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The map label for this gene is fcl [H]

Identifier: 150006426

GI number: 150006426

Start: 4859154

End: 4860230

Strand: Reverse

Name: fcl [H]

Synonym: BVU_3945

Alternate gene names: 150006426

Gene position: 4860230-4859154 (Counterclockwise)

Preceding gene: 150006427

Following gene: 150006420

Centisome position: 94.13

GC content: 46.61

Gene sequence:

>1077_bases
ATGGAAAAAACAGCCAAGATATATGTAGCAGGCCACCACGGACTGGTGGGGTCTGCTATATGGAATAATTTGCAGCAAAA
GGGATATACCAATCTGGTAGGCCGTTCTCACAAAGAACTGGATTTGCTGGACGGGCAGGCTGTGAAGAAGTTTTTTGATG
AAGAGCAGCCCCAGTATGTCATTCTGGCAGCGGCACATGTGGGAGGCATCATGGCGAACAGTCTTTACCGTGCCGATTTT
ATTTATCAGAACTTGCAGATTCAGCAGAATGTGATAGGGGAGAGTTTCCGCCATGATGTAAAGAAACTCTTGTTTTTGGG
AAGCACTTGCATTTATCCTCGTGATGCCGTACAACCCATGAAGGAAGATGTGTTACTGACTTCTCCCTTGGAATATACCA
ACGAACCGTATGCTATTGCGAAGATTGCCGGGTTGAAGATGTGCGAAAGCTTTAACTTGCAATATGGAACCAATTACATA
GCCGTGATGCCTACGAACCTTTACGGTCCCAATGATAATTTCCATTTGGAGAACAGCCATGTGCTGCCTGCCATGATTCG
TAAGATTCATTTGGGAAAATGCCTGAATGAAGGGGACTGGGACGCGGTGCGTAAAGATATGAATCTTCGTCCCGTAGAGG
GGATAGACGGTTCGCATACGGATGAGGAGATTCTCTCCATTCTGAAAAAGTATGGTATAACCGGGCAGGAAGTAACTTTG
TGGGGAACAGGCAAGCCGTTGCGTGAGTTCTTATGGAGTGAGGAGATGGCTGATGCCAGTGTCTATATCATGGAGCATGT
GGATTTTAAGGATACCTATGCTGCCGGCTCCAAGGATATCCGCAACTGTCATATCAATATCGGTACGGGGAAAGAAATCA
CCATTGCCCAACTGGCGGACAAGATTGTCAAGGAGGTGGGTTATCAGGGCAAACTGACTTTTGACGCTACGAAACCGGAC
GGCACTATGCGTAAGATGACGGATGTAAGCAAATTGCACCGGCTGGGCTGGCAGCATAAGATTGATATAGAAGAAGGGGT
ACACAGAATGTACCAATGGTACTTGTCTAAAGGATGA

Upstream 100 bases:

>100_bases
ATCCCCGTAAGACTTCTTTCCCCGAACTGGTGAAAATCATGGTGAAGCATGATATGAAGTTCGTGAAGAAACTGTATTTA
AAGGCTCAAATAGCAGAATA

Downstream 100 bases:

>100_bases
AGATGTAAGATTATAGATCTTGCGGGCATAAGATTATAAATCTTTCACATGCAAGATTATAGATCTTTCAAGCATGACAT
ATAAAAATTTCCGGCATAAC

Product: GDP-4-keto-6-deoxy-D-mannose-3, 5-epimerase-4-reductase

Products: NA

Alternate protein names: GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MEKTAKIYVAGHHGLVGSAIWNNLQQKGYTNLVGRSHKELDLLDGQAVKKFFDEEQPQYVILAAAHVGGIMANSLYRADF
IYQNLQIQQNVIGESFRHDVKKLLFLGSTCIYPRDAVQPMKEDVLLTSPLEYTNEPYAIAKIAGLKMCESFNLQYGTNYI
AVMPTNLYGPNDNFHLENSHVLPAMIRKIHLGKCLNEGDWDAVRKDMNLRPVEGIDGSHTDEEILSILKKYGITGQEVTL
WGTGKPLREFLWSEEMADASVYIMEHVDFKDTYAAGSKDIRNCHINIGTGKEITIAQLADKIVKEVGYQGKLTFDATKPD
GTMRKMTDVSKLHRLGWQHKIDIEEGVHRMYQWYLSKG

Sequences:

>Translated_358_residues
MEKTAKIYVAGHHGLVGSAIWNNLQQKGYTNLVGRSHKELDLLDGQAVKKFFDEEQPQYVILAAAHVGGIMANSLYRADF
IYQNLQIQQNVIGESFRHDVKKLLFLGSTCIYPRDAVQPMKEDVLLTSPLEYTNEPYAIAKIAGLKMCESFNLQYGTNYI
AVMPTNLYGPNDNFHLENSHVLPAMIRKIHLGKCLNEGDWDAVRKDMNLRPVEGIDGSHTDEEILSILKKYGITGQEVTL
WGTGKPLREFLWSEEMADASVYIMEHVDFKDTYAAGSKDIRNCHINIGTGKEITIAQLADKIVKEVGYQGKLTFDATKPD
GTMRKMTDVSKLHRLGWQHKIDIEEGVHRMYQWYLSKG
>Mature_358_residues
MEKTAKIYVAGHHGLVGSAIWNNLQQKGYTNLVGRSHKELDLLDGQAVKKFFDEEQPQYVILAAAHVGGIMANSLYRADF
IYQNLQIQQNVIGESFRHDVKKLLFLGSTCIYPRDAVQPMKEDVLLTSPLEYTNEPYAIAKIAGLKMCESFNLQYGTNYI
AVMPTNLYGPNDNFHLENSHVLPAMIRKIHLGKCLNEGDWDAVRKDMNLRPVEGIDGSHTDEEILSILKKYGITGQEVTL
WGTGKPLREFLWSEEMADASVYIMEHVDFKDTYAAGSKDIRNCHINIGTGKEITIAQLADKIVKEVGYQGKLTFDATKPD
GTMRKMTDVSKLHRLGWQHKIDIEEGVHRMYQWYLSKG

Specific function: Two step NADP-dependent conversion of GDP-4-dehydro-6- deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fucose synthase family [H]

Homologues:

Organism=Homo sapiens, GI4507709, Length=334, Percent_Identity=29.0419161676647, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1788365, Length=353, Percent_Identity=48.7252124645892, Blast_Score=338, Evalue=2e-94,
Organism=Escherichia coli, GI1788353, Length=390, Percent_Identity=22.8205128205128, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554428, Length=353, Percent_Identity=24.929178470255, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI19922778, Length=353, Percent_Identity=25.7790368271955, Blast_Score=135, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =1.1.1.271 [H]

Molecular weight: Translated: 40542; Mature: 40542

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTAKIYVAGHHGLVGSAIWNNLQQKGYTNLVGRSHKELDLLDGQAVKKFFDEEQPQYV
CCCCEEEEEEECCCCHHHHHHHHHHHCCCHHHHCCCCCCHHHCCHHHHHHHHCCCCCCEE
ILAAAHVGGIMANSLYRADFIYQNLQIQQNVIGESFRHDVKKLLFLGSTCIYPRDAVQPM
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
KEDVLLTSPLEYTNEPYAIAKIAGLKMCESFNLQYGTNYIAVMPTNLYGPNDNFHLENSH
HHCEEEECCHHHCCCCCHHHHHHHHHHHHHCCCEECCCEEEEEECCCCCCCCCEEECCCC
VLPAMIRKIHLGKCLNEGDWDAVRKDMNLRPVEGIDGSHTDEEILSILKKYGITGQEVTL
CHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEE
WGTGKPLREFLWSEEMADASVYIMEHVDFKDTYAAGSKDIRNCHINIGTGKEITIAQLAD
EECCHHHHHHHHHHHHCCCEEEEEEECCCCHHHCCCCCCCCEEEEEECCCCEEHHHHHHH
KIVKEVGYQGKLTFDATKPDGTMRKMTDVSKLHRLGWQHKIDIEEGVHRMYQWYLSKG
HHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEKTAKIYVAGHHGLVGSAIWNNLQQKGYTNLVGRSHKELDLLDGQAVKKFFDEEQPQYV
CCCCEEEEEEECCCCHHHHHHHHHHHCCCHHHHCCCCCCHHHCCHHHHHHHHCCCCCCEE
ILAAAHVGGIMANSLYRADFIYQNLQIQQNVIGESFRHDVKKLLFLGSTCIYPRDAVQPM
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
KEDVLLTSPLEYTNEPYAIAKIAGLKMCESFNLQYGTNYIAVMPTNLYGPNDNFHLENSH
HHCEEEECCHHHCCCCCHHHHHHHHHHHHHCCCEECCCEEEEEECCCCCCCCCEEECCCC
VLPAMIRKIHLGKCLNEGDWDAVRKDMNLRPVEGIDGSHTDEEILSILKKYGITGQEVTL
CHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEE
WGTGKPLREFLWSEEMADASVYIMEHVDFKDTYAAGSKDIRNCHINIGTGKEITIAQLAD
EECCHHHHHHHHHHHHCCCEEEEEEECCCCHHHCCCCCCCCEEEEEECCCCEEHHHHHHH
KIVKEVGYQGKLTFDATKPDGTMRKMTDVSKLHRLGWQHKIDIEEGVHRMYQWYLSKG
HHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7815923; 8759852; 9097040; 9278503; 9473059; 9862812 [H]