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The map label for this gene is macA [H]

Identifier: 150005325

GI number: 150005325

Start: 3574416

End: 3575639

Strand: Direct

Name: macA [H]

Synonym: BVU_2801

Alternate gene names: 150005325

Gene position: 3574416-3575639 (Clockwise)

Preceding gene: 150005324

Following gene: 150005326

Centisome position: 69.23

GC content: 47.88

Gene sequence:

>1224_bases
ATGGAAAAGAAGAAAATGATCCTTACTACAGCGGTAGCCGTAGTGGTCGTGGCAGGCGGTTTCTGGATGCTTGGCGGACC
GGAGGGAAAAAGTACGGTCGATTTCTCAACGGAAACCGTAACGAAAGGTAATGTCAGCAATTTCATTACTGCTACCGGAA
CCATAGAGCCGGTGACAGAGGTGGAAGTGGGTACGCAGGTATCTGGTATTATTGACAAGATTTATGTGGATTACAATTCT
GTGGTAAAGAAAGGAGAATTGATAGCCGAGATGGATAAAGTGACACTGCAAAGTGAACTTCAGTCGGCAAAGGCCACTTA
TGACGGCAATGAGGCCGAGTACGATTACCAAAAGAAATTATATGACCGCAACCGTAAACTGCACGAGAAGCAATTAATCA
GCGATATGGACTATGAAGAAACGGTTTATAATTTCCAACGTGCCCAAAGTGCATTGGAGCAAAGCAAGGCGGCTCTGGCA
AAGGCTGAGCGTAACCTGTCATACGCAACCATCACCTCGCCTATCGATGGAGTGGTGACCAGCCGTGATGTGGAAGAAGG
ACAGACCGTAGCATCCGGTTTCGAAACTCCGACACTGTTCACCATCGCTGCCGACTTGACCAAGATGCAGGTGGTGGCCG
ATGTGGATGAAGCCGATATTGCCGGGGTGGAGGAAGGAACCCGTGTAACCTTTACCGTGGATGCTTATCCCGACGATGTG
TTCGAAGGAGTAGTCAGACAGGTTCGTTTGGGAAGTACGAACAGCACGAGCAGCAGCTCTTCAACAACCACCAGTACCAC
TGTAGTTACTTATGAGGTAGTGATAACAGCTGATAATCCCTATTTGAAACTGAAACCGCGTCTTACCGCCAACGCTACCA
TTTATACATTGACCAAGGATAATGTGTTGACCGTTCCCAACAAGGCTTTGCGCTTTACTCCCAACAAAGACATAGTGGGA
GGTCGTAAGATAAACGATTGCCAGAGCAGTCATAAAGTGTGGACACTGGATAACAATACCTTTACCGCCCATCCTGTGAA
AATAGGTATTACTGATGGCAGCAAGACAGAGATTGTGAGTGGCATCACTGAAAATACGCCGGTAGTGACAGAAACGGTAG
TGAAAGGTGCTATGCCTGGAATGGAAGAGCCGTCTGCCGGAGAAGGTGAGAGAAGTCCGTTCATGCCAGGCCCTCCGGGA
AGCAATAAGAAAAAGAACAAGTAA

Upstream 100 bases:

>100_bases
TATTCAGGCCAAGTATATGGCTATCTTGGATCGGACTCTACTGAACTTCTATGCAGGTCAGGATATAAAATTATAATCAT
AACGCTATACATATTATATT

Downstream 100 bases:

>100_bases
TAAAAGGTAATGCTTCCGTTTACATTGAAAGAATAAATCATATGAAAAAGATAATCGAATTACAAAATATAAAACGGAAC
TTCCAGGTAGGCGATGAAAC

Product: periplasmic component of efflux system

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MEKKKMILTTAVAVVVVAGGFWMLGGPEGKSTVDFSTETVTKGNVSNFITATGTIEPVTEVEVGTQVSGIIDKIYVDYNS
VVKKGELIAEMDKVTLQSELQSAKATYDGNEAEYDYQKKLYDRNRKLHEKQLISDMDYEETVYNFQRAQSALEQSKAALA
KAERNLSYATITSPIDGVVTSRDVEEGQTVASGFETPTLFTIAADLTKMQVVADVDEADIAGVEEGTRVTFTVDAYPDDV
FEGVVRQVRLGSTNSTSSSSSTTTSTTVVTYEVVITADNPYLKLKPRLTANATIYTLTKDNVLTVPNKALRFTPNKDIVG
GRKINDCQSSHKVWTLDNNTFTAHPVKIGITDGSKTEIVSGITENTPVVTETVVKGAMPGMEEPSAGEGERSPFMPGPPG
SNKKKNK

Sequences:

>Translated_407_residues
MEKKKMILTTAVAVVVVAGGFWMLGGPEGKSTVDFSTETVTKGNVSNFITATGTIEPVTEVEVGTQVSGIIDKIYVDYNS
VVKKGELIAEMDKVTLQSELQSAKATYDGNEAEYDYQKKLYDRNRKLHEKQLISDMDYEETVYNFQRAQSALEQSKAALA
KAERNLSYATITSPIDGVVTSRDVEEGQTVASGFETPTLFTIAADLTKMQVVADVDEADIAGVEEGTRVTFTVDAYPDDV
FEGVVRQVRLGSTNSTSSSSSTTTSTTVVTYEVVITADNPYLKLKPRLTANATIYTLTKDNVLTVPNKALRFTPNKDIVG
GRKINDCQSSHKVWTLDNNTFTAHPVKIGITDGSKTEIVSGITENTPVVTETVVKGAMPGMEEPSAGEGERSPFMPGPPG
SNKKKNK
>Mature_407_residues
MEKKKMILTTAVAVVVVAGGFWMLGGPEGKSTVDFSTETVTKGNVSNFITATGTIEPVTEVEVGTQVSGIIDKIYVDYNS
VVKKGELIAEMDKVTLQSELQSAKATYDGNEAEYDYQKKLYDRNRKLHEKQLISDMDYEETVYNFQRAQSALEQSKAALA
KAERNLSYATITSPIDGVVTSRDVEEGQTVASGFETPTLFTIAADLTKMQVVADVDEADIAGVEEGTRVTFTVDAYPDDV
FEGVVRQVRLGSTNSTSSSSSTTTSTTVVTYEVVITADNPYLKLKPRLTANATIYTLTKDNVLTVPNKALRFTPNKDIVG
GRKINDCQSSHKVWTLDNNTFTAHPVKIGITDGSKTEIVSGITENTPVVTETVVKGAMPGMEEPSAGEGERSPFMPGPPG
SNKKKNK

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=395, Percent_Identity=27.3417721518987, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87082036, Length=338, Percent_Identity=24.2603550295858, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789929, Length=351, Percent_Identity=25.6410256410256, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 44091; Mature: 44091

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKKMILTTAVAVVVVAGGFWMLGGPEGKSTVDFSTETVTKGNVSNFITATGTIEPVTE
CCCCHHHHHHHHHHHHHHCCEEEEECCCCCCEEECCCCEEECCCCCCEEEECCCCCCCCE
VEVGTQVSGIIDKIYVDYNSVVKKGELIAEMDKVTLQSELQSAKATYDGNEAEYDYQKKL
EECCCHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
YDRNRKLHEKQLISDMDYEETVYNFQRAQSALEQSKAALAKAERNLSYATITSPIDGVVT
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEE
SRDVEEGQTVASGFETPTLFTIAADLTKMQVVADVDEADIAGVEEGTRVTFTVDAYPDDV
CCCHHCCCHHHCCCCCCEEEEEEHHHHHEEEEECCCCCCCCCCCCCCEEEEEEECCCHHH
FEGVVRQVRLGSTNSTSSSSSTTTSTTVVTYEVVITADNPYLKLKPRLTANATIYTLTKD
HHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCCEEEECCCEECCEEEEEEECC
NVLTVPNKALRFTPNKDIVGGRKINDCQSSHKVWTLDNNTFTAHPVKIGITDGSKTEIVS
CEEECCCCEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEECEEEEEECCCCHHHHHH
GITENTPVVTETVVKGAMPGMEEPSAGEGERSPFMPGPPGSNKKKNK
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEKKKMILTTAVAVVVVAGGFWMLGGPEGKSTVDFSTETVTKGNVSNFITATGTIEPVTE
CCCCHHHHHHHHHHHHHHCCEEEEECCCCCCEEECCCCEEECCCCCCEEEECCCCCCCCE
VEVGTQVSGIIDKIYVDYNSVVKKGELIAEMDKVTLQSELQSAKATYDGNEAEYDYQKKL
EECCCHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
YDRNRKLHEKQLISDMDYEETVYNFQRAQSALEQSKAALAKAERNLSYATITSPIDGVVT
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEE
SRDVEEGQTVASGFETPTLFTIAADLTKMQVVADVDEADIAGVEEGTRVTFTVDAYPDDV
CCCHHCCCHHHCCCCCCEEEEEEHHHHHEEEEECCCCCCCCCCCCCCEEEEEEECCCHHH
FEGVVRQVRLGSTNSTSSSSSTTTSTTVVTYEVVITADNPYLKLKPRLTANATIYTLTKD
HHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCCEEEECCCEECCEEEEEEECC
NVLTVPNKALRFTPNKDIVGGRKINDCQSSHKVWTLDNNTFTAHPVKIGITDGSKTEIVS
CEEECCCCEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEECEEEEEECCCCHHHHHH
GITENTPVVTETVVKGAMPGMEEPSAGEGERSPFMPGPPGSNKKKNK
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]