Click here to switch to the map view.

The map label for this gene is fklB [H]

Identifier: 150003992

GI number: 150003992

Start: 1905902

End: 1906768

Strand: Reverse

Name: fklB [H]

Synonym: BVU_1426

Alternate gene names: 150003992

Gene position: 1906768-1905902 (Counterclockwise)

Preceding gene: 150003993

Following gene: 150003991

Centisome position: 36.93

GC content: 40.83

Gene sequence:

>867_bases
ATGAAAAAAATTAGTTTTTTTGTAGCAATCGCTGCTGCAGCCAGCTTGGCTTCTTGTACAGCCCAAGCACCGAAAGCAAA
CATGAAGAATGACGTAGACTCACTTTCTTACATGATGGGTATCACCAACACGCAAGGTCTGGATATGTATATGAGCCAAC
AACTGGGCGTTGACACAGCCTATATGGCCGACTTCATCAGAGGTGTTAAAGAAGGTACCAGCAAGACAAGTCCTAAAGAT
GTTGCTTATATGGCAGGTCTTCAGATTGGTCAACAAGTTGGTGGACGTATGTTCGATATGATGAGCCAACGTATTTTCGG
AAATGACTCTACTCAAAGTTTAAGTAAAGAAAACTTCCTGGCAGGTTTCATGGCTGCTTTGCAGAAAAAAGGCATGAATG
TTACTATGGAAGAAGCCAACGCCTACGTTCAGTCTAAAGCAGAAGCAATCAAAACAAAAGCTACTGAAGCCCAATTCGCT
GAAAATAAGGCTGCCGGTGAAAAATTCCTAGCTGAAAATGCAAAGAAAGAGGGTGTTAAAACTACATCAAGCGGATTGCA
ATATAAGATAATTAAAGAAGGTAACGGCGCTGTTCCTACCGATTCTTCTAAAGTAAAAGTAAACTATAAAGGTACTTTGA
TTGACGGAACTCAGTTCGACAGTTCATATGATCGTAAAGAACCGACTACTTTCCGTGCTAATCAAGTAATCAAAGGATGG
ACTGAAGCACTGACAATGATGCCAGTAGGTTCTAAATGGGAACTTTACATCCCTCAAGACTTGGCTTATGGTGCACGTGA
AGCCGGTCAGATTAAACCTTTCTCTACTTTGATTTTCGAAGTAGAACTGGTTGGAATCGAAAAATAA

Upstream 100 bases:

>100_bases
TGGAGCACAACAGGCAGGAGAAATGATTCCTCCTCACAGCACATTGATTTTTGAAGTAGAATTAATCGAAGTATTATAAT
TATTAAAGCATTTAAGGCAA

Downstream 100 bases:

>100_bases
CCTCATTTTAATACGATTTACAAAAAAGCGTGGAACATTCGTGTCTCACGCTTTTCTTTTAACTTGTCCTTCTACAAAGG
GACATTCATTAAATATTACA

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: FKBP22; PPIase; Rotamase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MKKISFFVAIAAAASLASCTAQAPKANMKNDVDSLSYMMGITNTQGLDMYMSQQLGVDTAYMADFIRGVKEGTSKTSPKD
VAYMAGLQIGQQVGGRMFDMMSQRIFGNDSTQSLSKENFLAGFMAALQKKGMNVTMEEANAYVQSKAEAIKTKATEAQFA
ENKAAGEKFLAENAKKEGVKTTSSGLQYKIIKEGNGAVPTDSSKVKVNYKGTLIDGTQFDSSYDRKEPTTFRANQVIKGW
TEALTMMPVGSKWELYIPQDLAYGAREAGQIKPFSTLIFEVELVGIEK

Sequences:

>Translated_288_residues
MKKISFFVAIAAAASLASCTAQAPKANMKNDVDSLSYMMGITNTQGLDMYMSQQLGVDTAYMADFIRGVKEGTSKTSPKD
VAYMAGLQIGQQVGGRMFDMMSQRIFGNDSTQSLSKENFLAGFMAALQKKGMNVTMEEANAYVQSKAEAIKTKATEAQFA
ENKAAGEKFLAENAKKEGVKTTSSGLQYKIIKEGNGAVPTDSSKVKVNYKGTLIDGTQFDSSYDRKEPTTFRANQVIKGW
TEALTMMPVGSKWELYIPQDLAYGAREAGQIKPFSTLIFEVELVGIEK
>Mature_288_residues
MKKISFFVAIAAAASLASCTAQAPKANMKNDVDSLSYMMGITNTQGLDMYMSQQLGVDTAYMADFIRGVKEGTSKTSPKD
VAYMAGLQIGQQVGGRMFDMMSQRIFGNDSTQSLSKENFLAGFMAALQKKGMNVTMEEANAYVQSKAEAIKTKATEAQFA
ENKAAGEKFLAENAKKEGVKTTSSGLQYKIIKEGNGAVPTDSSKVKVNYKGTLIDGTQFDSSYDRKEPTTFRANQVIKGW
TEALTMMPVGSKWELYIPQDLAYGAREAGQIKPFSTLIFEVELVGIEK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm. Periplasm. Note=According to PubMed:7610040 it is periplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=42.0560747663551, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=42.0560747663551, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=40.1869158878505, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI206725530, Length=97, Percent_Identity=44.3298969072165, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI17149844, Length=97, Percent_Identity=44.3298969072165, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI17149842, Length=97, Percent_Identity=44.3298969072165, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI4503729, Length=100, Percent_Identity=44, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI87082390, Length=209, Percent_Identity=47.3684210526316, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1789745, Length=180, Percent_Identity=42.7777777777778, Blast_Score=133, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17540882, Length=89, Percent_Identity=46.0674157303371, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=40.5660377358491, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17561782, Length=99, Percent_Identity=48.4848484848485, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=95, Percent_Identity=48.4210526315789, Blast_Score=79, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6324194, Length=100, Percent_Identity=46, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=44.8598130841121, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281363946, Length=84, Percent_Identity=52.3809523809524, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17352457, Length=84, Percent_Identity=52.3809523809524, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24583150, Length=107, Percent_Identity=40.1869158878505, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21356629, Length=87, Percent_Identity=44.8275862068966, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 31371; Mature: 31371

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKISFFVAIAAAASLASCTAQAPKANMKNDVDSLSYMMGITNTQGLDMYMSQQLGVDTA
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHH
YMADFIRGVKEGTSKTSPKDVAYMAGLQIGQQVGGRMFDMMSQRIFGNDSTQSLSKENFL
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AGFMAALQKKGMNVTMEEANAYVQSKAEAIKTKATEAQFAENKAAGEKFLAENAKKEGVK
HHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
TTSSGLQYKIIKEGNGAVPTDSSKVKVNYKGTLIDGTQFDSSYDRKEPTTFRANQVIKGW
ECCCCCEEEEEECCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHH
TEALTMMPVGSKWELYIPQDLAYGAREAGQIKPFSTLIFEVELVGIEK
HHHHHHCCCCCCEEEECCHHHHHCCCCCCCCCCHHEEEEEEEEEEECC
>Mature Secondary Structure
MKKISFFVAIAAAASLASCTAQAPKANMKNDVDSLSYMMGITNTQGLDMYMSQQLGVDTA
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHH
YMADFIRGVKEGTSKTSPKDVAYMAGLQIGQQVGGRMFDMMSQRIFGNDSTQSLSKENFL
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AGFMAALQKKGMNVTMEEANAYVQSKAEAIKTKATEAQFAENKAAGEKFLAENAKKEGVK
HHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
TTSSGLQYKIIKEGNGAVPTDSSKVKVNYKGTLIDGTQFDSSYDRKEPTTFRANQVIKGW
ECCCCCEEEEEECCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHH
TEALTMMPVGSKWELYIPQDLAYGAREAGQIKPFSTLIFEVELVGIEK
HHHHHHCCCCCCEEEECCHHHHHCCCCCCCCCCHHEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 8703024; 9298646 [H]