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The map label for this gene is dctA [C]

Identifier: 150004741

GI number: 150004741

Start: 2840964

End: 2842145

Strand: Reverse

Name: dctA [C]

Synonym: BVU_2202

Alternate gene names: 150004741

Gene position: 2842145-2840964 (Counterclockwise)

Preceding gene: 150004742

Following gene: 150004740

Centisome position: 55.05

GC content: 41.37

Gene sequence:

>1182_bases
ATGAAAAAGTTTCTAAGTAATACTATCGTACAACTGCTTATTGCCGTAATTATCGGACTGTTGGCAGGCTTTGTTGTTAA
TGACGCAGTGCTGGAAGTCGTTATCTGTATAAAGCACATCACGGGACAGATTATATTTTTCCTGGTTCCCCTTATTATTC
TGGGATTCATAGCCCCCTCTATTGCCCATTTGCGCAGCAATGCATCAAAGATGCTTTTATTCGCTTTCGGCATAGCCTAC
CTATCATCTATCGGAGCCTCTTTTTTCGGAGCAGCCGTAGGTTACAATGTGATTCCTTTTCTGCATATAGCCGATGATGC
CAATACACTGAAAGCATTGCCGGAAAATTTACTAAAAATAGATATTCCACCGGTCATGAATGTTATGACGGCCCTTGTAC
TGGCAGCTTTGATAGGACTTGCTACTGCTTGGGTTAAATCGGATGAAATATCAAAACTACTGGATACTTTTCAAAAGATG
GTACTTGAATTGGTGAAAAGAGTACTGCTTCCCGTACTTCCCGTATTTATTGCCGCTAACTTCTGCATTCTTAGCTATCA
GGGAGCTGTTACGAAGCAGTTACCGGTATTCCTCTCCGTATTGATAGTTGTTATTGTTTGTCATTTCATCTGGCTGTCAT
TGCTTTATTTCATTGCAGCTGTTTACTCAAGAAAAAATAGTTGGCAGGTATTGAAATACTATGGTCCTGCTTACCTCACA
GCATTAGGTACAATGTCTTCAGCAGCTACGCTGGGAGTGGCGTTGGAATGTGCCCGCAAAAGCCCTATCCTTCGAAAAGA
AATCAGTGATGTGACGATACCTTTATTCGCCAATATACACCTATGCGGCTCTATCCTGACAGAAACCGTATTTGTACTCA
CTGTATCCCAAATGCTTTATGGAAGTATGCCCAGTATATTACAAATTACTTTATTCATCCTGTTATTAGGATTATTCGCC
ATCGGTGCACCGGGAGTACCGGGGGGAACAGTACTTGCCTCTTTAGGGCTAATCATCTCTGTTCTTCACTTTAATGAAGC
CGGAACGGCATTACTACTTACGATTTTTGCATTACAGGACAGTTTCGGAACAGCTTGTAATATTACCGGAGATGGGGCAC
TAACGCTTATTACAGATACTTTCGAAAAAAAGATAGCTTCGAAGCCGAAGGCTTTTAAATAA

Upstream 100 bases:

>100_bases
GGCATTCTATTTTATTTTTCTATCTTTGTTCAAGCTATGAAATAACATACCTATACAGCAAACTTTTTCCGGATATTCAT
CGTTTAACTGAAAAAAATAT

Downstream 100 bases:

>100_bases
AGGCTCTCTAATAACTATCTTTTTACTTAAGGGTTTTGTAAAGTTACTTTTTTGATATTATTGCAAATATTCTCAACCCA
TACTAACCACAAATCAAAAA

Product: glutamate/ aspartate transporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: SodiumDicarboxylate Symporter Family Protein; Serine/Threonine Sodium Symporter; Na+/H+-Dicarboxylate Symporter; Serine/Threonine Transporter; Na+/H+ Dicarboxylate Symporter; Proton/Sodium-Glutamate Symport Protein; Na(+)/H(+)-Dicarboxylate Symporter; Glutamate/Aspartate Transporter; Glutamate/ Aspartate Transporter; Na+H+-Dicarboxylate Symporter; Proton Glutamate Symporter Homolog; Proton/Glutamate Symporter Family Protein; Transmembrane Symporter; Na+/H+ Dicarboxylate Symporte; Dicarboxylate/Amino Acid Transporter; DAACS Family Dicarboxylate/Amino AcidCation Symporter; DAACS Family Transporter; Sodium-Glutamate Symporter; NaH+Dicarboxylate Symporter

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MKKFLSNTIVQLLIAVIIGLLAGFVVNDAVLEVVICIKHITGQIIFFLVPLIILGFIAPSIAHLRSNASKMLLFAFGIAY
LSSIGASFFGAAVGYNVIPFLHIADDANTLKALPENLLKIDIPPVMNVMTALVLAALIGLATAWVKSDEISKLLDTFQKM
VLELVKRVLLPVLPVFIAANFCILSYQGAVTKQLPVFLSVLIVVIVCHFIWLSLLYFIAAVYSRKNSWQVLKYYGPAYLT
ALGTMSSAATLGVALECARKSPILRKEISDVTIPLFANIHLCGSILTETVFVLTVSQMLYGSMPSILQITLFILLLGLFA
IGAPGVPGGTVLASLGLIISVLHFNEAGTALLLTIFALQDSFGTACNITGDGALTLITDTFEKKIASKPKAFK

Sequences:

>Translated_393_residues
MKKFLSNTIVQLLIAVIIGLLAGFVVNDAVLEVVICIKHITGQIIFFLVPLIILGFIAPSIAHLRSNASKMLLFAFGIAY
LSSIGASFFGAAVGYNVIPFLHIADDANTLKALPENLLKIDIPPVMNVMTALVLAALIGLATAWVKSDEISKLLDTFQKM
VLELVKRVLLPVLPVFIAANFCILSYQGAVTKQLPVFLSVLIVVIVCHFIWLSLLYFIAAVYSRKNSWQVLKYYGPAYLT
ALGTMSSAATLGVALECARKSPILRKEISDVTIPLFANIHLCGSILTETVFVLTVSQMLYGSMPSILQITLFILLLGLFA
IGAPGVPGGTVLASLGLIISVLHFNEAGTALLLTIFALQDSFGTACNITGDGALTLITDTFEKKIASKPKAFK
>Mature_393_residues
MKKFLSNTIVQLLIAVIIGLLAGFVVNDAVLEVVICIKHITGQIIFFLVPLIILGFIAPSIAHLRSNASKMLLFAFGIAY
LSSIGASFFGAAVGYNVIPFLHIADDANTLKALPENLLKIDIPPVMNVMTALVLAALIGLATAWVKSDEISKLLDTFQKM
VLELVKRVLLPVLPVFIAANFCILSYQGAVTKQLPVFLSVLIVVIVCHFIWLSLLYFIAAVYSRKNSWQVLKYYGPAYLT
ALGTMSSAATLGVALECARKSPILRKEISDVTIPLFANIHLCGSILTETVFVLTVSQMLYGSMPSILQITLFILLLGLFA
IGAPGVPGGTVLASLGLIISVLHFNEAGTALLLTIFALQDSFGTACNITGDGALTLITDTFEKKIASKPKAFK

Specific function: Responsible For The Aerobic Transport Of The Dicarboxylates Fumarate And Malate And To A Lesser Extent Succinate, From The Periplasm Across The Inner Membrane. [C]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI40254478, Length=242, Percent_Identity=28.9256198347107, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI169790839, Length=279, Percent_Identity=24.7311827956989, Blast_Score=66, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17537407, Length=253, Percent_Identity=28.4584980237154, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71996953, Length=272, Percent_Identity=25.7352941176471, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 42231; Mature: 42231

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFLSNTIVQLLIAVIIGLLAGFVVNDAVLEVVICIKHITGQIIFFLVPLIILGFIAPS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAHLRSNASKMLLFAFGIAYLSSIGASFFGAAVGYNVIPFLHIADDANTLKALPENLLKI
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCHHHHHHHHHHHHEE
DIPPVMNVMTALVLAALIGLATAWVKSDEISKLLDTFQKMVLELVKRVLLPVLPVFIAAN
CCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FCILSYQGAVTKQLPVFLSVLIVVIVCHFIWLSLLYFIAAVYSRKNSWQVLKYYGPAYLT
HHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHCHHHHH
ALGTMSSAATLGVALECARKSPILRKEISDVTIPLFANIHLCGSILTETVFVLTVSQMLY
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSMPSILQITLFILLLGLFAIGAPGVPGGTVLASLGLIISVLHFNEAGTALLLTIFALQD
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
SFGTACNITGDGALTLITDTFEKKIASKPKAFK
CCCCEEEECCCCCEEEHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKKFLSNTIVQLLIAVIIGLLAGFVVNDAVLEVVICIKHITGQIIFFLVPLIILGFIAPS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAHLRSNASKMLLFAFGIAYLSSIGASFFGAAVGYNVIPFLHIADDANTLKALPENLLKI
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCHHHHHHHHHHHHEE
DIPPVMNVMTALVLAALIGLATAWVKSDEISKLLDTFQKMVLELVKRVLLPVLPVFIAAN
CCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FCILSYQGAVTKQLPVFLSVLIVVIVCHFIWLSLLYFIAAVYSRKNSWQVLKYYGPAYLT
HHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHCHHHHH
ALGTMSSAATLGVALECARKSPILRKEISDVTIPLFANIHLCGSILTETVFVLTVSQMLY
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSMPSILQITLFILLLGLFAIGAPGVPGGTVLASLGLIISVLHFNEAGTALLLTIFALQD
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
SFGTACNITGDGALTLITDTFEKKIASKPKAFK
CCCCEEEECCCCCEEEHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA