| Definition | Bacteroides vulgatus ATCC 8482 chromosome, complete genome. |
|---|---|
| Accession | NC_009614 |
| Length | 5,163,189 |
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The map label for this gene is metH [H]
Identifier: 150005063
GI number: 150005063
Start: 3229622
End: 3232375
Strand: Direct
Name: metH [H]
Synonym: BVU_2528
Alternate gene names: 150005063
Gene position: 3229622-3232375 (Clockwise)
Preceding gene: 150005062
Following gene: 150005068
Centisome position: 62.55
GC content: 45.75
Gene sequence:
>2754_bases ATGGCTACATTAAAACAACTAATTGACGAGAGAGTTCTCATTCTTGATGGTGCAATGGGAACTATGATACAAAGGTATAA TTTGTCTGAACAGGATTTCCGGGGAGAGCGTTTTGCTGAGATGCCCGGACAGATGAAGGGCAATAATGACTTGCTTTGTC TTACCCGCCCTGATGTGATAAAGGATATCCACCATAAATATCTGGAAGCAGGGGCTGATATTATTGAAACAAATACGTTC AATGCCCAACGGGTTTCGATGGCAGATTATCATATGCAGGATTTGTGCCGTGAGATTAATCTGGCCGCTGCCGGACTTGC TCGCGAAATGGCTGACGAATATACCGCGAAGACCCCTCATAAACCTAGATTTGTAGCAGGTTCGGTAGGTCCTACCAACA AAACTTGTTCCATGAGTCCGGATGTCAATAATCCGGCCTTGCGTGCTTTGACATACGATGAACTGGCCGCTGCCTATCAG GAACAAATGGAAGCTTTGCTGGAAGGAGGAGTGGATGCGCTTCTGATAGAAACCATTTTCGATTCCCTGAATGCCAAAGC GGCCATTTATGCTGCGGAAACGGCAATGAAGAAGATAGGGCGTGAGGTTCCTCTTATGCTTTCTGTTACTGTTTCGGATA TTGCAGGACGTACTCTTTCGGGGCAAACATTGGATGCTTTTCTGGCATCCGTACAGCATGCGCCTATTTTTTCTATCGGC CTGAACTGCTCGTTCGGAGCGAAACAATTGAAACCTTTTCTGGAAGGGCTGGCTGCACGGGCACCTTATTATATAAGTGC CTATCCCAATGCCGGACTTCCTAACAGTTTGGGACAGTATGACCAGACTCCGGAGGAAATGGCTTCAGAAGTGAAGGAAT ATATCGATGAAGGATTAGTAAACATTATCGGTGGTTGTTGTGGTACAACGGAGGAATATATTGCAAAATATCAGGAATTG ATCGTTTCCGGTTCTGCCTGGGTATCTCCTCATATCCCTGCCACCACTCCTGAGAGGCTGTGGCTTTCCGGGTTGGAGCT GTTGGAGCAGACTCCCGAAATGAATTTTATTAATGTAGGCGAACGGTGCAATGTGGCCGGATCCCGTAAGTTCCTCCGTT TAATCAATGAAAAGAAATATGAGGAAGCGCTAAGTATCGCTCGCAAGCAGGTGGAAGACGGTGCTTTGGTGATTGATGTA AATATGGATGACGGTTTGCTGGACGCCCGGGAGGAGATGACTACTTTCTTGAATCTGGTCATGTCCGAACCCGACATAGC CCGTGTACCTGTTATGATTGACTCTTCCAAGTGGGAAGTCATTGAGGCCGGACTGAAATGCCTGCAAGGAAAGTCCATTG TCAATTCTATTTCTTTGAAGGAAGGGGAGGAGATATTTATAGAACATGCCCGTCTGATAAAAAAACTGGGAGCTGCCGTT GTAGTGATGGCTTTCGATGAAAAAGGACAGGCAGATACTTTTGAACGTAAGATTGAAGTCTGTGCCCGTGCTTATAAAAT ATTGACAGAACAGGTGGATTTTAATCCTCATGATATCATTTTCGACCCTAATGTACTGGCTGTGGCTACGGGTATTGAGG AACATGATAATTATGCGGTGGATTTTATCAAGGCTACCGGATGGATCAAAAAGAATTTGCCCGGTGCACACGTCAGTGGT GGCGTGAGCAACCTGTCGTTCTCCTTCCGTGGAAATAACTATATCCGTGAGGCGATGCATGCCGTGTTTCTTTATCACGC TATCCGTCAAGGTATGGATATGGGTATTGTAAATCCTGCTGCTTCGGTGCTCTATACGGATATTCCTGCTGATGTGCTGG AACGGATAGAGGATGTGGTCTTAAACCGTAGGCCCGATGCTGCCGAACGTTTGATAGAGACTGCTGAGGCGTTGAAAAAT ACGGCGACCGGAACAGAAGCGGTGAAACAGGATGTGTGGCGTGAAGAACCGATGGTAGAGAAACGGCTTCAGTATGCCTT GATAAAAGGCATTGGCGATCATTTGGAAGAGGATTTGGCAGAAGCGGTTAAACTGTATCCTAAAGCAGTGGATATTATTG AGGGTCCGCTAATGGAAGGTATGAATAAAGTCGGAGAATTGTTTGGAGCAGGGAAAATGTTTTTACCGCAAGTTGTGAAG ACTGCCCGTACCATGAAAAAGGCGGTAGCGATTTTGCAGCCGCTTATTGAGGCCGACAAACAGGAAGGTGTCCGCAGTGC AGGAAAAGTATTGATGGCTACCGTAAAAGGGGATGTGCATGATATTGGGAAGAATATCGTATCAGTGGTCATGGCTTGTA ATAACTATGAAATTATAGACCTTGGCGTGATGGTTCCTGCCGAAATGATAGTCAGGAAGGCTATAGAGGAAAAGGTGGAT ATAATAGGATTAAGCGGGCTGATTACTCCATCATTGGAAGAAATGGCGCATGTGGCTGTAGAGTTAAAGCGTGCGGGGCT GGACATTCCCATTATGATTGGAGGAGCCACTACTTCCAAGCTACATACTGCCTTGAAAATAGCACCTGTTTATGGAGGTC CGGTCATTCACATGAAAGATGCTTCACAGAATGCCTTGGTAGCCGCCCGTTTGCTGAATCCGGAATCTTCTTTTGAGTTT GTGGAAAGGCTGAACAAAGAATATGAGGATCTTCGTCTGAAAAACAGTGCCAAGCAGGTAAAAACGGTATCTTTGGAAGA AGCTCAGAAAAATAAATTGAACCTTTGGTCATAA
Upstream 100 bases:
>100_bases AAGCGCGAGTCATTGAAAGAGAAGGACGACCGTCGCGAAATGGACCGTATGTTTAAAAGGTAAGTGAAATCCGTGTTATC CGTACCCCAAAAATAGACTT
Downstream 100 bases:
>100_bases AGAAGTGTCCCCCAAAAAGTTAAACACAAAACTTTTTGGGGGCACTTCATAAAATTACGACTTTTTTTATCTGCCCATTT TATTCGAAAGAATAAGAAGC
Product: 5-methyltetrahydrofolate-homocysteine methyltransferase
Products: NA
Alternate protein names: 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12 dependent; MS [H]
Number of amino acids: Translated: 917; Mature: 916
Protein sequence:
>917_residues MATLKQLIDERVLILDGAMGTMIQRYNLSEQDFRGERFAEMPGQMKGNNDLLCLTRPDVIKDIHHKYLEAGADIIETNTF NAQRVSMADYHMQDLCREINLAAAGLAREMADEYTAKTPHKPRFVAGSVGPTNKTCSMSPDVNNPALRALTYDELAAAYQ EQMEALLEGGVDALLIETIFDSLNAKAAIYAAETAMKKIGREVPLMLSVTVSDIAGRTLSGQTLDAFLASVQHAPIFSIG LNCSFGAKQLKPFLEGLAARAPYYISAYPNAGLPNSLGQYDQTPEEMASEVKEYIDEGLVNIIGGCCGTTEEYIAKYQEL IVSGSAWVSPHIPATTPERLWLSGLELLEQTPEMNFINVGERCNVAGSRKFLRLINEKKYEEALSIARKQVEDGALVIDV NMDDGLLDAREEMTTFLNLVMSEPDIARVPVMIDSSKWEVIEAGLKCLQGKSIVNSISLKEGEEIFIEHARLIKKLGAAV VVMAFDEKGQADTFERKIEVCARAYKILTEQVDFNPHDIIFDPNVLAVATGIEEHDNYAVDFIKATGWIKKNLPGAHVSG GVSNLSFSFRGNNYIREAMHAVFLYHAIRQGMDMGIVNPAASVLYTDIPADVLERIEDVVLNRRPDAAERLIETAEALKN TATGTEAVKQDVWREEPMVEKRLQYALIKGIGDHLEEDLAEAVKLYPKAVDIIEGPLMEGMNKVGELFGAGKMFLPQVVK TARTMKKAVAILQPLIEADKQEGVRSAGKVLMATVKGDVHDIGKNIVSVVMACNNYEIIDLGVMVPAEMIVRKAIEEKVD IIGLSGLITPSLEEMAHVAVELKRAGLDIPIMIGGATTSKLHTALKIAPVYGGPVIHMKDASQNALVAARLLNPESSFEF VERLNKEYEDLRLKNSAKQVKTVSLEEAQKNKLNLWS
Sequences:
>Translated_917_residues MATLKQLIDERVLILDGAMGTMIQRYNLSEQDFRGERFAEMPGQMKGNNDLLCLTRPDVIKDIHHKYLEAGADIIETNTF NAQRVSMADYHMQDLCREINLAAAGLAREMADEYTAKTPHKPRFVAGSVGPTNKTCSMSPDVNNPALRALTYDELAAAYQ EQMEALLEGGVDALLIETIFDSLNAKAAIYAAETAMKKIGREVPLMLSVTVSDIAGRTLSGQTLDAFLASVQHAPIFSIG LNCSFGAKQLKPFLEGLAARAPYYISAYPNAGLPNSLGQYDQTPEEMASEVKEYIDEGLVNIIGGCCGTTEEYIAKYQEL IVSGSAWVSPHIPATTPERLWLSGLELLEQTPEMNFINVGERCNVAGSRKFLRLINEKKYEEALSIARKQVEDGALVIDV NMDDGLLDAREEMTTFLNLVMSEPDIARVPVMIDSSKWEVIEAGLKCLQGKSIVNSISLKEGEEIFIEHARLIKKLGAAV VVMAFDEKGQADTFERKIEVCARAYKILTEQVDFNPHDIIFDPNVLAVATGIEEHDNYAVDFIKATGWIKKNLPGAHVSG GVSNLSFSFRGNNYIREAMHAVFLYHAIRQGMDMGIVNPAASVLYTDIPADVLERIEDVVLNRRPDAAERLIETAEALKN TATGTEAVKQDVWREEPMVEKRLQYALIKGIGDHLEEDLAEAVKLYPKAVDIIEGPLMEGMNKVGELFGAGKMFLPQVVK TARTMKKAVAILQPLIEADKQEGVRSAGKVLMATVKGDVHDIGKNIVSVVMACNNYEIIDLGVMVPAEMIVRKAIEEKVD IIGLSGLITPSLEEMAHVAVELKRAGLDIPIMIGGATTSKLHTALKIAPVYGGPVIHMKDASQNALVAARLLNPESSFEF VERLNKEYEDLRLKNSAKQVKTVSLEEAQKNKLNLWS >Mature_916_residues ATLKQLIDERVLILDGAMGTMIQRYNLSEQDFRGERFAEMPGQMKGNNDLLCLTRPDVIKDIHHKYLEAGADIIETNTFN AQRVSMADYHMQDLCREINLAAAGLAREMADEYTAKTPHKPRFVAGSVGPTNKTCSMSPDVNNPALRALTYDELAAAYQE QMEALLEGGVDALLIETIFDSLNAKAAIYAAETAMKKIGREVPLMLSVTVSDIAGRTLSGQTLDAFLASVQHAPIFSIGL NCSFGAKQLKPFLEGLAARAPYYISAYPNAGLPNSLGQYDQTPEEMASEVKEYIDEGLVNIIGGCCGTTEEYIAKYQELI VSGSAWVSPHIPATTPERLWLSGLELLEQTPEMNFINVGERCNVAGSRKFLRLINEKKYEEALSIARKQVEDGALVIDVN MDDGLLDAREEMTTFLNLVMSEPDIARVPVMIDSSKWEVIEAGLKCLQGKSIVNSISLKEGEEIFIEHARLIKKLGAAVV VMAFDEKGQADTFERKIEVCARAYKILTEQVDFNPHDIIFDPNVLAVATGIEEHDNYAVDFIKATGWIKKNLPGAHVSGG VSNLSFSFRGNNYIREAMHAVFLYHAIRQGMDMGIVNPAASVLYTDIPADVLERIEDVVLNRRPDAAERLIETAEALKNT ATGTEAVKQDVWREEPMVEKRLQYALIKGIGDHLEEDLAEAVKLYPKAVDIIEGPLMEGMNKVGELFGAGKMFLPQVVKT ARTMKKAVAILQPLIEADKQEGVRSAGKVLMATVKGDVHDIGKNIVSVVMACNNYEIIDLGVMVPAEMIVRKAIEEKVDI IGLSGLITPSLEEMAHVAVELKRAGLDIPIMIGGATTSKLHTALKIAPVYGGPVIHMKDASQNALVAARLLNPESSFEFV ERLNKEYEDLRLKNSAKQVKTVSLEEAQKNKLNLWS
Specific function: Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate [H]
COG id: COG1410
COG function: function code E; Methionine synthase I, cobalamin-binding domain
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 pterin-binding domain [H]
Homologues:
Organism=Homo sapiens, GI169790923, Length=931, Percent_Identity=53.1686358754028, Blast_Score=985, Evalue=0.0, Organism=Escherichia coli, GI1790450, Length=913, Percent_Identity=57.9408543263965, Blast_Score=1075, Evalue=0.0, Organism=Escherichia coli, GI1786456, Length=323, Percent_Identity=24.4582043343653, Blast_Score=63, Evalue=9e-11, Organism=Caenorhabditis elegans, GI17535405, Length=933, Percent_Identity=52.625937834941, Blast_Score=964, Evalue=0.0,
Paralogues:
None
Copy number: 513 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 1320 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR006158 - InterPro: IPR011005 - InterPro: IPR003759 - InterPro: IPR011822 - InterPro: IPR000489 - InterPro: IPR003726 - InterPro: IPR004223 [H]
Pfam domain/function: PF02310 B12-binding; PF02607 B12-binding_2; PF02965 Met_synt_B12; PF00809 Pterin_bind; PF02574 S-methyl_trans [H]
EC number: =2.1.1.13 [H]
Molecular weight: Translated: 100857; Mature: 100726
Theoretical pI: Translated: 4.85; Mature: 4.85
Prosite motif: PS50970 HCY ; PS50972 PTERIN_BINDING
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.1 %Cys (Translated Protein) 3.7 %Met (Translated Protein) 4.8 %Cys+Met (Translated Protein) 1.1 %Cys (Mature Protein) 3.6 %Met (Mature Protein) 4.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MATLKQLIDERVLILDGAMGTMIQRYNLSEQDFRGERFAEMPGQMKGNNDLLCLTRPDVI CCHHHHHHCCCEEEEECHHHHHHHHCCCCHHHCCCCHHHHCCCCCCCCCCEEEEECCHHH KDIHHKYLEAGADIIETNTFNAQRVSMADYHMQDLCREINLAAAGLAREMADEYTAKTPH HHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC KPRFVAGSVGPTNKTCSMSPDVNNPALRALTYDELAAAYQEQMEALLEGGVDALLIETIF CCCEEECCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH DSLNAKAAIYAAETAMKKIGREVPLMLSVTVSDIAGRTLSGQTLDAFLASVQHAPIFSIG HHCCCCEEEHHHHHHHHHCCCCCCEEEEEEHHHHCCCCCCCCHHHHHHHHHCCCCEEEEC LNCSFGAKQLKPFLEGLAARAPYYISAYPNAGLPNSLGQYDQTPEEMASEVKEYIDEGLV CCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH NIIGGCCGTTEEYIAKYQELIVSGSAWVSPHIPATTPERLWLSGLELLEQTPEMNFINVG HHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECC ERCNVAGSRKFLRLINEKKYEEALSIARKQVEDGALVIDVNMDDGLLDAREEMTTFLNLV CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHH MSEPDIARVPVMIDSSKWEVIEAGLKCLQGKSIVNSISLKEGEEIFIEHARLIKKLGAAV HCCCCCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCEE VVMAFDEKGQADTFERKIEVCARAYKILTEQVDFNPHDIIFDPNVLAVATGIEEHDNYAV EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEECCHHCCCCEE DFIKATGWIKKNLPGAHVSGGVSNLSFSFRGNNYIREAMHAVFLYHAIRQGMDMGIVNPA EHHHHCCHHHCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCHH ASVLYTDIPADVLERIEDVVLNRRPDAAERLIETAEALKNTATGTEAVKQDVWREEPMVE HHHHEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHH KRLQYALIKGIGDHLEEDLAEAVKLYPKAVDIIEGPLMEGMNKVGELFGAGKMFLPQVVK HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH TARTMKKAVAILQPLIEADKQEGVRSAGKVLMATVKGDVHDIGKNIVSVVMACNNYEIID HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHCCHHHHHHHHHHHHHHHCCCCEEEE LGVMVPAEMIVRKAIEEKVDIIGLSGLITPSLEEMAHVAVELKRAGLDIPIMIGGATTSK ECHHCCHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHH LHTALKIAPVYGGPVIHMKDASQNALVAARLLNPESSFEFVERLNKEYEDLRLKNSAKQV HHHHHEEEEECCCCEEEECCCCCCCEEHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHH KTVSLEEAQKNKLNLWS HHCCHHHHHCCCCCCCC >Mature Secondary Structure ATLKQLIDERVLILDGAMGTMIQRYNLSEQDFRGERFAEMPGQMKGNNDLLCLTRPDVI CHHHHHHCCCEEEEECHHHHHHHHCCCCHHHCCCCHHHHCCCCCCCCCCEEEEECCHHH KDIHHKYLEAGADIIETNTFNAQRVSMADYHMQDLCREINLAAAGLAREMADEYTAKTPH HHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC KPRFVAGSVGPTNKTCSMSPDVNNPALRALTYDELAAAYQEQMEALLEGGVDALLIETIF CCCEEECCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH DSLNAKAAIYAAETAMKKIGREVPLMLSVTVSDIAGRTLSGQTLDAFLASVQHAPIFSIG HHCCCCEEEHHHHHHHHHCCCCCCEEEEEEHHHHCCCCCCCCHHHHHHHHHCCCCEEEEC LNCSFGAKQLKPFLEGLAARAPYYISAYPNAGLPNSLGQYDQTPEEMASEVKEYIDEGLV CCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH NIIGGCCGTTEEYIAKYQELIVSGSAWVSPHIPATTPERLWLSGLELLEQTPEMNFINVG HHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECC ERCNVAGSRKFLRLINEKKYEEALSIARKQVEDGALVIDVNMDDGLLDAREEMTTFLNLV CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHH MSEPDIARVPVMIDSSKWEVIEAGLKCLQGKSIVNSISLKEGEEIFIEHARLIKKLGAAV HCCCCCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCEE VVMAFDEKGQADTFERKIEVCARAYKILTEQVDFNPHDIIFDPNVLAVATGIEEHDNYAV EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEECCHHCCCCEE DFIKATGWIKKNLPGAHVSGGVSNLSFSFRGNNYIREAMHAVFLYHAIRQGMDMGIVNPA EHHHHCCHHHCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCHH ASVLYTDIPADVLERIEDVVLNRRPDAAERLIETAEALKNTATGTEAVKQDVWREEPMVE HHHHEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHH KRLQYALIKGIGDHLEEDLAEAVKLYPKAVDIIEGPLMEGMNKVGELFGAGKMFLPQVVK HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH TARTMKKAVAILQPLIEADKQEGVRSAGKVLMATVKGDVHDIGKNIVSVVMACNNYEIID HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHCCHHHHHHHHHHHHHHHCCCCEEEE LGVMVPAEMIVRKAIEEKVDIIGLSGLITPSLEEMAHVAVELKRAGLDIPIMIGGATTSK ECHHCCHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHH LHTALKIAPVYGGPVIHMKDASQNALVAARLLNPESSFEFVERLNKEYEDLRLKNSAKQV HHHHHEEEEECCCCEEEECCCCCCCEEHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHH KTVSLEEAQKNKLNLWS HHCCHHHHHCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12620739 [H]