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The map label for this gene is patB [H]

Identifier: 150004609

GI number: 150004609

Start: 2676724

End: 2677899

Strand: Direct

Name: patB [H]

Synonym: BVU_2066

Alternate gene names: 150004609

Gene position: 2676724-2677899 (Clockwise)

Preceding gene: 150004608

Following gene: 150004617

Centisome position: 51.84

GC content: 40.65

Gene sequence:

>1176_bases
ATGAAATACAATTTTGATAAAGTGATAGATCGCAGCGGTACGTCTGCTGAGAAAGTAGAAGGGCTGAAACATATTTGGGG
ACGTACGGATTTGATTCCTTTATGGGTGGCTGATATGGATTTTGCCACAGCTCCTTTTGTAACAGATGCTATTCGTAAAC
GTTGCGAAAATGAAGTTTTAGGGTATACCGGCAAACCAGATAGCTATTATAATGCGATTATAAACTGGGTAAAACAGCGT
TATGATTTGATCGTGACCAAGGAAGTGATAAATTTTGTTCCCGGCATTGTACCGGGCATCGGTATGGCTATGAATTGTTT
TACTCAGAAAGGGGATAAGGTAATGATTCAACCTCCTGTTTATCATCCTTTTGCATGGGTTACGACTCGTAATGAGCGTA
CTTTGGTCATAAATCCGTTGAGATGGGAGAACGGGATGTACCGTATGGATTTGGATGCTTTTCGTGAACAAATTAAAGGT
TGTAAGCTCTTTATTTTATGTAATCCTCATAATCCGGGTGGCGTTGTGTGGACTGAAGCAGAGTTACGAGCGATAGCTGA
TATCTGTTATGATGAGAAAGTATTGGTCTTCTCGGATGAAATTCATGCGGATTTGACTTTACCTCCTCATACGCATCGTC
CTTTTGCTACTGTCAGTGAAAAGGCTCGAATGAACTCCGTTACTTTTATGTCTCCTAGCAAGGCTTTTAATATGCCGGGA
CTATCTGCCTCACATGCTCTTATTTTTAATGAAGATTTGCGTAAACGCTTCCGTATCTATATGGATGCCGGTGAGTTGGA
TATGGGACATGTCTTTGCTTTTCTTTCTGTTGAGGCTGCTTATAGTCATGGTACGGAATGGCTTGACCAATGTTTGGCGT
ATATACAAGGAAATATAGATTTTGTCGACGAATTTTTGAAAAAACATGCACCTAAAATCAAGGCCATTCGTCCGGAGGCT
TCTTATTTAGTTTGGTTGGATTGCCGTGAACTGGAGTTGAGCCAGAAAGATTTGAATGAATTCTTTGTAGATAAAGCGCA
TTTGGCATTGAATGACGGGGAAATGTTTGGTAAGGAAGGCATTGGCTTTATGCGTTTAAACGTGGCAAGTCCGCGTTGTA
TCATTGAAAAGGCGATGAAACAACTGGCGGATGCTTATCAACTATATATAAAGTGA

Upstream 100 bases:

>100_bases
TGCCTCAGGTAATTGAAGCCTTGAAAAAATAAGGGAATATTAATGTCGCCCAATGTAGAAATTTCCTATATTTGGGCGAC
AATTCCTAAAAATAGAAACA

Downstream 100 bases:

>100_bases
TTATTTTAAGTATTGCGTCTTAAAGATATTCACGCATAAAATGAAGATGGATAACAATAACGGTCCGAATATGACACCCA
TGAATCCGAATAAGGAAAGT

Product: putative aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MKYNFDKVIDRSGTSAEKVEGLKHIWGRTDLIPLWVADMDFATAPFVTDAIRKRCENEVLGYTGKPDSYYNAIINWVKQR
YDLIVTKEVINFVPGIVPGIGMAMNCFTQKGDKVMIQPPVYHPFAWVTTRNERTLVINPLRWENGMYRMDLDAFREQIKG
CKLFILCNPHNPGGVVWTEAELRAIADICYDEKVLVFSDEIHADLTLPPHTHRPFATVSEKARMNSVTFMSPSKAFNMPG
LSASHALIFNEDLRKRFRIYMDAGELDMGHVFAFLSVEAAYSHGTEWLDQCLAYIQGNIDFVDEFLKKHAPKIKAIRPEA
SYLVWLDCRELELSQKDLNEFFVDKAHLALNDGEMFGKEGIGFMRLNVASPRCIIEKAMKQLADAYQLYIK

Sequences:

>Translated_391_residues
MKYNFDKVIDRSGTSAEKVEGLKHIWGRTDLIPLWVADMDFATAPFVTDAIRKRCENEVLGYTGKPDSYYNAIINWVKQR
YDLIVTKEVINFVPGIVPGIGMAMNCFTQKGDKVMIQPPVYHPFAWVTTRNERTLVINPLRWENGMYRMDLDAFREQIKG
CKLFILCNPHNPGGVVWTEAELRAIADICYDEKVLVFSDEIHADLTLPPHTHRPFATVSEKARMNSVTFMSPSKAFNMPG
LSASHALIFNEDLRKRFRIYMDAGELDMGHVFAFLSVEAAYSHGTEWLDQCLAYIQGNIDFVDEFLKKHAPKIKAIRPEA
SYLVWLDCRELELSQKDLNEFFVDKAHLALNDGEMFGKEGIGFMRLNVASPRCIIEKAMKQLADAYQLYIK
>Mature_391_residues
MKYNFDKVIDRSGTSAEKVEGLKHIWGRTDLIPLWVADMDFATAPFVTDAIRKRCENEVLGYTGKPDSYYNAIINWVKQR
YDLIVTKEVINFVPGIVPGIGMAMNCFTQKGDKVMIQPPVYHPFAWVTTRNERTLVINPLRWENGMYRMDLDAFREQIKG
CKLFILCNPHNPGGVVWTEAELRAIADICYDEKVLVFSDEIHADLTLPPHTHRPFATVSEKARMNSVTFMSPSKAFNMPG
LSASHALIFNEDLRKRFRIYMDAGELDMGHVFAFLSVEAAYSHGTEWLDQCLAYIQGNIDFVDEFLKKHAPKIKAIRPEA
SYLVWLDCRELELSQKDLNEFFVDKAHLALNDGEMFGKEGIGFMRLNVASPRCIIEKAMKQLADAYQLYIK

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787909, Length=387, Percent_Identity=30.4909560723514, Blast_Score=215, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44768; Mature: 44768

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYNFDKVIDRSGTSAEKVEGLKHIWGRTDLIPLWVADMDFATAPFVTDAIRKRCENEVL
CCCCHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCC
GYTGKPDSYYNAIINWVKQRYDLIVTKEVINFVPGIVPGIGMAMNCFTQKGDKVMIQPPV
CCCCCCHHHHHHHHHHHHHHHHEEHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCC
YHPFAWVTTRNERTLVINPLRWENGMYRMDLDAFREQIKGCKLFILCNPHNPGGVVWTEA
CCCEEEEEECCCCEEEEECEECCCCEEEECHHHHHHHHCCCEEEEEECCCCCCCEEEEHH
ELRAIADICYDEKVLVFSDEIHADLTLPPHTHRPFATVSEKARMNSVTFMSPSKAFNMPG
HHHHHHHHHCCCEEEEEECCCCEEEECCCCCCCCCHHHHHHHHCCEEEEECCCHHCCCCC
LSASHALIFNEDLRKRFRIYMDAGELDMGHVFAFLSVEAAYSHGTEWLDQCLAYIQGNID
CCCCEEEEECHHHHHHEEEEECCCCCCHHHEEEEHHHHHHHHCCHHHHHHHHHHHCCCHH
FVDEFLKKHAPKIKAIRPEASYLVWLDCRELELSQKDLNEFFVDKAHLALNDGEMFGKEG
HHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHCHHEEEECCCHHCCCCC
IGFMRLNVASPRCIIEKAMKQLADAYQLYIK
CCEEEEECCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKYNFDKVIDRSGTSAEKVEGLKHIWGRTDLIPLWVADMDFATAPFVTDAIRKRCENEVL
CCCCHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCC
GYTGKPDSYYNAIINWVKQRYDLIVTKEVINFVPGIVPGIGMAMNCFTQKGDKVMIQPPV
CCCCCCHHHHHHHHHHHHHHHHEEHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCC
YHPFAWVTTRNERTLVINPLRWENGMYRMDLDAFREQIKGCKLFILCNPHNPGGVVWTEA
CCCEEEEEECCCCEEEEECEECCCCEEEECHHHHHHHHCCCEEEEEECCCCCCCEEEEHH
ELRAIADICYDEKVLVFSDEIHADLTLPPHTHRPFATVSEKARMNSVTFMSPSKAFNMPG
HHHHHHHHHCCCEEEEEECCCCEEEECCCCCCCCCHHHHHHHHCCEEEEECCCHHCCCCC
LSASHALIFNEDLRKRFRIYMDAGELDMGHVFAFLSVEAAYSHGTEWLDQCLAYIQGNID
CCCCEEEEECHHHHHHEEEEECCCCCCHHHEEEEHHHHHHHHCCHHHHHHHHHHHCCCHH
FVDEFLKKHAPKIKAIRPEASYLVWLDCRELELSQKDLNEFFVDKAHLALNDGEMFGKEG
HHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHCHHEEEECCCHHCCCCC
IGFMRLNVASPRCIIEKAMKQLADAYQLYIK
CCEEEEECCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]