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The map label for this gene is mro [H]

Identifier: 150004763

GI number: 150004763

Start: 2876396

End: 2877529

Strand: Direct

Name: mro [H]

Synonym: BVU_2225

Alternate gene names: 150004763

Gene position: 2876396-2877529 (Clockwise)

Preceding gene: 150004762

Following gene: 150004764

Centisome position: 55.71

GC content: 36.77

Gene sequence:

>1134_bases
ATGAATAAGCTGTTCTTTTGGGTATGTGCAGTCCTTATGACTGCATGTGCTTCTTATAAAAATGATGAGGTCTTGACTGA
ATCCGGTTTAAGTAACAGTCGTTTTCAAACGGAGATAAATGGTGAGAAAACTGATCTGTTTGTATTGAAGAATAAAAATA
AGATGGAAGTTTGTATCACCAACTATGGCGGTCGTATTGTTTCTGTTATGGTTCCTGATAAAGATGGAATAATGAGGGAT
GTAGTATTGGGTTTTGATTCCATACAGGACTATATCAAATATCCGTCGGATTTTGGAGCAAGTATAGGGCGTTATGCCAA
CCGTATAAATCAGGGACGTTTTTCATTGGATGGGATAGTATACCAATTGCCTCGAAACAATTACGGACATTGTTTGCATG
GAGGTCCTCAAGGATTTCAATATCGTATTTATAGAGGTATTCAAGTGAGTGACAGAGAGGTGAAACTGACTTACTTGTCT
AAAAATGGTGAAGAGGGTTTTCCTGGAAATTTGAATTGTACTATTATAATGAAATTGACGGACGATAATGCTATTGATAT
TCAGTATGAAGCAGAAACGGATAAACCGACTGTTGTAAACATGACTAATCATTCTTATTTTAATTTAGATGGAGATCCGT
CAAAAGATAATTCTGATTATTTATTGACTTTGAACGCGGATTATTATACTCCTGTTGACAGTACTTTTATGACGACTGGA
GAAATTGTTCCGGTTGAGGGTACTCCTATGGATTTCAGACTTCCTGCTGTCATTGGAACTCGTATTAATCAAGATTTTGA
ACAATTAAGATATGGGAATGGCATTGATCATAATTGGGTATTGAATACTAAGGGGGATATTCATCAAGTTTGTGCCACAT
TGGAGTCACCTGTTACGGGGATTGTACTCAATGTTTATACTGACGAGCCGGGTATTCAGGTTTATTGTGGTAATTTTCTA
GATGGGACATTGACGGGTAAAAAAAATACAATATATAATTTTCGGGCCTCTGTGTGCTTGGAAACGCAAAAATATCCCGA
TACACCTAATAAGGCAGACTGGCCTACGGCAGTAGTGAGACCAGGAGAAAAATATCAAAGTCATTGTATTTACAAGTTTT
CGGTACATAAATAA

Upstream 100 bases:

>100_bases
TGAACGGACTGATGACTTATGATCGTAAGGTGATTAAAGTAGATGAAAAACGAGTGAGAGAAGCCAACGCACGTATCTGT
AAATCATTAAAGTAAGGAAT

Downstream 100 bases:

>100_bases
TGTATGTTAAGGTAGAAGGAATTGTGGAATATAACATTTGGGATAAATAAGATTCAGAGAGGAAGAGTCCTGAAAGAAGC
GGTGAGAGTAAACACTGGTT

Product: aldose 1-epimerase precursor

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MNKLFFWVCAVLMTACASYKNDEVLTESGLSNSRFQTEINGEKTDLFVLKNKNKMEVCITNYGGRIVSVMVPDKDGIMRD
VVLGFDSIQDYIKYPSDFGASIGRYANRINQGRFSLDGIVYQLPRNNYGHCLHGGPQGFQYRIYRGIQVSDREVKLTYLS
KNGEEGFPGNLNCTIIMKLTDDNAIDIQYEAETDKPTVVNMTNHSYFNLDGDPSKDNSDYLLTLNADYYTPVDSTFMTTG
EIVPVEGTPMDFRLPAVIGTRINQDFEQLRYGNGIDHNWVLNTKGDIHQVCATLESPVTGIVLNVYTDEPGIQVYCGNFL
DGTLTGKKNTIYNFRASVCLETQKYPDTPNKADWPTAVVRPGEKYQSHCIYKFSVHK

Sequences:

>Translated_377_residues
MNKLFFWVCAVLMTACASYKNDEVLTESGLSNSRFQTEINGEKTDLFVLKNKNKMEVCITNYGGRIVSVMVPDKDGIMRD
VVLGFDSIQDYIKYPSDFGASIGRYANRINQGRFSLDGIVYQLPRNNYGHCLHGGPQGFQYRIYRGIQVSDREVKLTYLS
KNGEEGFPGNLNCTIIMKLTDDNAIDIQYEAETDKPTVVNMTNHSYFNLDGDPSKDNSDYLLTLNADYYTPVDSTFMTTG
EIVPVEGTPMDFRLPAVIGTRINQDFEQLRYGNGIDHNWVLNTKGDIHQVCATLESPVTGIVLNVYTDEPGIQVYCGNFL
DGTLTGKKNTIYNFRASVCLETQKYPDTPNKADWPTAVVRPGEKYQSHCIYKFSVHK
>Mature_377_residues
MNKLFFWVCAVLMTACASYKNDEVLTESGLSNSRFQTEINGEKTDLFVLKNKNKMEVCITNYGGRIVSVMVPDKDGIMRD
VVLGFDSIQDYIKYPSDFGASIGRYANRINQGRFSLDGIVYQLPRNNYGHCLHGGPQGFQYRIYRGIQVSDREVKLTYLS
KNGEEGFPGNLNCTIIMKLTDDNAIDIQYEAETDKPTVVNMTNHSYFNLDGDPSKDNSDYLLTLNADYYTPVDSTFMTTG
EIVPVEGTPMDFRLPAVIGTRINQDFEQLRYGNGIDHNWVLNTKGDIHQVCATLESPVTGIVLNVYTDEPGIQVYCGNFL
DGTLTGKKNTIYNFRASVCLETQKYPDTPNKADWPTAVVRPGEKYQSHCIYKFSVHK

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=321, Percent_Identity=42.0560747663551, Blast_Score=252, Evalue=5e-67,
Organism=Escherichia coli, GI1786971, Length=336, Percent_Identity=39.8809523809524, Blast_Score=235, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17557428, Length=328, Percent_Identity=31.7073170731707, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI115533334, Length=328, Percent_Identity=31.7073170731707, Blast_Score=174, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6322004, Length=353, Percent_Identity=27.7620396600567, Blast_Score=106, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6319493, Length=352, Percent_Identity=27.2727272727273, Blast_Score=106, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6324399, Length=357, Percent_Identity=26.6106442577031, Blast_Score=99, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24659048, Length=340, Percent_Identity=37.0588235294118, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24583720, Length=337, Percent_Identity=34.7181008902077, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24668278, Length=343, Percent_Identity=34.9854227405248, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24668282, Length=345, Percent_Identity=34.7826086956522, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24641876, Length=344, Percent_Identity=29.9418604651163, Blast_Score=145, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 42507; Mature: 42507

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKLFFWVCAVLMTACASYKNDEVLTESGLSNSRFQTEINGEKTDLFVLKNKNKMEVCIT
CCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEECCCEEEEEEEECCCCEEEEEE
NYGGRIVSVMVPDKDGIMRDVVLGFDSIQDYIKYPSDFGASIGRYANRINQGRFSLDGIV
ECCCEEEEEEECCCCCCHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCEE
YQLPRNNYGHCLHGGPQGFQYRIYRGIQVSDREVKLTYLSKNGEEGFPGNLNCTIIMKLT
EECCCCCCCCEECCCCCCCEEEEEECEEECCCEEEEEEEECCCCCCCCCCCEEEEEEEEC
DDNAIDIQYEAETDKPTVVNMTNHSYFNLDGDPSKDNSDYLLTLNADYYTPVDSTFMTTG
CCCEEEEEEECCCCCCEEEEECCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCEEECC
EIVPVEGTPMDFRLPAVIGTRINQDFEQLRYGNGIDHNWVLNTKGDIHQVCATLESPVTG
CEEECCCCCCCEECHHHHCCCCCCCHHHHHCCCCCCCCEEEECCCHHHHHHHHHCCCCEE
IVLNVYTDEPGIQVYCGNFLDGTLTGKKNTIYNFRASVCLETQKYPDTPNKADWPTAVVR
EEEEEEECCCCCEEEECCCCCCEECCCCCEEEEEEEEEEEECCCCCCCCCCCCCCEEEEC
PGEKYQSHCIYKFSVHK
CCHHHCCEEEEEEEECC
>Mature Secondary Structure
MNKLFFWVCAVLMTACASYKNDEVLTESGLSNSRFQTEINGEKTDLFVLKNKNKMEVCIT
CCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEECCCEEEEEEEECCCCEEEEEE
NYGGRIVSVMVPDKDGIMRDVVLGFDSIQDYIKYPSDFGASIGRYANRINQGRFSLDGIV
ECCCEEEEEEECCCCCCHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCEE
YQLPRNNYGHCLHGGPQGFQYRIYRGIQVSDREVKLTYLSKNGEEGFPGNLNCTIIMKLT
EECCCCCCCCEECCCCCCCEEEEEECEEECCCEEEEEEEECCCCCCCCCCCEEEEEEEEC
DDNAIDIQYEAETDKPTVVNMTNHSYFNLDGDPSKDNSDYLLTLNADYYTPVDSTFMTTG
CCCEEEEEEECCCCCCEEEEECCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCEEECC
EIVPVEGTPMDFRLPAVIGTRINQDFEQLRYGNGIDHNWVLNTKGDIHQVCATLESPVTG
CEEECCCCCCCEECHHHHCCCCCCCHHHHHCCCCCCCCEEEECCCHHHHHHHHHCCCCEE
IVLNVYTDEPGIQVYCGNFLDGTLTGKKNTIYNFRASVCLETQKYPDTPNKADWPTAVVR
EEEEEEECCCCCEEEECCCCCCEECCCCCEEEEEEEEEEEECCCCCCCCCCCCCCEEEEC
PGEKYQSHCIYKFSVHK
CCHHHCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]