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The map label for this gene is clcA [H]

Identifier: 150004961

GI number: 150004961

Start: 3111345

End: 3112943

Strand: Direct

Name: clcA [H]

Synonym: BVU_2424

Alternate gene names: 150004961

Gene position: 3111345-3112943 (Clockwise)

Preceding gene: 150004960

Following gene: 150004962

Centisome position: 60.26

GC content: 45.78

Gene sequence:

>1599_bases
ATGAAACTGGAGAAATGGAAAAACAAGTGGAAGGAGTGGAGCAATCTGCGCAAATGGCAAATATGGAAACTGAAGCTGAT
TGATGCCCGTCTGTATTTCGTGAGCATATTCGTGGGGCTGCTTACGGGACTGGTTGCTGTGCCTTATCACTATCTTCTCT
GGTATTTCTTTGATGTGCGGAAAACTTTTTTCACGGCGCATTATCCGTGGTATTGGCATGTATTGTTGTTTTTTATCTTA
TGGGGGATTCTGATCTTTGTCGCTTCTTTGGTAAAACGTATGCCATTGATAGCCGGAGGCGGTATTCCTCAGACACGTGC
GGCCAATAACGGTCGTATCCGTTATGAGCATCCTTTTAAGGAACTGGTGGCCAAATTCTGCGGAGGTGTGTTGGCTCTCA
GTGCGGGGCTGTCCTTGGGACGCGAGGGGCCGTCTGTTCAGATAGGGTCTTATATAGGAACACTTATCTCCCGTTGGGGA
CATATCCTGAAAGGGGAACGGAAACAATTGCTGGCTGCCGGAGCCGGTGCGGGCTTGTCTGCCGCTTTTGCCGCTCCGTT
GTCTTCTTCTTTGCTGGTAATAGAATCCATCGAGCGTTTTGATGCGCCTAAAACCGCCATTACTACCTTGTTGGCCGGCG
TGGTAGCCGGAGGAGTGGCTAGTTGGATGTTCCCCACGACTCCTTATCATCTGATTAGTGCGGTCGTTCCCGGTTTATCT
TTTATCCGTCAGGCAGAGCTTTATATTATCTTTGCCGCCCTTATGGCTGTCATTGCAAAGTTTTATTCGCTCATCGTTCC
TTTCTTTCAAGAAAGGATACCTGCCATGAAACTCTCCATTCCTGTCAAGATGTTGTATTTATTGATCATAGCTTATGCCA
TATCGTTAACAGAGACGAATCTGACAGGTGGCGGAGAGCAGTTTTTGATGATGCAGGGAATGAATGGAACTCATGATATC
CGGTGGCTTACTATCATGATGCTTATTCATTTTGTTTTTACGCTGTTTTCTCTTTCTTCGGGTTTGCCGGGAGGAAGTTT
CATTCCTACCTTGGTTACGGGAGGATTATTGGGACAAATCTTCGGGTTGGTATTGGTACAGCGCGGATGGATAGGGTATG
AGAATGTGAGTTATATGATGCTGATCGGGATGGTGGCTTTTTTGGTGGCTGTGGTGCGTACCCCTTTGACTGCCATTGTT
CTGATAACGGAGATTACCGGTCATTTCGAGGTGTTCTATCCTTCCATCGTGGTAGGTGGGTTGACTTATTATTTCACCGA
ATTGTTACAGATAAAACCTTACAATGTATTGCTGTATGACAGGATGTTCCGTAGCCATAATCCGAAGTCTTCCGAAGGGG
CTGGTGCCCGCTATCATCTTTTTGTCGAGATAATGGATGGGTCTTATTTTGACGGAAAGGAAGTGGATACATTGGCTTTA
CCTAATCATTGTATCATTCGTAGTATACACCGGAATCGTAAAAACTTACTTCCTCAGGGGCAAACCCTGGTTCCCGGTGA
TCAAGTGGAGATAGAAATGGATGCGCAGGATATAGAAAAATTATACGAACCGTTGGTCAGTATGGCAAATATCTATTAA

Upstream 100 bases:

>100_bases
AATGTTTGGAAGCGCTGAAAGCAAATGAAATAGAAATACCGGAACTATTAAAGCCATTGTTTAAATAAACCCTTCTCTTT
TCCATTTGTTTATTCCGGAT

Downstream 100 bases:

>100_bases
ATTTGCCGTATGAAAAAGAAATTCCAGCTTGAAGTTCCGGGAGGAGCCGACAAAGTGTTGCTTCATACTTGTTGTGCTCC
TTGTTCATCAGCCATCATAG

Product: putative transporter periplasmic binding protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MKLEKWKNKWKEWSNLRKWQIWKLKLIDARLYFVSIFVGLLTGLVAVPYHYLLWYFFDVRKTFFTAHYPWYWHVLLFFIL
WGILIFVASLVKRMPLIAGGGIPQTRAANNGRIRYEHPFKELVAKFCGGVLALSAGLSLGREGPSVQIGSYIGTLISRWG
HILKGERKQLLAAGAGAGLSAAFAAPLSSSLLVIESIERFDAPKTAITTLLAGVVAGGVASWMFPTTPYHLISAVVPGLS
FIRQAELYIIFAALMAVIAKFYSLIVPFFQERIPAMKLSIPVKMLYLLIIAYAISLTETNLTGGGEQFLMMQGMNGTHDI
RWLTIMMLIHFVFTLFSLSSGLPGGSFIPTLVTGGLLGQIFGLVLVQRGWIGYENVSYMMLIGMVAFLVAVVRTPLTAIV
LITEITGHFEVFYPSIVVGGLTYYFTELLQIKPYNVLLYDRMFRSHNPKSSEGAGARYHLFVEIMDGSYFDGKEVDTLAL
PNHCIIRSIHRNRKNLLPQGQTLVPGDQVEIEMDAQDIEKLYEPLVSMANIY

Sequences:

>Translated_532_residues
MKLEKWKNKWKEWSNLRKWQIWKLKLIDARLYFVSIFVGLLTGLVAVPYHYLLWYFFDVRKTFFTAHYPWYWHVLLFFIL
WGILIFVASLVKRMPLIAGGGIPQTRAANNGRIRYEHPFKELVAKFCGGVLALSAGLSLGREGPSVQIGSYIGTLISRWG
HILKGERKQLLAAGAGAGLSAAFAAPLSSSLLVIESIERFDAPKTAITTLLAGVVAGGVASWMFPTTPYHLISAVVPGLS
FIRQAELYIIFAALMAVIAKFYSLIVPFFQERIPAMKLSIPVKMLYLLIIAYAISLTETNLTGGGEQFLMMQGMNGTHDI
RWLTIMMLIHFVFTLFSLSSGLPGGSFIPTLVTGGLLGQIFGLVLVQRGWIGYENVSYMMLIGMVAFLVAVVRTPLTAIV
LITEITGHFEVFYPSIVVGGLTYYFTELLQIKPYNVLLYDRMFRSHNPKSSEGAGARYHLFVEIMDGSYFDGKEVDTLAL
PNHCIIRSIHRNRKNLLPQGQTLVPGDQVEIEMDAQDIEKLYEPLVSMANIY
>Mature_532_residues
MKLEKWKNKWKEWSNLRKWQIWKLKLIDARLYFVSIFVGLLTGLVAVPYHYLLWYFFDVRKTFFTAHYPWYWHVLLFFIL
WGILIFVASLVKRMPLIAGGGIPQTRAANNGRIRYEHPFKELVAKFCGGVLALSAGLSLGREGPSVQIGSYIGTLISRWG
HILKGERKQLLAAGAGAGLSAAFAAPLSSSLLVIESIERFDAPKTAITTLLAGVVAGGVASWMFPTTPYHLISAVVPGLS
FIRQAELYIIFAALMAVIAKFYSLIVPFFQERIPAMKLSIPVKMLYLLIIAYAISLTETNLTGGGEQFLMMQGMNGTHDI
RWLTIMMLIHFVFTLFSLSSGLPGGSFIPTLVTGGLLGQIFGLVLVQRGWIGYENVSYMMLIGMVAFLVAVVRTPLTAIV
LITEITGHFEVFYPSIVVGGLTYYFTELLQIKPYNVLLYDRMFRSHNPKSSEGAGARYHLFVEIMDGSYFDGKEVDTLAL
PNHCIIRSIHRNRKNLLPQGQTLVPGDQVEIEMDAQDIEKLYEPLVSMANIY

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557473, Length=399, Percent_Identity=27.8195488721804, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI189217923, Length=399, Percent_Identity=27.8195488721804, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI189217921, Length=399, Percent_Identity=27.8195488721804, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI153252026, Length=402, Percent_Identity=26.1194029850746, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1786350, Length=445, Percent_Identity=28.5393258426966, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71980828, Length=479, Percent_Identity=21.0855949895616, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71980824, Length=192, Percent_Identity=25, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71980820, Length=192, Percent_Identity=25, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17532615, Length=391, Percent_Identity=23.2736572890026, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24665008, Length=402, Percent_Identity=25.3731343283582, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI45551566, Length=355, Percent_Identity=26.1971830985915, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 59617; Mature: 59617

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLEKWKNKWKEWSNLRKWQIWKLKLIDARLYFVSIFVGLLTGLVAVPYHYLLWYFFDVR
CCCHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KTFFTAHYPWYWHVLLFFILWGILIFVASLVKRMPLIAGGGIPQTRAANNGRIRYEHPFK
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCEEEEECCHH
ELVAKFCGGVLALSAGLSLGREGPSVQIGSYIGTLISRWGHILKGERKQLLAAGAGAGLS
HHHHHHHCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCH
AAFAAPLSSSLLVIESIERFDAPKTAITTLLAGVVAGGVASWMFPTTPYHLISAVVPGLS
HHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
FIRQAELYIIFAALMAVIAKFYSLIVPFFQERIPAMKLSIPVKMLYLLIIAYAISLTETN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHCCC
LTGGGEQFLMMQGMNGTHDIRWLTIMMLIHFVFTLFSLSSGLPGGSFIPTLVTGGLLGQI
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
FGLVLVQRGWIGYENVSYMMLIGMVAFLVAVVRTPLTAIVLITEITGHFEVFYPSIVVGG
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHH
LTYYFTELLQIKPYNVLLYDRMFRSHNPKSSEGAGARYHLFVEIMDGSYFDGKEVDTLAL
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCEEEC
PNHCIIRSIHRNRKNLLPQGQTLVPGDQVEIEMDAQDIEKLYEPLVSMANIY
CCHHHHHHHHHHHHHCCCCCCEECCCCCEEEEECHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLEKWKNKWKEWSNLRKWQIWKLKLIDARLYFVSIFVGLLTGLVAVPYHYLLWYFFDVR
CCCHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KTFFTAHYPWYWHVLLFFILWGILIFVASLVKRMPLIAGGGIPQTRAANNGRIRYEHPFK
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCEEEEECCHH
ELVAKFCGGVLALSAGLSLGREGPSVQIGSYIGTLISRWGHILKGERKQLLAAGAGAGLS
HHHHHHHCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCH
AAFAAPLSSSLLVIESIERFDAPKTAITTLLAGVVAGGVASWMFPTTPYHLISAVVPGLS
HHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
FIRQAELYIIFAALMAVIAKFYSLIVPFFQERIPAMKLSIPVKMLYLLIIAYAISLTETN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHCCC
LTGGGEQFLMMQGMNGTHDIRWLTIMMLIHFVFTLFSLSSGLPGGSFIPTLVTGGLLGQI
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
FGLVLVQRGWIGYENVSYMMLIGMVAFLVAVVRTPLTAIVLITEITGHFEVFYPSIVVGG
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHH
LTYYFTELLQIKPYNVLLYDRMFRSHNPKSSEGAGARYHLFVEIMDGSYFDGKEVDTLAL
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCEEEC
PNHCIIRSIHRNRKNLLPQGQTLVPGDQVEIEMDAQDIEKLYEPLVSMANIY
CCHHHHHHHHHHHHHCCCCCCEECCCCCEEEEECHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA