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The map label for this gene is hisB [H]

Identifier: 150004901

GI number: 150004901

Start: 3043623

End: 3044741

Strand: Direct

Name: hisB [H]

Synonym: BVU_2364

Alternate gene names: 150004901

Gene position: 3043623-3044741 (Clockwise)

Preceding gene: 150004900

Following gene: 150004903

Centisome position: 58.95

GC content: 41.47

Gene sequence:

>1119_bases
ATGAAGAAAGCGTTGTTTATAGATCGTGACGGTACGTTGGTTATAGAGCCACCGGTTGACTACCAATTGGATTCTTTCCA
TAAATTGGAGTTTTATCCTAAGGTATTTCGTAATTTGGGATTTATCCGCAGCAAACTCGACTTTGAATTTGTGATGGTTA
CCAATCAAGACGGCCTCGGTACTTCTTCTTTTCCTGAGGATACCTTTTGGCCGGTGCACAACCTGGTGTTGAAGACATTG
GAGGGGGAAGGCATCATTTTTGATGATATCTTGATAGACCGCAGTTTTCCGGAAGACCATGTGTCTACCCGTAAGCCTGG
AACAGGAATGATGGGAAAATATCTTATCGGTGATTATGATTTGGCAAACAGTTTTGTTATTGGTGATCGTGCTACAGATG
TGGAACTGGCTAAAAATATGGGCTGTAAGGCTATTTTGTTGCAAGAAAATATGGATATTCTGAAGGAAAAGAACTTGGAA
TCCTACTGTGTATTGGCGACTACGGATTGGGATAAGGTCGCTGAATTCCTTTTTGCCGGAGAACGTATAACGGAGGTCCG
TCGTACTACGAAGGAAACGGATATTTATATCAGTTTAAATTTAGATGGCAGCGGAAAATGTGATATTTCCACAGGTATTG
GTTTTTTTGATCACATGTTGGAACAGATTGGAAAGCATGGTGGTATTGACCTGACCATTAAAGTAAAAGGTGATTTGGAA
GTGGACGAACATCATACTATTGAAGATACCGCCATTGCTTTGGGTGAATGTATTTATCGGGCATTGGGCAGCAAGCGTGG
CATTGAGCGTTACGGATATTGCTTGCCCATGGATGATTGTCTTTGTCGGGTAGCTTTGGATTTTGGCGGTAGAGCATGGT
TGGTATGGGATGCTGAGTTTCATCGGGAGAAAATAGGGGAGATGCCTACCGAGATGTTTCTTCATTTTTTTAAATCATTG
AGTGATGCAGCTCGTATGAATTTAAATATCAAAGCCGAGGGGCAGAATGAGCATCATAAAATAGAAGGTATTTTCAAAGC
TTTGGCTCGTGCCATAAAGATGGCTGTGCGAAGAGATATTTACCATTTTGAAGTACCCTCAAGCAAGGGATGTATTTAA

Upstream 100 bases:

>100_bases
CAGTATTTCTTTATGTCGTGATTGTTTGCGTGTGACTATTGGTACACGTCCGGAGAATGATATGTTGTTGGAAGCATTGA
AGAATTATGAATGTTGAAGT

Downstream 100 bases:

>100_bases
GTCGGCTTCAAAGACAAAGTAACTTAACTTAGTTGGGCGAGTAAGTTAAGTTACTTTGTCTTTGAAGCCGACTTACTTTT
TTATGTGGTTTATAGCTCTT

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MKKALFIDRDGTLVIEPPVDYQLDSFHKLEFYPKVFRNLGFIRSKLDFEFVMVTNQDGLGTSSFPEDTFWPVHNLVLKTL
EGEGIIFDDILIDRSFPEDHVSTRKPGTGMMGKYLIGDYDLANSFVIGDRATDVELAKNMGCKAILLQENMDILKEKNLE
SYCVLATTDWDKVAEFLFAGERITEVRRTTKETDIYISLNLDGSGKCDISTGIGFFDHMLEQIGKHGGIDLTIKVKGDLE
VDEHHTIEDTAIALGECIYRALGSKRGIERYGYCLPMDDCLCRVALDFGGRAWLVWDAEFHREKIGEMPTEMFLHFFKSL
SDAARMNLNIKAEGQNEHHKIEGIFKALARAIKMAVRRDIYHFEVPSSKGCI

Sequences:

>Translated_372_residues
MKKALFIDRDGTLVIEPPVDYQLDSFHKLEFYPKVFRNLGFIRSKLDFEFVMVTNQDGLGTSSFPEDTFWPVHNLVLKTL
EGEGIIFDDILIDRSFPEDHVSTRKPGTGMMGKYLIGDYDLANSFVIGDRATDVELAKNMGCKAILLQENMDILKEKNLE
SYCVLATTDWDKVAEFLFAGERITEVRRTTKETDIYISLNLDGSGKCDISTGIGFFDHMLEQIGKHGGIDLTIKVKGDLE
VDEHHTIEDTAIALGECIYRALGSKRGIERYGYCLPMDDCLCRVALDFGGRAWLVWDAEFHREKIGEMPTEMFLHFFKSL
SDAARMNLNIKAEGQNEHHKIEGIFKALARAIKMAVRRDIYHFEVPSSKGCI
>Mature_372_residues
MKKALFIDRDGTLVIEPPVDYQLDSFHKLEFYPKVFRNLGFIRSKLDFEFVMVTNQDGLGTSSFPEDTFWPVHNLVLKTL
EGEGIIFDDILIDRSFPEDHVSTRKPGTGMMGKYLIGDYDLANSFVIGDRATDVELAKNMGCKAILLQENMDILKEKNLE
SYCVLATTDWDKVAEFLFAGERITEVRRTTKETDIYISLNLDGSGKCDISTGIGFFDHMLEQIGKHGGIDLTIKVKGDLE
VDEHHTIEDTAIALGECIYRALGSKRGIERYGYCLPMDDCLCRVALDFGGRAWLVWDAEFHREKIGEMPTEMFLHFFKSL
SDAARMNLNIKAEGQNEHHKIEGIFKALARAIKMAVRRDIYHFEVPSSKGCI

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=372, Percent_Identity=45.6989247311828, Blast_Score=329, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6324776, Length=213, Percent_Identity=37.0892018779343, Blast_Score=145, Evalue=8e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =3.1.3.15; =4.2.1.19 [H]

Molecular weight: Translated: 42234; Mature: 42234

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKALFIDRDGTLVIEPPVDYQLDSFHKLEFYPKVFRNLGFIRSKLDFEFVMVTNQDGLG
CCCCEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCC
TSSFPEDTFWPVHNLVLKTLEGEGIIFDDILIDRSFPEDHVSTRKPGTGMMGKYLIGDYD
CCCCCCCCCHHHHHHHHHHCCCCCEEEEHEEEECCCCHHHCCCCCCCCCCCCCCEECCCC
LANSFVIGDRATDVELAKNMGCKAILLQENMDILKEKNLESYCVLATTDWDKVAEFLFAG
CCCEEEECCCCCHHHHHHCCCCEEEEEECCHHHHHHCCCCCEEEEEECCHHHHHHHHHCC
ERITEVRRTTKETDIYISLNLDGSGKCDISTGIGFFDHMLEQIGKHGGIDLTIKVKGDLE
HHHHHHHHCCCCCEEEEEEEECCCCCEEECCCCHHHHHHHHHHCCCCCEEEEEEEECCCC
VDEHHTIEDTAIALGECIYRALGSKRGIERYGYCLPMDDCLCRVALDFGGRAWLVWDAEF
CCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHCCCCEEEEEECHHH
HREKIGEMPTEMFLHFFKSLSDAARMNLNIKAEGQNEHHKIEGIFKALARAIKMAVRRDI
HHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC
YHFEVPSSKGCI
EEEECCCCCCCC
>Mature Secondary Structure
MKKALFIDRDGTLVIEPPVDYQLDSFHKLEFYPKVFRNLGFIRSKLDFEFVMVTNQDGLG
CCCCEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCC
TSSFPEDTFWPVHNLVLKTLEGEGIIFDDILIDRSFPEDHVSTRKPGTGMMGKYLIGDYD
CCCCCCCCCHHHHHHHHHHCCCCCEEEEHEEEECCCCHHHCCCCCCCCCCCCCCEECCCC
LANSFVIGDRATDVELAKNMGCKAILLQENMDILKEKNLESYCVLATTDWDKVAEFLFAG
CCCEEEECCCCCHHHHHHCCCCEEEEEECCHHHHHHCCCCCEEEEEECCHHHHHHHHHCC
ERITEVRRTTKETDIYISLNLDGSGKCDISTGIGFFDHMLEQIGKHGGIDLTIKVKGDLE
HHHHHHHHCCCCCEEEEEEEECCCCCEEECCCCHHHHHHHHHHCCCCCEEEEEEEECCCC
VDEHHTIEDTAIALGECIYRALGSKRGIERYGYCLPMDDCLCRVALDFGGRAWLVWDAEF
CCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHCCCCEEEEEECHHH
HREKIGEMPTEMFLHFFKSLSDAARMNLNIKAEGQNEHHKIEGIFKALARAIKMAVRRDI
HHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC
YHFEVPSSKGCI
EEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA