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The map label for this gene is wecB [H]

Identifier: 150005463

GI number: 150005463

Start: 3743362

End: 3744516

Strand: Direct

Name: wecB [H]

Synonym: BVU_2946

Alternate gene names: 150005463

Gene position: 3743362-3744516 (Clockwise)

Preceding gene: 150005462

Following gene: 150005464

Centisome position: 72.5

GC content: 38.87

Gene sequence:

>1155_bases
ATGAAAACAGTAATGCTCGTTTTTGGAACTCGCCCAGAAGCTATTAAAATGGCTCCATTAGTGAAAAAATTCCAAAAGTA
TTCAAGTGATTTCAAAACTGTAGTGTGTGTCACAGGCCAGCATCGAGAAATGTTAGACCAAGTACTTAAAATTTTTGATA
TCAAGCCTGATTATGACTTGAATATTATGAAACAAGGACAAGATCTCTATGACATCACGGCTCGTGTGTTGTTAGGAATG
CGAGATGTGCTGAATGAGGTAAAACCTGATGTGGTACTAGTACACGGAGATACTACTACATCAATGGCAGCATCCCTTGC
GGCCTTCTATCAGCAAATAGCAGTAGGTCACGTTGAGGCAGGTCTCCGTACATATGATATTTATTCTCCTTGGCCCGAAG
AGATGAATCGCCAAATAACGAGTCGCATTGCTACATACAACTTTTCACCGACACCATTATCCGAAAAAAATTTAAAGGAG
GAAAAAGTTCATGGGAATATTTATGTTACGGGGAACACTGTAATTGATGCTCTTCATATGGTGGTAGAGAAGTTGAAAAA
TGATGTAACTCTTGCGGCAAAGCAGGAGCAAATGCTTGCTAAGGCTGGCTATGATGTTGCTAGATTGGCTGATGGTAAAA
AATTAGTTTTAATAACAGGTCATCGTAGAGAAAATTTTGGAGAAGGTTTTATCAATATGGTGACTGCTATCAAGAATTTG
ACAGAGAAATATCCTAATGTTGATTTTGTCTATCCAATGCATCTTAATCCTAATGTGCGTAAGCCTATTCATGAGGTGTT
TGGAGAGAATTTGTCCGATTTAGGTAATATGTTTTTTATTGAGCCATTGCAATATTTGGAGTTTATTTATTTGATGGAAA
AGTCTACCATTGTGCTTACTGACTCTGGTGGTATACAAGAAGAAGCACCAGGGCTTGGTAAGCCCGTACTTGTAATGCGA
GATACAACGGAGCGTCCAGAAGCTCTTGAGAGCGGTACTGTTCGTTTGGTTGGTACCAACCATGATTTAATCGTTGAAGA
AGTTAGTACATTGCTTGATAACCAGTCTGTTTATGACAAAATGTCGAGAGCGGTTAATCCCTATGGTGACGGAAAAGCGT
GTGACAGAATTGTTTATGCATTAAGAAATAGGTAA

Upstream 100 bases:

>100_bases
TTGTTCTCTATTATTACTTTATTGCGTTATTTATTTAGACTTTTTGATACATATTTAAAGATAGTCCCTCCCCGTTAGTG
TAAATTAGAAAAATTAGAAA

Downstream 100 bases:

>100_bases
AACATTAAATATATTACGTTAAAGGCGCATAAGCTGTATCTTGAGAAATTGTTGAAAAGATATTGAGAATGTAGTTATGT
GGAAATGTATGAATTTATTA

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MKTVMLVFGTRPEAIKMAPLVKKFQKYSSDFKTVVCVTGQHREMLDQVLKIFDIKPDYDLNIMKQGQDLYDITARVLLGM
RDVLNEVKPDVVLVHGDTTTSMAASLAAFYQQIAVGHVEAGLRTYDIYSPWPEEMNRQITSRIATYNFSPTPLSEKNLKE
EKVHGNIYVTGNTVIDALHMVVEKLKNDVTLAAKQEQMLAKAGYDVARLADGKKLVLITGHRRENFGEGFINMVTAIKNL
TEKYPNVDFVYPMHLNPNVRKPIHEVFGENLSDLGNMFFIEPLQYLEFIYLMEKSTIVLTDSGGIQEEAPGLGKPVLVMR
DTTERPEALESGTVRLVGTNHDLIVEEVSTLLDNQSVYDKMSRAVNPYGDGKACDRIVYALRNR

Sequences:

>Translated_384_residues
MKTVMLVFGTRPEAIKMAPLVKKFQKYSSDFKTVVCVTGQHREMLDQVLKIFDIKPDYDLNIMKQGQDLYDITARVLLGM
RDVLNEVKPDVVLVHGDTTTSMAASLAAFYQQIAVGHVEAGLRTYDIYSPWPEEMNRQITSRIATYNFSPTPLSEKNLKE
EKVHGNIYVTGNTVIDALHMVVEKLKNDVTLAAKQEQMLAKAGYDVARLADGKKLVLITGHRRENFGEGFINMVTAIKNL
TEKYPNVDFVYPMHLNPNVRKPIHEVFGENLSDLGNMFFIEPLQYLEFIYLMEKSTIVLTDSGGIQEEAPGLGKPVLVMR
DTTERPEALESGTVRLVGTNHDLIVEEVSTLLDNQSVYDKMSRAVNPYGDGKACDRIVYALRNR
>Mature_384_residues
MKTVMLVFGTRPEAIKMAPLVKKFQKYSSDFKTVVCVTGQHREMLDQVLKIFDIKPDYDLNIMKQGQDLYDITARVLLGM
RDVLNEVKPDVVLVHGDTTTSMAASLAAFYQQIAVGHVEAGLRTYDIYSPWPEEMNRQITSRIATYNFSPTPLSEKNLKE
EKVHGNIYVTGNTVIDALHMVVEKLKNDVTLAAKQEQMLAKAGYDVARLADGKKLVLITGHRRENFGEGFINMVTAIKNL
TEKYPNVDFVYPMHLNPNVRKPIHEVFGENLSDLGNMFFIEPLQYLEFIYLMEKSTIVLTDSGGIQEEAPGLGKPVLVMR
DTTERPEALESGTVRLVGTNHDLIVEEVSTLLDNQSVYDKMSRAVNPYGDGKACDRIVYALRNR

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=381, Percent_Identity=57.742782152231, Blast_Score=417, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 43299; Mature: 43299

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVMLVFGTRPEAIKMAPLVKKFQKYSSDFKTVVCVTGQHREMLDQVLKIFDIKPDYDL
CCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCC
NIMKQGQDLYDITARVLLGMRDVLNEVKPDVVLVHGDTTTSMAASLAAFYQQIAVGHVEA
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHC
GLRTYDIYSPWPEEMNRQITSRIATYNFSPTPLSEKNLKEEKVHGNIYVTGNTVIDALHM
CCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCEEEECHHHHHHHHH
VVEKLKNDVTLAAKQEQMLAKAGYDVARLADGKKLVLITGHRRENFGEGFINMVTAIKNL
HHHHHHCCEEEEHHHHHHHHHCCCCCEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
TEKYPNVDFVYPMHLNPNVRKPIHEVFGENLSDLGNMFFIEPLQYLEFIYLMEKSTIVLT
HHHCCCCEEEEEECCCCCCHHHHHHHHCCCHHHHCCEEEECHHHHHHHHHHCCCCEEEEE
DSGGIQEEAPGLGKPVLVMRDTTERPEALESGTVRLVGTNHDLIVEEVSTLLDNQSVYDK
CCCCCCCCCCCCCCCEEEEECCCCCCHHHCCCCEEEEECCCCHHHHHHHHHHCCHHHHHH
MSRAVNPYGDGKACDRIVYALRNR
HHHHCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKTVMLVFGTRPEAIKMAPLVKKFQKYSSDFKTVVCVTGQHREMLDQVLKIFDIKPDYDL
CCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCC
NIMKQGQDLYDITARVLLGMRDVLNEVKPDVVLVHGDTTTSMAASLAAFYQQIAVGHVEA
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHC
GLRTYDIYSPWPEEMNRQITSRIATYNFSPTPLSEKNLKEEKVHGNIYVTGNTVIDALHM
CCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCEEEECHHHHHHHHH
VVEKLKNDVTLAAKQEQMLAKAGYDVARLADGKKLVLITGHRRENFGEGFINMVTAIKNL
HHHHHHCCEEEEHHHHHHHHHCCCCCEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
TEKYPNVDFVYPMHLNPNVRKPIHEVFGENLSDLGNMFFIEPLQYLEFIYLMEKSTIVLT
HHHCCCCEEEEEECCCCCCHHHHHHHHCCCHHHHCCEEEECHHHHHHHHHHCCCCEEEEE
DSGGIQEEAPGLGKPVLVMRDTTERPEALESGTVRLVGTNHDLIVEEVSTLLDNQSVYDK
CCCCCCCCCCCCCCCEEEEECCCCCCHHHCCCCEEEEECCCCHHHHHHHHHHCCHHHHHH
MSRAVNPYGDGKACDRIVYALRNR
HHHHCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]