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The map label for this gene is kbl [C]

Identifier: 150005306

GI number: 150005306

Start: 3549780

End: 3550949

Strand: Direct

Name: kbl [C]

Synonym: BVU_2780

Alternate gene names: 150005306

Gene position: 3549780-3550949 (Clockwise)

Preceding gene: 150005305

Following gene: 150005307

Centisome position: 68.75

GC content: 43.85

Gene sequence:

>1170_bases
TTGGGAAAAATAGAAAAAATGAGTTCATTAACAGACTGGGAAAGAGAATTAGCCCTGCTTGAAAATAAAAGTAATCTTCG
TAAGTTGCCTGTTATCCGCCATTTGGGAAAAGAGGTGGAGGTGAATGGAAAAGTGATGCTTAACCTTTCATCCAACGATT
ATCTGGGATTGGCTGCTTATCTGCCATTACGTACGGAATTCTTGCAAAGTCTTACTCCCGACACTTTTCTTCCTTCCTCT
TCATCCTCTCGGCTGCTGACAGGAAATTTTAATATCTATGTTCAGATAGAGGATTTGCTTGCCCGACTGTTTCGGAAGGA
AAGCGCGTTGGTTTTTAATAGTGGTTATCACATGAATGCCGGTATTCTTCCTGCAGTGAGCGATGCTCGTACATTGATTC
TTGCCGATAAACTGGTACATGCCAGCATTATTGACGGCATTCGTTTATCGGCGGCCAAGTGTATCCGGTACCGGCATAAC
CGATATGACCAATTGGAACAGTTGCTGGTTTCCAATCATGCCGGGTATGATAGAATAATTATTGTAACCGAAAGTATTTT
CAGTATGGACGGTGATGAGGCCGATCTCCGCCGTTTGGTCACTTTGAAGCAACAATATGATAATGTATTGCTGTATGTGG
ATGAAGCGCATGCTGTAGGGGTGCGGGGGATGCATGGCCTGGGGTGTGCGGAAGAACAGGATTGTGTGGCTGACATCGAT
TTTTTATGTGGAACTTTTGGTAAAGCGTTGGCCTCAGTAGGAGGCTATATTGTTTGTTCGAAGACCATCCGTGATTATTT
GATCAATAAAATGCGTACATTCATATTTACAACGGCTCTTCCTCCTGTCAACTTGCTATGGACATTCTTTATCCTGGAGC
ATTTGGACAGTTTCAGCTTCCGGAGGGAAAGGTTGAAGAGAATATCCTCTCTTTTGAAAGACGCGTTGGTAAAGAAAGGC
TACGCTTGTCCTTCTACCAGCCATATTCTGCCAATGACGATAGGCGATAGCGGTGATACGGTGTTAAAGGCCGATTTCTT
GCAGCGTAAAGGTTTTTATGCGTTGCCGGTGCGTCCTCCCACTGTGCCCGAAGGAACATCGCGTATCCGTTTTTCGTTGA
CAGCGGATATTACTGAAGAAGAAATAAAAAGTCTGATAGAATTGATATGA

Upstream 100 bases:

>100_bases
GTATATCATGCCGCCTTTTATAATTCAGCCGGAAGAATTGAGCAAATTGACGCATTCACTGGTAAAGATAGTAGGAGAAT
TAAAAGAATAAGTGATAGTA

Downstream 100 bases:

>100_bases
AACATTATTTTATACAACAAAAGCATCTTCCCCGATTGACACTTTTTTTTGCCGGTTGGGGAATGGATGAATGTCCTTTC
ATGGATCATTGCCCCGAAAA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MGKIEKMSSLTDWERELALLENKSNLRKLPVIRHLGKEVEVNGKVMLNLSSNDYLGLAAYLPLRTEFLQSLTPDTFLPSS
SSSRLLTGNFNIYVQIEDLLARLFRKESALVFNSGYHMNAGILPAVSDARTLILADKLVHASIIDGIRLSAAKCIRYRHN
RYDQLEQLLVSNHAGYDRIIIVTESIFSMDGDEADLRRLVTLKQQYDNVLLYVDEAHAVGVRGMHGLGCAEEQDCVADID
FLCGTFGKALASVGGYIVCSKTIRDYLINKMRTFIFTTALPPVNLLWTFFILEHLDSFSFRRERLKRISSLLKDALVKKG
YACPSTSHILPMTIGDSGDTVLKADFLQRKGFYALPVRPPTVPEGTSRIRFSLTADITEEEIKSLIELI

Sequences:

>Translated_389_residues
MGKIEKMSSLTDWERELALLENKSNLRKLPVIRHLGKEVEVNGKVMLNLSSNDYLGLAAYLPLRTEFLQSLTPDTFLPSS
SSSRLLTGNFNIYVQIEDLLARLFRKESALVFNSGYHMNAGILPAVSDARTLILADKLVHASIIDGIRLSAAKCIRYRHN
RYDQLEQLLVSNHAGYDRIIIVTESIFSMDGDEADLRRLVTLKQQYDNVLLYVDEAHAVGVRGMHGLGCAEEQDCVADID
FLCGTFGKALASVGGYIVCSKTIRDYLINKMRTFIFTTALPPVNLLWTFFILEHLDSFSFRRERLKRISSLLKDALVKKG
YACPSTSHILPMTIGDSGDTVLKADFLQRKGFYALPVRPPTVPEGTSRIRFSLTADITEEEIKSLIELI
>Mature_388_residues
GKIEKMSSLTDWERELALLENKSNLRKLPVIRHLGKEVEVNGKVMLNLSSNDYLGLAAYLPLRTEFLQSLTPDTFLPSSS
SSRLLTGNFNIYVQIEDLLARLFRKESALVFNSGYHMNAGILPAVSDARTLILADKLVHASIIDGIRLSAAKCIRYRHNR
YDQLEQLLVSNHAGYDRIIIVTESIFSMDGDEADLRRLVTLKQQYDNVLLYVDEAHAVGVRGMHGLGCAEEQDCVADIDF
LCGTFGKALASVGGYIVCSKTIRDYLINKMRTFIFTTALPPVNLLWTFFILEHLDSFSFRRERLKRISSLLKDALVKKGY
ACPSTSHILPMTIGDSGDTVLKADFLQRKGFYALPVRPPTVPEGTSRIRFSLTADITEEEIKSLIELI

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=389, Percent_Identity=30.8483290488432, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI83977442, Length=373, Percent_Identity=31.6353887399464, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI83977444, Length=373, Percent_Identity=31.6353887399464, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI83977440, Length=373, Percent_Identity=31.6353887399464, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI284448556, Length=345, Percent_Identity=31.5942028985507, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI119220554, Length=366, Percent_Identity=27.3224043715847, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI4502025, Length=351, Percent_Identity=29.6296296296296, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI40316939, Length=351, Percent_Identity=29.6296296296296, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4758668, Length=369, Percent_Identity=28.4552845528455, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI5454084, Length=252, Percent_Identity=27.7777777777778, Blast_Score=101, Evalue=9e-22,
Organism=Escherichia coli, GI1790046, Length=350, Percent_Identity=32.2857142857143, Blast_Score=184, Evalue=7e-48,
Organism=Escherichia coli, GI1786993, Length=363, Percent_Identity=32.5068870523416, Blast_Score=179, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71994529, Length=381, Percent_Identity=32.2834645669291, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI32566772, Length=374, Percent_Identity=29.4117647058824, Blast_Score=144, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17560912, Length=362, Percent_Identity=28.7292817679558, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17560914, Length=372, Percent_Identity=29.0322580645161, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71982617, Length=428, Percent_Identity=21.9626168224299, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71982625, Length=423, Percent_Identity=21.9858156028369, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320438, Length=367, Percent_Identity=31.3351498637602, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6320267, Length=358, Percent_Identity=31.2849162011173, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323954, Length=281, Percent_Identity=26.6903914590747, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24662918, Length=350, Percent_Identity=34.2857142857143, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI17137420, Length=347, Percent_Identity=31.700288184438, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI17136286, Length=364, Percent_Identity=29.1208791208791, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24653280, Length=296, Percent_Identity=27.7027027027027, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24653276, Length=296, Percent_Identity=27.7027027027027, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24653278, Length=296, Percent_Identity=27.7027027027027, Blast_Score=111, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43684; Mature: 43553

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKIEKMSSLTDWERELALLENKSNLRKLPVIRHLGKEVEVNGKVMLNLSSNDYLGLAAY
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEECCEEEEEECCCCCEEHEEH
LPLRTEFLQSLTPDTFLPSSSSSRLLTGNFNIYVQIEDLLARLFRKESALVFNSGYHMNA
HHHHHHHHHHCCCCCCCCCCCCCEEEEECCEEEEEHHHHHHHHHCCCCCEEEECCCEECC
GILPAVSDARTLILADKLVHASIIDGIRLSAAKCIRYRHNRYDQLEQLLVSNHAGYDRII
CCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCEEE
IVTESIFSMDGDEADLRRLVTLKQQYDNVLLYVDEAHAVGVRGMHGLGCAEEQDCVADID
EEEEHHHCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
FLCGTFGKALASVGGYIVCSKTIRDYLINKMRTFIFTTALPPVNLLWTFFILEHLDSFSF
HHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
RRERLKRISSLLKDALVKKGYACPSTSHILPMTIGDSGDTVLKADFLQRKGFYALPVRPP
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEHHHHHCCCCEEECCCCC
TVPEGTSRIRFSLTADITEEEIKSLIELI
CCCCCCCEEEEEEEECCCHHHHHHHHHHC
>Mature Secondary Structure 
GKIEKMSSLTDWERELALLENKSNLRKLPVIRHLGKEVEVNGKVMLNLSSNDYLGLAAY
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEECCEEEEEECCCCCEEHEEH
LPLRTEFLQSLTPDTFLPSSSSSRLLTGNFNIYVQIEDLLARLFRKESALVFNSGYHMNA
HHHHHHHHHHCCCCCCCCCCCCCEEEEECCEEEEEHHHHHHHHHCCCCCEEEECCCEECC
GILPAVSDARTLILADKLVHASIIDGIRLSAAKCIRYRHNRYDQLEQLLVSNHAGYDRII
CCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCEEE
IVTESIFSMDGDEADLRRLVTLKQQYDNVLLYVDEAHAVGVRGMHGLGCAEEQDCVADID
EEEEHHHCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
FLCGTFGKALASVGGYIVCSKTIRDYLINKMRTFIFTTALPPVNLLWTFFILEHLDSFSF
HHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
RRERLKRISSLLKDALVKKGYACPSTSHILPMTIGDSGDTVLKADFLQRKGFYALPVRPP
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEHHHHHCCCCEEECCCCC
TVPEGTSRIRFSLTADITEEEIKSLIELI
CCCCCCCEEEEEEEECCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA