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The map label for this gene is nanH [H]

Identifier: 150006623

GI number: 150006623

Start: 5102345

End: 5103985

Strand: Reverse

Name: nanH [H]

Synonym: BVU_4143

Alternate gene names: 150006623

Gene position: 5103985-5102345 (Counterclockwise)

Preceding gene: 150006624

Following gene: 150006622

Centisome position: 98.85

GC content: 44.24

Gene sequence:

>1641_bases
ATGAGAAACCCTAGCTTATTACTGCTAATTGTTGTTTTTATATTAGCACCCTTCAAGTTGAGTGCGGCGGCAGATACGGT
TGTTGTCCGCGAAACCCGGATTCCTGTGTTGATTGAAAGGCAGGATAATGAGTTGTTTCATTTACGTATAGAGGCTACTC
AAAGTCAGATGCTGAATGAAGTGAAGTTGGACTTCGGCAAAGACGTGAATTTGAATGAAATTGAATCTGTGAAACTGTAT
TATGGTGGAACTGAAAGCGTGGAGAGGAGGGGAAAGACTTATTTTGCTCCGGTAGATTATATATCTAATAATACTCCGGG
AAAAACATTGGCTGCCAATACTTCTTATTCCGTTTTGAAGTCGGAAGTGAAGGCCCCGAAGCGTGAGGTTGTATTGAAAG
CTGACCAAAAATTGTTTCCGGGAGTGAATTATTTTTGGATTAGCCTGCAAATGAAGCCTGTTGCTTCTATCTTGTCCAAA
GTGTCGGCAGAAGTGGTGGAAGCTAAGATTGACGGACAGGTTGCTCCTTTGAAGATAGCCCGTAAGGCGGATACCCATTA
TATGGGGATCGGCGTGCGTCATGCCGGTGACGACGGGGCTGCTGCCTATCGTATTCCCGGATTGGCCACTTCAAATAAAG
GAACCTTGTTGGGGGTATATGATGTACGCTATAATAATAGTGCGGATTTACAGGAGTATGTGGAAATAGGTCTGAGCAGA
AGTACGGACGGAGGTCAGACTTGGGAGAAAATGCGCATTCCGATGGCATTTGGTGAATATGATGGGTTGCCTAAAGCACA
GAATGGAGTAGGCGATCCGGCCATTTTGGTTGATAAGAAGACAGGAACTATCTGGATTGTCGCTGCCTGGACACATGGTA
TGGGAAATGGGCGTGCGTGGTGGAATTCACAAACAGGCATGGACCGTAATCATACAGCACAATTAATGATGGTGAAAAGT
GATGATGATGGTAAGACCTGGTCGGAGCCTATGAATATAACAGAACAGGTGAAAGATCCGTCATGGTATTTCTTGCTGCA
AGGTCCCGGTAGAGGTATCTCTATGGAAGATGGAACATTGGTCTTTGCCAGCCAGTATATTGGCAATGACCGTATTCCTA
ATGCCGGTATTATATACAGTAAGGATCATGGAAAAACCTGGAATATCAGTACATTGGCACGCACTAATACAACTGAATCT
CAGGTAGCGGAAGTGGAACCGGGAGTGCTGATGCTGAATATGCGTGATAATCGTGGTGGCAGTCGTGCCGTTTCTACAAC
TACAGATTTAGGTAAAACATGGAAAGAACATGAGTCTTCACGTACAGCCTTACAGGAACCGGTTTGTATGGCCAGTTTGA
TTAGTGTTAAAGCTAAAGAGAATGTATTGGGTAAAGACATCCTTTTGTTCTCTAATCCGAATGATGCCAAGAACCGTCAT
AGCATTACCATCAAAGCAAGTCTGGATGGTGGGGTGACTTGGTTGCCCGAGAATCAATTGCTGCTGGATGCCGGTTGGGG
TTGGGGATACAGCTGCTTGACTATGATTGACAAGGAAACAGTAGGAATTTTATATGAAAGCAGTGTGGCCCACATGACTT
TCCAAGCGATAAAGCTGAAAGATATTATTAAGACCAAATAA

Upstream 100 bases:

>100_bases
AAAAGACGGTGTTCTTTATGAAATTAATAAAGAAACCGTCTTTTTATTTTCTAATTTCAATAAAAACTTTTATTTTTACA
CCCGTAAAATTATAAATATT

Downstream 100 bases:

>100_bases
ATAATGAAACGCAGATTTTCTAGTTTTATTGGTATGATACTGGTTTGTGCTGTAACTATAGCACAAACCAGTATCTCGTT
ACTTCCTAAACCTCAGTTGT

Product: sialidase

Products: NA

Alternate protein names: Neuraminidase [H]

