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The map label for this gene is thrA [H]

Identifier: 150004593

GI number: 150004593

Start: 2655934

End: 2658366

Strand: Direct

Name: thrA [H]

Synonym: BVU_2050

Alternate gene names: 150004593

Gene position: 2655934-2658366 (Clockwise)

Preceding gene: 150004587

Following gene: 150004594

Centisome position: 51.44

GC content: 44.35

Gene sequence:

>2433_bases
ATGAAAGTTATGAAATTCGGCGGGACATCCGTAGGTTCCGTGAACAGCATTTTAAGCGTCAAACAGATAGTAGAGGCAGT
TGAAGAGCCCGTAATTGTAGTTGTGTCGGCATTGGGCGGTATAACTGACAAGTTAATCAATACTTCGCAGATGGCTGCCA
ATGGGGATTCCGCATACGAGAAAGAATACCGTGAAATTGTGAATCGTCACATTGAAATGGTATATACCGTAATTCCGGCA
GGTAATGAGCGTACTGTTTTATTGGATAAGGTCAATGAATTGTTGAGTGAACTGAAGGATATTTTTCAGGGAATTTATCT
GATAAAGGACTTGTCGTCTAAAACGTCGGCTACTATTGTAAGTTATGGTGAGCGCTTGTCGTCTATTATTGTAGCTTCGT
TGATAAAGGGGGCTGTATGGTATGACTCCCGCAACTTCATTAAGACTGAAAAAAAACATGCCAAACATATTCTGGATTCC
GAACTGACCACTCGCTTGGTTAAAGAAACTTTCCAGAAATTACCGGAAGTGGCATTGGTTCCCGGATTTATCTCTACTGA
TAAGAACAGTGGTGAAGTGACCAATTTGGGACGTGGCGGTTCAGATTATACCGCTTCTGTCATAGCTGCGGCACTGAATG
CGGATAGCTTGGAAATATGGACGGATGTGGATGGTTTCATGACGGCAGACCCGCGTGTAATCAGTACGGCCTATACCATT
AATGAGTTGAGCTATGTGGAAGCGATGGAGCTTTGTAACTTTGGAGCGAAGGTGGTTTATCCGCCGACTATTTATCCGGT
ATGTCATAAGAATATTCCTATTCTGATTAAGAATACATTCAATCCTCAAGGCGAGGGAACTATCATAAAGCAGGAAGTGA
ATTCCGGTTCTAAAGCCATTAAAGGTATCTCATCCATCAATGATACGAGTTTGATTACGGTTACCGGTCTGGGAATGGTG
GGAGTGATCGGAGTGAATTTCCGGATTTTTAAAGCATTGGCACAAAACGGCATCAGCGTGTTTATGGTATCGCAGGCATC
TTCCGAGAACAGTACTTCTATCGGTGTGCGTAATCAAGATGCGGCGCTGGCTTGTGAAGTGCTGAATGAGGAATTCTCCA
AAGAAATAGAAATGGGGGAAATCAGTCCGGTTGTTGCCGAAATGAATTTGGCTACCATTGCCATTGTCGGTGAGAACATG
AAACATACACCGGGCATCGCCGGTAAGCTGTTCGGGACTTTAGGCCGTAACGGCATTAGTGTGATTGCTTGTGCGCAAGG
TGCTTCGGAAACCAATATCTCTTTCGTGGTAGAATCCAAGTCACTGCGCAAATCATTGAATGTGATTCATGATTCGTTCT
TCCTGTCCGAATATCAGGTGCTGAACCTTTTTATCTGCGGTACAGGTACGGTAGGAGGCAGTTTGATAGAGCAAATCCGT
TGTCAGCAACAAAAGTTGATGCAGGAACGCGGTTTGAAGCTGAAAGTGGTAGGTATAGCCGATGGACATCATGCGTTGTT
TACCCGTGCAGGCGTAGACTTGTCACATTATAAGGAAGAGTTGGCAGAGAAAGGAATGCCTTCGTCCACCCAGGTGTTGC
ATGACGAGATTATAGGTATGAATATATTCAACTCTGTGTTTGTGGATTGTACAGCCAGTGCAGAAGTTGCATCCTTATAT
AAAGATTTTCTGATGAATAATATTTCGGTGGTAGCGGCCAACAAAATTGCCGCTTCTTCCGAATACTCCGTTTATAGCGA
ACTGAAACAAATAGCCCGCCGTCGCGGTGTAAAATTCTTGTTTGAAACCAATGTAGGTGCAGGGCTACCCATTATCAACA
CAATCAATGACTTGATAAACAGCGGAGACAAGATATTGAAAATAGAGGCGGTATTGAGCGGTACGCTGAATTACATCTTT
AACAAAATCAGCGCGGACATTCCTTTCAGCAAGACCATCAAAATGGCACAGGAAGAGCGCTACTCGGAACCCGATCCGCG
TATTGACCTGAGTGGCAAGGATGTGATTCGTAAACTGGTTATTCTGGCTCGTGAAGCCGGATATAAATTGGAACAGGAAG
ATGTGGAAAAACATCTTTTTGTACCGAATGATTTCTTTGAAGGCCCGTTGGAGGAGTTCTGGAAGAAAGTACCTTCCCTG
GATGCGGATTTTGAATCACGCCGTCAAAAGCTGGAGGATGAAAACAAACGCTGGCGTTTTGTAGCCAAACTGGAAGATGG
GAAAGGCAGTGTGTCTTTGCAGGAAGTGGACAGCAAACATCCATTCTATGGTCTGGAAGGCAGCAACAACATTATTCTGC
TTACAACCGAGCGATATAAAGAGTATCCGATGATGATACAAGGATATGGGGCCGGTGCCAGTGTGACTGCCGCCGGAGTA
TTTGCCGATATCATGAGCATCGCTAATATTTAG

Upstream 100 bases:

>100_bases
GTTGTCATGCTGGGTGAAACGAAAGTAGATTCTTTACCGGACTTGAAATGGCTCGGAGGACAGAATGGCAAAAGAAGCTG
GAATAAAAATAGATAATTGC

Downstream 100 bases:

>100_bases
GCTTATGAAACATATTATTATTTTAGGCGACGGTATGGCCGACTGGCCTGCCGAATCACTGGGAAACAAAACATTGCTGC
AATACTCCAGTACACCTTAT

Product: bifunctional aspartokinase I/homeserine dehydrogenase I

Products: NA

Alternate protein names: Aspartokinase I/homoserine dehydrogenase I; AKI-HDI; Aspartokinase; Homoserine dehydrogenase [H]

Number of amino acids: Translated: 810; Mature: 810

Protein sequence:

>810_residues
MKVMKFGGTSVGSVNSILSVKQIVEAVEEPVIVVVSALGGITDKLINTSQMAANGDSAYEKEYREIVNRHIEMVYTVIPA
GNERTVLLDKVNELLSELKDIFQGIYLIKDLSSKTSATIVSYGERLSSIIVASLIKGAVWYDSRNFIKTEKKHAKHILDS
ELTTRLVKETFQKLPEVALVPGFISTDKNSGEVTNLGRGGSDYTASVIAAALNADSLEIWTDVDGFMTADPRVISTAYTI
NELSYVEAMELCNFGAKVVYPPTIYPVCHKNIPILIKNTFNPQGEGTIIKQEVNSGSKAIKGISSINDTSLITVTGLGMV
GVIGVNFRIFKALAQNGISVFMVSQASSENSTSIGVRNQDAALACEVLNEEFSKEIEMGEISPVVAEMNLATIAIVGENM
KHTPGIAGKLFGTLGRNGISVIACAQGASETNISFVVESKSLRKSLNVIHDSFFLSEYQVLNLFICGTGTVGGSLIEQIR
CQQQKLMQERGLKLKVVGIADGHHALFTRAGVDLSHYKEELAEKGMPSSTQVLHDEIIGMNIFNSVFVDCTASAEVASLY
KDFLMNNISVVAANKIAASSEYSVYSELKQIARRRGVKFLFETNVGAGLPIINTINDLINSGDKILKIEAVLSGTLNYIF
NKISADIPFSKTIKMAQEERYSEPDPRIDLSGKDVIRKLVILAREAGYKLEQEDVEKHLFVPNDFFEGPLEEFWKKVPSL
DADFESRRQKLEDENKRWRFVAKLEDGKGSVSLQEVDSKHPFYGLEGSNNIILLTTERYKEYPMMIQGYGAGASVTAAGV
FADIMSIANI

Sequences:

