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The map label for this gene is hprA [H]

Identifier: 150006391

GI number: 150006391

Start: 4819887

End: 4820843

Strand: Reverse

Name: hprA [H]

Synonym: BVU_3910

Alternate gene names: 150006391

Gene position: 4820843-4819887 (Counterclockwise)

Preceding gene: 150006392

Following gene: 150006390

Centisome position: 93.37

GC content: 55.9

Gene sequence:

>957_bases
ATGAAAATAGTAGTTTTAGACGGTTACGGATTGAATCCCGGTGATTTGTCATGGGAGGAGATGCGGGCGTTGGGCGAGCT
GACGGTGTACGACCGCACAGCCCCTGCCGAGTTATTGGAGCGTTCTGCCGGAGCGGAAGTGCTGATTACAAATAAAACGG
TGATTACGGCGGAGGATATGGCCGCTCTGCCTGCCTTGAAATACATCGGCGTGCTGGCTACGGGATATAATATTGTGGAC
ATCCAGGCTGCGAAAGCGCGGGGCATCATTGTCACCAACATACCTGCCTACAGCACCGCTTCCGTTGCCCAGATGGTCTT
TGCGCATATACTGAACATCACCCAGCGTGTAGGCCATTATGCCTATGCCAACCGTCACGGGCGTTGGGCGAACAATCCCG
ACTTCTGCTACTGGGATACCGACCTGGTGGAGCTGGACGGGAAGAAACTGGGAATCATCGGCTTGGGAAACACCGGACAG
GCGACGGCGCGCATCGCTGCCGCTTTCGGAATGCAGGTATGCGCCTATACTTCCAAGCCGCAGTCACAACTTCCCGGAGG
AATCCGGAAAATGGAGCTGGATGAGCTGTTCCGCGAATGTGACGTGGTGAGCCTGCACTGCCCCCTTACACCCGATACCA
AAGAGCTGGTCAATGCCGACCGCCTGGCTCTTATGAAACCGACGGCCATTCTGATAAATACCGGCCGCGGTCCCTTGGTG
AACGAGAAAGACCTGGCCGACGCACTGAACAAGGGTGTGATAGCGGCTGCCGGACTGGACGTGCTTTCTTCCGAGCCTCC
CCAATATACCAACCCCCTGCTGACGGCGAAGAACTGCTTCATTACGCCGCATATCGCCTGGGCCACGAAAGAAGCCCGTG
TCCGGCTGATGCGGATTGCGGTGGGGAACTTGAAAGGATTCATCAAGGGTGAGATTGTAAACAATGTGGCGGAATGA

Upstream 100 bases:

>100_bases
GGCCGGTTTATATCCATACTGTGCAGCTGTTAATGTGCGTTATTCGCGTTCCAATCTAACCGAATAAATGGACAAAACAT
GGAATTTAACTTTTGAGCAT

Downstream 100 bases:

>100_bases
GAACAAAGGAAAAAGACGGAAAGAAAAGAAGGAGGTAAGAAAAATGGAAGAAGACAAGAATACGTTGGATTTGCATACGG
AAGCTAGGGAAGAGGACAGG

Product: glycerate dehydrogenase

Products: NA

Alternate protein names: GDH; Glyoxylate reductase; Hydroxypyruvate dehydrogenase; NADH-dependent hydroxypyruvate reductase; HPR; HPR-A [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MKIVVLDGYGLNPGDLSWEEMRALGELTVYDRTAPAELLERSAGAEVLITNKTVITAEDMAALPALKYIGVLATGYNIVD
IQAAKARGIIVTNIPAYSTASVAQMVFAHILNITQRVGHYAYANRHGRWANNPDFCYWDTDLVELDGKKLGIIGLGNTGQ
ATARIAAAFGMQVCAYTSKPQSQLPGGIRKMELDELFRECDVVSLHCPLTPDTKELVNADRLALMKPTAILINTGRGPLV
NEKDLADALNKGVIAAAGLDVLSSEPPQYTNPLLTAKNCFITPHIAWATKEARVRLMRIAVGNLKGFIKGEIVNNVAE

Sequences:

>Translated_318_residues
MKIVVLDGYGLNPGDLSWEEMRALGELTVYDRTAPAELLERSAGAEVLITNKTVITAEDMAALPALKYIGVLATGYNIVD
IQAAKARGIIVTNIPAYSTASVAQMVFAHILNITQRVGHYAYANRHGRWANNPDFCYWDTDLVELDGKKLGIIGLGNTGQ
ATARIAAAFGMQVCAYTSKPQSQLPGGIRKMELDELFRECDVVSLHCPLTPDTKELVNADRLALMKPTAILINTGRGPLV
NEKDLADALNKGVIAAAGLDVLSSEPPQYTNPLLTAKNCFITPHIAWATKEARVRLMRIAVGNLKGFIKGEIVNNVAE
>Mature_318_residues
MKIVVLDGYGLNPGDLSWEEMRALGELTVYDRTAPAELLERSAGAEVLITNKTVITAEDMAALPALKYIGVLATGYNIVD
IQAAKARGIIVTNIPAYSTASVAQMVFAHILNITQRVGHYAYANRHGRWANNPDFCYWDTDLVELDGKKLGIIGLGNTGQ
ATARIAAAFGMQVCAYTSKPQSQLPGGIRKMELDELFRECDVVSLHCPLTPDTKELVNADRLALMKPTAILINTGRGPLV
NEKDLADALNKGVIAAAGLDVLSSEPPQYTNPLLTAKNCFITPHIAWATKEARVRLMRIAVGNLKGFIKGEIVNNVAE

Specific function: Plays a central role in assimilation of carbon. It converts hydroxypyruvate to glycerate as a key step in the serine cycle, and may also play an important role in C2 reactions, by interconverting glyoxylate and glycolate [H]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557497, Length=285, Percent_Identity=35.0877192982456, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI61743967, Length=285, Percent_Identity=35.0877192982456, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI145580578, Length=281, Percent_Identity=35.5871886120996, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI4557499, Length=281, Percent_Identity=35.5871886120996, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI145580575, Length=281, Percent_Identity=35.5871886120996, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI6912396, Length=291, Percent_Identity=35.3951890034364, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI23308577, Length=272, Percent_Identity=30.5147058823529, Blast_Score=138, Evalue=6e-33,
Organism=Escherichia coli, GI87082289, Length=276, Percent_Identity=35.5072463768116, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1789279, Length=249, Percent_Identity=35.3413654618474, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1787645, Length=264, Percent_Identity=32.5757575757576, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI87081824, Length=194, Percent_Identity=26.8041237113402, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1788660, Length=277, Percent_Identity=27.0758122743682, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=297, Percent_Identity=31.986531986532, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI25147481, Length=270, Percent_Identity=31.1111111111111, Blast_Score=111, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6320925, Length=307, Percent_Identity=31.5960912052117, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322116, Length=270, Percent_Identity=32.2222222222222, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6324055, Length=332, Percent_Identity=27.4096385542169, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324964, Length=289, Percent_Identity=27.681660899654, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321253, Length=176, Percent_Identity=28.4090909090909, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6325144, Length=171, Percent_Identity=28.6549707602339, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324980, Length=180, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24646446, Length=285, Percent_Identity=33.6842105263158, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646448, Length=285, Percent_Identity=33.6842105263158, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646452, Length=285, Percent_Identity=33.6842105263158, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646450, Length=285, Percent_Identity=33.6842105263158, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI62472511, Length=285, Percent_Identity=33.6842105263158, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28571528, Length=306, Percent_Identity=32.3529411764706, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI28574286, Length=287, Percent_Identity=32.404181184669, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24585514, Length=282, Percent_Identity=31.9148936170213, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI28574282, Length=282, Percent_Identity=31.9148936170213, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI19921140, Length=255, Percent_Identity=31.7647058823529, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI28574284, Length=282, Percent_Identity=31.9148936170213, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45551003, Length=282, Percent_Identity=31.9148936170213, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45552429, Length=282, Percent_Identity=31.9148936170213, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24585516, Length=310, Percent_Identity=26.4516129032258, Blast_Score=115, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.29 [H]

Molecular weight: Translated: 34401; Mature: 34401

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVVLDGYGLNPGDLSWEEMRALGELTVYDRTAPAELLERSAGAEVLITNKTVITAEDM
CEEEEEECCCCCCCCCCHHHHHHHHCEEEECCCCHHHHHHHCCCCEEEEECCEEEEHHHH
AALPALKYIGVLATGYNIVDIQAAKARGIIVTNIPAYSTASVAQMVFAHILNITQRVGHY
HHHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
AYANRHGRWANNPDFCYWDTDLVELDGKKLGIIGLGNTGQATARIAAAFGMQVCAYTSKP
HHHCCCCCCCCCCCEEEECCCEEEECCCEEEEEEECCCCCHHHHHHHHHHHHEEEECCCC
QSQLPGGIRKMELDELFRECDVVSLHCPLTPDTKELVNADRLALMKPTAILINTGRGPLV
HHHCCCCCCCCCHHHHHHHCCEEEEECCCCCCHHHHHCCCCEEEECCEEEEEECCCCCCC
NEKDLADALNKGVIAAAGLDVLSSEPPQYTNPLLTAKNCFITPHIAWATKEARVRLMRIA
CHHHHHHHHCCCEEEECCCHHHCCCCCCCCCCCEECCCEEECCCEEECCHHHHHEEEEEH
VGNLKGFIKGEIVNNVAE
HHCCCCEEHHHHHHHHCC
>Mature Secondary Structure
MKIVVLDGYGLNPGDLSWEEMRALGELTVYDRTAPAELLERSAGAEVLITNKTVITAEDM
CEEEEEECCCCCCCCCCHHHHHHHHCEEEECCCCHHHHHHHCCCCEEEEECCEEEEHHHH
AALPALKYIGVLATGYNIVDIQAAKARGIIVTNIPAYSTASVAQMVFAHILNITQRVGHY
HHHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
AYANRHGRWANNPDFCYWDTDLVELDGKKLGIIGLGNTGQATARIAAAFGMQVCAYTSKP
HHHCCCCCCCCCCCEEEECCCEEEECCCEEEEEEECCCCCHHHHHHHHHHHHEEEECCCC
QSQLPGGIRKMELDELFRECDVVSLHCPLTPDTKELVNADRLALMKPTAILINTGRGPLV
HHHCCCCCCCCCHHHHHHHCCEEEEECCCCCCHHHHHCCCCEEEECCEEEEEECCCCCCC
NEKDLADALNKGVIAAAGLDVLSSEPPQYTNPLLTAKNCFITPHIAWATKEARVRLMRIA
CHHHHHHHHCCCEEEECCCHHHCCCCCCCCCCCEECCCEEECCCEEECCHHHHHEEEEEH
VGNLKGFIKGEIVNNVAE
HHCCCCEEHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8144463; 1729225; 1657886 [H]