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The map label for this gene is ispD [H]

Identifier: 150005468

GI number: 150005468

Start: 3748950

End: 3749672

Strand: Direct

Name: ispD [H]

Synonym: BVU_2951

Alternate gene names: 150005468

Gene position: 3748950-3749672 (Clockwise)

Preceding gene: 150005467

Following gene: 150005469

Centisome position: 72.61

GC content: 38.04

Gene sequence:

>723_bases
ATGAATATAGCTGTTATAATTGCAGGGGGATCAGGTCAGCGAATGGGTCAGGACATTCCAAAACAATTTATCAATGTGTA
TGATAAACCTGTTATTATTTATACGTTGGAAGGATTTCAGCGACATCCTCAGATAGATGCCATTGAAGTGGTATGCATTG
ATGGATGGCATGATGTCCTTTGGGCTTATGCTCATCAGTTTAATATCACCAAACTTAAATGGGTGATAAGTGGAGGAAAT
ACAGGACAGGAAAGTATCAGGAATGGCGTGTTCAATCTTGAGGGTAAAGTTGGTGATGAGGATATAATTGTGATTCATGA
TGGCATTCGGCCATTGGTGGATGAAACGGTTCTTACCGATGTGATAATGAAAGCCCAAATACATGGGAATGCAGTTACTT
CATTGCCCTATAATGAGCAAATTTTCGTTGTAAATCCTGAGAATGAGAAAACAACGAAACAGTATATTCCACGTGAAATA
TTGAGAAGGGTTTCTACTCCGCAGGCTTATAAGTTTGGAAAACTAGACTGGGCGTATCATGAAGCGTTTGAGAAGGAGAT
TGGTATTAAAGGCTCTGCCTATACCAATACGATGATGGTAGAATTAGGTGAAACACTCTATTTTGCCGCCGGTTCAGATA
AAAATATTAAACTGACTACAAAAGATGATTTGGAAATGTTTAAGGGATATCTAAAGAAAGAAAAGGATAATTGGTTGAAG
TAA

Upstream 100 bases:

>100_bases
ATATTTTAAAAGAAAAAGAATTATCAGTGTTGGATCGTAAGATAAAATTGCACTACTATTGTTATCCATTATTTTGGTTA
TACGTAAAACTATTTATAAA

Downstream 100 bases:

>100_bases
TGAATCTGATAGAAAATACTATGTATCAGGATGATATAATGAAAATTATAACTCATCCTCTTCCTTGGAATAAGTTGCAG
AATAAGGCTTTGTTAATTTC

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MNIAVIIAGGSGQRMGQDIPKQFINVYDKPVIIYTLEGFQRHPQIDAIEVVCIDGWHDVLWAYAHQFNITKLKWVISGGN
TGQESIRNGVFNLEGKVGDEDIIVIHDGIRPLVDETVLTDVIMKAQIHGNAVTSLPYNEQIFVVNPENEKTTKQYIPREI
LRRVSTPQAYKFGKLDWAYHEAFEKEIGIKGSAYTNTMMVELGETLYFAAGSDKNIKLTTKDDLEMFKGYLKKEKDNWLK

Sequences:

>Translated_240_residues
MNIAVIIAGGSGQRMGQDIPKQFINVYDKPVIIYTLEGFQRHPQIDAIEVVCIDGWHDVLWAYAHQFNITKLKWVISGGN
TGQESIRNGVFNLEGKVGDEDIIVIHDGIRPLVDETVLTDVIMKAQIHGNAVTSLPYNEQIFVVNPENEKTTKQYIPREI
LRRVSTPQAYKFGKLDWAYHEAFEKEIGIKGSAYTNTMMVELGETLYFAAGSDKNIKLTTKDDLEMFKGYLKKEKDNWLK
>Mature_240_residues
MNIAVIIAGGSGQRMGQDIPKQFINVYDKPVIIYTLEGFQRHPQIDAIEVVCIDGWHDVLWAYAHQFNITKLKWVISGGN
TGQESIRNGVFNLEGKVGDEDIIVIHDGIRPLVDETVLTDVIMKAQIHGNAVTSLPYNEQIFVVNPENEKTTKQYIPREI
LRRVSTPQAYKFGKLDWAYHEAFEKEIGIKGSAYTNTMMVELGETLYFAAGSDKNIKLTTKDDLEMFKGYLKKEKDNWLK

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Homo sapiens, GI157412259, Length=235, Percent_Identity=28.5106382978723, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI157671913, Length=133, Percent_Identity=33.8345864661654, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.60 [H]

Molecular weight: Translated: 27268; Mature: 27268

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIAVIIAGGSGQRMGQDIPKQFINVYDKPVIIYTLEGFQRHPQIDAIEVVCIDGWHDVL
CEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEEECCHHHHH
WAYAHQFNITKLKWVISGGNTGQESIRNGVFNLEGKVGDEDIIVIHDGIRPLVDETVLTD
HHHHHHCCCEEEEEEEECCCCCHHHHHCCCEEECCCCCCCCEEEEECCCCHHHHHHHHHH
VIMKAQIHGNAVTSLPYNEQIFVVNPENEKTTKQYIPREILRRVSTPQAYKFGKLDWAYH
HHHHHEECCCEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEECCCCCHHHH
EAFEKEIGIKGSAYTNTMMVELGETLYFAAGSDKNIKLTTKDDLEMFKGYLKKEKDNWLK
HHHHHHCCCCCCCCCCEEEEEECCEEEEEECCCCCEEEEEHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNIAVIIAGGSGQRMGQDIPKQFINVYDKPVIIYTLEGFQRHPQIDAIEVVCIDGWHDVL
CEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEEECCHHHHH
WAYAHQFNITKLKWVISGGNTGQESIRNGVFNLEGKVGDEDIIVIHDGIRPLVDETVLTD
HHHHHHCCCEEEEEEEECCCCCHHHHHCCCEEECCCCCCCCEEEEECCCCHHHHHHHHHH
VIMKAQIHGNAVTSLPYNEQIFVVNPENEKTTKQYIPREILRRVSTPQAYKFGKLDWAYH
HHHHHEECCCEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEECCCCCHHHH
EAFEKEIGIKGSAYTNTMMVELGETLYFAAGSDKNIKLTTKDDLEMFKGYLKKEKDNWLK
HHHHHHCCCCCCCCCCEEEEEECCEEEEEECCCCCEEEEEHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA