Click here to switch to the map view.

The map label for this gene is ziaA [H]

Identifier: 150005019

GI number: 150005019

Start: 3186164

End: 3187882

Strand: Reverse

Name: ziaA [H]

Synonym: BVU_2484

Alternate gene names: 150005019

Gene position: 3187882-3186164 (Counterclockwise)

Preceding gene: 150005022

Following gene: 150005018

Centisome position: 61.74

GC content: 39.97

Gene sequence:

>1719_bases
ATGAAAAAAATAAAATTAGAATCAGTTTTCAATGAATTCACTTTAATGGGAATAGCTGTATCAGGAGCATTCTATCTAGG
AGAATACTGGGAAGGTATTGCCGTTATTCTGTTCTATCTCATAGGTGAATGGTTCCAACACAAAGCTGTACACAAAGCAC
GCAGCGACATCAAAGCATTATTGGATGTACGTCCCGAAACAGCCACTGTAATATATAACAACACATATAAAATAACAGTA
CCGGAAAAAGTACAGCCAGGAGAAACCATTGAAGTAAAAGTTGGAGAAAAAGTACCTCTAGACGGATTTTTGCTGGAAGA
TTCCGCTTCATTTAATACGGCCGCCCTAACCGGAGAAAGTGTTCCCCGGACTCTATATAAACAAGAAGAAGTTTTAGCAG
GAATGATCGCTTCAGATAAAGTGGTACGGATCAAAGTAAACAAACCGTATGATCAAAGTACGTTAGCACGTATCCTCACT
TTAGTACAAGATGCAGCAGAAAGAAAAGCCCCTGCCGAATTATTTATCCGCCGTTTTGCACGAATTTATACACCGATAGT
GACAGGACTGGCGATACTAGTTGTCATACTCCCCTATTTATACTCTCTGATAAAACCTGAATTCATTTTTGTTTTTGATG
ATTGGTTCTATCGGGCTTTAGTATTCCTAGTCATATCATGTCCTTGCGCATTAGTGGTCAGCATTCCATTAGGATACTTT
GGAGGTATTGGTGCCGCATCTCACAAAGGGATTCTTTTCAAAGGGGGTAATTATCTAGATGCCATAACCCAAATAAACAC
CGTAGTATTCGATAAAACCGGAACACTCACCCAAGGTGTATTCAGTGTCCAGGCAATATCGGCAGCCGAAGGTGTTTCGC
AAAAAGAACTGCTTCAACTTATCGCCTCTATAGAGAGTTTCAGCAATCATCCTATCGCAAAAGCCATTGTCAAATATGCA
GAAGAACAAAGTATATCCCTTAACTCGTCACTGAAAATAACCGAATTTGCCGGATATGGAATAAAAGCCGTAACAAACGG
TAAAGAAGTATATGTAGGAAATACACGGTTATTATCAAAATACGGCATCTCTTTTCCCTATGAAATCAGCGACATGACAG
AAACAATCGTGTTATGTGCAATGGAAAACAAATATTTGGGATATCTTTCATTGGCGGATACACCAAAACCAGATGCTGTA
CAAGCCATCCGCGAACTGAAAGACTTAAATATTAATAATATTCAAATATTATCGGGAGACAAACAGACAATTGTTTCTAA
TTTAGCCGAAAAGATAGGTGTCACACAGGCTTTCGGCGATTTACTACCCGAAGGTAAGGTAGCACATTTAGAACAATTAA
AAGCAAATTCTGAAAATCGTGTAGCTTTTGTAGGAGACGGTATCAATGATACTCCCGTACTGGCACTCAGCGATGTTGGG
ATTGCCATGGGTGGCCTAGGATGTGACGCTGCTATAGAAACTGCGGATGTAGTGATACAAACAGACCAACCCAGTAAAGT
GGCGGAAGCTATAAAAATAGGGAAACAGACCCATCGCATCGTATGGCAAAATATATCAATGGCATTCGGAGTGAAATTGT
TAGTATTGCTATTGGGAGCCGGCGGAATGGCCACTATGTGGGAAGCCATATTTGCAGATGTAGGCGTAGCTTTACTCGCC
ATTTTTAATGCAATGAGAATACAGAAATGGAAAGAATAA

Upstream 100 bases:

>100_bases
CATGTATATAAAAAATTACCCGATGTAAAGGTACAATATAATTTGCAATTTAGTTGCATCTTCTTTCCGCTATCTTTGTT
GTCATAAATAAAAAGAAACA

Downstream 100 bases:

>100_bases
AATGATTTGACCTATGAATGAAACAATCTATTTAAAAAAACTGGAACAGCGGGAAATCAAACCGACAGCCATACGTCTGC
TTATTCTAAAAACCATGATG

Product: cation-transporting ATPase, P-type, putative zinc-transporting ATPase

Products: NA

Alternate protein names: Zn(2+)-translocating P-type ATPase [H]

Number of amino acids: Translated: 572; Mature: 572

Protein sequence:

>572_residues
MKKIKLESVFNEFTLMGIAVSGAFYLGEYWEGIAVILFYLIGEWFQHKAVHKARSDIKALLDVRPETATVIYNNTYKITV
PEKVQPGETIEVKVGEKVPLDGFLLEDSASFNTAALTGESVPRTLYKQEEVLAGMIASDKVVRIKVNKPYDQSTLARILT
LVQDAAERKAPAELFIRRFARIYTPIVTGLAILVVILPYLYSLIKPEFIFVFDDWFYRALVFLVISCPCALVVSIPLGYF
GGIGAASHKGILFKGGNYLDAITQINTVVFDKTGTLTQGVFSVQAISAAEGVSQKELLQLIASIESFSNHPIAKAIVKYA
EEQSISLNSSLKITEFAGYGIKAVTNGKEVYVGNTRLLSKYGISFPYEISDMTETIVLCAMENKYLGYLSLADTPKPDAV
QAIRELKDLNINNIQILSGDKQTIVSNLAEKIGVTQAFGDLLPEGKVAHLEQLKANSENRVAFVGDGINDTPVLALSDVG
IAMGGLGCDAAIETADVVIQTDQPSKVAEAIKIGKQTHRIVWQNISMAFGVKLLVLLLGAGGMATMWEAIFADVGVALLA
IFNAMRIQKWKE

Sequences:

>Translated_572_residues
MKKIKLESVFNEFTLMGIAVSGAFYLGEYWEGIAVILFYLIGEWFQHKAVHKARSDIKALLDVRPETATVIYNNTYKITV
PEKVQPGETIEVKVGEKVPLDGFLLEDSASFNTAALTGESVPRTLYKQEEVLAGMIASDKVVRIKVNKPYDQSTLARILT
LVQDAAERKAPAELFIRRFARIYTPIVTGLAILVVILPYLYSLIKPEFIFVFDDWFYRALVFLVISCPCALVVSIPLGYF
GGIGAASHKGILFKGGNYLDAITQINTVVFDKTGTLTQGVFSVQAISAAEGVSQKELLQLIASIESFSNHPIAKAIVKYA
EEQSISLNSSLKITEFAGYGIKAVTNGKEVYVGNTRLLSKYGISFPYEISDMTETIVLCAMENKYLGYLSLADTPKPDAV
QAIRELKDLNINNIQILSGDKQTIVSNLAEKIGVTQAFGDLLPEGKVAHLEQLKANSENRVAFVGDGINDTPVLALSDVG
IAMGGLGCDAAIETADVVIQTDQPSKVAEAIKIGKQTHRIVWQNISMAFGVKLLVLLLGAGGMATMWEAIFADVGVALLA
IFNAMRIQKWKE
>Mature_572_residues
MKKIKLESVFNEFTLMGIAVSGAFYLGEYWEGIAVILFYLIGEWFQHKAVHKARSDIKALLDVRPETATVIYNNTYKITV
PEKVQPGETIEVKVGEKVPLDGFLLEDSASFNTAALTGESVPRTLYKQEEVLAGMIASDKVVRIKVNKPYDQSTLARILT
LVQDAAERKAPAELFIRRFARIYTPIVTGLAILVVILPYLYSLIKPEFIFVFDDWFYRALVFLVISCPCALVVSIPLGYF
GGIGAASHKGILFKGGNYLDAITQINTVVFDKTGTLTQGVFSVQAISAAEGVSQKELLQLIASIESFSNHPIAKAIVKYA
EEQSISLNSSLKITEFAGYGIKAVTNGKEVYVGNTRLLSKYGISFPYEISDMTETIVLCAMENKYLGYLSLADTPKPDAV
QAIRELKDLNINNIQILSGDKQTIVSNLAEKIGVTQAFGDLLPEGKVAHLEQLKANSENRVAFVGDGINDTPVLALSDVG
IAMGGLGCDAAIETADVVIQTDQPSKVAEAIKIGKQTHRIVWQNISMAFGVKLLVLLLGAGGMATMWEAIFADVGVALLA
IFNAMRIQKWKE

Specific function: Involved In Export Of Lead, Cadmium, Zinc And Mercury. [C]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=592, Percent_Identity=28.0405405405405, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI55743073, Length=524, Percent_Identity=28.6259541984733, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI115529486, Length=339, Percent_Identity=28.3185840707965, Blast_Score=141, Evalue=2e-33,
Organism=Escherichia coli, GI1789879, Length=572, Percent_Identity=36.3636363636364, Blast_Score=341, Evalue=6e-95,
Organism=Escherichia coli, GI1786691, Length=558, Percent_Identity=30.1075268817204, Blast_Score=225, Evalue=5e-60,
Organism=Escherichia coli, GI1786914, Length=467, Percent_Identity=26.5524625267666, Blast_Score=116, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17556548, Length=586, Percent_Identity=26.1092150170648, Blast_Score=177, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6320475, Length=541, Percent_Identity=28.0961182994455, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6319772, Length=525, Percent_Identity=23.6190476190476, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6321271, Length=160, Percent_Identity=28.75, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI221329854, Length=346, Percent_Identity=28.0346820809249, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI281366676, Length=269, Percent_Identity=26.0223048327138, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.5 [H]

Molecular weight: Translated: 62499; Mature: 62499

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIKLESVFNEFTLMGIAVSGAFYLGEYWEGIAVILFYLIGEWFQHKAVHKARSDIKAL
CCCEEHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDVRPETATVIYNNTYKITVPEKVQPGETIEVKVGEKVPLDGFLLEDSASFNTAALTGES
HHCCCCCEEEEECCEEEEEECCCCCCCCEEEEEECCCCCCCCEEECCCCCCCEEEECCCC
VPRTLYKQEEVLAGMIASDKVVRIKVNKPYDQSTLARILTLVQDAAERKAPAELFIRRFA
CHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
RIYTPIVTGLAILVVILPYLYSLIKPEFIFVFDDWFYRALVFLVISCPCALVVSIPLGYF
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHCCHHHHHHHHHHHC
GGIGAASHKGILFKGGNYLDAITQINTVVFDKTGTLTQGVFSVQAISAAEGVSQKELLQL
CCCCCCCCCCEEEECCCHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHH
IASIESFSNHPIAKAIVKYAEEQSISLNSSLKITEFAGYGIKAVTNGKEVYVGNTRLLSK
HHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCEEEECCCEEHHH
YGISFPYEISDMTETIVLCAMENKYLGYLSLADTPKPDAVQAIRELKDLNINNIQILSGD
HCCCCCEEHHHHHCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCC
KQTIVSNLAEKIGVTQAFGDLLPEGKVAHLEQLKANSENRVAFVGDGINDTPVLALSDVG
HHHHHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCEEEEECCC
IAMGGLGCDAAIETADVVIQTDQPSKVAEAIKIGKQTHRIVWQNISMAFGVKLLVLLLGA
HHHCCCCCCHHHCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
GGMATMWEAIFADVGVALLAIFNAMRIQKWKE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKIKLESVFNEFTLMGIAVSGAFYLGEYWEGIAVILFYLIGEWFQHKAVHKARSDIKAL
CCCEEHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDVRPETATVIYNNTYKITVPEKVQPGETIEVKVGEKVPLDGFLLEDSASFNTAALTGES
HHCCCCCEEEEECCEEEEEECCCCCCCCEEEEEECCCCCCCCEEECCCCCCCEEEECCCC
VPRTLYKQEEVLAGMIASDKVVRIKVNKPYDQSTLARILTLVQDAAERKAPAELFIRRFA
CHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
RIYTPIVTGLAILVVILPYLYSLIKPEFIFVFDDWFYRALVFLVISCPCALVVSIPLGYF
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHCCHHHHHHHHHHHC
GGIGAASHKGILFKGGNYLDAITQINTVVFDKTGTLTQGVFSVQAISAAEGVSQKELLQL
CCCCCCCCCCEEEECCCHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHH
IASIESFSNHPIAKAIVKYAEEQSISLNSSLKITEFAGYGIKAVTNGKEVYVGNTRLLSK
HHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCEEEECCCEEHHH
YGISFPYEISDMTETIVLCAMENKYLGYLSLADTPKPDAVQAIRELKDLNINNIQILSGD
HCCCCCEEHHHHHCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCC
KQTIVSNLAEKIGVTQAFGDLLPEGKVAHLEQLKANSENRVAFVGDGINDTPVLALSDVG
HHHHHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCEEEEECCC
IAMGGLGCDAAIETADVVIQTDQPSKVAEAIKIGKQTHRIVWQNISMAFGVKLLVLLLGA
HHHCCCCCCHHHCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
GGMATMWEAIFADVGVALLAIFNAMRIQKWKE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231; 9724772 [H]