>Translated_810_residues
MKVMKFGGTSVGSVNSILSVKQIVEAVEEPVIVVVSALGGITDKLINTSQMAANGDSAYEKEYREIVNRHIEMVYTVIPA
GNERTVLLDKVNELLSELKDIFQGIYLIKDLSSKTSATIVSYGERLSSIIVASLIKGAVWYDSRNFIKTEKKHAKHILDS
ELTTRLVKETFQKLPEVALVPGFISTDKNSGEVTNLGRGGSDYTASVIAAALNADSLEIWTDVDGFMTADPRVISTAYTI
NELSYVEAMELCNFGAKVVYPPTIYPVCHKNIPILIKNTFNPQGEGTIIKQEVNSGSKAIKGISSINDTSLITVTGLGMV
GVIGVNFRIFKALAQNGISVFMVSQASSENSTSIGVRNQDAALACEVLNEEFSKEIEMGEISPVVAEMNLATIAIVGENM
KHTPGIAGKLFGTLGRNGISVIACAQGASETNISFVVESKSLRKSLNVIHDSFFLSEYQVLNLFICGTGTVGGSLIEQIR
CQQQKLMQERGLKLKVVGIADGHHALFTRAGVDLSHYKEELAEKGMPSSTQVLHDEIIGMNIFNSVFVDCTASAEVASLY
KDFLMNNISVVAANKIAASSEYSVYSELKQIARRRGVKFLFETNVGAGLPIINTINDLINSGDKILKIEAVLSGTLNYIF
NKISADIPFSKTIKMAQEERYSEPDPRIDLSGKDVIRKLVILAREAGYKLEQEDVEKHLFVPNDFFEGPLEEFWKKVPSL
DADFESRRQKLEDENKRWRFVAKLEDGKGSVSLQEVDSKHPFYGLEGSNNIILLTTERYKEYPMMIQGYGAGASVTAAGV
FADIMSIANI
>Mature_810_residues
MKVMKFGGTSVGSVNSILSVKQIVEAVEEPVIVVVSALGGITDKLINTSQMAANGDSAYEKEYREIVNRHIEMVYTVIPA
GNERTVLLDKVNELLSELKDIFQGIYLIKDLSSKTSATIVSYGERLSSIIVASLIKGAVWYDSRNFIKTEKKHAKHILDS
ELTTRLVKETFQKLPEVALVPGFISTDKNSGEVTNLGRGGSDYTASVIAAALNADSLEIWTDVDGFMTADPRVISTAYTI
NELSYVEAMELCNFGAKVVYPPTIYPVCHKNIPILIKNTFNPQGEGTIIKQEVNSGSKAIKGISSINDTSLITVTGLGMV
GVIGVNFRIFKALAQNGISVFMVSQASSENSTSIGVRNQDAALACEVLNEEFSKEIEMGEISPVVAEMNLATIAIVGENM
KHTPGIAGKLFGTLGRNGISVIACAQGASETNISFVVESKSLRKSLNVIHDSFFLSEYQVLNLFICGTGTVGGSLIEQIR
CQQQKLMQERGLKLKVVGIADGHHALFTRAGVDLSHYKEELAEKGMPSSTQVLHDEIIGMNIFNSVFVDCTASAEVASLY
KDFLMNNISVVAANKIAASSEYSVYSELKQIARRRGVKFLFETNVGAGLPIINTINDLINSGDKILKIEAVLSGTLNYIF
NKISADIPFSKTIKMAQEERYSEPDPRIDLSGKDVIRKLVILAREAGYKLEQEDVEKHLFVPNDFFEGPLEEFWKKVPSL
DADFESRRQKLEDENKRWRFVAKLEDGKGSVSLQEVDSKHPFYGLEGSNNIILLTTERYKEYPMMIQGYGAGASVTAAGV
FADIMSIANI

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=820, Percent_Identity=37.5609756097561, Blast_Score=513, Evalue=1e-146,
Organism=Escherichia coli, GI1790376, Length=826, Percent_Identity=28.5714285714286, Blast_Score=328, Evalue=1e-90,
Organism=Escherichia coli, GI1790455, Length=465, Percent_Identity=27.741935483871, Blast_Score=166, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6322599, Length=369, Percent_Identity=35.230352303523, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6320893, Length=509, Percent_Identity=28.4872298624754, Blast_Score=161, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005106
- InterPro:   IPR001341
- InterPro:   IPR018042
- InterPro:   IPR011147
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =2.7.2.4; =1.1.1.3 [H]

Molecular weight: Translated: 88622; Mature: 88622

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVMKFGGTSVGSVNSILSVKQIVEAVEEPVIVVVSALGGITDKLINTSQMAANGDSAYE
CCEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHCCHHHHHHCHHHHCCCCCHHHH
KEYREIVNRHIEMVYTVIPAGNERTVLLDKVNELLSELKDIFQGIYLIKDLSSKTSATIV
HHHHHHHHHHHHEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
SYGERLSSIIVASLIKGAVWYDSRNFIKTEKKHAKHILDSELTTRLVKETFQKLPEVALV
HHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEC
PGFISTDKNSGEVTNLGRGGSDYTASVIAAALNADSLEIWTDVDGFMTADPRVISTAYTI
CCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEEH
NELSYVEAMELCNFGAKVVYPPTIYPVCHKNIPILIKNTFNPQGEGTIIKQEVNSGSKAI
HHHHHHHHHHHHCCCCEEEECCCCCHHHCCCCCEEEEECCCCCCCCCEEEEHHCCCHHHH
KGISSINDTSLITVTGLGMVGVIGVNFRIFKALAQNGISVFMVSQASSENSTSIGVRNQD
HHHCCCCCCEEEEEECCCEEHHHCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCC
AALACEVLNEEFSKEIEMGEISPVVAEMNLATIAIVGENMKHTPGIAGKLFGTLGRNGIS
HHHHHHHHHHHHHHHCCCCCCCHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCE
VIACAQGASETNISFVVESKSLRKSLNVIHDSFFLSEYQVLNLFICGTGTVGGSLIEQIR
EEEEECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCEEEEEEEEEECCCCCHHHHHHHH
CQQQKLMQERGLKLKVVGIADGHHALFTRAGVDLSHYKEELAEKGMPSSTQVLHDEIIGM
HHHHHHHHHCCCEEEEEEEECCCHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
NIFNSVFVDCTASAEVASLYKDFLMNNISVVAANKIAASSEYSVYSELKQIARRRGVKFL
HHHHHHHEECCCCHHHHHHHHHHHHCCCEEEEECHHCCCCCHHHHHHHHHHHHHCCCEEE
FETNVGAGLPIINTINDLINSGDKILKIEAVLSGTLNYIFNKISADIPFSKTIKMAQEER
EECCCCCCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
YSEPDPRIDLSGKDVIRKLVILAREAGYKLEQEDVEKHLFVPNDFFEGPLEEFWKKVPSL
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHCCCHHHHHHHHCCCC
DADFESRRQKLEDENKRWRFVAKLEDGKGSVSLQEVDSKHPFYGLEGSNNIILLTTERYK
CCCHHHHHHHCCCCCCEEEEEEEEECCCCCEEHHHHCCCCCEEEECCCCCEEEEECCCCC
EYPMMIQGYGAGASVTAAGVFADIMSIANI
CCCCEEEECCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVMKFGGTSVGSVNSILSVKQIVEAVEEPVIVVVSALGGITDKLINTSQMAANGDSAYE
CCEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHCCHHHHHHCHHHHCCCCCHHHH
KEYREIVNRHIEMVYTVIPAGNERTVLLDKVNELLSELKDIFQGIYLIKDLSSKTSATIV
HHHHHHHHHHHHEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
SYGERLSSIIVASLIKGAVWYDSRNFIKTEKKHAKHILDSELTTRLVKETFQKLPEVALV
HHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEC
PGFISTDKNSGEVTNLGRGGSDYTASVIAAALNADSLEIWTDVDGFMTADPRVISTAYTI
CCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEEH
NELSYVEAMELCNFGAKVVYPPTIYPVCHKNIPILIKNTFNPQGEGTIIKQEVNSGSKAI
HHHHHHHHHHHHCCCCEEEECCCCCHHHCCCCCEEEEECCCCCCCCCEEEEHHCCCHHHH
KGISSINDTSLITVTGLGMVGVIGVNFRIFKALAQNGISVFMVSQASSENSTSIGVRNQD
HHHCCCCCCEEEEEECCCEEHHHCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCC
AALACEVLNEEFSKEIEMGEISPVVAEMNLATIAIVGENMKHTPGIAGKLFGTLGRNGIS
HHHHHHHHHHHHHHHCCCCCCCHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCE
VIACAQGASETNISFVVESKSLRKSLNVIHDSFFLSEYQVLNLFICGTGTVGGSLIEQIR
EEEEECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCEEEEEEEEEECCCCCHHHHHHHH
CQQQKLMQERGLKLKVVGIADGHHALFTRAGVDLSHYKEELAEKGMPSSTQVLHDEIIGM
HHHHHHHHHCCCEEEEEEEECCCHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
NIFNSVFVDCTASAEVASLYKDFLMNNISVVAANKIAASSEYSVYSELKQIARRRGVKFL
HHHHHHHEECCCCHHHHHHHHHHHHCCCEEEEECHHCCCCCHHHHHHHHHHHHHCCCEEE
FETNVGAGLPIINTINDLINSGDKILKIEAVLSGTLNYIFNKISADIPFSKTIKMAQEER
EECCCCCCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
YSEPDPRIDLSGKDVIRKLVILAREAGYKLEQEDVEKHLFVPNDFFEGPLEEFWKKVPSL
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHCCCHHHHHHHHCCCC
DADFESRRQKLEDENKRWRFVAKLEDGKGSVSLQEVDSKHPFYGLEGSNNIILLTTERYK
CCCHHHHHHHCCCCCCEEEEEEEEECCCCCEEHHHHCCCCCEEEECCCCCEEEEECCCCC
EYPMMIQGYGAGASVTAAGVFADIMSIANI
CCCCEEEECCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7003595; 1630901; 7610040; 9278503; 6277952; 2410621; 387092; 6298218; 390305 [H]