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The map label for this gene is mip [H]

Identifier: 150003993

GI number: 150003993

Start: 1906790

End: 1907374

Strand: Reverse

Name: mip [H]

Synonym: BVU_1427

Alternate gene names: 150003993

Gene position: 1907374-1906790 (Counterclockwise)

Preceding gene: 150003997

Following gene: 150003992

Centisome position: 36.94

GC content: 41.37

Gene sequence:

>585_bases
ATGGATAAATTCAGTTACGCCATCGGCCTTGGTATTGGCCAGAATTTATTGAGCATGGGTGCTCAAAGTATTAATGTTGA
AGACTTTGCTCAAGCAATCAAAGACGTATTAGATAGAAAAGAAACGGCTATCAGCCACAACGAAGCACGTGAAATCGTAA
ACAAGTACTTTGAAGAGCTGGAAACCAAATTGAATGCAGAGAATATTGAAAAGGGAAAATCATTTTTGGAGGAAAACGCA
AAAAGACCGGGGGTCGTGACACTTCCCAGCGGCTTACAGTACGAAGTTATCACAGAAGGTAACGGAAAAAAACCGAGTGC
AACCGACCGTGTAAAATGCCATTATGAAGGTACCTTGATTGATGGGACTTTGTTTGACAGTTCTATCAAACGCGGCGAAC
CGGCTATCTTTGGTGTGAACCAAGTAATCAAAGGATGGGTGGAAGCACTCCAACTGATGACTGAAGGTGCTAAATGGAAA
CTTTTCATTCCTTCAGAACTAGCCTATGGAGCACAACAGGCAGGAGAAATGATTCCTCCTCACAGCACATTGATTTTTGA
AGTAGAATTAATCGAAGTATTATAA

Upstream 100 bases:

>100_bases
CACAAAAATAAGAAAAATTAAATTGTTAAAAACAGATTCATTCAAATAAAACACCTACCTTTGTGCGTTTTGTATAAAAC
ATCTTATAAAATAAATAGTT

Downstream 100 bases:

>100_bases
TTATTAAAGCATTTAAGGCAAATGAAAAAAATTAGTTTTTTTGTAGCAATCGCTGCTGCAGCCAGCTTGGCTTCTTGTAC
AGCCCAAGCACCGAAAGCAA

Product: putative FkbP-type 22 kDa peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: Macrophage infectivity potentiator; Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MDKFSYAIGLGIGQNLLSMGAQSINVEDFAQAIKDVLDRKETAISHNEAREIVNKYFEELETKLNAENIEKGKSFLEENA
KRPGVVTLPSGLQYEVITEGNGKKPSATDRVKCHYEGTLIDGTLFDSSIKRGEPAIFGVNQVIKGWVEALQLMTEGAKWK
LFIPSELAYGAQQAGEMIPPHSTLIFEVELIEVL

Sequences:

>Translated_194_residues
MDKFSYAIGLGIGQNLLSMGAQSINVEDFAQAIKDVLDRKETAISHNEAREIVNKYFEELETKLNAENIEKGKSFLEENA
KRPGVVTLPSGLQYEVITEGNGKKPSATDRVKCHYEGTLIDGTLFDSSIKRGEPAIFGVNQVIKGWVEALQLMTEGAKWK
LFIPSELAYGAQQAGEMIPPHSTLIFEVELIEVL
>Mature_194_residues
MDKFSYAIGLGIGQNLLSMGAQSINVEDFAQAIKDVLDRKETAISHNEAREIVNKYFEELETKLNAENIEKGKSFLEENA
KRPGVVTLPSGLQYEVITEGNGKKPSATDRVKCHYEGTLIDGTLFDSSIKRGEPAIFGVNQVIKGWVEALQLMTEGAKWK
LFIPSELAYGAQQAGEMIPPHSTLIFEVELIEVL

Specific function: Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=92, Percent_Identity=50, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI17149844, Length=92, Percent_Identity=50, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI17149842, Length=92, Percent_Identity=50, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=42.4528301886792, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=42.4528301886792, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI4503727, Length=99, Percent_Identity=45.4545454545455, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4503729, Length=100, Percent_Identity=43, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=39.622641509434, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI192448443, Length=87, Percent_Identity=43.6781609195402, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI224809329, Length=96, Percent_Identity=41.6666666666667, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI224809327, Length=96, Percent_Identity=41.6666666666667, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI4758384, Length=96, Percent_Identity=41.6666666666667, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI8923659, Length=96, Percent_Identity=43.75, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI224809331, Length=96, Percent_Identity=41.6666666666667, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI87082390, Length=194, Percent_Identity=50.5154639175258, Blast_Score=181, Evalue=3e-47,
Organism=Escherichia coli, GI1789745, Length=129, Percent_Identity=50.3875968992248, Blast_Score=113, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=42.4528301886792, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17540882, Length=93, Percent_Identity=44.0860215053763, Blast_Score=73, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17561782, Length=97, Percent_Identity=46.3917525773196, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320727, Length=88, Percent_Identity=51.1363636363636, Blast_Score=87, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324194, Length=105, Percent_Identity=43.8095238095238, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323566, Length=129, Percent_Identity=34.8837209302326, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323482, Length=119, Percent_Identity=35.2941176470588, Blast_Score=62, Evalue=5e-11,
Organism=Drosophila melanogaster, GI281363946, Length=107, Percent_Identity=48.5981308411215, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17352457, Length=107, Percent_Identity=48.5981308411215, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=42.4528301886792, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21356629, Length=98, Percent_Identity=47.9591836734694, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=40.3846153846154, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008104
- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21446; Mature: 21446

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKFSYAIGLGIGQNLLSMGAQSINVEDFAQAIKDVLDRKETAISHNEAREIVNKYFEEL
CCCCCEEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETKLNAENIEKGKSFLEENAKRPGVVTLPSGLQYEVITEGNGKKPSATDRVKCHYEGTLI
HHHCCHHHHHHHHHHHHHCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCEEEEECCEEE
DGTLFDSSIKRGEPAIFGVNQVIKGWVEALQLMTEGAKWKLFIPSELAYGAQQAGEMIPP
ECHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHCHHHCCCCCCC
HSTLIFEVELIEVL
CCEEEEEEEEEECC
>Mature Secondary Structure
MDKFSYAIGLGIGQNLLSMGAQSINVEDFAQAIKDVLDRKETAISHNEAREIVNKYFEEL
CCCCCEEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETKLNAENIEKGKSFLEENAKRPGVVTLPSGLQYEVITEGNGKKPSATDRVKCHYEGTLI
HHHCCHHHHHHHHHHHHHCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCEEEEECCEEE
DGTLFDSSIKRGEPAIFGVNQVIKGWVEALQLMTEGAKWKLFIPSELAYGAQQAGEMIPP
ECHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHCHHHCCCCCCC
HSTLIFEVELIEVL
CCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7516906 [H]