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The map label for this gene is thrC [H]

Identifier: 150004595

GI number: 150004595

Start: 2659673

End: 2660974

Strand: Direct

Name: thrC [H]

Synonym: BVU_2052

Alternate gene names: 150004595

Gene position: 2659673-2660974 (Clockwise)

Preceding gene: 150004594

Following gene: 150004601

Centisome position: 51.51

GC content: 45.08

Gene sequence:

>1302_bases
ATGAAATATTACAGTACGAATCACCAGGCTTCCGATGCTTCTCTGGAAGAAGCTGTAGTGAAGGGGCTGGCTTCTGACAA
AGGTTTGTATATGCCCGAGGCCATCAAGCCATTGCCGCAAGAGTTTTATGATCAGATTGAGAATCTGTCGTTTCAGGAAA
TTGCTTATCGCGTGGCCGATGCTTTCTTCGGTGAGGATGTTCCTGCTGAAACACTGAAGCAGATCGTTTATGATACATTG
AGTTTTGATGTTCCTGCCGTAAAGGTAAAGGATAATATTTACTCTTTGGAACTGTTTCATGGTCCTACATTGGCATTTAA
AGATGTAGGTGGACGTTTCATGGCCCGTTTGTTGGGCTACTTCATTAAAAAAGAAGGGCAAAAGCAGGTGAATGTACTGG
TTGCGACTTCGGGGGATACCGGTAGTGCTGTAGCCAATGGCTTCCTCGGAGTGGAAGGTATTCATGTGTATGTGCTTTAT
CCGAAAGGAAAAGTCAGTGAAATTCAGGAAAAGCAGTTCACTACTCTGGGGCGGAATATCACAGCGTTAGAAGTGGACGG
TACTTTTGATGACTGTCAGGCATTGGTTAAGAATGCGTTTATGGATGCTGATTTGAATGCGCACATGAAGTTGACTTCTG
CCAACTCCATCAATGTGGCTCGTTTCCTGCCACAGGCATTTTATTACTTCTATGCCTACGCACAGTTAAAGAAAGAAGGA
AAAGCGGATCATCTGGTAGTGTGCGTACCTAGCGGAAACTTTGGTAATATCACCGCCGGACTATTTGGTAAACGCATGGG
CTTGCCTGTCAAGCGTTTTATTGCAGCCAATAACCGGAATGATATTTTCTACCAATACTTACAGACCGGAAAATACAATC
CTCGTCCTTCCATAGCTACTATTGCCAATGCAATGGATGTGGGAGATCCAAGTAATTTTGCCCGTGTACTGGCATTGTAC
GGTAACAGTCATGCTGCCATAACAGCGGATATCTCTGGTGCGACTTATGCGGATGAACAGATTCGTGAAACGGTGGGTGA
GGTATATCGGGAAACCGGTTACTTGCTCGATCCGCATGGAGCCTGCGGTTATCGTGCTTTATCCGAAGGATTGTCCCCCA
GCGAAACGGGTATTTTCCTGGAAACGGCACATCCGGCTAAATTCCTGGAAACTGTGGAAGGCATCATTGGCGACAAAGTG
GAGATTCCCGCCAAACTGCAAGCGTTTATGAAAGGAACCAAACAAAGTGTTCCGATGGAAAAAGACTTTGAAAGTTTCAA
AGGCTATTTGATGAAAGAATAG

Upstream 100 bases:

>100_bases
GAAAAAATAATGTGGCAGTTTGCTAATTTGCCCCAATGGCAACCCTCCATGCAAAGCCCTTGGCACATTAGCACATTGAC
GCATTGAAAAATTGTTTACT

Downstream 100 bases:

>100_bases
CTTTTAGAAATAGATATCTGATAAGAAAAGAGAGGGGCAAAAGTCCAAAGTAACTATCCAATGGTTCACCGTAGGGGCGG
ATTGAATAGTTACTTTGGGC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MKYYSTNHQASDASLEEAVVKGLASDKGLYMPEAIKPLPQEFYDQIENLSFQEIAYRVADAFFGEDVPAETLKQIVYDTL
SFDVPAVKVKDNIYSLELFHGPTLAFKDVGGRFMARLLGYFIKKEGQKQVNVLVATSGDTGSAVANGFLGVEGIHVYVLY
PKGKVSEIQEKQFTTLGRNITALEVDGTFDDCQALVKNAFMDADLNAHMKLTSANSINVARFLPQAFYYFYAYAQLKKEG
KADHLVVCVPSGNFGNITAGLFGKRMGLPVKRFIAANNRNDIFYQYLQTGKYNPRPSIATIANAMDVGDPSNFARVLALY
GNSHAAITADISGATYADEQIRETVGEVYRETGYLLDPHGACGYRALSEGLSPSETGIFLETAHPAKFLETVEGIIGDKV
EIPAKLQAFMKGTKQSVPMEKDFESFKGYLMKE

Sequences:

>Translated_433_residues
MKYYSTNHQASDASLEEAVVKGLASDKGLYMPEAIKPLPQEFYDQIENLSFQEIAYRVADAFFGEDVPAETLKQIVYDTL
SFDVPAVKVKDNIYSLELFHGPTLAFKDVGGRFMARLLGYFIKKEGQKQVNVLVATSGDTGSAVANGFLGVEGIHVYVLY
PKGKVSEIQEKQFTTLGRNITALEVDGTFDDCQALVKNAFMDADLNAHMKLTSANSINVARFLPQAFYYFYAYAQLKKEG
KADHLVVCVPSGNFGNITAGLFGKRMGLPVKRFIAANNRNDIFYQYLQTGKYNPRPSIATIANAMDVGDPSNFARVLALY
GNSHAAITADISGATYADEQIRETVGEVYRETGYLLDPHGACGYRALSEGLSPSETGIFLETAHPAKFLETVEGIIGDKV
EIPAKLQAFMKGTKQSVPMEKDFESFKGYLMKE
>Mature_433_residues
MKYYSTNHQASDASLEEAVVKGLASDKGLYMPEAIKPLPQEFYDQIENLSFQEIAYRVADAFFGEDVPAETLKQIVYDTL
SFDVPAVKVKDNIYSLELFHGPTLAFKDVGGRFMARLLGYFIKKEGQKQVNVLVATSGDTGSAVANGFLGVEGIHVYVLY
PKGKVSEIQEKQFTTLGRNITALEVDGTFDDCQALVKNAFMDADLNAHMKLTSANSINVARFLPQAFYYFYAYAQLKKEG
KADHLVVCVPSGNFGNITAGLFGKRMGLPVKRFIAANNRNDIFYQYLQTGKYNPRPSIATIANAMDVGDPSNFARVLALY
GNSHAAITADISGATYADEQIRETVGEVYRETGYLLDPHGACGYRALSEGLSPSETGIFLETAHPAKFLETVEGIIGDKV
EIPAKLQAFMKGTKQSVPMEKDFESFKGYLMKE

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=460, Percent_Identity=31.7391304347826, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI153792148, Length=471, Percent_Identity=29.5116772823779, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1786185, Length=431, Percent_Identity=44.0835266821346, Blast_Score=360, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6319901, Length=440, Percent_Identity=36.3636363636364, Blast_Score=261, Evalue=2e-70,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 47693; Mature: 47693

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYYSTNHQASDASLEEAVVKGLASDKGLYMPEAIKPLPQEFYDQIENLSFQEIAYRVAD
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHCCCHHHHHHHHHH
AFFGEDVPAETLKQIVYDTLSFDVPAVKVKDNIYSLELFHGPTLAFKDVGGRFMARLLGY
HHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCEEEEEEECCCCEEHHHCCHHHHHHHHHH
FIKKEGQKQVNVLVATSGDTGSAVANGFLGVEGIHVYVLYPKGKVSEIQEKQFTTLGRNI
HHHCCCCCEEEEEEEECCCCCHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCE
TALEVDGTFDDCQALVKNAFMDADLNAHMKLTSANSINVARFLPQAFYYFYAYAQLKKEG
EEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC
KADHLVVCVPSGNFGNITAGLFGKRMGLPVKRFIAANNRNDIFYQYLQTGKYNPRPSIAT
CCCEEEEEEECCCCCCCHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHH
IANAMDVGDPSNFARVLALYGNSHAAITADISGATYADEQIRETVGEVYRETGYLLDPHG
HHHHHCCCCCHHHHEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEECCCC
ACGYRALSEGLSPSETGIFLETAHPAKFLETVEGIIGDKVEIPAKLQAFMKGTKQSVPME
CCCHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCHHHCCCCH
KDFESFKGYLMKE
HHHHHHCCCCCCC
>Mature Secondary Structure
MKYYSTNHQASDASLEEAVVKGLASDKGLYMPEAIKPLPQEFYDQIENLSFQEIAYRVAD
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHCCCHHHHHHHHHH
AFFGEDVPAETLKQIVYDTLSFDVPAVKVKDNIYSLELFHGPTLAFKDVGGRFMARLLGY
HHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCEEEEEEECCCCEEHHHCCHHHHHHHHHH
FIKKEGQKQVNVLVATSGDTGSAVANGFLGVEGIHVYVLYPKGKVSEIQEKQFTTLGRNI
HHHCCCCCEEEEEEEECCCCCHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCE
TALEVDGTFDDCQALVKNAFMDADLNAHMKLTSANSINVARFLPQAFYYFYAYAQLKKEG
EEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC
KADHLVVCVPSGNFGNITAGLFGKRMGLPVKRFIAANNRNDIFYQYLQTGKYNPRPSIAT
CCCEEEEEEECCCCCCCHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHH
IANAMDVGDPSNFARVLALYGNSHAAITADISGATYADEQIRETVGEVYRETGYLLDPHG
HHHHHCCCCCHHHHEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEECCCC
ACGYRALSEGLSPSETGIFLETAHPAKFLETVEGIIGDKVEIPAKLQAFMKGTKQSVPME
CCCHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCHHHCCCCH
KDFESFKGYLMKE
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]