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The map label for this gene is pepD [H]

Identifier: 150004909

GI number: 150004909

Start: 3050027

End: 3051484

Strand: Direct

Name: pepD [H]

Synonym: BVU_2372

Alternate gene names: 150004909

Gene position: 3050027-3051484 (Clockwise)

Preceding gene: 150004904

Following gene: 150004910

Centisome position: 59.07

GC content: 41.98

Gene sequence:

>1458_bases
ATGAATGAAAAGAATTTAAAGCCTGCATCTGTCTTTTATTATTTTGAAGAGATATGTAAGGTACCCCGTCCCTCTAAAAG
AGAGGAGAAAATAATTGCTTATTTGAAAGCCTTCGGTAGAGAACATGGTTTGGAAACCAAGACAGATGAAGTAGGCAATG
TATTAATTAAAAAGCCTGCCACTCCGGGTAAGGAGAATTTGAAAACTGTGATTTTGCAGTCTCATATAGATATGGTTTGT
GAAAAAAACAGTGATGTGGAGCATGATTTTCTAATTGATCCTATTGAAACAGTGGTGGACGGTGAATGGTTGAAAGCCAA
AGGTACTACATTGGGGGCGGATAATGGTATCGGTGTGGCGACAGAATTAGCTATATTGGCTGCTACTGATATAGAGCATG
GTCCGCTAGAGTGTCTTTTCACGGTGGATGAAGAAACTGGATTGACAGGTGCTTTTGCATTGAAGCCAGGGTTTATGACT
GGTGATATTCTGATTAATTTGGACTCGGAAGATGAAGGAGAATTATTTATCGGCTGTGCCGGTGGTGCAAATACTACAGC
GGAATTTACTTATCAGCCTGTTTCTGCCCCACAGGATTATTTCTATTTCCGTGTGGCGGTCAAGGGATTGACTGGTGGGC
ACTCCGGTGATGATATTAATAAAGGTAGAGCGAATGCCAATAAGCTGCTGAATCGTTTTCTGACCCAGTTGGCTTCTAAA
TATATTTTATATTTATGTGAGATTGATGGTGGAAACCTGCATAATGCCATACCTCGTGAGGCACAGGCATTATGTGCGGT
ACCTATGAAGGATAAGGAATCGGTTCGTGTAGATTTGAATATCTATACCGCAGAACTGGAGAATGAATATGCTGCGACAG
AACCGAACTTGAGAACCGAACTCTCTTCTGAATCCCCTTGTAAGGAAGCGATAGATATGACTACTGCCGGACACCTTCTG
AGAGCTGTTTACGCTGTGCACAATGGAGTGTATGCCATGAGTCAGGATATTCCGGGATTAGTAGAAACTTCGTCTAATCT
TGCTTCCATCAAACAGGTAGAGGGAAACAAGATTAAAATAGTGACTAGCCAGCGCAGCTCCATTCTTTCATCACGCAAGG
ATATGTCCGAGATGATCCGTTCTGCTTTTCTTTTGGGAGGTGCTGAAGTAACAACTGGTGAAGGCTATCCAGGGTGGAAA
CCGAATACGGATTCTCCAGTTTTGAAAGTTGCGGTAGATAGCTATAAAAAACTTTTTGGTGTGGAACCTAAAGTAAAGGC
AATTCATGCCGGATTGGAGTGTGGTTTGTTCCTTGAGAAATATCCGTCACTGGATATGGTTTCTTTTGGACCTACTCTGC
GTGGTGTTCATTCACCTGATGAGCGTATGCTGATACCTACTGTAGATAAATTCTGGCGTCATTTGCTGGATGTATTGGTT
AATATACCGACAAAATAA

Upstream 100 bases:

>100_bases
TTCTCTTTTTTCATTAAAAAAGAGGAAGTGTCCTATTTAAGAGAATTATTTAACCATTTTTTGCAAATTTGGAAACTGAA
TTTTCCTAAACGACATGATT

Downstream 100 bases:

>100_bases
TTTATATGAAGAAAACAATTTTATTTCTTTGTTTGTGCTACCTGGTAGGGGTGACGTATGCACAGGAACCGTTTCGGGTA
ATGTTCTATAATGTAGAGAA

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MNEKNLKPASVFYYFEEICKVPRPSKREEKIIAYLKAFGREHGLETKTDEVGNVLIKKPATPGKENLKTVILQSHIDMVC
EKNSDVEHDFLIDPIETVVDGEWLKAKGTTLGADNGIGVATELAILAATDIEHGPLECLFTVDEETGLTGAFALKPGFMT
GDILINLDSEDEGELFIGCAGGANTTAEFTYQPVSAPQDYFYFRVAVKGLTGGHSGDDINKGRANANKLLNRFLTQLASK
YILYLCEIDGGNLHNAIPREAQALCAVPMKDKESVRVDLNIYTAELENEYAATEPNLRTELSSESPCKEAIDMTTAGHLL
RAVYAVHNGVYAMSQDIPGLVETSSNLASIKQVEGNKIKIVTSQRSSILSSRKDMSEMIRSAFLLGGAEVTTGEGYPGWK
PNTDSPVLKVAVDSYKKLFGVEPKVKAIHAGLECGLFLEKYPSLDMVSFGPTLRGVHSPDERMLIPTVDKFWRHLLDVLV
NIPTK

Sequences:

>Translated_485_residues
MNEKNLKPASVFYYFEEICKVPRPSKREEKIIAYLKAFGREHGLETKTDEVGNVLIKKPATPGKENLKTVILQSHIDMVC
EKNSDVEHDFLIDPIETVVDGEWLKAKGTTLGADNGIGVATELAILAATDIEHGPLECLFTVDEETGLTGAFALKPGFMT
GDILINLDSEDEGELFIGCAGGANTTAEFTYQPVSAPQDYFYFRVAVKGLTGGHSGDDINKGRANANKLLNRFLTQLASK
YILYLCEIDGGNLHNAIPREAQALCAVPMKDKESVRVDLNIYTAELENEYAATEPNLRTELSSESPCKEAIDMTTAGHLL
RAVYAVHNGVYAMSQDIPGLVETSSNLASIKQVEGNKIKIVTSQRSSILSSRKDMSEMIRSAFLLGGAEVTTGEGYPGWK
PNTDSPVLKVAVDSYKKLFGVEPKVKAIHAGLECGLFLEKYPSLDMVSFGPTLRGVHSPDERMLIPTVDKFWRHLLDVLV
NIPTK
>Mature_485_residues
MNEKNLKPASVFYYFEEICKVPRPSKREEKIIAYLKAFGREHGLETKTDEVGNVLIKKPATPGKENLKTVILQSHIDMVC
EKNSDVEHDFLIDPIETVVDGEWLKAKGTTLGADNGIGVATELAILAATDIEHGPLECLFTVDEETGLTGAFALKPGFMT
GDILINLDSEDEGELFIGCAGGANTTAEFTYQPVSAPQDYFYFRVAVKGLTGGHSGDDINKGRANANKLLNRFLTQLASK
YILYLCEIDGGNLHNAIPREAQALCAVPMKDKESVRVDLNIYTAELENEYAATEPNLRTELSSESPCKEAIDMTTAGHLL
RAVYAVHNGVYAMSQDIPGLVETSSNLASIKQVEGNKIKIVTSQRSSILSSRKDMSEMIRSAFLLGGAEVTTGEGYPGWK
PNTDSPVLKVAVDSYKKLFGVEPKVKAIHAGLECGLFLEKYPSLDMVSFGPTLRGVHSPDERMLIPTVDKFWRHLLDVLV
NIPTK

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=481, Percent_Identity=44.4906444906445, Blast_Score=419, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 53120; Mature: 53120

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEKNLKPASVFYYFEEICKVPRPSKREEKIIAYLKAFGREHGLETKTDEVGNVLIKKPA
CCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCEEEECCC
TPGKENLKTVILQSHIDMVCEKNSDVEHDFLIDPIETVVDGEWLKAKGTTLGADNGIGVA
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHCCCEEEECCCEECCCCCCCHH
TELAILAATDIEHGPLECLFTVDEETGLTGAFALKPGFMTGDILINLDSEDEGELFIGCA
HHEEEEEECCCCCCCEEEEEEECCCCCCEEEEEECCCCEECEEEEEECCCCCCCEEEEEC
GGANTTAEFTYQPVSAPQDYFYFRVAVKGLTGGHSGDDINKGRANANKLLNRFLTQLASK
CCCCCCEEEEECCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
YILYLCEIDGGNLHNAIPREAQALCAVPMKDKESVRVDLNIYTAELENEYAATEPNLRTE
EEEEEEEECCCCCCCCCCHHHHHEEECCCCCCCCEEEEEEEEEEEECCCCCCCCCCCHHC
LSSESPCKEAIDMTTAGHLLRAVYAVHNGVYAMSQDIPGLVETSSNLASIKQVEGNKIKI
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHCCCCHHHHHHCCCCEEEE
VTSQRSSILSSRKDMSEMIRSAFLLGGAEVTTGEGYPGWKPNTDSPVLKVAVDSYKKLFG
EECCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHC
VEPKVKAIHAGLECGLFLEKYPSLDMVSFGPTLRGVHSPDERMLIPTVDKFWRHLLDVLV
CCCHHHHHHCCCHHCCHHHHCCCCCEEECCCCCCCCCCCCCCEECCCHHHHHHHHHHHHH
NIPTK
CCCCC
>Mature Secondary Structure
MNEKNLKPASVFYYFEEICKVPRPSKREEKIIAYLKAFGREHGLETKTDEVGNVLIKKPA
CCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCEEEECCC
TPGKENLKTVILQSHIDMVCEKNSDVEHDFLIDPIETVVDGEWLKAKGTTLGADNGIGVA
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHCCCEEEECCCEECCCCCCCHH
TELAILAATDIEHGPLECLFTVDEETGLTGAFALKPGFMTGDILINLDSEDEGELFIGCA
HHEEEEEECCCCCCCEEEEEEECCCCCCEEEEEECCCCEECEEEEEECCCCCCCEEEEEC
GGANTTAEFTYQPVSAPQDYFYFRVAVKGLTGGHSGDDINKGRANANKLLNRFLTQLASK
CCCCCCEEEEECCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
YILYLCEIDGGNLHNAIPREAQALCAVPMKDKESVRVDLNIYTAELENEYAATEPNLRTE
EEEEEEEECCCCCCCCCCHHHHHEEECCCCCCCCEEEEEEEEEEEECCCCCCCCCCCHHC
LSSESPCKEAIDMTTAGHLLRAVYAVHNGVYAMSQDIPGLVETSSNLASIKQVEGNKIKI
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHCCCCHHHHHHCCCCEEEE
VTSQRSSILSSRKDMSEMIRSAFLLGGAEVTTGEGYPGWKPNTDSPVLKVAVDSYKKLFG
EECCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHC
VEPKVKAIHAGLECGLFLEKYPSLDMVSFGPTLRGVHSPDERMLIPTVDKFWRHLLDVLV
CCCHHHHHHCCCHHCCHHHHCCCCCEEECCCCCCCCCCCCCCEECCCHHHHHHHHHHHHH
NIPTK
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]