATACTTTCACCATCGATTATGAAGATTTAGAGCGTAAGACTGCTGATCCGAAAGTGAAG
GTGATGCTGCTGTGCAATCCTCACAATCCTGCCGGAAGGGTGTGGAAACGTGAAGAACTGGTACGTATTGGTGAAATTTG
TATTCGACACGATGTTACGGTCGTTTCGGATGAGATTCATTGCGAACTGGTTTTTCCAGAGTACCGTTACACACCGTTTG
CTTCCATCTCAGAAAATTTCCGTCACCATTCTGTAGTCTGTATATCTCCCAGTAAAGCGTTCAATATTGCCGGATTACAG
ATTGCGAACATTATTTGTGCTGATGCTAACCGTCGAGCGAAAATCGACCGGGCCATTAACGATAACGAAGTATGTGATGT
CAATCCTTTTGGTGTAATTGCGACTCAAGTAGCTTACAACGAAGGGGAAGAGTGGCTGAACCAACTCATCAAATATTTAC
AGGCCAATTTTCTCTATATGCAGGAGTTCTGTCGGGAACATCTGCCCGAGTTTCCTATCACGGTATTGGAGGGAACCTAT
CTCGTTTGGATGGACTGTCACAGACTCGGCATACACTCGCAGGAACTCGAACAGCGATTGGTTAACGAAGCCGGATTATG
GCTCAATGCAGGAACAATGTATGGGACTGAAGGAAAAGGATTCATGCGCTGGAATATCGCCTGCCCACGTACTACACTGG
CAGAAGGATTGAAACGTTTTACTGGTTTCGTAAGAAATCTTTAA

Upstream 100 bases:

>100_bases
ATTCGGTTCCATAACCATAGATGAGAACATCAAGGCTCCTGCCGATTGTGAAATCCGTCTCCGGGACGAGCGTACCTGTT
TTACCGATTAAGATGAAGAT

Downstream 100 bases:

>100_bases
GAGATATATACGGCAAATTCATTTTTAATAGAACGCAACTATATAGTTTACCATACCAAGCATTACGTATAACAAAGTAA
ATAGTTGCGACTTAATTTTT

Product: putative aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKYNFDKQISRRGTDSYKWDSAESENVLPMWVADMDFRTAPAIVDALRRRVEHGIFGYTRVPDSYYEAVTGWFARRHGWT
IDREWIIYTSGVVPAISAVIKALTVPGDKVLVQTPVYNCFFSSIRNNGCEMVSSPLVFASNTFTIDYEDLERKTADPKVK
VMLLCNPHNPAGRVWKREELVRIGEICIRHDVTVVSDEIHCELVFPEYRYTPFASISENFRHHSVVCISPSKAFNIAGLQ
IANIICADANRRAKIDRAINDNEVCDVNPFGVIATQVAYNEGEEWLNQLIKYLQANFLYMQEFCREHLPEFPITVLEGTY
LVWMDCHRLGIHSQELEQRLVNEAGLWLNAGTMYGTEGKGFMRWNIACPRTTLAEGLKRFTGFVRNL

Sequences:

>Translated_387_residues
MKYNFDKQISRRGTDSYKWDSAESENVLPMWVADMDFRTAPAIVDALRRRVEHGIFGYTRVPDSYYEAVTGWFARRHGWT
IDREWIIYTSGVVPAISAVIKALTVPGDKVLVQTPVYNCFFSSIRNNGCEMVSSPLVFASNTFTIDYEDLERKTADPKVK
VMLLCNPHNPAGRVWKREELVRIGEICIRHDVTVVSDEIHCELVFPEYRYTPFASISENFRHHSVVCISPSKAFNIAGLQ
IANIICADANRRAKIDRAINDNEVCDVNPFGVIATQVAYNEGEEWLNQLIKYLQANFLYMQEFCREHLPEFPITVLEGTY
LVWMDCHRLGIHSQELEQRLVNEAGLWLNAGTMYGTEGKGFMRWNIACPRTTLAEGLKRFTGFVRNL
>Mature_387_residues
MKYNFDKQISRRGTDSYKWDSAESENVLPMWVADMDFRTAPAIVDALRRRVEHGIFGYTRVPDSYYEAVTGWFARRHGWT
IDREWIIYTSGVVPAISAVIKALTVPGDKVLVQTPVYNCFFSSIRNNGCEMVSSPLVFASNTFTIDYEDLERKTADPKVK
VMLLCNPHNPAGRVWKREELVRIGEICIRHDVTVVSDEIHCELVFPEYRYTPFASISENFRHHSVVCISPSKAFNIAGLQ
IANIICADANRRAKIDRAINDNEVCDVNPFGVIATQVAYNEGEEWLNQLIKYLQANFLYMQEFCREHLPEFPITVLEGTY
LVWMDCHRLGIHSQELEQRLVNEAGLWLNAGTMYGTEGKGFMRWNIACPRTTLAEGLKRFTGFVRNL