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MRNPSLLLLIVVFILAPFKLSAAADTVVVRETRIPVLIERQDNELFHLRIEATQSQMLNEVKLDFGKDVNLNEIESVKLY
YGGTESVERRGKTYFAPVDYISNNTPGKTLAANTSYSVLKSEVKAPKREVVLKADQKLFPGVNYFWISLQMKPVASILSK
VSAEVVEAKIDGQVAPLKIARKADTHYMGIGVRHAGDDGAAAYRIPGLATSNKGTLLGVYDVRYNNSADLQEYVEIGLSR
STDGGQTWEKMRIPMAFGEYDGLPKAQNGVGDPAILVDKKTGTIWIVAAWTHGMGNGRAWWNSQTGMDRNHTAQLMMVKS
DDDGKTWSEPMNITEQVKDPSWYFLLQGPGRGISMEDGTLVFASQYIGNDRIPNAGIIYSKDHGKTWNISTLARTNTTES
QVAEVEPGVLMLNMRDNRGGSRAVSTTTDLGKTWKEHESSRTALQEPVCMASLISVKAKENVLGKDILLFSNPNDAKNRH
SITIKASLDGGVTWLPENQLLLDAGWGWGYSCLTMIDKETVGILYESSVAHMTFQAIKLKDIIKTK

Sequences:

>Translated_546_residues
MRNPSLLLLIVVFILAPFKLSAAADTVVVRETRIPVLIERQDNELFHLRIEATQSQMLNEVKLDFGKDVNLNEIESVKLY
YGGTESVERRGKTYFAPVDYISNNTPGKTLAANTSYSVLKSEVKAPKREVVLKADQKLFPGVNYFWISLQMKPVASILSK
VSAEVVEAKIDGQVAPLKIARKADTHYMGIGVRHAGDDGAAAYRIPGLATSNKGTLLGVYDVRYNNSADLQEYVEIGLSR
STDGGQTWEKMRIPMAFGEYDGLPKAQNGVGDPAILVDKKTGTIWIVAAWTHGMGNGRAWWNSQTGMDRNHTAQLMMVKS
DDDGKTWSEPMNITEQVKDPSWYFLLQGPGRGISMEDGTLVFASQYIGNDRIPNAGIIYSKDHGKTWNISTLARTNTTES
QVAEVEPGVLMLNMRDNRGGSRAVSTTTDLGKTWKEHESSRTALQEPVCMASLISVKAKENVLGKDILLFSNPNDAKNRH
SITIKASLDGGVTWLPENQLLLDAGWGWGYSCLTMIDKETVGILYESSVAHMTFQAIKLKDIIKTK
>Mature_546_residues
MRNPSLLLLIVVFILAPFKLSAAADTVVVRETRIPVLIERQDNELFHLRIEATQSQMLNEVKLDFGKDVNLNEIESVKLY
YGGTESVERRGKTYFAPVDYISNNTPGKTLAANTSYSVLKSEVKAPKREVVLKADQKLFPGVNYFWISLQMKPVASILSK
VSAEVVEAKIDGQVAPLKIARKADTHYMGIGVRHAGDDGAAAYRIPGLATSNKGTLLGVYDVRYNNSADLQEYVEIGLSR
STDGGQTWEKMRIPMAFGEYDGLPKAQNGVGDPAILVDKKTGTIWIVAAWTHGMGNGRAWWNSQTGMDRNHTAQLMMVKS
DDDGKTWSEPMNITEQVKDPSWYFLLQGPGRGISMEDGTLVFASQYIGNDRIPNAGIIYSKDHGKTWNISTLARTNTTES
QVAEVEPGVLMLNMRDNRGGSRAVSTTTDLGKTWKEHESSRTALQEPVCMASLISVKAKENVLGKDILLFSNPNDAKNRH
SITIKASLDGGVTWLPENQLLLDAGWGWGYSCLTMIDKETVGILYESSVAHMTFQAIKLKDIIKTK

Specific function: Sialidases have been suggested to be pathogenic factors in microbial infections [H]

COG id: COG4409

COG function: function code G; Neuraminidase (sialidase)

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 5 BNR repeats [H]

Homologues:

Organism=Homo sapiens, GI222352170, Length=304, Percent_Identity=27.3026315789474, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI4557791, Length=441, Percent_Identity=24.4897959183673, Blast_Score=80, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002860
- InterPro:   IPR011040
- InterPro:   IPR008377 [H]

Pfam domain/function: PF02012 BNR [H]

EC number: =3.2.1.18 [H]

