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The map label for this gene is sdhA [H]

Identifier: 150003808

GI number: 150003808

Start: 1663999

End: 1665963

Strand: Direct

Name: sdhA [H]

Synonym: BVU_1240

Alternate gene names: 150003808

Gene position: 1663999-1665963 (Clockwise)

Preceding gene: 150003807

Following gene: 150003809

Centisome position: 32.23

GC content: 47.33

Gene sequence:

>1965_bases
ATGAATATGGCTACTATAGATTCTAAAATTCCTGAAGGCGCTTTAGCCGAGAAATGGACCAATTATAAAGCTCATCAAAA
ATTGGTAAACCCTGCCAACAAACGTCGTCTTGACATTATTGTGGTAGGTACCGGTTTGGCAGGTGCTTCGGCTGCTGCTT
CACTGGGTGCTCTGGGTTTCAAGGTATTAAACTTCTGTATCCAGGACTCTCCCCGTCGTGCACACTCTATTGCTGCACAG
GGAGGTATCAATGCTGCTAAGAATTATCAAAATGATGGTGACTCTGTTTACCGTCTTTTCTACGATACAATCAAAGGTGG
TGACTACCGTGCACGCGAAGCTAACGTTTATCGTCTGGCCGAAGTGTCAAATGCTATCATCGACCAGTGCGTAGCTCAAG
GTGTTCCTTTCGCTCGCGAATACGGTGGTTTGCTGGATAACCGTTCATTCGGTGGTGCTCAGGTATCACGTACATTCTAT
GCCCGCGGTCAAACCGGACAGCAGTTGTTGCTGGGTGCTTATTCTGCATTGAGCCGTGAAGTTCAGCGTGGTAACGTGAA
GTTGTACACTCGTTATGAGATGTTGGACGTTGTGCTGATTAAGGATAACGAAGGTGTGGAACGCGCCCGTGGTATCATCG
CCCGTAATTTGGTTACAGGTAAGATTGAACGTTTCGCTGCCCATGCGGTAGTTATCGGTACCGGCGGTTATGGTAATACT
TACTTCTTGTCTACCAACGCTATGGCGTCAAATGGTTCGGCTGCTATGCAGGTTTACCGCAAAGGTGCTTACTTTGCCAA
TCCTTGCTTTGCACAGATCCACCCGACTTGTATCCCTGTACACGGTGACAAGCAGTCTAAACTGACTTTGATGTCCGAGT
CATTGCGTAATGACGGACGTATCTGGGTTCCGAAAAAGCTGGAAGATGCCAAGGCATTGCAGGCAGGAACTAAGAAACCG
ACCGATATTCCTGATGCAGACCGTGACTTCTACTTGGAACGCCGTTATCCGGCATTCGGTAACCTGGTTCCCCGTGACGT
TGCTTCACGTGCTGCGAAAGAACGTTGCGACGCCGGTTTCGGTGTGAACAACACAGGTCTGGCCGTATTCCTTGACTTTA
AATACGCTATCGACCGTCTGGGTGAAGATGTAGTTCGTGCCCGTTACGGTAACTTGTTCGATATGTACGAAGAAATCACT
GACGAAAATCCGTACAAGACTCCGATGATGATCTTCCCGGCTATCCACTATACGATGGGTGGTATCTGGGTTGACTATGA
ACTGATGACTTCTATCAAGGGCTTGTATGCTATCGGTGAAGCTAACTTCTCTGACCACGGTGCAAACCGTTTGGGTGCAT
CTGCATTGATGCAGGGATTGGCTGACGGTTACTTCGTATTGCCTTATACTATCCAGAACTATTTGTCAGACCAGATTCAG
GTTCCCCGTTTCTCGACAGACCTTCCTGAATTTGTGGCTGCCGAAAAGGCTGTAAACGATAAGATCCAGAAACTGATGAA
TATCAAGGGTCATCGTTCAGTAGACTCTATTCACAAGGAACTGGGCCACATCATGTGGGACTTCGTAGGTATGGGACGTA
CCAAGGAATCTTTGACTACTGCTCTGGCTAAACTGAAAGAAGTAAGAAAGACCTTCTGGAGCGACCTTCGCATTCCGGGT
GAAGCTAATGAATTGAATGTGGAACTTGAAAAGGCGATCCGCCTGGCTGATTTCATCGAAATCGGTGAGCTGATGGCTTA
CGATGCATTGAACCGTGAGGAATCTTGTGGTGGTCACTTCCGTGAAGAACACCAGACTCCGGAGGGTGAAGCGCTTCGTC
ACGATGACAAGTTCTCGTATGTAGCTTGCTGGAAATACACAGGTGAAGGAAAAGAACCCGAATTGATCAAGGAAGATTTG
AACTATCAGTTCGTTAAGGTTCAAACTCGTAACTATAAGTCTTAA

Upstream 100 bases:

>100_bases
TTGGTAGTTCTTGGTTTTGCAGCAGTAGTCGTTATCTACTTCGTGAAATCACTCGCTTGTGGTGCTTGCTAATCGTAAAT
TGTAAATGATAAAATTGTAA

Downstream 100 bases:

>100_bases
TTATTAATTGTATAGAAATCATGGATAAAAATATAAGTTTCACACTGAAAGTTTGGCGTCAGAAAGGTCCTAAGGATAAA
GGACATTTTGATACCTTCCA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 654; Mature: 654

Protein sequence:

>654_residues
MNMATIDSKIPEGALAEKWTNYKAHQKLVNPANKRRLDIIVVGTGLAGASAAASLGALGFKVLNFCIQDSPRRAHSIAAQ
GGINAAKNYQNDGDSVYRLFYDTIKGGDYRAREANVYRLAEVSNAIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFY
ARGQTGQQLLLGAYSALSREVQRGNVKLYTRYEMLDVVLIKDNEGVERARGIIARNLVTGKIERFAAHAVVIGTGGYGNT
YFLSTNAMASNGSAAMQVYRKGAYFANPCFAQIHPTCIPVHGDKQSKLTLMSESLRNDGRIWVPKKLEDAKALQAGTKKP
TDIPDADRDFYLERRYPAFGNLVPRDVASRAAKERCDAGFGVNNTGLAVFLDFKYAIDRLGEDVVRARYGNLFDMYEEIT
DENPYKTPMMIFPAIHYTMGGIWVDYELMTSIKGLYAIGEANFSDHGANRLGASALMQGLADGYFVLPYTIQNYLSDQIQ
VPRFSTDLPEFVAAEKAVNDKIQKLMNIKGHRSVDSIHKELGHIMWDFVGMGRTKESLTTALAKLKEVRKTFWSDLRIPG
EANELNVELEKAIRLADFIEIGELMAYDALNREESCGGHFREEHQTPEGEALRHDDKFSYVACWKYTGEGKEPELIKEDL
NYQFVKVQTRNYKS

Sequences:

>Translated_654_residues
MNMATIDSKIPEGALAEKWTNYKAHQKLVNPANKRRLDIIVVGTGLAGASAAASLGALGFKVLNFCIQDSPRRAHSIAAQ
GGINAAKNYQNDGDSVYRLFYDTIKGGDYRAREANVYRLAEVSNAIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFY
ARGQTGQQLLLGAYSALSREVQRGNVKLYTRYEMLDVVLIKDNEGVERARGIIARNLVTGKIERFAAHAVVIGTGGYGNT
YFLSTNAMASNGSAAMQVYRKGAYFANPCFAQIHPTCIPVHGDKQSKLTLMSESLRNDGRIWVPKKLEDAKALQAGTKKP
TDIPDADRDFYLERRYPAFGNLVPRDVASRAAKERCDAGFGVNNTGLAVFLDFKYAIDRLGEDVVRARYGNLFDMYEEIT
DENPYKTPMMIFPAIHYTMGGIWVDYELMTSIKGLYAIGEANFSDHGANRLGASALMQGLADGYFVLPYTIQNYLSDQIQ
VPRFSTDLPEFVAAEKAVNDKIQKLMNIKGHRSVDSIHKELGHIMWDFVGMGRTKESLTTALAKLKEVRKTFWSDLRIPG
EANELNVELEKAIRLADFIEIGELMAYDALNREESCGGHFREEHQTPEGEALRHDDKFSYVACWKYTGEGKEPELIKEDL
NYQFVKVQTRNYKS
>Mature_654_residues
MNMATIDSKIPEGALAEKWTNYKAHQKLVNPANKRRLDIIVVGTGLAGASAAASLGALGFKVLNFCIQDSPRRAHSIAAQ
GGINAAKNYQNDGDSVYRLFYDTIKGGDYRAREANVYRLAEVSNAIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFY
ARGQTGQQLLLGAYSALSREVQRGNVKLYTRYEMLDVVLIKDNEGVERARGIIARNLVTGKIERFAAHAVVIGTGGYGNT
YFLSTNAMASNGSAAMQVYRKGAYFANPCFAQIHPTCIPVHGDKQSKLTLMSESLRNDGRIWVPKKLEDAKALQAGTKKP
TDIPDADRDFYLERRYPAFGNLVPRDVASRAAKERCDAGFGVNNTGLAVFLDFKYAIDRLGEDVVRARYGNLFDMYEEIT
DENPYKTPMMIFPAIHYTMGGIWVDYELMTSIKGLYAIGEANFSDHGANRLGASALMQGLADGYFVLPYTIQNYLSDQIQ
VPRFSTDLPEFVAAEKAVNDKIQKLMNIKGHRSVDSIHKELGHIMWDFVGMGRTKESLTTALAKLKEVRKTFWSDLRIPG
EANELNVELEKAIRLADFIEIGELMAYDALNREESCGGHFREEHQTPEGEALRHDDKFSYVACWKYTGEGKEPELIKEDL
NYQFVKVQTRNYKS

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=553, Percent_Identity=26.9439421338156, Blast_Score=158, Evalue=1e-38,
Organism=Escherichia coli, GI1790597, Length=558, Percent_Identity=29.0322580645161, Blast_Score=195, Evalue=8e-51,
Organism=Escherichia coli, GI1786942, Length=557, Percent_Identity=26.032315978456, Blast_Score=141, Evalue=2e-34,
Organism=Escherichia coli, GI1788928, Length=592, Percent_Identity=26.0135135135135, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17505833, Length=555, Percent_Identity=27.5675675675676, Blast_Score=168, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17550100, Length=552, Percent_Identity=27.3550724637681, Blast_Score=154, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6322701, Length=594, Percent_Identity=29.96632996633, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6322416, Length=588, Percent_Identity=28.5714285714286, Blast_Score=187, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6320788, Length=492, Percent_Identity=25.2032520325203, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17137288, Length=600, Percent_Identity=27.5, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24655642, Length=600, Percent_Identity=27.5, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24655647, Length=600, Percent_Identity=27.5, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24663005, Length=591, Percent_Identity=26.3959390862944, Blast_Score=149, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 72894; Mature: 72894

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMATIDSKIPEGALAEKWTNYKAHQKLVNPANKRRLDIIVVGTGLAGASAAASLGALGF
CCCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHH
KVLNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKGGDYRAREANVYRLA
HHHHHHHCCCCHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHH
EVSNAIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFYARGQTGQQLLLGAYSALSRE
HHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHH
VQRGNVKLYTRYEMLDVVLIKDNEGVERARGIIARNLVTGKIERFAAHAVVIGTGGYGNT
HHCCCEEEEEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCE
YFLSTNAMASNGSAAMQVYRKGAYFANPCFAQIHPTCIPVHGDKQSKLTLMSESLRNDGR
EEEECCCCCCCCHHHHHHHHCCCCCCCCCHHCCCCEEEEECCCCCHHHHHHHHHHCCCCE
IWVPKKLEDAKALQAGTKKPTDIPDADRDFYLERRYPAFGNLVPRDVASRAAKERCDAGF
EECCCCCCHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCC
GVNNTGLAVFLDFKYAIDRLGEDVVRARYGNLFDMYEEITDENPYKTPMMIFPAIHYTMG
CCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCEEHHHHHHHHC
GIWVDYELMTSIKGLYAIGEANFSDHGANRLGASALMQGLADGYFVLPYTIQNYLSDQIQ
CEEEHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCEE
VPRFSTDLPEFVAAEKAVNDKIQKLMNIKGHRSVDSIHKELGHIMWDFVGMGRTKESLTT
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
ALAKLKEVRKTFWSDLRIPGEANELNVELEKAIRLADFIEIGELMAYDALNREESCGGHF
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
REEHQTPEGEALRHDDKFSYVACWKYTGEGKEPELIKEDLNYQFVKVQTRNYKS
HHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHCCCEEEEEEECCCCCC
>Mature Secondary Structure
MNMATIDSKIPEGALAEKWTNYKAHQKLVNPANKRRLDIIVVGTGLAGASAAASLGALGF
CCCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHH
KVLNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKGGDYRAREANVYRLA
HHHHHHHCCCCHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHH
EVSNAIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFYARGQTGQQLLLGAYSALSRE
HHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHH
VQRGNVKLYTRYEMLDVVLIKDNEGVERARGIIARNLVTGKIERFAAHAVVIGTGGYGNT
HHCCCEEEEEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCE
YFLSTNAMASNGSAAMQVYRKGAYFANPCFAQIHPTCIPVHGDKQSKLTLMSESLRNDGR
EEEECCCCCCCCHHHHHHHHCCCCCCCCCHHCCCCEEEEECCCCCHHHHHHHHHHCCCCE
IWVPKKLEDAKALQAGTKKPTDIPDADRDFYLERRYPAFGNLVPRDVASRAAKERCDAGF
EECCCCCCHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCC
GVNNTGLAVFLDFKYAIDRLGEDVVRARYGNLFDMYEEITDENPYKTPMMIFPAIHYTMG
CCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCEEHHHHHHHHC
GIWVDYELMTSIKGLYAIGEANFSDHGANRLGASALMQGLADGYFVLPYTIQNYLSDQIQ
CEEEHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCEE
VPRFSTDLPEFVAAEKAVNDKIQKLMNIKGHRSVDSIHKELGHIMWDFVGMGRTKESLTT
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
ALAKLKEVRKTFWSDLRIPGEANELNVELEKAIRLADFIEIGELMAYDALNREESCGGHF
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
REEHQTPEGEALRHDDKFSYVACWKYTGEGKEPELIKEDLNYQFVKVQTRNYKS
HHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]