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=210, Percent_Identity=28.0952380952381, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI56713254, Length=210, Percent_Identity=28.0952380952381, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI4507369, Length=402, Percent_Identity=22.8855721393035, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI95147551, Length=324, Percent_Identity=21.9135802469136, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI169881279, Length=324, Percent_Identity=21.9135802469136, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1787909, Length=389, Percent_Identity=32.6478149100257, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1788722, Length=373, Percent_Identity=22.7882037533512, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786816, Length=261, Percent_Identity=22.9885057471264, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788627, Length=201, Percent_Identity=23.8805970149254, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=143, Percent_Identity=30.7692307692308, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71994472, Length=143, Percent_Identity=30.7692307692308, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17567369, Length=162, Percent_Identity=28.3950617283951, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322401, Length=293, Percent_Identity=25.5972696245734, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28573069, Length=194, Percent_Identity=25.7731958762887, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646114, Length=194, Percent_Identity=25.7731958762887, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573067, Length=194, Percent_Identity=25.7731958762887, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573065, Length=194, Percent_Identity=25.7731958762887, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44387; Mature: 44387

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYNFDKQISRRGTDSYKWDSAESENVLPMWVADMDFRTAPAIVDALRRRVEHGIFGYTR
CCCCCHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEC
VPDSYYEAVTGWFARRHGWTIDREWIIYTSGVVPAISAVIKALTVPGDKVLVQTPVYNCF
CCHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCHHHHH
FSSIRNNGCEMVSSPLVFASNTFTIDYEDLERKTADPKVKVMLLCNPHNPAGRVWKREEL
HHHHHCCCHHHHCCCEEEECCEEEEEHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHH
VRIGEICIRHDVTVVSDEIHCELVFPEYRYTPFASISENFRHHSVVCISPSKAFNIAGLQ
HHHHHHHHHCCCEEEECCEEEEEECCCCCCCCCHHHHHCCCCCEEEEECCCCCCEECCEE
IANIICADANRRAKIDRAINDNEVCDVNPFGVIATQVAYNEGEEWLNQLIKYLQANFLYM
EEEEEEECCCCCHHHHHCCCCCCEECCCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHH
QEFCREHLPEFPITVLEGTYLVWMDCHRLGIHSQELEQRLVNEAGLWLNAGTMYGTEGKG
HHHHHHHCCCCCEEEECCCEEEEEEHHHHCCCHHHHHHHHHHHCCCEEECCEEECCCCCC
FMRWNIACPRTTLAEGLKRFTGFVRNL
EEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKYNFDKQISRRGTDSYKWDSAESENVLPMWVADMDFRTAPAIVDALRRRVEHGIFGYTR
CCCCCHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEC
VPDSYYEAVTGWFARRHGWTIDREWIIYTSGVVPAISAVIKALTVPGDKVLVQTPVYNCF
CCHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCHHHHH
FSSIRNNGCEMVSSPLVFASNTFTIDYEDLERKTADPKVKVMLLCNPHNPAGRVWKREEL
HHHHHCCCHHHHCCCEEEECCEEEEEHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHH
VRIGEICIRHDVTVVSDEIHCELVFPEYRYTPFASISENFRHHSVVCISPSKAFNIAGLQ
HHHHHHHHHCCCEEEECCEEEEEECCCCCCCCCHHHHHCCCCCEEEEECCCCCCEECCEE
IANIICADANRRAKIDRAINDNEVCDVNPFGVIATQVAYNEGEEWLNQLIKYLQANFLYM
EEEEEEECCCCCHHHHHCCCCCCEECCCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHH
QEFCREHLPEFPITVLEGTYLVWMDCHRLGIHSQELEQRLVNEAGLWLNAGTMYGTEGKG
HHHHHHHCCCCCEEEECCCEEEEEEHHHHCCCHHHHHHHHHHHCCCEEECCEEECCCCCC
FMRWNIACPRTTLAEGLKRFTGFVRNL
EEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]