Molecular weight: Translated: 60313; Mature: 60313

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS00308 LECTIN_LEGUME_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNPSLLLLIVVFILAPFKLSAAADTVVVRETRIPVLIERQDNELFHLRIEATQSQMLNE
CCCCHHHHHHHHHHHCCCEECCCCCEEEEEECCCCEEEEECCCCEEEEEEECHHHHHHHH
VKLDFGKDVNLNEIESVKLYYGGTESVERRGKTYFAPVDYISNNTPGKTLAANTSYSVLK
HHHCCCCCCCCCCEEEEEEEECCCHHHHHCCCEEEEEEHHCCCCCCCCEEECCCCHHHHH
SEVKAPKREVVLKADQKLFPGVNYFWISLQMKPVASILSKVSAEVVEAKIDGQVAPLKIA
HHHCCCCCEEEEECCHHHCCCCEEEEEEEEECHHHHHHHHHHHHHHHHHCCCCEEEEEEE
RKADTHYMGIGVRHAGDDGAAAYRIPGLATSNKGTLLGVYDVRYNNSADLQEYVEIGLSR
ECCCCEEEEEEEEECCCCCCEEEECCCEEECCCCCEEEEEEEEECCCCCHHHHHHHCCCC
STDGGQTWEKMRIPMAFGEYDGLPKAQNGVGDPAILVDKKTGTIWIVAAWTHGMGNGRAW
CCCCCCCHHHEECCEEECCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEEECCCCCCCEE
WNSQTGMDRNHTAQLMMVKSDDDGKTWSEPMNITEQVKDPSWYFLLQGPGRGISMEDGTL
ECCCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCCCCCCEE
VFASQYIGNDRIPNAGIIYSKDHGKTWNISTLARTNTTESQVAEVEPGVLMLNMRDNRGG
EEEEECCCCCCCCCCCEEEECCCCCEEEEEEEEECCCCHHHHHCCCCCEEEEEEECCCCC
SRAVSTTTDLGKTWKEHESSRTALQEPVCMASLISVKAKENVLGKDILLFSNPNDAKNRH
CEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCE
SITIKASLDGGVTWLPENQLLLDAGWGWGYSCLTMIDKETVGILYESSVAHMTFQAIKLK
EEEEEEECCCCEEECCCCCEEEECCCCCCCCEEEEECCCCEEEEEECCHHHEEEEHHHHH
DIIKTK
HHHCCC
>Mature Secondary Structure
MRNPSLLLLIVVFILAPFKLSAAADTVVVRETRIPVLIERQDNELFHLRIEATQSQMLNE
CCCCHHHHHHHHHHHCCCEECCCCCEEEEEECCCCEEEEECCCCEEEEEEECHHHHHHHH
VKLDFGKDVNLNEIESVKLYYGGTESVERRGKTYFAPVDYISNNTPGKTLAANTSYSVLK
HHHCCCCCCCCCCEEEEEEEECCCHHHHHCCCEEEEEEHHCCCCCCCCEEECCCCHHHHH
SEVKAPKREVVLKADQKLFPGVNYFWISLQMKPVASILSKVSAEVVEAKIDGQVAPLKIA
HHHCCCCCEEEEECCHHHCCCCEEEEEEEEECHHHHHHHHHHHHHHHHHCCCCEEEEEEE
RKADTHYMGIGVRHAGDDGAAAYRIPGLATSNKGTLLGVYDVRYNNSADLQEYVEIGLSR
ECCCCEEEEEEEEECCCCCCEEEECCCEEECCCCCEEEEEEEEECCCCCHHHHHHHCCCC
STDGGQTWEKMRIPMAFGEYDGLPKAQNGVGDPAILVDKKTGTIWIVAAWTHGMGNGRAW
CCCCCCCHHHEECCEEECCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEEECCCCCCCEE
WNSQTGMDRNHTAQLMMVKSDDDGKTWSEPMNITEQVKDPSWYFLLQGPGRGISMEDGTL
ECCCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCCCCCCEE
VFASQYIGNDRIPNAGIIYSKDHGKTWNISTLARTNTTESQVAEVEPGVLMLNMRDNRGG
EEEEECCCCCCCCCCCEEEECCCCCEEEEEEEEECCCCHHHHHCCCCCEEEEEEECCCCC
SRAVSTTTDLGKTWKEHESSRTALQEPVCMASLISVKAKENVLGKDILLFSNPNDAKNRH
CEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCE
SITIKASLDGGVTWLPENQLLLDAGWGWGYSCLTMIDKETVGILYESSVAHMTFQAIKLK
EEEEEEECCCCEEECCCCCEEEECCCCCCCCEEEEECCCCEEEEEECCHHHEEEEHHHHH
DIIKTK
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8093075; 2158974 [H]