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The map label for this gene is uxaB [H]

Identifier: 150005587

GI number: 150005587

Start: 3886947

End: 3888386

Strand: Direct

Name: uxaB [H]

Synonym: BVU_3075

Alternate gene names: 150005587

Gene position: 3886947-3888386 (Clockwise)

Preceding gene: 150005585

Following gene: 150005589

Centisome position: 75.28

GC content: 44.03

Gene sequence:

>1440_bases
ATGAAAGCATTAAACAAGGAGACAGCAGCAAAGACTCAACGTCCCGAAAGAATCATTCAATTTGGTGAGGGTAACTTCCT
GCGTGCGTTTGTGGATTGGATTATCTACAACATGAACGAAAAAACTGATTTCAACAGCAGTGTGGTGGTGGTTCAACCTA
TTGAAAAAGGTATGGTTGACATGTTGAACGCACAAGATTGTCTGTATCATGTAAACTTGCAGGGTTTGGATAAAGGACAG
GTGGTAAACAGCCTGACAAAAATTGATGTGATCAGTCGTGCCTTGAATCCTTATTCTCAGAATGATGAATTTATGAAATT
GGCGGAACAGCCGGAAATGCGTTTCGTTATCTCTAATACGACAGAGGCCGGTATCGCTTTTGATCCTGCCTGCAAGCTGG
ATGATGCCCCTGCTTCATCTTATCCGGGCAAACTGACCCAGTTGCTGTATCACCGTTATAAAACGTTCAATGGTGACAAG
AGCAAAGGTTTGATAATTTTCCCTTGCGAATTGATTTTCCTGAACGGCCATAAACTGAAAGAAACCATCTATCAATATAT
TGATTTGTGGAACTTGGGTGAAGACTTCAAGCAATGGTTTGAGGAAGCTTGTGGTGTCTATGCTACTTTGGTAGACCGTA
TTGTGCCGGGATTCCCCCGCAAAGATATCGCTGCTATTAAAGAAAAATTGCAGTATGATGACAATCTGGTGGTACAGGCA
GAAATCTTCCATTTGTGGGTAATTGAAGCTCCGCAGGAGGTCGCCAAGGAATTCCCTGCCGACAAAGCCGGTTTGAATGT
ATTGTTCGTTCCGTCTGAAGCTCCTTATCACGAAAGAAAAGTTACTTTGCTGAACGGTCCTCACACAGTGCTGTCTCCGG
TAGCTTATCTGTCTGGAATCAACATTGTGCGCGAGGCTTGCGAGCATGAAGTGGTAGGTAAATACATTCATAAAGTTATG
TTCGATGAGTTGATGGAAACCCTGAACCTGCCGAAAGAAGAATTGAAGAAGTTTGCGGAAGATGTTTTGGAGCGTTTCAA
CAATCCGTTTGTTGATCACCAGGTGACTTCTATCATGCTGAATTCATTCCCTAAATATGAAACTCGCGACCTCCCGGGCT
TGAAAGTTTATCTGGAGCGTAAGGGTGAGTTGCCTAAAGGCTTGGTATTGGGACTGGCGGCTATCATCACTTATTATAAA
GGTGGTGTTCGTGCTGACGGTGCTGAGATTGTTCCGAACGATGCTCCTGAAATCATGAATCTGCTGAAAGAACTTTGGGC
TACAGGCTGCACTCAGAAAGTGGCGGAAGGCGTGTTGGCAGCAGAATCTATTTGGGGTGAGAACTTGAACAACATTCCGG
GTTTGACCGCCGCAGTAAAAGCTGATCTTGACTCTATTCAAGAAAAGGGTATGCTGGAAACAGTAAAGGGTATTCTCTAA

Upstream 100 bases:

>100_bases
TACCATTTAAAAGAAAGCATGAATACTATGAGTACACAATAAAATCTGATTCGTCTTCAATAAGTACAGGTATGGATAAA
CACATAATATAATTAAAAAT

Downstream 100 bases:

>100_bases
TCAGATTAATTGTTAGAAATAGTTTATAAATTCCTTGAGGGAGATTTGGTTATAAAACTGAATCTCCCTATTTTTGTATC
TATACAAGATAGATGTGGCA

Product: altronate oxidoreductase

Products: NA

Alternate protein names: Tagaturonate dehydrogenase; Tagaturonate reductase [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MKALNKETAAKTQRPERIIQFGEGNFLRAFVDWIIYNMNEKTDFNSSVVVVQPIEKGMVDMLNAQDCLYHVNLQGLDKGQ
VVNSLTKIDVISRALNPYSQNDEFMKLAEQPEMRFVISNTTEAGIAFDPACKLDDAPASSYPGKLTQLLYHRYKTFNGDK
SKGLIIFPCELIFLNGHKLKETIYQYIDLWNLGEDFKQWFEEACGVYATLVDRIVPGFPRKDIAAIKEKLQYDDNLVVQA
EIFHLWVIEAPQEVAKEFPADKAGLNVLFVPSEAPYHERKVTLLNGPHTVLSPVAYLSGINIVREACEHEVVGKYIHKVM
FDELMETLNLPKEELKKFAEDVLERFNNPFVDHQVTSIMLNSFPKYETRDLPGLKVYLERKGELPKGLVLGLAAIITYYK
GGVRADGAEIVPNDAPEIMNLLKELWATGCTQKVAEGVLAAESIWGENLNNIPGLTAAVKADLDSIQEKGMLETVKGIL

Sequences:

>Translated_479_residues
MKALNKETAAKTQRPERIIQFGEGNFLRAFVDWIIYNMNEKTDFNSSVVVVQPIEKGMVDMLNAQDCLYHVNLQGLDKGQ
VVNSLTKIDVISRALNPYSQNDEFMKLAEQPEMRFVISNTTEAGIAFDPACKLDDAPASSYPGKLTQLLYHRYKTFNGDK
SKGLIIFPCELIFLNGHKLKETIYQYIDLWNLGEDFKQWFEEACGVYATLVDRIVPGFPRKDIAAIKEKLQYDDNLVVQA
EIFHLWVIEAPQEVAKEFPADKAGLNVLFVPSEAPYHERKVTLLNGPHTVLSPVAYLSGINIVREACEHEVVGKYIHKVM
FDELMETLNLPKEELKKFAEDVLERFNNPFVDHQVTSIMLNSFPKYETRDLPGLKVYLERKGELPKGLVLGLAAIITYYK
GGVRADGAEIVPNDAPEIMNLLKELWATGCTQKVAEGVLAAESIWGENLNNIPGLTAAVKADLDSIQEKGMLETVKGIL
>Mature_479_residues
MKALNKETAAKTQRPERIIQFGEGNFLRAFVDWIIYNMNEKTDFNSSVVVVQPIEKGMVDMLNAQDCLYHVNLQGLDKGQ
VVNSLTKIDVISRALNPYSQNDEFMKLAEQPEMRFVISNTTEAGIAFDPACKLDDAPASSYPGKLTQLLYHRYKTFNGDK
SKGLIIFPCELIFLNGHKLKETIYQYIDLWNLGEDFKQWFEEACGVYATLVDRIVPGFPRKDIAAIKEKLQYDDNLVVQA
EIFHLWVIEAPQEVAKEFPADKAGLNVLFVPSEAPYHERKVTLLNGPHTVLSPVAYLSGINIVREACEHEVVGKYIHKVM
FDELMETLNLPKEELKKFAEDVLERFNNPFVDHQVTSIMLNSFPKYETRDLPGLKVYLERKGELPKGLVLGLAAIITYYK
GGVRADGAEIVPNDAPEIMNLLKELWATGCTQKVAEGVLAAESIWGENLNNIPGLTAAVKADLDSIQEKGMLETVKGIL

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxaB subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994885, Length=482, Percent_Identity=46.0580912863071, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI1788497, Length=499, Percent_Identity=25.4509018036072, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1790779, Length=485, Percent_Identity=25.5670103092783, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1787823, Length=482, Percent_Identity=25.7261410788382, Blast_Score=113, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324401, Length=479, Percent_Identity=25.0521920668058, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320765, Length=479, Percent_Identity=25.0521920668058, Blast_Score=98, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR013118
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.58 [H]

Molecular weight: Translated: 53905; Mature: 53905

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALNKETAAKTQRPERIIQFGEGNFLRAFVDWIIYNMNEKTDFNSSVVVVQPIEKGMVD
CCCCCHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHH
MLNAQDCLYHVNLQGLDKGQVVNSLTKIDVISRALNPYSQNDEFMKLAEQPEMRFVISNT
HHCCCHHEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEECC
TEAGIAFDPACKLDDAPASSYPGKLTQLLYHRYKTFNGDKSKGLIIFPCELIFLNGHKLK
CCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEECCHHHH
ETIYQYIDLWNLGEDFKQWFEEACGVYATLVDRIVPGFPRKDIAAIKEKLQYDDNLVVQA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEE
EIFHLWVIEAPQEVAKEFPADKAGLNVLFVPSEAPYHERKVTLLNGPHTVLSPVAYLSGI
EEEEEEEECCHHHHHHHCCCCHHCCEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHH
NIVREACEHEVVGKYIHKVMFDELMETLNLPKEELKKFAEDVLERFNNPFVDHQVTSIML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
NSFPKYETRDLPGLKVYLERKGELPKGLVLGLAAIITYYKGGVRADGAEIVPNDAPEIMN
HCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
LLKELWATGCTQKVAEGVLAAESIWGENLNNIPGLTAAVKADLDSIQEKGMLETVKGIL
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHCCC
>Mature Secondary Structure
MKALNKETAAKTQRPERIIQFGEGNFLRAFVDWIIYNMNEKTDFNSSVVVVQPIEKGMVD
CCCCCHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHH
MLNAQDCLYHVNLQGLDKGQVVNSLTKIDVISRALNPYSQNDEFMKLAEQPEMRFVISNT
HHCCCHHEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEECC
TEAGIAFDPACKLDDAPASSYPGKLTQLLYHRYKTFNGDKSKGLIIFPCELIFLNGHKLK
CCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEECCHHHH
ETIYQYIDLWNLGEDFKQWFEEACGVYATLVDRIVPGFPRKDIAAIKEKLQYDDNLVVQA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEE
EIFHLWVIEAPQEVAKEFPADKAGLNVLFVPSEAPYHERKVTLLNGPHTVLSPVAYLSGI
EEEEEEEECCHHHHHHHCCCCHHCCEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHH
NIVREACEHEVVGKYIHKVMFDELMETLNLPKEELKKFAEDVLERFNNPFVDHQVTSIML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
NSFPKYETRDLPGLKVYLERKGELPKGLVLGLAAIITYYKGGVRADGAEIVPNDAPEIMN
HCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
LLKELWATGCTQKVAEGVLAAESIWGENLNNIPGLTAAVKADLDSIQEKGMLETVKGIL
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]