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The map label for this gene is relA [H]

Identifier: 150004463

GI number: 150004463

Start: 2486610

End: 2488880

Strand: Reverse

Name: relA [H]

Synonym: BVU_1911

Alternate gene names: 150004463

Gene position: 2488880-2486610 (Counterclockwise)

Preceding gene: 150004464

Following gene: 150004460

Centisome position: 48.2

GC content: 43.81

Gene sequence:

>2271_bases
ATGACGGATGAAAAGCAGACTCAGGAACAGGCGGATGAGGAAATGATAAACCAAGGGTTTCAGGAACTTTTGGACAGTTA
TCTAGCGACCAAGCACCGCAAAAAAGTAGAAATCATCACAAAGGCATTCAATTTTGCCAAACAAGCACATAAAGGAGTAA
AACGACGCTCGGGTGAACCATACATCATGCATCCCATAGCCGTTGCTAAAATTGTATGTACCGAAATAGGACTGGGATCA
ACTTCCATTTGTTCGGCTTTACTGCATGATGTGGTTGAAGATACAGACTACACTGTGGAAGACATTGAAAATCTGTTTGG
TCCTAAAATCGCACAGATTGTAGATGGCCTGACTAAAATATCCGGCGGCATATTCGGAGACCGGGCTTCCGCACAAGCCG
AGAATTTCAAGAAATTGCTACTGACCATGAGTGATGACATCCGGGTTATCCTCATCAAAATAGCCGACCGTCTGCATAAT
ATGCGTACACTTGGCTCCATGCTTCCCAACAAACAATACAAAATTGCCGGAGAAACCTTATACATCTATGCGCCACTGGC
TAACCGCTTGGGGTTAAACAAAATAAAGACAGAACTGGAAGATCTCAGTTTCAAATATGAGCATCCGGAAGAATATGCAC
AGATAGAATCCAAGCTACAAGAAACACAAGCGGAACGCGAAGAAGTATTCCGTGAATTTACAGCACCTATCCGCGCACAA
CTGGACAAAATGGGTATCAGCTATCAATTGATAGCACGAGTCAAATCCCCTTATTCCATCTGGAACAAGATGCAGACCAA
GCATATCACATTTGAAGAAATATATGATATCCTGGCTGTCCGTATCATCTTCTGTCCCAAAAATCCGGAAGAAGAACTCA
ACGAGTGCTTTAACATATACGTATCCATATCCAAGATTTATAAACCGCACCCAGACCGCTTGCGCGACTGGGTAAGCCAT
CCTAAAGCCAACGGCTATCAGGCACTTCACGTAACTCTGATGAGCAACAAAGGCCAATGGATAGAAGTGCAGATACGCAG
CGAGCGGATGAATGATGTAGCCGAACAAGGCTTTGCCGCACACTGGAAATATAAAGAAGGCGGAGGCAGTGAGGACGAGG
GCGAACTGGAAAAATGGCTGCGTACCATCAAGGAAATTCTGGATGATCCGCAACCGGATGCCATGGACTTTCTGGATACC
ATCAAACTGAACCTGTTCGCTTCTGAAATATTTGTCTTCACTCCGAAAGGTGAAATCAAAACGATGCCGCAAAACTGTAC
GGCACTGGATTTTGCATTCTCCATCCATACATTCTTGGGCAGCCATTGCATCGGAGCTAAAGTCAACCACAAGCTGGTGC
CCTTGAGCCACAAACTGCAAAGCGGCGACCAGGTGGAGATTCTTACTTCCAAATCACAACATGTACAGCCTTCGTGGATA
AACTTTGCCACCACTGCAAAAGCCAAGGCTAAGATACAGGCCATACTGAAACGCGAACAGCGAGGTATGCAGCAGGCCGG
TGAGGAAATGTTACGGGAATTCTTCTCCAGGGAGGGAGTAGAGTACACTCCCGAAAACATACGAAAGATCTGTAATCTGC
ATACCCTCAAGACACAGGAAGAATTGTTTGCAGCCATCGGATTCAAAACAATCATTCTAGGAGAAAACGATAAAAACGAA
CTGAAAGACAAACCGGTTTCCAGTAACTGGAAAAAGTATATCTCTTTCGCTTTCGGAGGCAGCAAGACAAACAAGGAGAA
ACCGACAGAAGAGAAGGTTCCCCTACCAAAGATAGACAGCAAGAAAATATTGAAACTGACTCCCGAAGCTATCCAAAAGA
ACTATGTGATAGCAGAATGCTGCAAACCTATTCCGGGAGATGACGTTTTGGGATATATAGGCGACAATAATCGTATCATC
ATCCACAAACGCCAATGTCCGTTGGCTACCAAACTGAAAAGCAGTTATGGCAACCGCTTGTTGGCTGTCCAATGGGAAAC
AGGAAAGTCCTTGTACTTCCCTGTAAATATCTACATAAAAGGTATTGACCACATCGGTCTGTTAAACAAGGTAACAGAAA
TCATTTCACAACAATTGAATGTAAATATCCACAAGTTGAATATTGAAAGTAACGATGGTATCTTTGAAGGAAGAATACAG
CTATTTGTGCACGATGTGGATGATGTAAAATCCATCACTACCAACCTAAGGAAAATAGATGAGATAAAAACCGTCACCCG
TATCGAAAAGTTCGAAGACGAGCCGAATTAA

Upstream 100 bases:

>100_bases
TGATAAAAAATACAGATTTAACACTATACATTTTCTGAAAATACTTGCTTGAATATGTTTTTTGTATATTTTTGCAGTAT
AGATTATAGGAGGCAAAGAT

Downstream 100 bases:

>100_bases
CCAATACCAGTTTCACCGCAGATTACACTGATTTGTCCATAACGATTATCTGCAACTCGTTTTTAATCCGTGCAATCTGT
GGTGAATATTCTTAAGTCAG

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 756; Mature: 755

Protein sequence:

>756_residues
MTDEKQTQEQADEEMINQGFQELLDSYLATKHRKKVEIITKAFNFAKQAHKGVKRRSGEPYIMHPIAVAKIVCTEIGLGS
TSICSALLHDVVEDTDYTVEDIENLFGPKIAQIVDGLTKISGGIFGDRASAQAENFKKLLLTMSDDIRVILIKIADRLHN
MRTLGSMLPNKQYKIAGETLYIYAPLANRLGLNKIKTELEDLSFKYEHPEEYAQIESKLQETQAEREEVFREFTAPIRAQ
LDKMGISYQLIARVKSPYSIWNKMQTKHITFEEIYDILAVRIIFCPKNPEEELNECFNIYVSISKIYKPHPDRLRDWVSH
PKANGYQALHVTLMSNKGQWIEVQIRSERMNDVAEQGFAAHWKYKEGGGSEDEGELEKWLRTIKEILDDPQPDAMDFLDT
IKLNLFASEIFVFTPKGEIKTMPQNCTALDFAFSIHTFLGSHCIGAKVNHKLVPLSHKLQSGDQVEILTSKSQHVQPSWI
NFATTAKAKAKIQAILKREQRGMQQAGEEMLREFFSREGVEYTPENIRKICNLHTLKTQEELFAAIGFKTIILGENDKNE
LKDKPVSSNWKKYISFAFGGSKTNKEKPTEEKVPLPKIDSKKILKLTPEAIQKNYVIAECCKPIPGDDVLGYIGDNNRII
IHKRQCPLATKLKSSYGNRLLAVQWETGKSLYFPVNIYIKGIDHIGLLNKVTEIISQQLNVNIHKLNIESNDGIFEGRIQ
LFVHDVDDVKSITTNLRKIDEIKTVTRIEKFEDEPN

Sequences:

>Translated_756_residues
MTDEKQTQEQADEEMINQGFQELLDSYLATKHRKKVEIITKAFNFAKQAHKGVKRRSGEPYIMHPIAVAKIVCTEIGLGS
TSICSALLHDVVEDTDYTVEDIENLFGPKIAQIVDGLTKISGGIFGDRASAQAENFKKLLLTMSDDIRVILIKIADRLHN
MRTLGSMLPNKQYKIAGETLYIYAPLANRLGLNKIKTELEDLSFKYEHPEEYAQIESKLQETQAEREEVFREFTAPIRAQ
LDKMGISYQLIARVKSPYSIWNKMQTKHITFEEIYDILAVRIIFCPKNPEEELNECFNIYVSISKIYKPHPDRLRDWVSH
PKANGYQALHVTLMSNKGQWIEVQIRSERMNDVAEQGFAAHWKYKEGGGSEDEGELEKWLRTIKEILDDPQPDAMDFLDT
IKLNLFASEIFVFTPKGEIKTMPQNCTALDFAFSIHTFLGSHCIGAKVNHKLVPLSHKLQSGDQVEILTSKSQHVQPSWI
NFATTAKAKAKIQAILKREQRGMQQAGEEMLREFFSREGVEYTPENIRKICNLHTLKTQEELFAAIGFKTIILGENDKNE
LKDKPVSSNWKKYISFAFGGSKTNKEKPTEEKVPLPKIDSKKILKLTPEAIQKNYVIAECCKPIPGDDVLGYIGDNNRII
IHKRQCPLATKLKSSYGNRLLAVQWETGKSLYFPVNIYIKGIDHIGLLNKVTEIISQQLNVNIHKLNIESNDGIFEGRIQ
LFVHDVDDVKSITTNLRKIDEIKTVTRIEKFEDEPN
>Mature_755_residues
TDEKQTQEQADEEMINQGFQELLDSYLATKHRKKVEIITKAFNFAKQAHKGVKRRSGEPYIMHPIAVAKIVCTEIGLGST
SICSALLHDVVEDTDYTVEDIENLFGPKIAQIVDGLTKISGGIFGDRASAQAENFKKLLLTMSDDIRVILIKIADRLHNM
RTLGSMLPNKQYKIAGETLYIYAPLANRLGLNKIKTELEDLSFKYEHPEEYAQIESKLQETQAEREEVFREFTAPIRAQL
DKMGISYQLIARVKSPYSIWNKMQTKHITFEEIYDILAVRIIFCPKNPEEELNECFNIYVSISKIYKPHPDRLRDWVSHP
KANGYQALHVTLMSNKGQWIEVQIRSERMNDVAEQGFAAHWKYKEGGGSEDEGELEKWLRTIKEILDDPQPDAMDFLDTI
KLNLFASEIFVFTPKGEIKTMPQNCTALDFAFSIHTFLGSHCIGAKVNHKLVPLSHKLQSGDQVEILTSKSQHVQPSWIN
FATTAKAKAKIQAILKREQRGMQQAGEEMLREFFSREGVEYTPENIRKICNLHTLKTQEELFAAIGFKTIILGENDKNEL
KDKPVSSNWKKYISFAFGGSKTNKEKPTEEKVPLPKIDSKKILKLTPEAIQKNYVIAECCKPIPGDDVLGYIGDNNRIII
HKRQCPLATKLKSSYGNRLLAVQWETGKSLYFPVNIYIKGIDHIGLLNKVTEIISQQLNVNIHKLNIESNDGIFEGRIQL
FVHDVDDVKSITTNLRKIDEIKTVTRIEKFEDEPN

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=134, Percent_Identity=33.5820895522388, Blast_Score=70, Evalue=1e-11,
Organism=Escherichia coli, GI1790082, Length=739, Percent_Identity=34.7767253044655, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI1789147, Length=590, Percent_Identity=33.0508474576271, Blast_Score=343, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI25143118, Length=134, Percent_Identity=34.3283582089552, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24650996, Length=147, Percent_Identity=31.9727891156463, Blast_Score=73, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 86305; Mature: 86174

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00090 NITROGENASE_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDEKQTQEQADEEMINQGFQELLDSYLATKHRKKVEIITKAFNFAKQAHKGVKRRSGEP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YIMHPIAVAKIVCTEIGLGSTSICSALLHDVVEDTDYTVEDIENLFGPKIAQIVDGLTKI
EEECHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHH
SGGIFGDRASAQAENFKKLLLTMSDDIRVILIKIADRLHNMRTLGSMLPNKQYKIAGETL
CCCCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEE
YIYAPLANRLGLNKIKTELEDLSFKYEHPEEYAQIESKLQETQAEREEVFREFTAPIRAQ
EEEECCHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDKMGISYQLIARVKSPYSIWNKMQTKHITFEEIYDILAVRIIFCPKNPEEELNECFNIY
HHHHCCHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHEEEEECCCCCHHHHHHHHHHH
VSISKIYKPHPDRLRDWVSHPKANGYQALHVTLMSNKGQWIEVQIRSERMNDVAEQGFAA
HHHHHHCCCCHHHHHHHHCCCCCCCCEEEEEEEEECCCCEEEEEECHHHHHHHHHCCCEE
HWKYKEGGGSEDEGELEKWLRTIKEILDDPQPDAMDFLDTIKLNLFASEIFVFTPKGEIK
EEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEEEEEECCCCCCE
TMPQNCTALDFAFSIHTFLGSHCIGAKVNHKLVPLSHKLQSGDQVEILTSKSQHVQPSWI
ECCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHCCCCCEEEEEECCCCCCCCCCC
NFATTAKAKAKIQAILKREQRGMQQAGEEMLREFFSREGVEYTPENIRKICNLHTLKTQE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHH
ELFAAIGFKTIILGENDKNELKDKPVSSNWKKYISFAFGGSKTNKEKPTEEKVPLPKIDS
HHHHHHCCEEEEECCCCHHHHCCCCCCCCHHHHHHHEECCCCCCCCCCCCCCCCCCCCCC
KKILKLTPEAIQKNYVIAECCKPIPGDDVLGYIGDNNRIIIHKRQCPLATKLKSSYGNRL
CHHEECCHHHHHCCCCHHHHCCCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHCCEE
LAVQWETGKSLYFPVNIYIKGIDHIGLLNKVTEIISQQLNVNIHKLNIESNDGIFEGRIQ
EEEEEECCCEEEEEEEEEEECCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEE
LFVHDVDDVKSITTNLRKIDEIKTVTRIEKFEDEPN
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TDEKQTQEQADEEMINQGFQELLDSYLATKHRKKVEIITKAFNFAKQAHKGVKRRSGEP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YIMHPIAVAKIVCTEIGLGSTSICSALLHDVVEDTDYTVEDIENLFGPKIAQIVDGLTKI
EEECHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHH
SGGIFGDRASAQAENFKKLLLTMSDDIRVILIKIADRLHNMRTLGSMLPNKQYKIAGETL
CCCCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEE
YIYAPLANRLGLNKIKTELEDLSFKYEHPEEYAQIESKLQETQAEREEVFREFTAPIRAQ
EEEECCHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDKMGISYQLIARVKSPYSIWNKMQTKHITFEEIYDILAVRIIFCPKNPEEELNECFNIY
HHHHCCHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHEEEEECCCCCHHHHHHHHHHH
VSISKIYKPHPDRLRDWVSHPKANGYQALHVTLMSNKGQWIEVQIRSERMNDVAEQGFAA
HHHHHHCCCCHHHHHHHHCCCCCCCCEEEEEEEEECCCCEEEEEECHHHHHHHHHCCCEE
HWKYKEGGGSEDEGELEKWLRTIKEILDDPQPDAMDFLDTIKLNLFASEIFVFTPKGEIK
EEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEEEEEECCCCCCE
TMPQNCTALDFAFSIHTFLGSHCIGAKVNHKLVPLSHKLQSGDQVEILTSKSQHVQPSWI
ECCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHCCCCCEEEEEECCCCCCCCCCC
NFATTAKAKAKIQAILKREQRGMQQAGEEMLREFFSREGVEYTPENIRKICNLHTLKTQE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHH
ELFAAIGFKTIILGENDKNELKDKPVSSNWKKYISFAFGGSKTNKEKPTEEKVPLPKIDS
HHHHHHCCEEEEECCCCHHHHCCCCCCCCHHHHHHHEECCCCCCCCCCCCCCCCCCCCCC
KKILKLTPEAIQKNYVIAECCKPIPGDDVLGYIGDNNRIIIHKRQCPLATKLKSSYGNRL
CHHEECCHHHHHCCCCHHHHCCCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHCCEE
LAVQWETGKSLYFPVNIYIKGIDHIGLLNKVTEIISQQLNVNIHKLNIESNDGIFEGRIQ
EEEEEECCCEEEEEEEEEEECCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEE
LFVHDVDDVKSITTNLRKIDEIKTVTRIEKFEDEPN
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383190; 9384377 [H]