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The map label for this gene is ptpA [H]

Identifier: 150006357

GI number: 150006357

Start: 4779203

End: 4781434

Strand: Direct

Name: ptpA [H]

Synonym: BVU_3876

Alternate gene names: 150006357

Gene position: 4779203-4781434 (Clockwise)

Preceding gene: 150006356

Following gene: 150006358

Centisome position: 92.56

GC content: 46.55

Gene sequence:

>2232_bases
ATGACGAAAAAGAACTTATTTACATTAGTCTTATGCTTATTCTGTTTCGGAACCACAACTCATGCGCAACGTATCCCCAC
ATTGGAGGAGGCCGTATACGGAGGACTGATCAAGACAGAAGGCGGAAGTAACGTGAACTGGATGAAAGATGGAGAACGTT
ATTCCAAAATAGAGAAAAATGCCGAGGGAGCATACGAAGTCACTGCCTACAAAGCAAAGGACAATTCCAAAGAAGTGCTG
ATCCCTGCCAATATGCTTTTGAATCCGCAAACAGGAAAACCTATCTCTGTCCGCAATTTCGTATTCAGCGAGGATAACTC
CAAAGTATTGATCTATACCAATACCCGTCGCGTATGGCGTTATGATACCCGCGGTGATTACTGGGTGCTTAATTTGAAAG
ACGGCAAACTGCAACAATTGGGCAAAAGCTTGCCGGAAGCTACCTTGATGTTCGCCAAGTTCTCGCCGGATGCCAGCCGG
GTAGCATATGTCTCCAGAAACAACATTTATGTAGAGAGTCTGGTTGACGGGAAAATCAACCAACTAACTCAAGACGGAAA
TAATGAAATTGTAAACGGAACATTCGACTGGGTATACGAAGAAGAATTCAACTGCCGCGACGGTTTCCGCTGGAGTCCCG
ACGGGCAATACATAGCCTATTGGCAAAGCGATACCCAAGGTACGGGATGGTTTGATATCATCAATAATGTAGATTCCATT
TATCCTAAAATCCAACGTTTTCCCTACCCTAAAGCCGGAACAGCAAACTCCGCTGTAAAAGTAGGCTATGTATCAGCCGA
CGGTGGAAACACCACTTGGCTGGCTCTTCCAGGTGATGCACGCAACCACTATATTCCACGTATGGAATTCATTCCGGGCT
GCAACGAACTGTTCATCCAGCAAATGAACCGTGCCCAAAACACCAATAAAGTATGGATTGCGAAAATAGGTGAAAATACC
CCCGTCAATATCTTTACCGATCAAGATGCCGCATGGTTGGAAACGAATGACAATGTGCGTTGGTTGAAAGGGAACAAGTA
TTTCACTTGGGAAAGCGAACGTGACGGATGGCGCCACCTGTATCGTGTAAGCCGTGATGGTAAAGAAATCAAGCCCATCA
CCCAAGGAGCTTTTGATTATATTCAAGAAGTAGGTGCGGATATGGATAAAGGTTTTGTGTACTTTATCGCCTCTCCCGAC
AACTTCACCCAGCGCTATCTCTACCGGGCACGTCTTTTCGGCAATGGAGAGGTAAAGCGGCTAAGTCCTGTTGACCAAAG
CGGGCAACATCGTTATATCATGTCACCGTCCGGCAAATGGGCAGTCCATACATTCAGTAACTCGGAAACTCCCCCTGTAA
TCGACATGGTGTCTTTCCCTGCCCATAAAAGTATACGTCTGATTACTGACAATGCAAAAGCCAAGGAGCAATACAAAGCC
TTGGGGCTGCAACCGAAAGAATTTGTAAAAACCCGTTCAGGAGAACTGGAACTGGATGCATGGATGATCAAACCCGTAAA
CTTTGATCCCAGCAAAAAATATCCGGTCATAATTGATGTCTATGGAGAACCTGCCAACGCCACCGTGCAGGATGTATGGA
GCGGAGGAAGTTTATGGCACCAGTACTTGGCAAACCTGGGGTATATCATAGTCAGCATCGAGAACCGTGGTGCCAATGCA
CCCCGTGGACGCGAATGGCGCAAATGTATTTATGGAGAAGTCGGAACCTTTGCCAGTGAAGATCAGGCAAGAGGCATCCA
AGACTTGGCACGTCAATACTCTTTCATTGACACCGCACGTATCGGTATCACCGGCTGGAGTGGCGGAGGCAGCCAGACGC
TGAACAGTATGTTCCGTTATCCCGATGTTTTCCACACAGGTATTGCCATTGCTTTTGTGGCCGACCAGCGTCTGTATGAC
ACGGTTTATCAAGAACGTTATATGAATACTCCTCAAAATAATCCGGAGGGTTACCGCAAAGGGTCTCCCATCTCGTATGC
AGCAGGATTGAAAGGCAACTTGCTGTTAATTCACGGTACAGGAGATGACAATGTCCATTATCAGAATTGTGAAATGTTGG
TCAATGAACTGGTACGGCACGGAAAAATCTTCTCACAGATTTCTTACCCGATGCGTTCCCATGGAATTTACGAAGGCGAG
GGAACCAGCTTGCATCTGCGAAAGACAATGGCTGATTACTGGCTGAAAAACCTGCCTGCCGGAGGAAAATAA

Upstream 100 bases:

>100_bases
AAATAGACGCCCGTTTTTTGAAAACAGATATCCGGAATCCCAATACATACTTGTGTTTTCAAATGGACATCTATTTTTTA
GTAAAAGATTCATAATAACT

Downstream 100 bases:

>100_bases
ATATGCCAAAATTCCTGCTGATATGATTATACAGTCGGCCATTCTGAACATTAGTGAAACTTTTCATATACATAAAATGA
TTAGAGTCCAAATTTTTCAC

Product: dipeptidyl aminopeptidase

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 743; Mature: 742

Protein sequence:

>743_residues
MTKKNLFTLVLCLFCFGTTTHAQRIPTLEEAVYGGLIKTEGGSNVNWMKDGERYSKIEKNAEGAYEVTAYKAKDNSKEVL
IPANMLLNPQTGKPISVRNFVFSEDNSKVLIYTNTRRVWRYDTRGDYWVLNLKDGKLQQLGKSLPEATLMFAKFSPDASR
VAYVSRNNIYVESLVDGKINQLTQDGNNEIVNGTFDWVYEEEFNCRDGFRWSPDGQYIAYWQSDTQGTGWFDIINNVDSI
YPKIQRFPYPKAGTANSAVKVGYVSADGGNTTWLALPGDARNHYIPRMEFIPGCNELFIQQMNRAQNTNKVWIAKIGENT
PVNIFTDQDAAWLETNDNVRWLKGNKYFTWESERDGWRHLYRVSRDGKEIKPITQGAFDYIQEVGADMDKGFVYFIASPD
NFTQRYLYRARLFGNGEVKRLSPVDQSGQHRYIMSPSGKWAVHTFSNSETPPVIDMVSFPAHKSIRLITDNAKAKEQYKA
LGLQPKEFVKTRSGELELDAWMIKPVNFDPSKKYPVIIDVYGEPANATVQDVWSGGSLWHQYLANLGYIIVSIENRGANA
PRGREWRKCIYGEVGTFASEDQARGIQDLARQYSFIDTARIGITGWSGGGSQTLNSMFRYPDVFHTGIAIAFVADQRLYD
TVYQERYMNTPQNNPEGYRKGSPISYAAGLKGNLLLIHGTGDDNVHYQNCEMLVNELVRHGKIFSQISYPMRSHGIYEGE
GTSLHLRKTMADYWLKNLPAGGK

Sequences:

>Translated_743_residues
MTKKNLFTLVLCLFCFGTTTHAQRIPTLEEAVYGGLIKTEGGSNVNWMKDGERYSKIEKNAEGAYEVTAYKAKDNSKEVL
IPANMLLNPQTGKPISVRNFVFSEDNSKVLIYTNTRRVWRYDTRGDYWVLNLKDGKLQQLGKSLPEATLMFAKFSPDASR
VAYVSRNNIYVESLVDGKINQLTQDGNNEIVNGTFDWVYEEEFNCRDGFRWSPDGQYIAYWQSDTQGTGWFDIINNVDSI
YPKIQRFPYPKAGTANSAVKVGYVSADGGNTTWLALPGDARNHYIPRMEFIPGCNELFIQQMNRAQNTNKVWIAKIGENT
PVNIFTDQDAAWLETNDNVRWLKGNKYFTWESERDGWRHLYRVSRDGKEIKPITQGAFDYIQEVGADMDKGFVYFIASPD
NFTQRYLYRARLFGNGEVKRLSPVDQSGQHRYIMSPSGKWAVHTFSNSETPPVIDMVSFPAHKSIRLITDNAKAKEQYKA
LGLQPKEFVKTRSGELELDAWMIKPVNFDPSKKYPVIIDVYGEPANATVQDVWSGGSLWHQYLANLGYIIVSIENRGANA
PRGREWRKCIYGEVGTFASEDQARGIQDLARQYSFIDTARIGITGWSGGGSQTLNSMFRYPDVFHTGIAIAFVADQRLYD
TVYQERYMNTPQNNPEGYRKGSPISYAAGLKGNLLLIHGTGDDNVHYQNCEMLVNELVRHGKIFSQISYPMRSHGIYEGE
GTSLHLRKTMADYWLKNLPAGGK
>Mature_742_residues
TKKNLFTLVLCLFCFGTTTHAQRIPTLEEAVYGGLIKTEGGSNVNWMKDGERYSKIEKNAEGAYEVTAYKAKDNSKEVLI
PANMLLNPQTGKPISVRNFVFSEDNSKVLIYTNTRRVWRYDTRGDYWVLNLKDGKLQQLGKSLPEATLMFAKFSPDASRV
AYVSRNNIYVESLVDGKINQLTQDGNNEIVNGTFDWVYEEEFNCRDGFRWSPDGQYIAYWQSDTQGTGWFDIINNVDSIY
PKIQRFPYPKAGTANSAVKVGYVSADGGNTTWLALPGDARNHYIPRMEFIPGCNELFIQQMNRAQNTNKVWIAKIGENTP
VNIFTDQDAAWLETNDNVRWLKGNKYFTWESERDGWRHLYRVSRDGKEIKPITQGAFDYIQEVGADMDKGFVYFIASPDN
FTQRYLYRARLFGNGEVKRLSPVDQSGQHRYIMSPSGKWAVHTFSNSETPPVIDMVSFPAHKSIRLITDNAKAKEQYKAL
GLQPKEFVKTRSGELELDAWMIKPVNFDPSKKYPVIIDVYGEPANATVQDVWSGGSLWHQYLANLGYIIVSIENRGANAP
RGREWRKCIYGEVGTFASEDQARGIQDLARQYSFIDTARIGITGWSGGGSQTLNSMFRYPDVFHTGIAIAFVADQRLYDT
VYQERYMNTPQNNPEGYRKGSPISYAAGLKGNLLLIHGTGDDNVHYQNCEMLVNELVRHGKIFSQISYPMRSHGIYEGEG
TSLHLRKTMADYWLKNLPAGGK

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI18765694, Length=706, Percent_Identity=29.4617563739377, Blast_Score=216, Evalue=7e-56,
Organism=Homo sapiens, GI16933540, Length=684, Percent_Identity=27.3391812865497, Blast_Score=215, Evalue=1e-55,
Organism=Homo sapiens, GI18450280, Length=710, Percent_Identity=26.4788732394366, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI37577089, Length=710, Percent_Identity=26.4788732394366, Blast_Score=194, Evalue=3e-49,
Organism=Homo sapiens, GI85787627, Length=674, Percent_Identity=23.8872403560831, Blast_Score=187, Evalue=3e-47,
Organism=Homo sapiens, GI295842403, Length=674, Percent_Identity=23.8872403560831, Blast_Score=187, Evalue=3e-47,
Organism=Homo sapiens, GI52426756, Length=674, Percent_Identity=23.8872403560831, Blast_Score=187, Evalue=3e-47,
Organism=Homo sapiens, GI295842359, Length=674, Percent_Identity=23.8872403560831, Blast_Score=187, Evalue=4e-47,
Organism=Homo sapiens, GI295849272, Length=674, Percent_Identity=23.8872403560831, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI86792774, Length=718, Percent_Identity=22.4233983286908, Blast_Score=167, Evalue=4e-41,
Organism=Homo sapiens, GI86792863, Length=718, Percent_Identity=22.4233983286908, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI86792778, Length=718, Percent_Identity=22.4233983286908, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI194394146, Length=366, Percent_Identity=31.9672131147541, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI37577091, Length=710, Percent_Identity=23.6619718309859, Blast_Score=131, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17508019, Length=236, Percent_Identity=38.135593220339, Blast_Score=151, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17508017, Length=236, Percent_Identity=38.135593220339, Blast_Score=151, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17550672, Length=656, Percent_Identity=25.7621951219512, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17564632, Length=630, Percent_Identity=24.2857142857143, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17564634, Length=621, Percent_Identity=24.3156199677939, Blast_Score=123, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6321817, Length=731, Percent_Identity=26.9493844049248, Blast_Score=236, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6324793, Length=725, Percent_Identity=25.1034482758621, Blast_Score=177, Evalue=5e-45,
Organism=Drosophila melanogaster, GI45550825, Length=707, Percent_Identity=24.1867043847242, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI45553511, Length=707, Percent_Identity=24.1867043847242, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI45551969, Length=707, Percent_Identity=24.6110325318246, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI17933704, Length=653, Percent_Identity=27.718223583461, Blast_Score=180, Evalue=4e-45,
Organism=Drosophila melanogaster, GI161083744, Length=653, Percent_Identity=27.718223583461, Blast_Score=179, Evalue=8e-45,
Organism=Drosophila melanogaster, GI221331178, Length=653, Percent_Identity=27.718223583461, Blast_Score=179, Evalue=9e-45,
Organism=Drosophila melanogaster, GI24582032, Length=662, Percent_Identity=26.1329305135952, Blast_Score=169, Evalue=8e-42,
Organism=Drosophila melanogaster, GI24582257, Length=275, Percent_Identity=30.5454545454545, Blast_Score=125, Evalue=2e-28,
Organism=Drosophila melanogaster, GI221372266, Length=442, Percent_Identity=25.1131221719457, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221372263, Length=442, Percent_Identity=25.1131221719457, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45551475, Length=442, Percent_Identity=25.1131221719457, Blast_Score=95, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 84406; Mature: 84275

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKNLFTLVLCLFCFGTTTHAQRIPTLEEAVYGGLIKTEGGSNVNWMKDGERYSKIEKN
CCCHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHC
AEGAYEVTAYKAKDNSKEVLIPANMLLNPQTGKPISVRNFVFSEDNSKVLIYTNTRRVWR
CCCCEEEEEEECCCCCCEEEEECCEEECCCCCCCEEEEEEEEECCCCEEEEEECCCEEEE
YDTRGDYWVLNLKDGKLQQLGKSLPEATLMFAKFSPDASRVAYVSRNNIYVESLVDGKIN
ECCCCCEEEEEECCCHHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCEEEEEECCCHHH
QLTQDGNNEIVNGTFDWVYEEEFNCRDGFRWSPDGQYIAYWQSDTQGTGWFDIINNVDSI
HHHCCCCCCEECCEEEEEEECCCCCCCCCEECCCCCEEEEECCCCCCCCHHHHHHHHHHH
YPKIQRFPYPKAGTANSAVKVGYVSADGGNTTWLALPGDARNHYIPRMEFIPGCNELFIQ
HHHHHHCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCHHCCCCHHHHHHH
QMNRAQNTNKVWIAKIGENTPVNIFTDQDAAWLETNDNVRWLKGNKYFTWESERDGWRHL
HHHHCCCCCEEEEEEECCCCCEEEEECCCCEEEECCCCEEEEECCEEEEECCCCCHHHHH
YRVSRDGKEIKPITQGAFDYIQEVGADMDKGFVYFIASPDNFTQRYLYRARLFGNGEVKR
HHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHEEECCCCEEE
LSPVDQSGQHRYIMSPSGKWAVHTFSNSETPPVIDMVSFPAHKSIRLITDNAKAKEQYKA
ECCCCCCCCEEEEECCCCCEEEEEECCCCCCCEEEEECCCCCCEEEEEECCCHHHHHHHH
LGLQPKEFVKTRSGELELDAWMIKPVNFDPSKKYPVIIDVYGEPANATVQDVWSGGSLWH
CCCCHHHHHHCCCCCEEEEEEEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHCCHHHHH
QYLANLGYIIVSIENRGANAPRGREWRKCIYGEVGTFASEDQARGIQDLARQYSFIDTAR
HHHHCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHEEEE
IGITGWSGGGSQTLNSMFRYPDVFHTGIAIAFVADQRLYDTVYQERYMNTPQNNPEGYRK
EEEEECCCCCHHHHHHHHCCCCHHHCCEEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCC
GSPISYAAGLKGNLLLIHGTGDDNVHYQNCEMLVNELVRHGKIFSQISYPMRSHGIYEGE
CCCCEEECCCCCCEEEEECCCCCCEEEHHHHHHHHHHHHCCHHHHHHCCCHHHCCEECCC
GTSLHLRKTMADYWLKNLPAGGK
CCEEEHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TKKNLFTLVLCLFCFGTTTHAQRIPTLEEAVYGGLIKTEGGSNVNWMKDGERYSKIEKN
CCHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHC
AEGAYEVTAYKAKDNSKEVLIPANMLLNPQTGKPISVRNFVFSEDNSKVLIYTNTRRVWR
CCCCEEEEEEECCCCCCEEEEECCEEECCCCCCCEEEEEEEEECCCCEEEEEECCCEEEE
YDTRGDYWVLNLKDGKLQQLGKSLPEATLMFAKFSPDASRVAYVSRNNIYVESLVDGKIN
ECCCCCEEEEEECCCHHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCEEEEEECCCHHH
QLTQDGNNEIVNGTFDWVYEEEFNCRDGFRWSPDGQYIAYWQSDTQGTGWFDIINNVDSI
HHHCCCCCCEECCEEEEEEECCCCCCCCCEECCCCCEEEEECCCCCCCCHHHHHHHHHHH
YPKIQRFPYPKAGTANSAVKVGYVSADGGNTTWLALPGDARNHYIPRMEFIPGCNELFIQ
HHHHHHCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCHHCCCCHHHHHHH
QMNRAQNTNKVWIAKIGENTPVNIFTDQDAAWLETNDNVRWLKGNKYFTWESERDGWRHL
HHHHCCCCCEEEEEEECCCCCEEEEECCCCEEEECCCCEEEEECCEEEEECCCCCHHHHH
YRVSRDGKEIKPITQGAFDYIQEVGADMDKGFVYFIASPDNFTQRYLYRARLFGNGEVKR
HHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHEEECCCCEEE
LSPVDQSGQHRYIMSPSGKWAVHTFSNSETPPVIDMVSFPAHKSIRLITDNAKAKEQYKA
ECCCCCCCCEEEEECCCCCEEEEEECCCCCCCEEEEECCCCCCEEEEEECCCHHHHHHHH
LGLQPKEFVKTRSGELELDAWMIKPVNFDPSKKYPVIIDVYGEPANATVQDVWSGGSLWH
CCCCHHHHHHCCCCCEEEEEEEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHCCHHHHH
QYLANLGYIIVSIENRGANAPRGREWRKCIYGEVGTFASEDQARGIQDLARQYSFIDTAR
HHHHCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHEEEE
IGITGWSGGGSQTLNSMFRYPDVFHTGIAIAFVADQRLYDTVYQERYMNTPQNNPEGYRK
EEEEECCCCCHHHHHHHHCCCCHHHCCEEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCC
GSPISYAAGLKGNLLLIHGTGDDNVHYQNCEMLVNELVRHGKIFSQISYPMRSHGIYEGE
CCCCEEECCCCCCEEEEECCCCCCEEEHHHHHHHHHHHHCCHHHHHHCCCHHHCCEECCC
GTSLHLRKTMADYWLKNLPAGGK
CCEEEHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA