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The map label for this gene is cbh [H]

Identifier: 150006474

GI number: 150006474

Start: 4913664

End: 4914722

Strand: Direct

Name: cbh [H]

Synonym: BVU_3993

Alternate gene names: 150006474

Gene position: 4913664-4914722 (Clockwise)

Preceding gene: 150006472

Following gene: 150006475

Centisome position: 95.17

GC content: 42.59

Gene sequence:

>1059_bases
ATGAAATTAAAAAAAGGAAGTATTGCATTACTAACATTGGCAGGTATGTTCTATATGAGCGTACAAAAAGCGGATGCATG
CACGCGTGCCGTCTATATCGGACCGGACCATATGGTAGTAACCGGACGTACAATGGACTGGAAAGAAGATATTATGAGTA
ATATCTATGTTTTCCCCAGAGGAATACAACGTGCAGGATATAATAAAGAAAATGCCGTGAAATGGACTTCAAAATACGGC
AGCGTCATTGCAACAGGATATGATATAGGTACGTGTGACGGAATGAATGAAAAAGGATTGGTTGCCAGTCTGTTATTTTT
GCCAGAATCCGTCTTTGACCGTCCGGGAGATACACGTCCTGTCATGGGAATCAGCATATGGACACAATATGTACTGGACA
ATTTTGCCACCGTACATGAAGCTGTTGAGGAGCTGAAAAAAGAATCATTCCGCATTGATGCTCCCCACATGCCCAACGGT
TCAGCTTCCACTCTTCACCTGGCTATTACAGATGAAACAGGAAATACAGCGGTTTTGGAATATCTGGACGGGAATTTAAG
CATACACGAAGGAAAAGAATTCCAAGTGATGACCAATTCTCCACGATATGATTATCAGTTGGCTATCAATGATTACTGGA
AAGAAGTAGGAGGATTGCAAATGCTGCCGGGCACGAACCGTTCCAGCGACCGCTTTGTGCGTGCCTCTTTTTATATACAT
GCAATCCCTCAGACTCCGGACGCTAAAATAGCTGTACCCAGTGTACTCAGTGTGATGCGTAATGTATCTGTCCCTTTCGG
AATTACCACACCGGACAAACCTCATATATCTTCCACCCGCTGGCGTTCTGTATCCGATCAGAAGAATAAAATATATTATT
TTGAATCGGTCATGACTCCTAATCTGTTTTGGTTGGATTTGAAGAAAATCGACTTCAGTCCCAAAGCCGGAATCAAGAAA
CTGCCCCTCACCAACGGAAAGATTTATGCAGGAGATGCTGTAAAAGATTTAAAAGACAGCGACTCATTTGTATTCTTATT
CCAAACCCCTGTGATGTAA

Upstream 100 bases:

>100_bases
TTTATCAACAAATGTATCACAAATCACTGCATTTCCATAAACCTGTTCCTTATCCGGTTTGTTCTAAATGGCAAAGACAA
TCTTTATAAATGATAGAATC

Downstream 100 bases:

>100_bases
AACAGTAAAAATCAATATGACGTTCATGCCTCATTAAAATCGGTTAAGAGCCTCGTGAACGTCATACTTTTCTGCAAAAG
TACTCCCCTCCGGCATTGAG

Product: choloylglycine hydrolase

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MKLKKGSIALLTLAGMFYMSVQKADACTRAVYIGPDHMVVTGRTMDWKEDIMSNIYVFPRGIQRAGYNKENAVKWTSKYG
SVIATGYDIGTCDGMNEKGLVASLLFLPESVFDRPGDTRPVMGISIWTQYVLDNFATVHEAVEELKKESFRIDAPHMPNG
SASTLHLAITDETGNTAVLEYLDGNLSIHEGKEFQVMTNSPRYDYQLAINDYWKEVGGLQMLPGTNRSSDRFVRASFYIH
AIPQTPDAKIAVPSVLSVMRNVSVPFGITTPDKPHISSTRWRSVSDQKNKIYYFESVMTPNLFWLDLKKIDFSPKAGIKK
LPLTNGKIYAGDAVKDLKDSDSFVFLFQTPVM

Sequences:

>Translated_352_residues
MKLKKGSIALLTLAGMFYMSVQKADACTRAVYIGPDHMVVTGRTMDWKEDIMSNIYVFPRGIQRAGYNKENAVKWTSKYG
SVIATGYDIGTCDGMNEKGLVASLLFLPESVFDRPGDTRPVMGISIWTQYVLDNFATVHEAVEELKKESFRIDAPHMPNG
SASTLHLAITDETGNTAVLEYLDGNLSIHEGKEFQVMTNSPRYDYQLAINDYWKEVGGLQMLPGTNRSSDRFVRASFYIH
AIPQTPDAKIAVPSVLSVMRNVSVPFGITTPDKPHISSTRWRSVSDQKNKIYYFESVMTPNLFWLDLKKIDFSPKAGIKK
LPLTNGKIYAGDAVKDLKDSDSFVFLFQTPVM
>Mature_352_residues
MKLKKGSIALLTLAGMFYMSVQKADACTRAVYIGPDHMVVTGRTMDWKEDIMSNIYVFPRGIQRAGYNKENAVKWTSKYG
SVIATGYDIGTCDGMNEKGLVASLLFLPESVFDRPGDTRPVMGISIWTQYVLDNFATVHEAVEELKKESFRIDAPHMPNG
SASTLHLAITDETGNTAVLEYLDGNLSIHEGKEFQVMTNSPRYDYQLAINDYWKEVGGLQMLPGTNRSSDRFVRASFYIH
AIPQTPDAKIAVPSVLSVMRNVSVPFGITTPDKPHISSTRWRSVSDQKNKIYYFESVMTPNLFWLDLKKIDFSPKAGIKK
LPLTNGKIYAGDAVKDLKDSDSFVFLFQTPVM

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 39401; Mature: 39401

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKKGSIALLTLAGMFYMSVQKADACTRAVYIGPDHMVVTGRTMDWKEDIMSNIYVFPR
CCCCCCCEEEHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCCHHHHHHHCEEEECC
GIQRAGYNKENAVKWTSKYGSVIATGYDIGTCDGMNEKGLVASLLFLPESVFDRPGDTRP
CHHHCCCCCCCCEEEECCCCCEEEECCCCCCCCCCCCCCHHHHHHHCCHHHHCCCCCCCC
VMGISIWTQYVLDNFATVHEAVEELKKESFRIDAPHMPNGSASTLHLAITDETGNTAVLE
EEHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCEEEEEEECCCCCEEEEE
YLDGNLSIHEGKEFQVMTNSPRYDYQLAINDYWKEVGGLQMLPGTNRSSDRFVRASFYIH
EECCCEEEECCCEEEEEECCCCEEEEEEEEHHHHHHCCEEECCCCCCCCCCEEEEEEEEE
AIPQTPDAKIAVPSVLSVMRNVSVPFGITTPDKPHISSTRWRSVSDQKNKIYYFESVMTP
ECCCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCC
NLFWLDLKKIDFSPKAGIKKLPLTNGKIYAGDAVKDLKDSDSFVFLFQTPVM
CEEEEEEEECCCCCCCCCEECCCCCCEEEECCHHHHCCCCCCEEEEEECCCC
>Mature Secondary Structure
MKLKKGSIALLTLAGMFYMSVQKADACTRAVYIGPDHMVVTGRTMDWKEDIMSNIYVFPR
CCCCCCCEEEHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCCHHHHHHHCEEEECC
GIQRAGYNKENAVKWTSKYGSVIATGYDIGTCDGMNEKGLVASLLFLPESVFDRPGDTRP
CHHHCCCCCCCCEEEECCCCCEEEECCCCCCCCCCCCCCHHHHHHHCCHHHHCCCCCCCC
VMGISIWTQYVLDNFATVHEAVEELKKESFRIDAPHMPNGSASTLHLAITDETGNTAVLE
EEHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCEEEEEEECCCCCEEEEE
YLDGNLSIHEGKEFQVMTNSPRYDYQLAINDYWKEVGGLQMLPGTNRSSDRFVRASFYIH
EECCCEEEECCCEEEEEECCCCEEEEEEEEHHHHHHCCEEECCCCCCCCCCEEEEEEEEE
AIPQTPDAKIAVPSVLSVMRNVSVPFGITTPDKPHISSTRWRSVSDQKNKIYYFESVMTP
ECCCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCC
NLFWLDLKKIDFSPKAGIKKLPLTNGKIYAGDAVKDLKDSDSFVFLFQTPVM
CEEEEEEEECCCCCCCCCEECCCCCCEEEECCHHHHCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7618863; 11792842 [H]