Click here to switch to the map view.

The map label for this gene is nhaA

Identifier: 150006385

GI number: 150006385

Start: 4813649

End: 4814989

Strand: Reverse

Name: nhaA

Synonym: BVU_3904

Alternate gene names: 150006385

Gene position: 4814989-4813649 (Counterclockwise)

Preceding gene: 150006386

Following gene: 150006381

Centisome position: 93.26

GC content: 51.38

Gene sequence:

>1341_bases
ATGGAAAAACTGAAAATTCTGAACTTGAACTTTTCCTTCCAGCGGGCGGCGCACTATCATATTAATGGAGGGATGTTGCT
GATGGGGGTAGTCTTGCTGGCTATGTTCCTGGCCAATTCTCCGTGGGGGGATATTTATGCCTCCTTTTGGAATTACGAGG
TGCATCTTCAGATAGGAGAATTTAATTTCTTCAGTCATAACGGGCATCACATGACCTTGATGACTTTTATCAACGATGCT
TTGATGGCTGTCTTTTTCTTCAGTGTGGGGCTGGAGATAAAGCGTGAGATACTGGTGGGCGAGTTGTCCAGTTTCCGGCA
GGCGCTTTTGCCCATCGTGGCGGCGTGCGGCGGTATGCTGGTTCCGGTGCTGATCTATTATTTCATGACGGCGGGAACTC
CGGCCCAAAGTGGTCTGGCCATACCGATGGCTACGGATATCGCCTTTTCGCTGGGAGTGCTCAGCCTGTTCGGCAAGCGG
GTTCCGCTGAGCTTGAAAGTCTTTCTGACCGCTTTCGCTGTGGTCGATGATATCGGCGGCATTCTGGTCATCGCCCTTTT
TTACACCTCTCATCTGTCGGTGAACTACCTGATTGCTTCGGCGGGTATCCTGCTGATACTTTGCGGCGGGAATTTCTTCC
GGGTGCACAACCGTTGGTTTTATATTTTCTGGGGAGTGATTATGTGGTATCTGTTTTTGCAGAGCGGCATCCACGCTACC
ATTGCGGGAGTTGTCGCAGCCTTCACGGTTCCCGCCACTCCTCATTACAAGATAGGTAAGTACATTAACCGCATCCGCGA
GAACATTGCTGTCTTTCCTGCCAGTGACAAGGAAAGTGTTGTGTTAAGCAAGATGCAGATCAATGTGCTGAAAAGCATCG
AGTCTTCCTCGGACCGTGTCATCTCTCCCTTGCAGTCATTGGAAGACAGTCTGCATGGAATGGTGAATTATATTATTCTT
CCCTTGTTCGCCTTTGCCAATGCGGGTGTCTCGCTCACGGCGGATCATGGCGGTCTGGAAGTGGGGATGGCTACCTGGGC
GGTGCTGGCGGGATTGCTGGCGGGTAAGTTTGCCGGCATTTATTTCTTTACCTGGCTGGTGATAAAGATGGGGTTCGCCG
GACTGCTGAAAGGCATGACCTGGGTGAACCTGACAGGTATCTGTCTTTTGGGAGGTATCGGTTTTACGGTTTCTTTGTTC
ATAGCCAACCTCTCTTTCGGGGATTCGCCGGTGTTGCTGACGCAGGCAAAGATGGGTGTCATACTGGGAACGGTGCTGGC
GGGTGTGCTGGCGTATCTGGTCTTGCAGTTCGCCCTGCCTAAACAGCCTGCACAGGAATAA

Upstream 100 bases:

>100_bases
AATAAGCGGGCTCTTTCTGTTAGTTGAAATTAAAAAGTCAATAACAGGAAGGGCTTGTGTTTTGATGGCAATTTATCACA
AACTCTTAAATTCAATTGAT

Downstream 100 bases:

>100_bases
AATTACAGATAGGGCAGTACGGCGGTGAAACGGCTGCCCTTGTTCACCTCGGATTGCACATCGATGTGTCCGTTCATTTT
TTCTACAATGACCTTGCTGA

Product: putative Na+/H+ antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MEKLKILNLNFSFQRAAHYHINGGMLLMGVVLLAMFLANSPWGDIYASFWNYEVHLQIGEFNFFSHNGHHMTLMTFINDA
LMAVFFFSVGLEIKREILVGELSSFRQALLPIVAACGGMLVPVLIYYFMTAGTPAQSGLAIPMATDIAFSLGVLSLFGKR
VPLSLKVFLTAFAVVDDIGGILVIALFYTSHLSVNYLIASAGILLILCGGNFFRVHNRWFYIFWGVIMWYLFLQSGIHAT
IAGVVAAFTVPATPHYKIGKYINRIRENIAVFPASDKESVVLSKMQINVLKSIESSSDRVISPLQSLEDSLHGMVNYIIL
PLFAFANAGVSLTADHGGLEVGMATWAVLAGLLAGKFAGIYFFTWLVIKMGFAGLLKGMTWVNLTGICLLGGIGFTVSLF
IANLSFGDSPVLLTQAKMGVILGTVLAGVLAYLVLQFALPKQPAQE

Sequences:

>Translated_446_residues
MEKLKILNLNFSFQRAAHYHINGGMLLMGVVLLAMFLANSPWGDIYASFWNYEVHLQIGEFNFFSHNGHHMTLMTFINDA
LMAVFFFSVGLEIKREILVGELSSFRQALLPIVAACGGMLVPVLIYYFMTAGTPAQSGLAIPMATDIAFSLGVLSLFGKR
VPLSLKVFLTAFAVVDDIGGILVIALFYTSHLSVNYLIASAGILLILCGGNFFRVHNRWFYIFWGVIMWYLFLQSGIHAT
IAGVVAAFTVPATPHYKIGKYINRIRENIAVFPASDKESVVLSKMQINVLKSIESSSDRVISPLQSLEDSLHGMVNYIIL
PLFAFANAGVSLTADHGGLEVGMATWAVLAGLLAGKFAGIYFFTWLVIKMGFAGLLKGMTWVNLTGICLLGGIGFTVSLF
IANLSFGDSPVLLTQAKMGVILGTVLAGVLAYLVLQFALPKQPAQE
>Mature_446_residues
MEKLKILNLNFSFQRAAHYHINGGMLLMGVVLLAMFLANSPWGDIYASFWNYEVHLQIGEFNFFSHNGHHMTLMTFINDA
LMAVFFFSVGLEIKREILVGELSSFRQALLPIVAACGGMLVPVLIYYFMTAGTPAQSGLAIPMATDIAFSLGVLSLFGKR
VPLSLKVFLTAFAVVDDIGGILVIALFYTSHLSVNYLIASAGILLILCGGNFFRVHNRWFYIFWGVIMWYLFLQSGIHAT
IAGVVAAFTVPATPHYKIGKYINRIRENIAVFPASDKESVVLSKMQINVLKSIESSSDRVISPLQSLEDSLHGMVNYIIL
PLFAFANAGVSLTADHGGLEVGMATWAVLAGLLAGKFAGIYFFTWLVIKMGFAGLLKGMTWVNLTGICLLGGIGFTVSLF
IANLSFGDSPVLLTQAKMGVILGTVLAGVLAYLVLQFALPKQPAQE

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=404, Percent_Identity=39.8514851485149, Blast_Score=253, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA_BACV8 (A6L743)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001301129.1
- ProteinModelPortal:   A6L743
- SMR:   A6L743
- STRING:   A6L743
- GeneID:   5304863
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_3904
- NMPDR:   fig|435590.6.peg.3619
- eggNOG:   COG3004
- HOGENOM:   HBG665619
- OMA:   DAGIHAT
- ProtClustDB:   CLSK822286
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 48635; Mature: 48635

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x11188abc)-; HASH(0x115404d0)-; HASH(0x1110ceec)-; HASH(0x1153693c)-; HASH(0x1110ccdc)-; HASH(0x11540590)-; HASH(0xfe67078)-; HASH(0x11536b58)-; HASH(0x1110cff4)-; HASH(0x11558608)-; HASH(0x11540698)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLKILNLNFSFQRAAHYHINGGMLLMGVVLLAMFLANSPWGDIYASFWNYEVHLQIGE
CCCEEEEEECCEEECCEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEEEEEEC
FNFFSHNGHHMTLMTFINDALMAVFFFSVGLEIKREILVGELSSFRQALLPIVAACGGML
EEEEECCCCEEEHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
VPVLIYYFMTAGTPAQSGLAIPMATDIAFSLGVLSLFGKRVPLSLKVFLTAFAVVDDIGG
HHHHHHHHHCCCCCCCCCEECEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
ILVIALFYTSHLSVNYLIASAGILLILCGGNFFRVHNRWFYIFWGVIMWYLFLQSGIHAT
HHHHHHHHHHCCHHHHHHHCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHCCHHHH
IAGVVAAFTVPATPHYKIGKYINRIRENIAVFPASDKESVVLSKMQINVLKSIESSSDRV
HHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCHH
ISPLQSLEDSLHGMVNYIILPLFAFANAGVSLTADHGGLEVGMATWAVLAGLLAGKFAGI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
YFFTWLVIKMGFAGLLKGMTWVNLTGICLLGGIGFTVSLFIANLSFGDSPVLLTQAKMGV
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHH
ILGTVLAGVLAYLVLQFALPKQPAQE
HHHHHHHHHHHHHHHHHHCCCCCCCH
>Mature Secondary Structure
MEKLKILNLNFSFQRAAHYHINGGMLLMGVVLLAMFLANSPWGDIYASFWNYEVHLQIGE
CCCEEEEEECCEEECCEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEEEEEEC
FNFFSHNGHHMTLMTFINDALMAVFFFSVGLEIKREILVGELSSFRQALLPIVAACGGML
EEEEECCCCEEEHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
VPVLIYYFMTAGTPAQSGLAIPMATDIAFSLGVLSLFGKRVPLSLKVFLTAFAVVDDIGG
HHHHHHHHHCCCCCCCCCEECEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
ILVIALFYTSHLSVNYLIASAGILLILCGGNFFRVHNRWFYIFWGVIMWYLFLQSGIHAT
HHHHHHHHHHCCHHHHHHHCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHCCHHHH
IAGVVAAFTVPATPHYKIGKYINRIRENIAVFPASDKESVVLSKMQINVLKSIESSSDRV
HHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCHH
ISPLQSLEDSLHGMVNYIILPLFAFANAGVSLTADHGGLEVGMATWAVLAGLLAGKFAGI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
YFFTWLVIKMGFAGLLKGMTWVNLTGICLLGGIGFTVSLFIANLSFGDSPVLLTQAKMGV
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHH
ILGTVLAGVLAYLVLQFALPKQPAQE
HHHHHHHHHHHHHHHHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA