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The map label for this gene is cobC [H]

Identifier: 150004422

GI number: 150004422

Start: 2440091

End: 2440609

Strand: Direct

Name: cobC [H]

Synonym: BVU_1869

Alternate gene names: 150004422

Gene position: 2440091-2440609 (Clockwise)

Preceding gene: 150004421

Following gene: 150004428

Centisome position: 47.26

GC content: 48.55

Gene sequence:

>519_bases
ATGATAACTTTATATTTAGCCCGTCACGGGCAGACAGAAGAGAATATCGCCCGTATTTTCCAAGGACATATGCCGGGCAC
GCTGACTGTTGAAGGAATAGCACAGGCTGAAGCGCTGCGTGATACTTTGCGGAATATCTCTTTGGATGCAGTGGTCAGTA
GTGATTTGAAACGGTGTGTGGATACGGCCCGTATCGCGGTGGAAGGTCGGAACCTGCCTTGGGAGAAAACGGTCTTGTTG
CGTGAAATCGATTGGGGGAGTTGGACAGGTCTTGCCATTAAAGAAGTTGATTTGCAACATTTTCCGGCAGATGTGGAAAC
GGAGGCAATGCTGTATGAGCGTGCGGGGCGTTTTGTGGACTACTTGAAAGAGCGATATGATGGAAAACAGGTGTTGGCAG
TCGGGCATGGACTGATAAACAGGGCGGTACAGGCACACATTCAAGGAGTGACTTTGGAACATTTACGTAGTGTGCCAAAG
ATGAATAATGCGGAACTACGCCGGTTCAAGTTAACGTAA

Upstream 100 bases:

>100_bases
ATCATCTGTCTGAAGATTGCTTTTCTTTGGAAAGGAGAATAAGAAGGTTGCCCTTTTGAAGTAAATCTGGCCGGTAAGCA
TTATCTTTGCATTAAAAAAG

Downstream 100 bases:

>100_bases
TTCCGCATTGAATAACACGTGGTTATTGCAAAGTGATTCCCATGATTCCTATCACCACATCATTGGACAGGGTTTCCAGG
GTCAGCCTTTTTAGTTCCTT

Product: putative phosphoglycerate mutase

Products: NA

Alternate protein names: Alpha-ribazole-5'-phosphate phosphatase [H]

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MITLYLARHGQTEENIARIFQGHMPGTLTVEGIAQAEALRDTLRNISLDAVVSSDLKRCVDTARIAVEGRNLPWEKTVLL
REIDWGSWTGLAIKEVDLQHFPADVETEAMLYERAGRFVDYLKERYDGKQVLAVGHGLINRAVQAHIQGVTLEHLRSVPK
MNNAELRRFKLT

Sequences:

>Translated_172_residues
MITLYLARHGQTEENIARIFQGHMPGTLTVEGIAQAEALRDTLRNISLDAVVSSDLKRCVDTARIAVEGRNLPWEKTVLL
REIDWGSWTGLAIKEVDLQHFPADVETEAMLYERAGRFVDYLKERYDGKQVLAVGHGLINRAVQAHIQGVTLEHLRSVPK
MNNAELRRFKLT
>Mature_172_residues
MITLYLARHGQTEENIARIFQGHMPGTLTVEGIAQAEALRDTLRNISLDAVVSSDLKRCVDTARIAVEGRNLPWEKTVLL
REIDWGSWTGLAIKEVDLQHFPADVETEAMLYERAGRFVDYLKERYDGKQVLAVGHGLINRAVQAHIQGVTLEHLRSVPK
MNNAELRRFKLT

Specific function: Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin [H]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family [H]

Homologues:

Organism=Escherichia coli, GI1786857, Length=147, Percent_Identity=32.6530612244898, Blast_Score=77, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6324857, Length=102, Percent_Identity=40.1960784313725, Blast_Score=68, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR017578 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =3.1.3.73 [H]

Molecular weight: Translated: 19475; Mature: 19475

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS00175 PG_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLYLARHGQTEENIARIFQGHMPGTLTVEGIAQAEALRDTLRNISLDAVVSSDLKRCV
CEEEEEECCCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
DTARIAVEGRNLPWEKTVLLREIDWGSWTGLAIKEVDLQHFPADVETEAMLYERAGRFVD
HHHHHEEECCCCCHHHHEEEEECCCCCCCCCEEEECCHHHCCCCCHHHHHHHHHHHHHHH
YLKERYDGKQVLAVGHGLINRAVQAHIQGVTLEHLRSVPKMNNAELRRFKLT
HHHHHCCCCEEEHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCEEEECC
>Mature Secondary Structure
MITLYLARHGQTEENIARIFQGHMPGTLTVEGIAQAEALRDTLRNISLDAVVSSDLKRCV
CEEEEEECCCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
DTARIAVEGRNLPWEKTVLLREIDWGSWTGLAIKEVDLQHFPADVETEAMLYERAGRFVD
HHHHHEEECCCCCHHHHEEEEECCCCCCCCCEEEECCHHHCCCCCHHHHHHHHHHHHHHH
YLKERYDGKQVLAVGHGLINRAVQAHIQGVTLEHLRSVPKMNNAELRRFKLT
HHHHHCCCCEEEHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]