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The map label for this gene is algA [H]

Identifier: 150005180

GI number: 150005180

Start: 3368571

End: 3369614

Strand: Reverse

Name: algA [H]

Synonym: BVU_2650

Alternate gene names: 150005180

Gene position: 3369614-3368571 (Counterclockwise)

Preceding gene: 150005181

Following gene: 150005179

Centisome position: 65.26

GC content: 47.7

Gene sequence:

>1044_bases
ATGGAAACTCATATCGTTATCATGGCAGGCGGCATAGGAAGCCGCTTCTGGCCCATGAGTACGCCGGAATGTCCCAAACA
GTTCATTGATGTGACGGGATGTGGCAAAAGCCTGATACAACTGACAGTGGAACGCTTTCAAGGGTTGTGCATTCCGGATA
ATATATGGATAGTGACTTCGGATAAGTATAAGGAGACGGTAAGGAAACAATTGCCATCCGTGCCGCCTCATCATATACTG
ACGGAGCCGGTTGCACGTAACACGGCACCCTGCATCACATACGCTTGCTGGAAAATCAAGAAACACCACCCGCACGCCAA
TATCGTAGTGACTCCTGCGGATGCATTGGTTATCAATACGGATGAATTCCGCCGGGTGATAGCCAAGGCACTGCTGATGA
CAGATCAAAGCAAGGCTATTGTAACCATAGGTATCAGACCTTGCCGCCCGGAAACGGGATACGGATATATAGCCGCGGGA
GAAGAGGTGGATCAGGATATACGGAAAGTGGATGAATTCAAAGAGAAACCGGACTTGAAAACGGCACGGCACTATGTGGA
CGCCGGGAATTATTTCTGGAATGCAGGGATCTTTGTATGGAATGTAAAGACCATAGAAGAGGCTATACGCCGTTATGCAC
CGGGCATTGCCGAGGTGTTCGACAGGATTTATCCGGAGTTCTATACCGAAAGAGAGAAAGAAACCATAGAAGAGCTGTTC
CCTGCTTGTGAAAGTATATCCATAGATTATGCCGTAATGGAAAAAGCGGAACGGATTTATGTATTGCCGGCAGAGTTCGG
ATGGTCTGATCTGGGTAGCTGGGGCTCATTGCATTCCTTGCTGCCCAAAGATGAACGGAACAATGCCGTTGTAGGCGAGA
ATGTCCGAATGTATGAATGCAATAACTGCATTGTACACACACCGCATTTGAAACAGGCGGTAATACAAGGACTGGACGGG
TATATCATAGCCGAGAAAGAGGGAACCCTGCTGATATGCAGACTGGCAGAGGAGCAGCGTATTAAAGAATTTTCGAAAAT
ATAA

Upstream 100 bases:

>100_bases
ATGAACTGGGATGGCATCACAAAATAGACATAGAGGAAGGGGTGCACAAGATGTACCAATGGTATCTGGAATATAAAAAG
AAATAAAGAGCATACGTGTT

Downstream 100 bases:

>100_bases
GGAATGATTATAGCAGTTGACTTTGACGGCACAATAGTGGAGCATAAATATCCCGAAATAGGCAGGGAACTACCATTTGC
CATAGAAACGCTGAAAAAAC

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
METHIVIMAGGIGSRFWPMSTPECPKQFIDVTGCGKSLIQLTVERFQGLCIPDNIWIVTSDKYKETVRKQLPSVPPHHIL
TEPVARNTAPCITYACWKIKKHHPHANIVVTPADALVINTDEFRRVIAKALLMTDQSKAIVTIGIRPCRPETGYGYIAAG
EEVDQDIRKVDEFKEKPDLKTARHYVDAGNYFWNAGIFVWNVKTIEEAIRRYAPGIAEVFDRIYPEFYTEREKETIEELF
PACESISIDYAVMEKAERIYVLPAEFGWSDLGSWGSLHSLLPKDERNNAVVGENVRMYECNNCIVHTPHLKQAVIQGLDG
YIIAEKEGTLLICRLAEEQRIKEFSKI

Sequences:

>Translated_347_residues
METHIVIMAGGIGSRFWPMSTPECPKQFIDVTGCGKSLIQLTVERFQGLCIPDNIWIVTSDKYKETVRKQLPSVPPHHIL
TEPVARNTAPCITYACWKIKKHHPHANIVVTPADALVINTDEFRRVIAKALLMTDQSKAIVTIGIRPCRPETGYGYIAAG
EEVDQDIRKVDEFKEKPDLKTARHYVDAGNYFWNAGIFVWNVKTIEEAIRRYAPGIAEVFDRIYPEFYTEREKETIEELF
PACESISIDYAVMEKAERIYVLPAEFGWSDLGSWGSLHSLLPKDERNNAVVGENVRMYECNNCIVHTPHLKQAVIQGLDG
YIIAEKEGTLLICRLAEEQRIKEFSKI
>Mature_347_residues
METHIVIMAGGIGSRFWPMSTPECPKQFIDVTGCGKSLIQLTVERFQGLCIPDNIWIVTSDKYKETVRKQLPSVPPHHIL
TEPVARNTAPCITYACWKIKKHHPHANIVVTPADALVINTDEFRRVIAKALLMTDQSKAIVTIGIRPCRPETGYGYIAAG
EEVDQDIRKVDEFKEKPDLKTARHYVDAGNYFWNAGIFVWNVKTIEEAIRRYAPGIAEVFDRIYPEFYTEREKETIEELF
PACESISIDYAVMEKAERIYVLPAEFGWSDLGSWGSLHSLLPKDERNNAVVGENVRMYECNNCIVHTPHLKQAVIQGLDG
YIIAEKEGTLLICRLAEEQRIKEFSKI

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=352, Percent_Identity=33.2386363636364, Blast_Score=174, Evalue=9e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 39470; Mature: 39470

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METHIVIMAGGIGSRFWPMSTPECPKQFIDVTGCGKSLIQLTVERFQGLCIPDNIWIVTS
CCEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCEECCCCEEEEEC
DKYKETVRKQLPSVPPHHILTEPVARNTAPCITYACWKIKKHHPHANIVVTPADALVINT
HHHHHHHHHHCCCCCCHHHHCCCHHCCCCCHHHHHHHHHHCCCCCCCEEEECCCEEEECH
DEFRRVIAKALLMTDQSKAIVTIGIRPCRPETGYGYIAAGEEVDQDIRKVDEFKEKPDLK
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCHH
TARHYVDAGNYFWNAGIFVWNVKTIEEAIRRYAPGIAEVFDRIYPEFYTEREKETIEELF
HHHHHHHCCCEEEECCEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
PACESISIDYAVMEKAERIYVLPAEFGWSDLGSWGSLHSLLPKDERNNAVVGENVRMYEC
HHHHHCCCHHHHHCCCCEEEEEECCCCCHHCCCCCHHHHHCCCCCCCCEEECCCEEEEEC
NNCIVHTPHLKQAVIQGLDGYIIAEKEGTLLICRLAEEQRIKEFSKI
CCCEEECCHHHHHHHCCCCCEEEEECCCCEEEEECCHHHHHHHHHCC
>Mature Secondary Structure
METHIVIMAGGIGSRFWPMSTPECPKQFIDVTGCGKSLIQLTVERFQGLCIPDNIWIVTS
CCEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCEECCCCEEEEEC
DKYKETVRKQLPSVPPHHILTEPVARNTAPCITYACWKIKKHHPHANIVVTPADALVINT
HHHHHHHHHHCCCCCCHHHHCCCHHCCCCCHHHHHHHHHHCCCCCCCEEEECCCEEEECH
DEFRRVIAKALLMTDQSKAIVTIGIRPCRPETGYGYIAAGEEVDQDIRKVDEFKEKPDLK
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCHH
TARHYVDAGNYFWNAGIFVWNVKTIEEAIRRYAPGIAEVFDRIYPEFYTEREKETIEELF
HHHHHHHCCCEEEECCEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
PACESISIDYAVMEKAERIYVLPAEFGWSDLGSWGSLHSLLPKDERNNAVVGENVRMYEC
HHHHHCCCHHHHHCCCCEEEEEECCCCCHHCCCCCHHHHHCCCCCCCCEEECCCEEEEEC
NNCIVHTPHLKQAVIQGLDGYIIAEKEGTLLICRLAEEQRIKEFSKI
CCCEEECCHHHHHHHCCCCCEEEEECCCCEEEEECCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]