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The map label for this gene is ilvC [H]

Identifier: 150005093

GI number: 150005093

Start: 3264323

End: 3265366

Strand: Direct

Name: ilvC [H]

Synonym: BVU_2558

Alternate gene names: 150005093

Gene position: 3264323-3265366 (Clockwise)

Preceding gene: 150005092

Following gene: 150005094

Centisome position: 63.22

GC content: 44.06

Gene sequence:

>1044_bases
ATGGCACAATTGAATTTTGGCGGCGTTACAGAAACTGTAGTTATCCGCGATGAATTTCCTTTGGAAAAAGCACGTGAAGT
ATTGAAAGATGAAACAATCGCTGTGATCGGGTATGGTGTGCAGGGACCGGGGCAGTCTTTGAATCTCCGGGACAATGGTT
TCAATGTAATCGTTGGTCAGCGTCCGGGAAAAACATATGAAAAAGCAGTTGCTGACGGATGGGTTCCGGGTGAAACTCTG
TTTGGTATTGAAGAGGCTTGTCAGAAAGCGACTATCGTAATGTGTCTGTTATCTGATGCAGCTGTTATGTCTGTATGGCC
GACTATCAAACCTTGCTTGACTCAAGGCAAGGCACTTTATTTCTCTCATGGCTTTGCTATTACTTGGAGTGACCGTACAG
GGGTAGTTCCTCCTGCTGATATTGATGTGATCATGGTAGCTCCTAAAGGGTCGGGTACTTCACTGCGTACCATGTTCTTG
GAAGGTCGTGGTTTGAACTCTTCATACGCTATCTATCAGGATGTAACCGGCAAGGCTTATGAACGTACTATTGCATTGGG
TATTGGTATCGGTTCAGGCTATTTGTTCGAAACGACTTTCCAGCGTGAAGCAACTTCTGACTTGACTGGTGAACGCGGTT
CTTTAATGGGGGCTATCCAGGGATTGTTGTTGGCTCAGTATGAAGTATTGCGTGAAAACGGACATAGCCCTTCTGAAGCG
TTTAATGAAACTGTAGAAGAATTAACCCAGTCATTGATGCCTTTGTTTGCTAAGAATGGTATGGACTGGATGTATGCTAA
CTGCTCTACTACTGCTCAGCGCGGTGCATTGGATTGGATGACTCCGTTTCATGATGCTATCAAACCTGTAGTTGAAAAGT
TATATCACAGTGTGAAGACTGGCAACGAGGCTCAGATTTCTATCGATTCTAACTCTAAACCCGATTATCGTGAAAAATTG
GAAGAAGAATTGAAAGCATTGCGTGAAAGCGAAATGTGGCAGACGGCTGTAACCGTACGTAAACTTCGTCCTGAAAATAA
TTAA

Upstream 100 bases:

>100_bases
TATGATATAGAGGTGAAGAAGAATGGCACAGATGTTGTCGTTCGCAGTAAGGTGATATTTATTTAGAATCTAATTTTTAA
TTTTTAATTTATAATTTAAA

Downstream 100 bases:

>100_bases
TAGTTAGTATTTAGTATAGAAAGCGGGGGTGCGATGAGGCATCTCCGCTTTCTTTTATATATATTAATGTTAGTGGTATT
GTTTATATCATGTGTAGTCG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MAQLNFGGVTETVVIRDEFPLEKAREVLKDETIAVIGYGVQGPGQSLNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETL
FGIEEACQKATIVMCLLSDAAVMSVWPTIKPCLTQGKALYFSHGFAITWSDRTGVVPPADIDVIMVAPKGSGTSLRTMFL
EGRGLNSSYAIYQDVTGKAYERTIALGIGIGSGYLFETTFQREATSDLTGERGSLMGAIQGLLLAQYEVLRENGHSPSEA
FNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMTPFHDAIKPVVEKLYHSVKTGNEAQISIDSNSKPDYREKL
EEELKALRESEMWQTAVTVRKLRPENN

Sequences:

>Translated_347_residues
MAQLNFGGVTETVVIRDEFPLEKAREVLKDETIAVIGYGVQGPGQSLNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETL
FGIEEACQKATIVMCLLSDAAVMSVWPTIKPCLTQGKALYFSHGFAITWSDRTGVVPPADIDVIMVAPKGSGTSLRTMFL
EGRGLNSSYAIYQDVTGKAYERTIALGIGIGSGYLFETTFQREATSDLTGERGSLMGAIQGLLLAQYEVLRENGHSPSEA
FNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMTPFHDAIKPVVEKLYHSVKTGNEAQISIDSNSKPDYREKL
EEELKALRESEMWQTAVTVRKLRPENN
>Mature_346_residues
AQLNFGGVTETVVIRDEFPLEKAREVLKDETIAVIGYGVQGPGQSLNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLF
GIEEACQKATIVMCLLSDAAVMSVWPTIKPCLTQGKALYFSHGFAITWSDRTGVVPPADIDVIMVAPKGSGTSLRTMFLE
GRGLNSSYAIYQDVTGKAYERTIALGIGIGSGYLFETTFQREATSDLTGERGSLMGAIQGLLLAQYEVLRENGHSPSEAF
NETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMTPFHDAIKPVVEKLYHSVKTGNEAQISIDSNSKPDYREKLE
EELKALRESEMWQTAVTVRKLRPENN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=300, Percent_Identity=28, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323387, Length=347, Percent_Identity=60.5187319884726, Blast_Score=429, Evalue=1e-121,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 38167; Mature: 38036

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQLNFGGVTETVVIRDEFPLEKAREVLKDETIAVIGYGVQGPGQSLNLRDNGFNVIVGQ
CCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCEEEEEEC
RPGKTYEKAVADGWVPGETLFGIEEACQKATIVMCLLSDAAVMSVWPTIKPCLTQGKALY
CCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEHHHCCCHHHHHCCCHHHHHCCCCEEE
FSHGFAITWSDRTGVVPPADIDVIMVAPKGSGTSLRTMFLEGRGLNSSYAIYQDVTGKAY
EECCEEEEECCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCEEEEECCCCCHH
ERTIALGIGIGSGYLFETTFQREATSDLTGERGSLMGAIQGLLLAQYEVLRENGHSPSEA
HEEEEEEEECCCCEEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHH
FNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMTPFHDAIKPVVEKLYHSVKT
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCC
GNEAQISIDSNSKPDYREKLEEELKALRESEMWQTAVTVRKLRPENN
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AQLNFGGVTETVVIRDEFPLEKAREVLKDETIAVIGYGVQGPGQSLNLRDNGFNVIVGQ
CCCCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCEEEEEEC
RPGKTYEKAVADGWVPGETLFGIEEACQKATIVMCLLSDAAVMSVWPTIKPCLTQGKALY
CCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEHHHCCCHHHHHCCCHHHHHCCCCEEE
FSHGFAITWSDRTGVVPPADIDVIMVAPKGSGTSLRTMFLEGRGLNSSYAIYQDVTGKAY
EECCEEEEECCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCEEEEECCCCCHH
ERTIALGIGIGSGYLFETTFQREATSDLTGERGSLMGAIQGLLLAQYEVLRENGHSPSEA
HEEEEEEEECCCCEEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHH
FNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMTPFHDAIKPVVEKLYHSVKT
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCC
GNEAQISIDSNSKPDYREKLEEELKALRESEMWQTAVTVRKLRPENN
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]