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The map label for this gene is wecB [H]

Identifier: 150004113

GI number: 150004113

Start: 2036181

End: 2037341

Strand: Direct

Name: wecB [H]

Synonym: BVU_1548

Alternate gene names: 150004113

Gene position: 2036181-2037341 (Clockwise)

Preceding gene: 150004112

Following gene: 150004115

Centisome position: 39.44

GC content: 43.24

Gene sequence:

>1161_bases
ATGAAGAAAGTGATGTTGGTCTTCGGCACCCGTCCGGAGGCAATCAAGATGGCTCCGCTGGTGAAAGAATTCCAGAAACA
GCCAAAACGGGTAGAGACTGTGGTGTGCGTAACCGGACAGCATCGGGAAATGCTGGATCAGGTGTTGAAGATATTCGACA
TCAAACCGGATTATGATTTGAATATCATGAAGCAGGGACAGGATCTGTATGATGTGACCGCTCGTGTGCTGACCGGTATG
CGTGATGTACTGAAAGAGGTAAAGCCCGATGTGGTATTGGTACATGGGGATACTACCACTTCTACAGCTGCAGCTTTGGC
TGCTTTTTATCAACAGATACCGGTGGGACATGTGGAAGCTGGTTTGCGTACACATAATATTTATAGCCCATGGCCGGAGG
AGATGAATCGGTTGTTGACGGGGCGTCTGGCGACCTATCATTTTTCTCCCACTCCGTTAAGTCGTAATAATCTGATTAAA
GAGAGCGTTGATGACCGCAATATCATTATAACTGGTAACACAGTGATTGATGCACTTTATTGGGTAGTGGATAAAATCAA
GAACAACAAGGAGCTAGATAATGAATTGGAAGATATATTGAGCAAAGCGGGTTATGATGTAAACCGCTTGAACAATGGCA
AGAAGCTGGTATTGATTACAGGGCATCGTCGTGAGAATTTTGGTGACGGATTTATCAATATGTGTACAGCTATTAAAGAT
TTGACGGTTAAATATCCAGATTTGGATTTTGTTTATCCTATGCACTTGAATCCTAATGTACGCAAGCCGATTCATGAGGT
GTTCGGGGAGAATCTGTCCGGCTTAAAAAATATGTTCTTCATTGAACCATTGGAGTATTTGAGTTTTGTGTATCTAATGG
AGAAGAGCAGCATCGTATTGACAGATAGCGGTGGCATTCAAGAGGAAGCTCCGGGACTGGGTAAACCGGTATTGGTGATG
CGTGATACCACGGAGCGACCAGAAGCATTAGATGCCGGAACGGTGAAACTGGTAGGTACGGACTATAATAAGATTGTAAA
CGAAGTATCATCTTTGATTGATGATAAAGCAGCTTATGAAAAAATGAGTAAGGCTGTAAATCCGTACGGTGACGGATTAG
CCTGCGGACGTATTGTAAATGCATTGTTATATAGGATATAA

Upstream 100 bases:

>100_bases
CTTATCGCTTGATAAAAGAACCCAAAAGAATTAAACGTCAGATCCACTTGGTGAAGTATGCTTGGTGGCTGATGAAGAAA
AAATTATAAACAGAGGAAAT

Downstream 100 bases:

>100_bases
GCTGAGCTATGAAGCTGATACTGAAAAATATTTTTACAAATCGAAATACTTGTTATTACTTATGGTTTGCATTACCAAGA
GCTAATAAACTTAAAGTGAA

Product: putative UDP-GlcNAc 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MKKVMLVFGTRPEAIKMAPLVKEFQKQPKRVETVVCVTGQHREMLDQVLKIFDIKPDYDLNIMKQGQDLYDVTARVLTGM
RDVLKEVKPDVVLVHGDTTTSTAAALAAFYQQIPVGHVEAGLRTHNIYSPWPEEMNRLLTGRLATYHFSPTPLSRNNLIK
ESVDDRNIIITGNTVIDALYWVVDKIKNNKELDNELEDILSKAGYDVNRLNNGKKLVLITGHRRENFGDGFINMCTAIKD
LTVKYPDLDFVYPMHLNPNVRKPIHEVFGENLSGLKNMFFIEPLEYLSFVYLMEKSSIVLTDSGGIQEEAPGLGKPVLVM
RDTTERPEALDAGTVKLVGTDYNKIVNEVSSLIDDKAAYEKMSKAVNPYGDGLACGRIVNALLYRI

Sequences:

>Translated_386_residues
MKKVMLVFGTRPEAIKMAPLVKEFQKQPKRVETVVCVTGQHREMLDQVLKIFDIKPDYDLNIMKQGQDLYDVTARVLTGM
RDVLKEVKPDVVLVHGDTTTSTAAALAAFYQQIPVGHVEAGLRTHNIYSPWPEEMNRLLTGRLATYHFSPTPLSRNNLIK
ESVDDRNIIITGNTVIDALYWVVDKIKNNKELDNELEDILSKAGYDVNRLNNGKKLVLITGHRRENFGDGFINMCTAIKD
LTVKYPDLDFVYPMHLNPNVRKPIHEVFGENLSGLKNMFFIEPLEYLSFVYLMEKSSIVLTDSGGIQEEAPGLGKPVLVM
RDTTERPEALDAGTVKLVGTDYNKIVNEVSSLIDDKAAYEKMSKAVNPYGDGLACGRIVNALLYRI
>Mature_386_residues
MKKVMLVFGTRPEAIKMAPLVKEFQKQPKRVETVVCVTGQHREMLDQVLKIFDIKPDYDLNIMKQGQDLYDVTARVLTGM
RDVLKEVKPDVVLVHGDTTTSTAAALAAFYQQIPVGHVEAGLRTHNIYSPWPEEMNRLLTGRLATYHFSPTPLSRNNLIK
ESVDDRNIIITGNTVIDALYWVVDKIKNNKELDNELEDILSKAGYDVNRLNNGKKLVLITGHRRENFGDGFINMCTAIKD
LTVKYPDLDFVYPMHLNPNVRKPIHEVFGENLSGLKNMFFIEPLEYLSFVYLMEKSSIVLTDSGGIQEEAPGLGKPVLVM
RDTTERPEALDAGTVKLVGTDYNKIVNEVSSLIDDKAAYEKMSKAVNPYGDGLACGRIVNALLYRI

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=380, Percent_Identity=61.0526315789474, Blast_Score=461, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 43448; Mature: 43448

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVMLVFGTRPEAIKMAPLVKEFQKQPKRVETVVCVTGQHREMLDQVLKIFDIKPDYDL
CCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCC
NIMKQGQDLYDVTARVLTGMRDVLKEVKPDVVLVHGDTTTSTAAALAAFYQQIPVGHVEA
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCCHHHC
GLRTHNIYSPWPEEMNRLLTGRLATYHFSPTPLSRNNLIKESVDDRNIIITGNTVIDALY
CCEECCCCCCCHHHHHHHHHHHHEEEECCCCCCCCCCCHHHCCCCCEEEEECHHHHHHHH
WVVDKIKNNKELDNELEDILSKAGYDVNRLNNGKKLVLITGHRRENFGDGFINMCTAIKD
HHHHHHCCCCHHHHHHHHHHHHCCCCHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHH
LTVKYPDLDFVYPMHLNPNVRKPIHEVFGENLSGLKNMFFIEPLEYLSFVYLMEKSSIVL
CEEECCCCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHEECCCEEE
TDSGGIQEEAPGLGKPVLVMRDTTERPEALDAGTVKLVGTDYNKIVNEVSSLIDDKAAYE
ECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHH
KMSKAVNPYGDGLACGRIVNALLYRI
HHHHHCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKVMLVFGTRPEAIKMAPLVKEFQKQPKRVETVVCVTGQHREMLDQVLKIFDIKPDYDL
CCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCC
NIMKQGQDLYDVTARVLTGMRDVLKEVKPDVVLVHGDTTTSTAAALAAFYQQIPVGHVEA
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCCHHHC
GLRTHNIYSPWPEEMNRLLTGRLATYHFSPTPLSRNNLIKESVDDRNIIITGNTVIDALY
CCEECCCCCCCHHHHHHHHHHHHEEEECCCCCCCCCCCHHHCCCCCEEEEECHHHHHHHH
WVVDKIKNNKELDNELEDILSKAGYDVNRLNNGKKLVLITGHRRENFGDGFINMCTAIKD
HHHHHHCCCCHHHHHHHHHHHHCCCCHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHH
LTVKYPDLDFVYPMHLNPNVRKPIHEVFGENLSGLKNMFFIEPLEYLSFVYLMEKSSIVL
CEEECCCCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHEECCCEEE
TDSGGIQEEAPGLGKPVLVMRDTTERPEALDAGTVKLVGTDYNKIVNEVSSLIDDKAAYE
ECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHH
KMSKAVNPYGDGLACGRIVNALLYRI
HHHHHCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]