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The map label for this gene is trxA [H]

Identifier: 150004906

GI number: 150004906

Start: 3048526

End: 3048822

Strand: Reverse

Name: trxA [H]

Synonym: BVU_2369

Alternate gene names: 150004906

Gene position: 3048822-3048526 (Counterclockwise)

Preceding gene: 150004907

Following gene: 150004905

Centisome position: 59.05

GC content: 35.35

Gene sequence:

>297_bases
ATGGAAAGATTTGAAGATTTAATCACCTCAAACATCCCTGTATTAGTTGATTTTTTTGCTGAATGGTGCGGACCTTGCAA
AGCCATGAAACCTATTTTAGAAGAATTAAAAGGAATAAAAGGGGAAAAAGTAAGAATTGTCAAGGTAGATGTAGACAAAC
ATAAAGAAATTGCTGCATACTATCAGATTCAGTCAGTTCCCACACTAATGATTTTTAAAAACGGTAAGCAATTGTGGCGA
CAAAGCGGTGTAATGCGTGCCAATGATTTAAGCACTATTCTAGCCCAATATGAGTAA

Upstream 100 bases:

>100_bases
TATGTAAAGCCGGAACAGTCTACTGTTCCGGCTTTACTTTTAAACAAAAAGCACCCTATAAACGTTTTTATTATAATAAA
AATAACGAAAGGAGAACATT

Downstream 100 bases:

>100_bases
AATATGAAGAAAACAATCACATGTATTCTATTAACTGCCGGATTAACGGGATATCTCAGTGCCCAAACTCCTGTCCAGGA
TAAGTCAGATAAAAATTCAG

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 98; Mature: 98

Protein sequence:

>98_residues
MERFEDLITSNIPVLVDFFAEWCGPCKAMKPILEELKGIKGEKVRIVKVDVDKHKEIAAYYQIQSVPTLMIFKNGKQLWR
QSGVMRANDLSTILAQYE

Sequences:

>Translated_98_residues
MERFEDLITSNIPVLVDFFAEWCGPCKAMKPILEELKGIKGEKVRIVKVDVDKHKEIAAYYQIQSVPTLMIFKNGKQLWR
QSGVMRANDLSTILAQYE
>Mature_98_residues
MERFEDLITSNIPVLVDFFAEWCGPCKAMKPILEELKGIKGEKVRIVKVDVDKHKEIAAYYQIQSVPTLMIFKNGKQLWR
QSGVMRANDLSTILAQYE

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=39.1304347826087, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788936, Length=75, Percent_Identity=42.6666666666667, Blast_Score=82, Evalue=6e-18,
Organism=Escherichia coli, GI87082331, Length=89, Percent_Identity=37.0786516853933, Blast_Score=75, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI212646193, Length=81, Percent_Identity=46.9135802469136, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25144092, Length=81, Percent_Identity=39.5061728395062, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=88, Percent_Identity=34.0909090909091, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI32566189, Length=79, Percent_Identity=34.1772151898734, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17569137, Length=79, Percent_Identity=34.1772151898734, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=79, Percent_Identity=34.1772151898734, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=85, Percent_Identity=35.2941176470588, Blast_Score=66, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6319925, Length=83, Percent_Identity=37.3493975903614, Blast_Score=65, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=77, Percent_Identity=37.6623376623377, Blast_Score=64, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28573567, Length=78, Percent_Identity=44.8717948717949, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17648013, Length=70, Percent_Identity=45.7142857142857, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583090, Length=70, Percent_Identity=45.7142857142857, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21358065, Length=76, Percent_Identity=42.1052631578947, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24639826, Length=65, Percent_Identity=41.5384615384615, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24664269, Length=74, Percent_Identity=39.1891891891892, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17530795, Length=71, Percent_Identity=33.8028169014084, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24639068, Length=88, Percent_Identity=31.8181818181818, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 11303; Mature: 11303

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERFEDLITSNIPVLVDFFAEWCGPCKAMKPILEELKGIKGEKVRIVKVDVDKHKEIAAY
CCHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHH
YQIQSVPTLMIFKNGKQLWRQSGVMRANDLSTILAQYE
HHHCCCCEEEEEECCHHHHHHCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MERFEDLITSNIPVLVDFFAEWCGPCKAMKPILEELKGIKGEKVRIVKVDVDKHKEIAAY
CCHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHH
YQIQSVPTLMIFKNGKQLWRQSGVMRANDLSTILAQYE
HHHCCCCEEEEEECCHHHHHHCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]